Yuji Nakamura

发表

Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs.

A. Naito, A. Sugiyama, Kentaro Ando, 2018, Journal of pharmacological sciences.

[Langendorff perfusion heart model].

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2012, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Analysis of proarrhythmic potential of antipsychotics risperidone and olanzapine in anesthetized dogs.

K. Hashimoto, A. Sugiyama, Kentaro Ando, 2007, European journal of pharmacology.

Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations.

H. Yamazaki, T. Ikeda, Ken Kitahara, 2015, The Journal of toxicological sciences.

Long‐term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine‐induced torsades de pointes arrhythmias

Y. Ishida, K. Hashimoto, A. Sugiyama, 2006, British journal of pharmacology.

Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs.

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2014, European journal of pharmacology.

Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K+ current.

A. Sugiyama, A. Takahara, Yuji Nakamura, 2009, The Journal of toxicological sciences.

A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.

K. Hashimoto, A. Sugiyama, A. Takahara, 2005, Journal of pharmacological sciences.

Impacts of Surgically Performed Renal Denervation on the Cardiovascular and Electrophysiological Variables in the Chronic Atrioventricular Block Dogs　- Comparison With Those of Amiodarone Treatment.

A. Sato, K. Aonuma, N. Murakoshi, 2016, Circulation journal : official journal of the Japanese Circulation Society.

In vivo electropharmacological effects of amiodarone and candesartan on atria of chronic atrioventricular block dogs.

K. Aonuma, M. Matsumoto, A. Sugiyama, 2007, Journal of pharmacological sciences.

QT/QTc study conducted in Japanese adult healthy subjects: A novel xanthine oxidase inhibitor topiroxostat was not associated with QT prolongation

T. Fujita, Y. Kumagai, A. Sugiyama, 2014, Journal of clinical pharmacology.

Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine.

A. Naito, A. Sugiyama, Kentaro Ando, 2018, The Journal of toxicological sciences.

Possibility as an anti-cancer drug of astemizole: Evaluation of arrhythmogenicity by the chronic atrioventricular block canine model.

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2016, Journal of pharmacological sciences.

Assessment of Safety Margin of an Antipsychotic Drug Haloperidol for Torsade de Pointes Using the Chronic Atrioventricular Block Dogs

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2016, Cardiovascular Toxicology.

Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K+ Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model

J. Katagi, A. Sugiyama, Kentaro Ando, 2015, Cardiovascular Toxicology.

Measurements of cardiac ion channel subunits in the chronic atrioventricular block dog.

A. Sugiyama, T. Konda, A. Takahara, 2011, Journal of pharmacological sciences.

Cardiovascular profile of the canine torsades de pointes arrhythmia model assessed by echocardiographic and haemodynamic methods.

K. Hashimoto, H. Iwasaki, A. Sugiyama, 2007, Basic & clinical pharmacology & toxicology.

Sunitinib does not acutely alter left ventricular systolic function, but induces diastolic dysfunction

A. Naito, A. Sugiyama, Kentaro Ando, 2018, Cancer Chemotherapy and Pharmacology.

Cardiac and haemodynamic effects of tacrolimus in the halothane-anaesthetized dog.

H. Sugiyama, M. Hoshiai, K. Sugita, 2009, Basic & clinical pharmacology & toxicology.

Comparison of direct effects of clinically available vasodilators; nitroglycerin, nifedipine, cilnidipine and diltiazem, on human skeletonized internal mammary harvested with ultrasonic scalpel

K. Takazawa, T. Mizoue, A. Sugiyama, 2016, Heart and Vessels.

Pharmacological characterization of microminipig as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies.

A. Sugiyama, Hiroyuki Saito, Kentaro Ando, 2017, The Journal of toxicological sciences.

Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence from In Vivo Canine Models

H. Yamazaki, N. Murayama, A. Sugiyama, 2015, Basic & clinical pharmacology & toxicology.

Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets.

Y. Sekino, A. Naito, Y. Kanda, 2017, Journal of Pharmacological Sciences.

Cardiovascular and adenylate cyclase stimulating effects of colforsin daropate, a water-soluble forskolin derivative, compared with those of isoproterenol, dopamine and dobutamine.

K. Hashimoto, A. Sugiyama, A. Takahara, 2002, Circulation journal : official journal of the Japanese Circulation Society.

Amelioration of Enalapril-Induced Dry Cough by Changing Dosing Time from Morning to Evening; A Preliminary Trial

K. Shimada, A. Fujimura, T. Shiigai, 1999 .

Impedance Threshold Device Combined With High-Quality Cardiopulmonary Resuscitation Improves Survival With Favorable Neurological Function After Witnessed Out-of-Hospital Cardiac Arrest.

S. Duval, D. Yannopoulos, A. Sugiyama, 2016, Circulation journal : official journal of the Japanese Circulation Society.

The endothelium-dependent vasodilator action of a new beverage made of red wine vinegar and grape juice.

