Lin Lei

发表

NEFA‐induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non‐alcoholic steatohepatitis

Guowen Liu, Xiaobing Li, Zhe Wang, 2018, Journal of cellular and molecular medicine.

Propionate alleviates palmitic acid-induced endoplasmic reticulum stress by enhancing autophagy in calf hepatic cells.

J. Loor, H. Ouyang, Guowen Liu, 2021, Journal of dairy science.

Propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes.

J. Loor, Guowen Liu, Xinwei Li, 2022, Journal of dairy science.

Alpha-lipoic acid attenuates endoplasmic reticulum stress-induced insulin resistance by improving mitochondrial function in HepG2 cells.

M. Zhang, Guowen Liu, Xiaobing Li, 2016, Cellular signalling.

Low abundance of mitophagy markers is associated with reactive oxygen species overproduction in cows with fatty liver and causes reactive oxygen species overproduction and lipid accumulation in calf hepatocytes.

J. Loor, Meng Chen, Guowen Liu, 2022, Journal of dairy science.

Targeting IRE1α and PERK in the endoplasmic reticulum stress pathway attenuates fatty acid-induced insulin resistance in bovine hepatocytes.

J. Loor, Guowen Liu, Zhe Wang, 2022, Journal of dairy science.

β-Hydroxybutyrate inhibits apoptosis in bovine neutrophils through activating ERK1/2 and AKT signaling pathways.

J. Loor, Guowen Liu, Xinwei Li, 2022, Journal of dairy science.

Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in primary cultured hepatocytes of dairy cows

H. Ding, Yu Li, Guowen Liu, 2018, Journal of Dairy Research.

Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway

Meng Chen, Guowen Liu, Zhe Wang, 2021, Acta pharmaceutica Sinica. B.

Cellular Physiology and Biochemistry Cellular Physiology and Biochemistry Β-hydroxybutyrate Facilitates Fatty Acids Synthesis Mediated by Sterol Regulatory Element-binding Protein1 in Bovine Mammary Epithelial Cells

Guowen Liu, Xiaobing Li, M. Zhang, 2022 .

Reducing hepatic endoplasmic reticulum stress ameliorates the impairment in insulin signaling induced by high levels of β-hydroxybutyrate in bovine hepatocytes.

J. Loor, Guowen Liu, M. Zhang, 2021, Journal of dairy science.

Impaired autophagy aggravates oxidative stress in mammary gland of dairy cows with clinical ketosis.

J. Loor, Guowen Liu, Xinwei Li, 2022, Journal of dairy science.

Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes.

J. Loor, Guowen Liu, Zhe Wang, 2022, Journal of dairy science.

β-Hydroxybutyrate impairs the release of bovine neutrophil extracellular traps through inhibiting phosphoinositide 3-kinase-mediated nicotinamide adenine dinucleotide phosphate oxidase reactive oxygen species production.

Xiaoping Zhou, J. Loor, Guowen Liu, 2022, Journal of dairy science.

Hepatic miR‐125b inhibits insulin signaling pathway by targeting PIK3CD

M. Zhang, Liang Chen, Guowen Liu, 2018, Journal of cellular physiology.

The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation

Guowen Liu, Xinwei Li, W. Gao, 2023, Acta pharmaceutica Sinica. B.

SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver.

Guowen Liu, Xiaobing Li, Zhe Wang, 2015, Cellular signalling.

Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin

Meng Chen, Guowen Liu, Zhe Wang, 2023, Autophagy.

Liver fibrosis is a common pathological change in the liver of dairy cows with fatty liver.

Yong Huang, Lei He, J. Loor, 2023, Journal of dairy science.

β-hydroxybutyrate enhances bovine neutrophil adhesion by inhibiting autophagy

Guowen Liu, Dong Li, Wen Zeng, 2023, Frontiers in Immunology.

Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis

M. Zhang, Chuang Xu, Guowen Liu, 2017, Oncotarget.

Nuciferine Ameliorates Nonesterified Fatty Acid-Induced Bovine Mammary Epithelial Cell Lipid Accumulation, Apoptosis, and Impaired Migration via Activating LKB1/AMPK Signaling Pathway.

Haihua Feng, Guowen Liu, Xinwei Li, 2022, Journal of agricultural and food chemistry.

Low abundance of insulin-induced gene 1 contributes to SREBP-1c processing and hepatic steatosis in dairy cows with severe fatty liver.

J. Loor, Guowen Liu, Xinwei Li, 2023, Journal of dairy science.

β-Hydroxybutyrate impairs the directionality of migrating neutrophil through inhibiting the autophagy-dependent degradation of Cdc42 and Rac1 in ketotic cows

J. Yang, Zhe Wang, Guowen Liu, 2023, Journal of Dairy Science.

Inhibition of cluster antigen 36 protects against fatty acids-induced lipid accumulation, oxidative stress, and inflammation in bovine hepatocytes

Guowen Liu, Xinwei Li, W. Gao, 2023, Journal of Dairy Science.

AdipoRon alleviates fatty acid-induced lipid accumulation and mitochondrial dysfunction in bovine hepatocytes by promoting autophagy.

J. Loor, Guowen Liu, Xinwei Li, 2023, Journal of dairy science.

Nuciferine protects bovine hepatocytes against free fatty acid-induced oxidative damage by activating the transcription factor EB/peroxisome proliferator-activated receptor γ coactivator 1 alpha pathway.

Meng Chen, Guowen Liu, Xinwei Li, 2023, Journal of dairy science.

Evaluation of hepatic AMP-activated protein kinase (AMPK), mechanistic target of rapamycin kinase complex 1 (mTORC1) and autophagy-lysosomal pathway in cows with mild or moderate fatty liver.

Guowen Liu, Xinwei Li, Xiliang Du, 2023, Journal of dairy science.

Expression of hepatic genes involved in bile acid metabolism in dairy cows with fatty liver.

Guowen Liu, E. Trevisi, W. Gao, 2024, Journal of dairy science.