P. Jenner

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The Copper Transport Protein Atox1 Promotes Neuronal Survival*

R. Maki, D. Bredesen, Moonhee Lee, 2000, The Journal of Biological Chemistry.

P. Jenner, J. Gorrod, 1975 .

The analysis of nicotine‐1‘‐N‐oxide in urine, in the presence of nicotine and cotinine, and its application to the study of in vivo nicotine metabolism in man

P. Jenner, A. Beckett, J. Gorrod, 1971, The Journal of pharmacy and pharmacology.

CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months

A. Clow, V. Glover, P. Jenner, 2000, Neuroscience Letters.

Altered Glial Function Causes Neuronal Death and Increases Neuronal Susceptibility to 1‐Methyl‐4‐Phenylpyridinium‐ and 6‐Hydroxydopamine‐Induced Toxicity in Astrocytic/Ventral Mesencephalic Co‐Cultures

K. McNaught, P. Jenner, P. Jenner, 1999, Journal of neurochemistry.

Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation.

K. McNaught, P. Jenner, 2000, Biochemical pharmacology.

Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production

Moonhee Lee, B. Halliwell, M. Lee, 2001, Journal of neurochemistry.

Impaired clearance of oxidised proteins in neurodegenerative diseases

B. Halliwell, P. Jenner, 1998, The Lancet.

The skin as a drug-metabolizing organ.

B. Testa, A. Pannatier, P. Jenner, 1978, Drug metabolism reviews.

Alterations in m-RNA expression for Cu,Zn-superoxide dismutase and glutathione peroxidase in the basal ganglia of MPTP-treated marmosets and patients with Parkinson’s disease

P. Jenner, G. Kunikowska, 2003, Brain Research.

6-Hydroxydopamine-lesioning of the nigrostriatal pathway in rats alters basal ganglia mRNA for copper, zinc- and manganese-superoxide dismutase, but not glutathione peroxidase

P. Jenner, G. Kunikowska, 2001, Brain Research.

Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species

A. Lees, S. Daniel, B. Halliwell, 1998, Journal of neurochemistry.

Effect of overexpression of wild‐type or mutant parkin on the cellular response induced by toxic insults

Moonhee Lee, B. Halliwell, P. Jenner, 2005, Journal of neuroscience research.

Toxic Effects of Sulphite in Combination with Peroxynitrite on Neuronal Cells

M. Reist, B. Halliwell, M. Reist, 1998, Journal of neurochemistry.

Intense oxidative DNA damage promoted by l‐DOPA and its metabolites implications for neurodegenerative disease

A. Lees, D. Dexter, B. Halliwell, 1994, FEBS letters.

Inhibition of &agr;‐Ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1 ‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

P. Carrupt, B. Testa, K. McNaught, 1995, Neuroreport.

Effect of overexpression of wild‐type and mutant Cu/Zn‐superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis

Moonhee Lee, B. Halliwell, P. Jenner, 2001, Journal of neurochemistry.

Effect of overexpression of wild‐type and mutant Cu/Zn‐superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4‐hydroxynonenal or serum deprivation: potentiation of injury by ALS‐related mutant superoxide dismutases and protection by Bcl‐2

Moonhee Lee, B. Halliwell, P. Jenner, 2001, Journal of neurochemistry.

Artefacts in HPLC Detection of 3‐Nitrotyrosine in Human Brain Tissue

B. Halliwell, L. Lyras, P. Jenner, 1998, Journal of neurochemistry.

Brain iron in the ferrocene-loaded rat: its chelation and influence on dopamine metabolism.

D. Dexter, R. Crichton, R. Hider, 1995, Biochemical pharmacology.

The neuronal toxicity of sulfite plus peroxynitrite is enhanced by glutathione depletion: implications for Parkinson's disease.