K. Hashimoto, A. Sugiyama, A. Takahara, 2005, Biological & pharmaceutical bulletin.

Cardiac safety profile of sildenafil: chronotropic, inotropic and coronary vasodilator effects in the canine isolated, blood-perfused heart preparations.

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2016, The Journal of toxicological sciences.

Azithromycin Can Prolong QT Interval and Suppress Ventricular Contraction, but Will Not Induce Torsade de Pointes

H. Yamazaki, T. Ikeda, A. Sugiyama, 2015, Cardiovascular Toxicology.

Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems.

Shuichi Sato, K. Hashimoto, K. Miyata, 2003, European journal of pharmacology.

In Vivo Canine Model Comparison of Cardiovascular Effects of Antidepressants Milnacipran and Imipramine

S. Koizumi, M. Matsumoto, A. Sugiyama, 2010, Cardiovascular Toxicology.

Beat-to-beat variability of repolarization differentiates the extent of torsadogenic potential of multi ion channel-blockers bepridil and amiodarone.

A. Sugiyama, A. Takahara, Yuji Nakamura, 2008, European journal of pharmacology.

Halothane-anaesthetized, closed-chest, guinea-pig model for assessment of drug-induced QT-interval prolongation.

A. Sugiyama, A. Takahara, Yuji Nakamura, 2009, Basic & clinical pharmacology & toxicology.

Sensitivity and Reliability of Halothane‐anaesthetized Microminipigs to Assess Risk of Drug‐induced Long QT Syndrome

A. Naito, A. Sugiyama, Kentaro Ando, 2017, Basic & clinical pharmacology & toxicology.

RESEARCH PAPER Long-term blockade of L/N-type Ca 2+ channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart

A. Sugiyama, A. Takahara, Yuji Nakamura, 2009 .

Comparison of electropharmacological effects of bepridil and sotalol in halothane-anesthetized dogs.

H. Iwasaki, A. Sugiyama, A. Takahara, 2008, Circulation journal : official journal of the Japanese Circulation Society.

L/N-type Ca2+ channels blocker cilnidipine ameliorated the repolarization abnormality in a chronic hemodialysis patient

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2016, Heart and Vessels.

Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs.

Koichiro Tanaka, A. Naito, A. Sugiyama, 2017, Journal of pharmacological sciences.

Effects of acute intravenous administration of pentamidine, a typical hERG-trafficking inhibitor, on the cardiac repolarization process of halothane-anesthetized dogs.

H. Iwasaki, A. Sugiyama, Yuji Nakamura, 2009, Journal of pharmacological sciences.

Effects of pH on nifekalant-induced electrophysiological change assessed in the Langendorff heart model of guinea pigs.

Katsuyuki Kazusa, A. Sugiyama, Kentaro Ando, 2014, Journal of pharmacological sciences.

Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs.

A. Sugiyama, Kentaro Ando, Y. Nakazato, 2016, The Journal of toxicological sciences.

Constitutional Rho-Kinase Regulates Atrioventricular Nodal Conduction and Ventricular Repolarization of the Canine Heart

Y. Yatomi, K. Hashimoto, A. Sugiyama, 2003, Journal of cardiovascular pharmacology.

Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome

A. Naito, A. Sugiyama, Kentaro Ando, 2017, Cardiovascular Toxicology.

Cardiovascular effects of azelnidipine in comparison with those of amlodipine assessed in the halothane-anaesthetized dog.

H. Iwasaki, A. Sugiyama, A. Takahara, 2010, Basic & clinical pharmacology & toxicology.

A red wine vinegar beverage can inhibit the renin-angiotensin system: experimental evidence in vivo.

K. Hashimoto, A. Sugiyama, A. Takahara, 2005, Biological & pharmaceutical bulletin.

Assessment of the Anti-anginal Effect of Tetramethylpyrazine Using Vasopressin-Induced Angina Model Rats.

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2016, Biological & pharmaceutical bulletin.

Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance.

Y. Sekino, Y. Kanda, A. Sugiyama, 2017, The Journal of toxicological sciences.

Microminipig, a non-rodent experimental animal optimized for life science research: in vivo proarrhythmia models of drug-induced long QT syndrome: development of chronic atrioventricular block model of microminipig.

H. Yamazaki, Y. Izumi, A. Sugiyama, 2011, Journal of pharmacological sciences.

Epinephrine Increases the Neurotoxic Potential of Intrathecally Administered Lidocaine in the Rat

A. Bollen, K. Drasner, J. Feiner, 1999, Anesthesiology.

Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs.

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2016, The Journal of toxicological sciences.

Epidural anesthesia for cesarean section in triplet pregnant women with toxemia and complications of ritodrine therapy: Five case reports

Yuji Nakamura, Y. Kosaka, Y. Yamamori, 1995, Journal of Anesthesia.

Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig

Y. Akasaka, A. Sugiyama, Kentaro Ando, 2016, The Journal of veterinary medical science.

Comparison of the direct negative dromotropic effect of a new calcium channel blocker, cilnidipine, with that of nicardipine

K. Hashimoto, A. Sugiyama, Kentaro Ando, 2005, Heart and Vessels.

Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model.

K. Hashimoto, A. Sugiyama, Kentaro Ando, 2004, Journal of pharmacological sciences.

Cardiac effects of L/N-type Ca2+ channel blocker cilnidipine in anesthetized dogs.

H. Iwasaki, A. Sugiyama, A. Takahara, 2007, European journal of pharmacology.

Cardiovascular effects of an L/N-type Ca2+ channel blocker cilnidipine assessed in the chronic atrioventricular conduction block dogs.

K. Hashimoto, A. Sugiyama, A. Takahara, 2004, Journal of pharmacological sciences.

Common parameters of acupuncture for the treatment of hypertension used in animal models.

Sheng-feng Lu, A. Sugiyama, Kentaro Ando, 2015, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects (pages.

J. Camm, Y. Kumagai, G. Ferber, 2012, British journal of clinical pharmacology.

Efficacy of Precordial Percussion Pacing Assessed in a Cardiac Standstill Microminipig Model.

K. Lurie, A. Sugiyama, Kentaro Ando, 2017, Circulation journal : official journal of the Japanese Circulation Society.

In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs

H. Yamazaki, A. Naito, A. Sugiyama, 2018, Cardiovascular Toxicology.

In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs

A. Naito, Kentaro Ando, Yuji Nakamura, 2017, Cardiovascular Toxicology.

Cardiohemodynamic and Electrophysiological Effects of Anti-influenza Drug Oseltamivir In Vivo and In Vitro

H. Yamazaki, T. Ikeda, Ken Kitahara, 2013, Cardiovascular Toxicology.

Analysis of Onset Mechanisms of a Sphingosine 1-Phosphate Receptor Modulator Fingolimod-Induced Atrioventricular Conduction Block and QT-Interval Prolongation.

Ken Kitahara, T. Ninomiya, A. Sugiyama, 2014, Toxicology and applied pharmacology.

Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs

A. Naito, A. Sugiyama, Kentaro Ando, 2018, Cardiovascular Toxicology.

Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs

A. Naito, Kentaro Ando, Yuji Nakamura, 2018, Cardiovascular Toxicology.

Simultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects on atria of chronic atrioventricular block dogs.

T. Nagai, H. Iwasaki, A. Sugiyama, 2009, Journal of pharmacological sciences.

Effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 on the left ventricular pressure-volume relationship in the halothane-anesthetized dogs.

J. Katagi, A. Sugiyama, Kentaro Ando, 2016, European journal of pharmacology.

Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay.

A. Sugiyama, Kentaro Ando, Hikaru Tanaka, 2016, Journal of pharmacological sciences.

Azithromycin Can Prolong QT Interval and Suppress Ventricular Contraction, but Will Not Induce Torsade de Pointes

H. Yamazaki, T. Ikeda, A. Sugiyama, 2015, Cardiovascular Toxicology.

Assessment of testing methods for drug-induced repolarization delay and arrhythmias in an iPS cell-derived cardiomyocyte sheet: multi-site validation study.

Yasunari Kanda, Kentaro Ando, Kohei Sawada, 2014, Journal of pharmacological sciences.

Anti-atrial Fibrillatory Versus Proarrhythmic Potentials of Amiodarone: A New Protocol for Safety Evaluation In Vivo

A. Sugiyama, Kentaro Ando, Yuji Nakamura, 2017, Cardiovascular Toxicology.

Epinephrine increases the neurotoxic potential of intrathecally administered lidocaine in the rat.

A. Bollen, K. Drasner, J. Feiner, 2001 .

Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology.

H. Yamazaki, A. Sugiyama, Kentaro Ando, 2017, Journal of pharmacological sciences.

Beneficial and Adverse Effects of Electro-acupuncture Assessed in the Canine Chronic Atrio-ventricular Block Model Having Severe Hypertension and Chronic Heart Failure.

Sheng-feng Lu, A. Sugiyama, Kentaro Ando, 2015, Acupuncture & electro-therapeutics research.

J. Katagi, A. Sugiyama, Kentaro Ando, 2016, Cardiovascular Toxicology.

Spontaneous respiration should be avoided in frequency domain analysis of heart rate variability

Yuji Nakamura, Y. Kosaka, A. Tanaka, 1995, Journal of Anesthesia.

Cardiac and haemodynamic effects of tacrolimus in the halothane-anaesthetized dog.

H. Sugiyama, M. Hoshiai, K. Sugita, 2009, Basic & clinical pharmacology & toxicology.

Electropharmacological characterization of microminipigs as a laboratory animal using anti-influenza virus drug oseltamivir.

A. Naito, A. Sugiyama, Kentaro Ando, 2018, The Journal of toxicological sciences.