D. Duckett

发表

Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38*

P. Lograsso, J. Habel, Y. Ling, 2009, Journal of Biological Chemistry.

Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.

M. Cameron, T. Kamenecka, Y. Shin, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.

P. Lograsso, M. Cameron, Y. Ling, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.

P. Lograsso, M. Cameron, Y. Ling, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.

M. Cameron, T. Kamenecka, Claudia H. Ruiz, 2011, Bioorganic & medicinal chemistry letters.

Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology.

T. Spicer, P. Hodder, E. Sturchler, 2014, Assay and drug development technologies.

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.

P. Lograsso, J. Habel, Y. Ling, 2009, Bioorganic & medicinal chemistry letters.

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.

P. Lograsso, J. Habel, Y. Ling, 2007, Bioorganic & medicinal chemistry letters.

In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.

W. Roush, J. Choi, Derek R Duckett, 2017, ACS medicinal chemistry letters.

Antiproliferation Activity of a Small Molecule Repressor of Liver Receptor Homolog 1

Graham M. West, P. Griffin, W. Roush, 2015, Molecular Pharmacology.

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

P. Lograsso, J. Habel, M. Cameron, 2010, Journal of medicinal chemistry.

Chroman-3-amides as potent Rho kinase inhibitors.

P. Lograsso, S. Schürer, M. Cameron, 2008, Bioorganic & medicinal chemistry letters.

Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer.

W. Roush, V. Quereda, Derek R Duckett, 2019, Cancer cell.

Development of an HTS-Compatible Assay for the Discovery of Ulk1 Inhibitors

J. Cleveland, L. H. Rosenberg, Derek R Duckett, 2015, Journal of biomolecular screening.

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

M. Cameron, Y. Ling, T. Kamenecka, 2012 .

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

B. Czerniecki, N. Tran, K. Smalley, 2021, Journal of visualized experiments : JoVE.

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

P. Lograsso, S. Schürer, J. Pocas, 2009, Bioorganic & medicinal chemistry letters.

A preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma

B. Czerniecki, N. Tran, M. Vogelbaum, 2022, Neuro-oncology.

Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target.

U. Rix, E. Schönbrunn, E. Haura, 2023, ACS chemical biology.

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

G. Warren, R. Copeland, T. J. Lansing, 2008, Journal of medicinal chemistry.

Synthesis of potent bicyclic bisarylimidazole c-Jun N-terminal kinase inhibitors by catalytic C-H bond activation.

P. Lograsso, J. Ellman, R. Bergman, 2007, Journal of the American Chemical Society.

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1

Kyle A. Emmitte, Masaaki Furuta, N. Noro, 2007, Molecular Cancer Therapeutics.

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.

J. Cleveland, S. Schürer, M. Cameron, 2013, Bioorganic & medicinal chemistry letters.

Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.

P. Griffin, D. Kojetin, Naresh Kumar, 2011, ACS chemical biology.

Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.

Robert A Copeland, Anthony E Choudhry, T. Gilmer, 2008, Cancer research.

The promise and current status of CDK12/13 inhibition for the treatment of cancer.

S. Tadesse, Derek R Duckett, D. Duckett, 2020, Future medicinal chemistry.

Identification of an EGFRvIII-JNK2-HGF/c-Met–Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion

M. Fallahi, Y. Ling, V. Quereda, 2015, Molecular Pharmacology.

Identification of an EGFRvIII-JNK 2-HGF / c-Met – Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion s

M. Fallahi, Y. Ling, V. Quereda, 2015 .

Metabolism considerations for kinase inhibitors in cancer treatment

M. Cameron, Derek R Duckett, D. Duckett, 2010, Expert opinion on drug metabolism & toxicology.

Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.

M. Zhang, Haitao Ji, V. Quereda, 2021, Journal of medicinal chemistry.

βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1

K. Xiao, Makoto R. Hara, P. McDonald, 2019, Cell Death & Differentiation.

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

Kunhong Xiao, Sudarshan Rajagopal, Wayne Grant, 2011, Nature.

The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells.

J. Cleveland, J. Pinilla-Ibarz, W. Roush, 2020, Blood advances.

Design of a small molecule against an oncogenic noncoding RNA

Matthew D Disney, Donald G Phinney, M. Disney, 2016, Proceedings of the National Academy of Sciences.

Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase

Mingxiang Teng, W. Roush, M. Aceti, 2020, Molecular Cancer Therapeutics.

Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer.

E. Sturchler, P. McDonald, D. Feurstein, 2013, Biochimica et biophysica acta.

Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation.

E. Sturchler, P. McDonald, D. Feurstein, 2010, Biochemistry.

Summarizing internal dynamics boosts differential analysis and functional interpretation of super enhancers

B. Fridley, Mingxiang Teng, Derek R Duckett, 2021, bioRxiv.

Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.

Li Lin, P. Lograsso, M. Cameron, 2011, ACS chemical neuroscience.

Autophagy is inhibited by ubiquitin ligase activity in the nervous system

A. Giles, Muriel Desbois, Derek R Duckett, 2019, Nature Communications.

Targeted Therapy Given after Anti–PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity

K. Tsai, U. Rix, B. Czerniecki, 2021, Cancer Immunology Research.

Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4+ Th1 Responses and Potential Use as a Cancer Vaccine

B. Czerniecki, K. Smalley, A. Basu, 2021, Cancer Immunology Research.

9 ASK 1 and Its Role in Neurodegenerative Diseases

E. Sturchler, P. McDonald, D. Feurstein, 2014 .

ASK1 and Its Role in Neurodegenerative Diseases

E. Sturchler, P. McDonald, D. Feurstein, 2011 .

Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors.

M. Cameron, W. Roush, V. Quereda, 2017, Bioorganic & medicinal chemistry letters.

Coordination games in cancer

Joel s. Brown, R. Gatenby, K. Staňková, 2021, bioRxiv.

Therapeutic targeting of casein kinase 1δ in breast cancer

Jenny C. Chang, M. Fallahi, J. Cleveland, 2015, Science Translational Medicine.

Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas

Yuan Ren, J. Tao, Xiaohong Zhao, 2021, Haematologica.