H. Yasukawa

发表

A. Yoshimura, T. Hanada, Mayu Suzuki, 2011, Front. Immun..

Role of SOCS proteins in inflammation and autoimmune diseases

A. Yoshimura, T. Fukaya, Mayu Suzuki, 2011 .

Negative Regulator of Cytokine Signaling (SOCS) Genes in Inflammation

A. Yoshimura, I. Kinjyo, H. Yasukawa, 2003 .

SOCS3 deficiency in cardiomyocytes elevates sensitivity of ischemic preconditioning that synergistically ameliorates myocardial ischemia reperfusion injury

Y. Fukumoto, T. Shibata, T. Nagata, 2021, PloS one.

Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning.

Y. Iwamoto, M. Takano, Y. Fukumoto, 2015, Circulation journal : official journal of the Japanese Circulation Society.

CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells

H. Sakamoto, A. Yoshimura, A. Sasaki, 1998, Oncogene.

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis

C. Uyttenhove, A. Yoshimura, G. Pasterkamp, 2009, The Journal of experimental medicine.

The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury.

M. Weitzman, A. Yoshimura, K. Chien, 2003, The Journal of clinical investigation.

Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats.

K. Okumura, T. Imaizumi, Y. Numaguchi, 2004, Human gene therapy.

HMG-CoA Reductase Inhibitor Protects Against In Vivo Arterial Thrombosis by Augmenting Platelet-Derived Nitric Oxide Release in Rats

S. Yokoyama, T. Imaizumi, A. Katoh, 2005, Journal of cardiovascular pharmacology.

Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms.

T. Murohara, N. Ouchi, Y. Numaguchi, 2014, Journal of the American College of Cardiology.

Pioglitazone attenuates atherosclerotic plaque inflammation in patients with impaired glucose tolerance or diabetes a prospective, randomized, comparator-controlled study using serial FDG PET/CT imaging study of carotid artery and ascending aorta.

T. Imaizumi, H. Kaida, M. Ishibashi, 2011, JACC. Cardiovascular imaging.

Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis

A. Yoshimura, Y. Yonemitsu, M. Ono, 2009, PloS one.

Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction.

D. Kang, K. Sasaki, T. Imaizumi, 2012, Journal of the American College of Cardiology.

Transient reduction and activation of circulating dendritic cells in patients with acute myocardial infarction.

T. Ueno, S. Yokoyama, T. Imaizumi, 2012, International journal of cardiology.

STATs in the Cardiovascular System

K. Chien, H. Hirota, H. Yasukawa, 2003 .

Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias

T. Matsuishi, M. Takano, G. Takemura, 2015, Scientific Reports.

Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury.

A. Yoshimura, R. Shibata, H. Kai, 2000, Circulation research.

SOCS3: A novel therapeutic target for cardioprotection.

T. Imaizumi, T. Nagata, H. Yasukawa, 2012, JAK-STAT.

Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways.

J. Ross, S. Pradervand, A. Yoshimura, 2001, The Journal of clinical investigation.

Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection

Y. Fukumoto, T. Imaizumi, M. Hayashi, 2018, Journal of the American Heart Association.

Small proline‐rich protein 1A is a gp130 pathway‐ and stress‐inducible cardioprotective protein

J. Ross, S. Pradervand, K. Chien, 2004, The EMBO journal.

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

S. Pradervand, Y. Fukumoto, T. Imaizumi, 2015, PloS one.

Innate Defense Mechanism Against Virus Infection Within the Cardiac Myocyte Requiring gp130-STAT3 Signaling

A. Yoshimura, K. Chien, E. Jeon, 2006, Circulation.

Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats

T. Imaizumi, S. Kato, N. Tahara, 2010, Basic Research in Cardiology.

Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3.

A. Yoshimura, H. Yasukawa, Reiko Takahashi, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice

T. Imaizumi, H. Aoki, S. Kyogoku, 2012, Hypertension Research.

Circulating Myeloid Dendritic Cells is Decreased in the Acute Phase of Kawasaki Disease

T. Matsuishi, T. Imaizumi, K. Suda, 2013 .

Reduction and activation of circulating dendritic cells in patients with decompensated heart failure.

T. Imaizumi, H. Kai, D. Fukui, 2011, International journal of cardiology.

Abstract 5164: Loss of SOCS3 Expression in T Cells Reveals a Regulatory Role for Interleukin-17 in Atherosclerosis

C. Uyttenhove, A. Yoshimura, G. Pasterkamp, 2009 .

Screening for Fabry disease in patients with left ventricular hypertrophy.