B. Halliwell, M. Reist, P. Jenner, 1999, Free radical biology & medicine.

6-Hydroxydopamine increases hydroxyl free radical production and DNA damage in rat striatum

B. Halliwell, A. Jenner, S. Rose, 2001, Neuroreport.

Effects of desferrithiocin and its derivatives on peripheral iron and striatal dopamine and 5-hydroxytryptamine metabolism in the ferrocene-loaded rat.

D. Dexter, R. Crichton, R. Ward, 1999, Biochemical pharmacology.

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.

B. Halliwell, M. Lee, P. Jenner, 2001, Journal of neurochemistry.

5‐S‐Cysteinyl‐conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase‐3 activity in neurons

B. Halliwell, M. Whiteman, J. Spencer, 2002, Journal of neurochemistry.

Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome.

L. Ellerby, D. Bredesen, B. Halliwell, 2001, Free radical biology & medicine.

Uptake and metabolism of epicatechin and its access to the brain after oral ingestion.

C. Rice-Evans, A. Rechner, Gunter K. Kuhnle, 2002, Free radical biology & medicine.

A possible relation between pKa1 and lipid solubility and the amounts excreted in urine of some tobacco alkaloids given to man

P. Jenner, A. Beckett, J. Gorrod, 1972, The Journal of pharmacy and pharmacology.

Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs.

D. Dexter, O. Aruoma, B. Halliwell, 1995, Biochemical pharmacology.

Preliminary investigation of the metabolism of piribedil (ET 495); a new central dopaminergic agonist and potential anti‐parkinson agent

P. Jenner, D. Campbell, A. Taylor, 1973, The Journal of pharmacy and pharmacology.

The absorption of nicotine-1'-N-oxide and its reduction in the gastro-intestinal tract in man.

P. Jenner, A. Beckett, J. Gorrod, 1973, Xenobiotica; the fate of foreign compounds in biological systems.

The influence of stereochemical factors on drug disposition.

B. Testa, P. Jenner, 1973, Drug metabolism reviews.

The thermodynamics of agonist and antagonist binding to dopamine D-2 receptors.

C. Marsden, H. van de Waterbeemd, B. Testa, 1986, Molecular pharmacology.

Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

C. Marsden, P. Carrupt, B. Testa, 1995, Neuroreport.

Xenobiotic metabolism by brain monooxygenases and other cerebral enzymes

B. Testa, M. Mesnil, P. Jenner, 1984 .

Novel pathways in drug metabolism.

B. Testa, P. Jenner, 1978, Xenobiotica; the fate of foreign compounds in biological systems.

Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo.

E. Perry, P. Houghton, N. Perry, 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Inhibitors of Cytochrome P-450s and their mechanism of action.

B. Testa, P. Jenner, 1981, Drug metabolism reviews.

Drug Metabolism: Chemical and Biochemical Aspects

Bernard Testa, B. Testa, P Jenner, 1976 .

The concept of regioselectivity in drug metabolism

B. Testa, P. Jenner, 1976, The Journal of pharmacy and pharmacology.

The role of nitrogen oxidation in the excretion of drugs and foreign compounds.

P. Jenner, 1971, Xenobiotica; the fate of foreign compounds in biological systems.

Basicity, Lipophilicity, and Lack of Receptor Interaction of N‐Aminoalkylbenzamides and N‐Aminoalkyl‐o‐anisamides as Model Compounds of Dopamine Antagonists

C. Marsden, B. Testa, H. Waterbeemd, 1983 .

Characterization of food antioxidants, illustrated using commercial garlic and ginger preparations

B. Halliwell, J. Spencer, O. Aruoma, 1997 .

Oxidative damage in neurodegenerative disease

P. Jenner, 1994, The Lancet.

Oxidative metabolism of nicotine by cigarette smokers with cancer of the urinary bladder.

P. Jenner, J. Gorrod, G. Keysell, 1974, Journal of the National Cancer Institute.

Evaluation of the pro-oxidant and antioxidant actions of L-DOPA and dopamine in vitro: implications for Parkinson's disease.

