E. Morris

发表

Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis.

Jiang Wu, Wei Liu, Y. Qiu, 2007, Arthritis and rheumatism.

The Effect of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) on the Healing of Full-Thickness Defects of Articular Cartilage*

E. Morris, R. Sellers, D. Peluso, 1997, The Journal of bone and joint surgery. American volume.

Recombinant human bone morphogenetic protein‐2 maintains the articular chondrocyte phenotype in long‐term culture

R. Hewick, E. Morris, L. Sailor, 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Chondrogenesis in Cartilage Repair is Induced by Members of the Transforming Growth Factor-Beta Superfamily

E. Hunziker, E. Morris, I. Driesang, 2001, Clinical orthopaedics and related research.

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor.

M. Rivera-Bermúdez, L. Lohmander, P. Chockalingam, 2011, Osteoarthritis and cartilage.

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.

H. Ma, B. Sheppard, S. Glasson, 2004, Arthritis and rheumatism.

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse.

S. Glasson, E. Morris, T. Blanchet, 2007, Osteoarthritis and cartilage.

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

H. Ma, B. Sheppard, S. Glasson, 2007, Nature.

In Vitro–In Vivo Correlation on Delivery of Drug Candidates to Articular Cartilage

Xin Xu, S. Glasson, Qin Wang, 2008, Pharmaceutical Research.

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.

E. Lavallie, L. Collins-Racie, C. Flannery, 2006, Biochimica et biophysica acta.

Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).

P. Chockalingam, C. Flannery, E. Morris, 2004, Arthritis and rheumatism.

LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

M. Rivera-Bermúdez, E. Lavallie, Y. Wang, 2010, Proceedings of the National Academy of Sciences.

Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis.

A. Dorner, E. Lavallie, S. Nagpal, 2009, Osteoarthritis and cartilage.

Identification of a Novel HtrA1-susceptible Cleavage Site in Human Aggrecan

E. Lavallie, L. Collins-Racie, C. Flannery, 2009, The Journal of Biological Chemistry.

Autocatalytic Cleavage of ADAMTS-4 (Aggrecanase-1) Reveals Multiple Glycosaminoglycan-binding Sites*

E. Lavallie, P. Chockalingam, L. Collins-Racie, 2002, The Journal of Biological Chemistry.

Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage

Weiyong Sun, P. Chockalingam, S. Glasson, 2011, BMC musculoskeletal disorders.

Involvement of protein kinase Cζ in interleukin‐1β induction of ADAMTS‐4 and type 2 nitric oxide synthase via NF‐κB signaling in primary human osteoarthritic chondrocytes

E. Lavallie, E. Fortier, P. Chockalingam, 2007 .

5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2).

A. Gilbert, M. Bursavich, C. Flannery, 2007, Bioorganic & medicinal chemistry letters.

5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5.

A. Gilbert, M. Bursavich, C. Flannery, 2007, Bioorganic & medicinal chemistry letters.

Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system.

A. Dorner, E. Lavallie, Dina B. Anderson, 2004, Osteoarthritis and cartilage.

Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.

S. Schelling, S. Glasson, N. Stedman, 2007, Arthritis and rheumatism.

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.

J. Skotnicki, E. Feyfant, J. Xiang, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.

T. Rush, J. Xiang, S. Tam, 2006, Bioorganic & medicinal chemistry letters.

N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).

A. Gilbert, M. Bursavich, C. Flannery, 2008, Bioorganic & medicinal chemistry letters.

3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.

T. Rush, J. Skotnicki, J. Levin, 2009, Bioorganic & medicinal chemistry letters.

089 SELECTIVE AGGRECANASE INHIBITION IS DISEASE MODIFYING AND PAIN ALLEVIATING IN A RAT MENISCAL TEAR MODEL OF OSTEOARTHRITIS

J. Skotnicki, M. Rivera-Bermúdez, A. Bendele, 2009 .

Osteoarthritis severity is sex dependent in a surgical mouse model.

S. Glasson, E. Morris, D. Peluso, 2007, Osteoarthritis and cartilage.

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

H. Ma, B. Sheppard, S. Glasson, 2005, Nature.

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin.