T. Imaizumi, H. Sakuraba, T. Togawa, 2013, International journal of cardiology.

Suppressor of cytokine signaling 1 protects mice against concanavalin A–induced hepatitis by inhibiting apoptosis

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, Hepatology.

Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling.

A. Yoshimura, D. Belsham, A. Sahu, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Inhibition of Progression and Stabilization of Plaques by Postnatal Interferon- (cid:1) Function Blocking in ApoE-Knockout Mice Molecular Medicine

T. Imaizumi, S. Kato, H. Kai, 2007 .

Interleukin-6-induced Activation of Signal Transducer and Activator of Transcription-3 in Ruptured Rotator Cuff Tendon

K. Nagata, H. Yasukawa, T. Imaizumi, 2006, The Journal of international medical research.

Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction.

A. Yoshimura, M. Yokoro, S. Yamagishi, 2014, Clinical immunology.

Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes.

T. Ueno, T. Imaizumi, H. Kai, 1998, Journal of the American College of Cardiology.

Negative regulation of cytokine signaling pathways.

A Sasaki, A. Yoshimura, A. Sasaki, 2000, Annual review of immunology.

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

S. Akira, T. Hirano, A. Yoshimura, 2003, Nature Immunology.

Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads1

A. Yoshimura, H. Yoshida, Y. Nakanishi, 2008, The Journal of Immunology.

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

A. Yoshimura, K. Chien, H. Mori, 2004, Nature Medicine.

Inhibition of intimal hyperplasia after balloon injury by antibodies to intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1.

M. Morimatsu, H. Matsuoka, H. Yasukawa, 1997, Circulation.

A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.

K Yuge, A Sasaki, H. Sakamoto, 1998, Blood.

The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

Masahiko Hoshijima, Andrew D. McCulloch, Nicholas J. Schork, 2002, Cell.

Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 Is Involved in gp130 Resistance in Cardiovascular System in Rat Treated With Cardiotrophin-1 In Vivo

K. Nakao, A. Yoshimura, I. Masuda, 2001, Circulation research.

The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

A. Yoshimura, T. Matsuda, J. Ihle, 1999, The EMBO journal.

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2*

S. Minoguchi, A. Yoshimura, K. Nakayama, 2001, The Journal of Biological Chemistry.

Inhibition of Progression and Stabilization of Plaques by Postnatal Interferon-γ Function Blocking in ApoE-Knockout Mice

T. Imaizumi, S. Kato, H. Kai, 2007, Circulation research.

Platelet P-selectin plays an important role in arterial thrombogenesis by forming large stable platelet-leukocyte aggregates.

Hisao Ikeda, Shinji Yokoyama, Toyoaki Murohara, 2002, Journal of the American College of Cardiology.

CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2*

A. Yoshimura, H. Yasukawa, T. Shouda, 2000, The Journal of Biological Chemistry.

Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain

J. Johnston, A. Yoshimura, A. Suzuki, 1999, Genes to cells : devoted to molecular & cellular mechanisms.

A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box*

Masato Kubo, S. Minoguchi, M. Kubo, 2001, The Journal of Biological Chemistry.

Cloning and characterization of novel CIS family genes.

H. Sakamoto, A. Yoshimura, M. Ohtsubo, 1997, Biochemical and biophysical research communications.

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

H. Pendeville, A. Yoshimura, J. Marine, 1999, Cell.

STAT 3 and Smads γ Effects of IFN-Differentiation by Enhancing Antagonistic Helper T Cells Leads to Defective Th 17 Loss of Suppressor of Cytokine Signaling 1 in

A. Yoshimura, H. Yoshida, Y. Nakanishi, 2008 .

Inhibition of Intrinsic Interferon-&ggr; Function Prevents Neointima Formation After Balloon Injury

T. Imaizumi, H. Kai, K. Egashira, 2007, Hypertension.

Postnatal Blocking of Interferon-γ Function Prevented Atherosclerotic Plaque Formation in Apolipoprotein E–Knockout Mice

T. Imaizumi, S. Kato, H. Kai, 2007, Hypertension Research.

Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction.