D. Dexter, O. Aruoma, B. Halliwell, 1996, Free radical research.

Concepts in drug metabolism

B. Testa, P. Jenner, 1980 .

Novel drug metabolites produced by functionalization reactions: chemistry and toxicology.

B. Testa, P. Jenner, 1978, Drug metabolism reviews.

Toxication of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and analogs by monoamine oxidase. A structure-reactivity relationship study.

N el Tayar, B Testa, P. Carrupt, 1990, Biochemical pharmacology.

Upregulation of the anti-apoptotic protein Bcl-2 may be an early event in neurodegeneration: studies on Parkinson's and incidental Lewy body disease.

N. Cairns, S. Daniel, B. Halliwell, 1997, Biochemical and biophysical research communications.

Species Variation in the Metabolism of R-(+)- and S-(-)-Nicotine by α-C- and N-Oxidation in vitro

P. Jenner, A. Beckett, J. Gorrod, 1973 .

Factors affecting the in vitro metabolism of R-(+)- and S-(-)-nicotine by guinea-pig liver preparations.

P. Jenner, A. Beckett, J. Gorrod, 1973, Xenobiotica; the fate of foreign compounds in biological systems.

Characterization of the diastereoisomers of nicotine-1'-N-oxide, a metabolite of nicotine, and other possible oxidation products by nuclear magnetic resonance spectroscopy.

P. Jenner, A. Beckett, J. Gorrod, 1973, Xenobiotica; the fate of foreign compounds in biological systems.

Selective inhibition of alternative oxidative pathways of nicotine metabolism.

P. Jenner, A. Beckett, J. Gorrod, 1971, Chemico-biological interactions.

Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins

Moonhee Lee, B. Halliwell, P. Jenner, 2003, Journal of neurochemistry.

Expression of a Gene for a Porin-Like Protein of the OmpA Family from Mycobacterium tuberculosisH37Rv

K. Papavinasasundaram, E. Lea, P. Draper, 1998, Journal of bacteriology.

Interference with ubiquitination causes oxidative damage and increased protein nitration: implications for neurodegenerative diseases

B. Halliwell, D. Gray, P. Jenner, 2004, Journal of neurochemistry.

Proteasomal dysfunction induced by 4‐hydroxy‐2,3‐trans‐nonenal, an end‐product of lipid peroxidation: a mechanism contributing to neurodegeneration?

B. Halliwell, M. Lee, P. Jenner, 2002, Journal of neurochemistry.

Effect of Wild-type or Mutant Parkin on Oxidative Damage, Nitric Oxide, Antioxidant Defenses, and the Proteasome*

N. Hattori, Moonhee Lee, B. Halliwell, 2002, The Journal of Biological Chemistry.

Effect of the overexpression of wild‐type or mutant α‐synuclein on cell susceptibility to insult

MoonHee Lee, Barry Halliwell, Dong-Hoon Hyun, 2001 .

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

N. Cairns, B. Halliwell, A. Jenner, 1997, Journal of neurochemistry.

Aryl hydrocarbon hydroxylase in rat brain microsomes

B. Testa, M. Mesnil, P. Jenner, 1985 .

Oxidative Damage to Proteins, Lipids, and DNA in Cortical Brain Regions from Patients with Dementia with Lewy Bodies

E. Perry, B. Halliwell, P. Ince, 1998, Journal of neurochemistry.

The effect of smoking on nicotine metabolism in vivo in man

P. Jenner, A. Beckett, J. W. GORROD, 1971, The Journal of pharmacy and pharmacology.

Cystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units

B. Tang, Zhuohua Zhang, Jiahong Lu, 2017, Cell Death & Disease.

Comparative in vitro hepatic metabolism of some tertiary N-methyl tobacco alkaloids in various species.