Jason P. Gleghorn, Lawrence J Bonassar, Jason P Gleghorn, 2009, Arthritis and rheumatism.

Isolation, characterization, and chondrogenic potential of human bone marrow‐derived multipotential stromal cells

E A Morris, M K Majumdar, V Banks, 2000, Journal of cellular physiology.

Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content.

W. B. van den Berg, P. M. van der Kraan, E. Vitters, 1997, Arthritis and rheumatism.

Synthesis and SAR of highly selective MMP-13 inhibitors.

T. Rush, J. Skotnicki, J. Levin, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2).

A. Gilbert, M. Bursavich, C. Flannery, 2007, Bioorganic & medicinal chemistry letters.

Repair of Articular Cartilage Defects One Year After Treatment with Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)*

R. Sellers, S. Glasson, Renwen Zhang, 2000, The Journal of bone and joint surgery. American volume.

Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP‐2 and pro‐inflammatory factor IL‐1

R. Bhat, P. Chockalingam, S. Glasson, 2008, Journal of cellular physiology.

Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype

R. Bhat, P. Chockalingam, S. Glasson, 2006, Journal of cellular physiology.

BMP‐2 and BMP‐9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL‐1

Manas Kumar Majumdar, Eunice Wang, Elisabeth Ann Morris, 2001, Journal of cellular physiology.

Identification of interleukin-1 in equine osteoarthritic joint effusions.

A. C. Webb, L. Rosenwasser, E. Morris, 1990, American journal of veterinary research.

Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes.

S. Trippel, E. Morris, Toshiaki Takahashi, 2007, International journal of molecular medicine.

ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain*

E. Lavallie, J. Sandy, A. Fosang, 2002, The Journal of Biological Chemistry.

Chondral Defect Repair after the Microfracture Procedure

T. Gill, S. Glasson, P. Mcculloch, 2005, The American journal of sports medicine.

Binding and localization of recombinant lubricin to articular cartilage surfaces

Jason P. Gleghorn, Lawrence J Bonassar, Bruce Caterson, 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Effect of dimethylsulfoxide on articular cartilage proteoglycan synthesis and degradation, chondrocyte viability, and matrix water content.

E. Morris, S. Engler, G. L. Matthews, 1998, Veterinary surgery : VS.

ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.

A. Dorner, E. Lavallie, X. Tan, 2004, Matrix biology : journal of the International Society for Matrix Biology.

Effect of interleukin 1 on articular cartilage from young and aged horses and comparison with metabolism of osteoarthritic cartilage.

E. Morris, B. Treadwell, 1994, American journal of veterinary research.

Bone morphogenetic protein 9 is a potent anabolic factor for juvenile bovine cartilage, but not adult cartilage

E. Morris, R. Hills, Leona M. Belanger, 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Protein Kinase Cζ Is Up-regulated in Osteoarthritic Cartilage and Is Required for Activation of NF-κB by Tumor Necrosis Factor and Interleukin-1 in Articular Chondrocytes*

A. Dorner, M. Leitges, E. Lavallie, 2006, Journal of Biological Chemistry.

002 IDENTIFICATION OF A NOVEL HTRA1-SUSCEPTIBLE CLEAVAGE SITE IN HUMAN AGGRECAN: EVIDENCE FOR THE INVOLVEMENT OF HTRA1 IN AGGRECAN PROTEOLYSIS IN VIVO

C. Flannery, Eunice Wang, E. Morris, 2009 .

Inhibition of interleukin 1-mediated proteoglycan degradation in bovine articular cartilage explants by addition of sodium hyaluronate.

E. Morris, S. Wilcon, Treadwell Bv, 1992, American journal of veterinary research.

Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes.

E. Lavallie, E. Fortier, P. Chockalingam, 2007, Arthritis and rheumatism.

LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

M. Rivera-Bermúdez, E. Lavallie, Y. Wang, 2010, Proceedings of the National Academy of Sciences.

Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.

J. Xiang, L. Xing, S. Tam, 2011, Bioorganic & medicinal chemistry letters.