R. Morita, A. Yoshimura, N. Inoue, 2011, Cancer letters.

SOCS3 Is a Physiological Negative Regulator for Granulopoiesis and Granulocyte Colony-stimulating Factor Receptor Signaling*

A. Yoshimura, K. Chien, M. Harada, 2004, Journal of Biological Chemistry.

Multidisciplinary Team-Based Palliative Care for Heart Failure and Food Intake at the End of Life

Y. Fukumoto, H. Aoki, H. Yasukawa, 2021, Nutrients.

JAK's SOCS: a mechanism of inhibition.

A. Yoshimura, H. Yasukawa, 2012, Immunity.

The N-terminal Truncated Isoform of SOCS3 Translated from an Alternative Initiation AUG Codon under Stress Conditions Is Stable Due to the Lack of a Major Ubiquitination Site, Lys-6*

Takafumi Yoshida, A. Yoshimura, A. Koromilas, 2003, The Journal of Biological Chemistry.

High Salt Intake Worsens Aortic Dissection in Mice

Y. Fukumoto, T. Imaizumi, M. Hayashi, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Abstract 2947: Cardiac-Specific Deletion of SOCS3 Prevented Myocardial Apoptosis After Acute Myocardial Infarction Through Inhibiting Mitochondrial Damage

T. Imaizumi, T. Yajima, K. Knowlton, 2009 .

Pressure-Independent Effects of Angiotensin II on Hypertensive Myocardial Fibrosis

T. Imaizumi, N. Tahara, H. Kai, 2004, Hypertension.

Endothelial injuries of coronary arteries distal to thrombotic sites: role of adhesive interaction between endothelial P-selectin and leukocyte sialyl LewisX.

T. Murohara, T. Imaizumi, H. Ikeda, 1999, Circulation research.

Interaction Between Endothelial P-Selectin and Leukocyte Sialyl LewisX Endothelial Injuries of Coronary Arteries Distal to Thrombotic Sites : Role of Adhesive

Shotaro, T. Murohara, H. Ikeda, 1999 .

Confers Resistance to Interferons Inducible Gene and - γ A Janus Kinase Inhibitor, JAB, Is an Interferon-

H. Sakamoto, A. Yoshimura, Y. Furukawa, 2013 .

Confers Resistance to Interferons A Janus Kinase Inhibitor, JAB, Is an Interferon-gamma -Inducible Gene and

H. Sakamoto, A. Yoshimura, Y. Furukawa, 2010 .

Confers Resistance to Interferons Inducible Gene and − γ Kinase Inhibitor , JAB , Is an Interferon-Janus A

H. Sakamoto, A. Yoshimura, Y. Furukawa, 1998 .

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

H. Sakamoto, A. Yoshimura, M. Ohtsubo, 1999, Oncogene.

Pressure Overload–Induced Transient Oxidative Stress Mediates Perivascular Inflammation and Cardiac Fibrosis through Angiotensin II

T. Imaizumi, N. Tahara, H. Kai, 2006, Hypertension Research.

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells

Nana Shimizu, R. Morita, A. Yoshimura, 2014, Proceedings of the National Academy of Sciences.

Absence of SOCS3 in the Cardiomyocyte Increases Mortality in a gp130-Dependent Manner Accompanied by Contractile Dysfunction and Ventricular Arrhythmias

Yusu Gu, N. Dalton, K. Peterson, 2011, Circulation.

Expression of stem cell factor in human aortic endothelial and smooth muscle cells.

Y. Sasaguri, M. Morimatsu, S. Kato, 1997, Atherosclerosis.

Adhesive interaction between P-selectin and sialyl Lewis(x) plays an important role in recurrent coronary arterial thrombosis in dogs.

T. Murohara, T. Imaizumi, A. Katoh, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice

Y. Fukumoto, T. Imaizumi, M. Hayashi, 2020, JACC. Basic to translational science.

Sertoli-stromal cell tumor containing metastatic lung cancer tissue.

M. Morimatsu, O. Tsuruta, M. Yakushiji, 1994, The Kurume medical journal.

Factors associated with plasma ghrelin level in Japanese general population

T. Imaizumi, M. Kojima, M. Enomoto, 2011, Clinical endocrinology.

Interleukin‐22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription‐3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury

Y. Fukumoto, T. Kakuma, H. Aoki, 2020, Journal of the American Heart Association.

Renal denervation prevents intraglomerular platelet aggregation and glomerular injury induced by chronic inhibition of nitric oxide synthesis.

M. Morimatsu, T. Imaizumi, H. Matsuoka, 1996, Nephron.

SOCS3

T. Imaizumi, H. Yasukawa, T. Oba, 2012, JAK-STAT.