P. Jenner, J. Gorrod, 1973, Research communications in chemical pathology and pharmacology.

Species variation in the metabolism of R-(+)- and S-(-)-nicotine by alpha-C- and N-oxidation in vitro.

P. Jenner, A. Beckett, J. Gorrod, 1973, Xenobiotica; the fate of foreign compounds in biological systems.

Absorption of (−)‐nicotine‐1′‐N‐oxide in man and its reduction in the gastrointestinal tract

P. Jenner, A. Beckett, J. Gorrod, 1970, The Journal of pharmacy and pharmacology.

The distribution of copper, zinc- and manganese-superoxide dismutase, and glutathione peroxidase messenger ribonucleic acid in rat basal ganglia.

P. Jenner, G. Kunikowska, 2002, Biochemical pharmacology.

No Evidence for Increased Oxidative Damage to Lipids, Proteins, or DNA in Huntington's Disease

B. Halliwell, P. Jenner, Z. Alam, 2000, Journal of neurochemistry.

Do thermodynamic studies provide information on both the binding to and the activation of dopaminergic and other receptors?

C. Marsden, H. van de Waterbeemd, B. Testa, 1987, Biochemical pharmacology.

Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

C. Marsden, P. Carrupt, B. Testa, 1995, Biochemical pharmacology.

The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism.

P. Carrupt, B. Testa, G. Maret, 1990, Drug metabolism reviews.

Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration.

C. Marsden, P. Carrupt, B. Testa, 1996, Biochemical pharmacology.

Inhibition of [3H]dopamine uptake into striatal synaptosomes by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

C. Marsden, P. Carrupt, B. Testa, 1996, Biochemical pharmacology.

Circular dichroic determination of the preferred conformation of nicotine and related chiral alkaloids in aqueous solution.

B. Testa, P. Jenner, 1973, Molecular pharmacology.

Xenobiotic and endobiotic metabolizing enzymes: an overstretched discrimination?

B. Testa, P. Jenner, F. J. D. Carlo, 1981 .

Long-term effects of pergolide and (−)-deprenyl on 3H-mazindol and 3H-spiperone binding in rat brain

A. Clow, V. Glover, P. Jenner, 1999, Neurobiology of Aging.

Effects of short- and long-term (−)-deprenyl administration on mRNA for copper, zinc- and manganese-superoxide dismutase and glutathione peroxidase in rat brain

A. Clow, V. Glover, P. Jenner, 2002, Brain Research.

Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease.

C D Marsden, B Testa, C. Marsden, 1998, Biochemical pharmacology.

Metabolic N-oxidation products of aliphatic amines as potential mediators in amine pharmacology.

P. Jenner, J. Gorrod, 1975, International journal of clinical pharmacology and biopharmacy.

Interaction of neuroleptic drugs with rat striatal D-1 and D-2 dopamine receptors: a quantitative structure—affinity relationship study

C. Marsden, B. Testa, H. Waterbeemd, 1988 .

Esters of L‐Dopa: Structure‐hydrolysis Relationships and Ability to Induce Circling Behaviour in an Experimental Model of Hemiparkinsonism

B Testa, B. Testa, P. Ventura, 1995, The Journal of pharmacy and pharmacology.

In vitro inhibition by stiripentol of rat brain cytochrome P-450-mediated naphthalene hydroxylation.

B. Testa, M. Mesnil, P. Jenner, 1988, Xenobiotica; the fate of foreign compounds in biological systems.

Ex vivo inhibition of rat brain cytochrome P-450 activity by stiripentol.

B. Testa, M. Mesnil, P. Jenner, 1988, Biochemical pharmacology.

Oxidative stress in Parkinson's disease and other neurodegenerative disorders.

P. Jenner, P. Jenner, 1996, Pathologie-biologie.

Inhibition of monoamine oxidase by isoquinoline derivatives. Qualitative and 3D-quantitative structure-activity relationships.

P. Carrupt, B. Testa, K. McNaught, 1995, Biochemical pharmacology.