N. Tamayo

发表

p38 MAP kinase inhibitors: many are made, but few are chosen.

C. Dominguez, D. Powers, N. Tamayo, 2005, Current opinion in drug discovery & development.

Solid support synthesis of 2-substituted dibenz[b,f]oxazepin-11(10H)-onesvia SNAr methodology on AMEBA resin

A. Kiselyov, N. Tamayo, Xiaohu Ouyang, 1999 .

Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides.

N. Chen, C. Fotsch, A. Bannon, 2005, Bioorganic & medicinal chemistry letters.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.

R. Kunz, Jiandong Zhang, S. Chmait, 2014, Journal of medicinal chemistry.

Synthesis of anthraquinone derivatives by palladium-catalyzed coupling of triflates with stannanes.

A. Echavarren, N. Tamayo, P. Noheda, 1991 .

Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.

T. Harvey, R. Syed, C. Dominguez, 2005, Bioorganic & medicinal chemistry letters.

Fusarin C and 8Z-fusarin C from Gibberella fujikuroi

J. E. Oltra, J. Avalos, R. Candau, 1991 .

Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists.

J. Treanor, P. Chakrabarti, Yunxin Y Bo, 2008, Bioorganic & medicinal chemistry letters.

Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.

M. Bartberger, Yunxin Y Bo, N. Gavva, 2012, Journal of medicinal chemistry.

Palladium-catalyzed coupling of 2-bromonaphthoquinones with stannanes : a concise synthesis of antibiotics WS 5995 A and C and related compounds

A. Echavarren, N. Tamayo, M. Paredes, 1991 .

Synthesis of benzo[b]carbazoloquinones by coupling of organostannanes with bromoquinones

Alicia García, A. Echavarren, Ó. D. Frutos, 1997 .

Palladium-Catalyzed Coupling of Naphthoquinone Triflates with Stannanes. Unprecedented Nucleophilic Aromatic Substitution on a Hydroxynaphthoquinone Triflate.

P. Calle, A. Echavarren, N. Tamayo, 1997, The Journal of organic chemistry.

IDENTIFICATION OF PREKINAMYCIN IN EXTRACTS OF STREPTOMYCES MURAYAMAENSIS

S. Gould, N. Tamayo, M. Gore, 1996 .

Synthesis of Antibiotics WS 5995 A and C and Related Compounds by Palladium-Catalyzed Coupling of 2-Bromonaphthoquinones with Organostannanes

D. Cárdenas, A. Echavarren, N. Tamayo, 1994 .

Synthesis of the benzo[b]carbazoloquinone with the structure proposed for prekinamycin

A. Echavarren, N. Tamayo, M. Paredes, 1993 .

Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.

S. Chmait, M. Bartberger, S. Jordan, 2015, Journal of medicinal chemistry.

Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.

H. Monenschein, M. Bartberger, Yunxin Y Bo, 2014, Journal of medicinal chemistry.

Solid support synthesis of 14-membered macrocycles containing 4-hydroxyproline structural unit via SNAr methodology

A. Kiselyov, Leon M. Smith, N. Tamayo, 1999 .

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).

Michael G Kelly, J. Cheetham, M. Jarosinski, 2003, Bioorganic & medicinal chemistry letters.

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.

L. Poppe, J. McCarter, Marc Payton, 2022, Journal of medicinal chemistry.

Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

N. Chen, J. McCarter, K. Rex, 2019, Journal of medicinal chemistry.

Revised Structures for the Kinamycin Antibiotics - 5-Diazobenzo(B)Fluorenes Rather Than Benzo(B)Carbazole Cyanamides

S. Gould, N. Tamayo, C. Melville, 1994 .

Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Daniel J. Freeman, J. McCarter, Nancy Zhang, 2012, Journal of medicinal chemistry.

Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.

Daniel J. Freeman, J. McCarter, D. Whittington, 2012, Journal of medicinal chemistry.

High-Content Screening Analysis of the p38 Pathway: Profiling of Structurally Related p38α Kinase Inhibitors Using Cell-Based Assays

C. Dominguez, D. Powers, S. Ross, 2006 .

p38 Inhibitors: beyond pyridinylimidazoles

C. Dominguez, Dawei Zhang, N. Tamayo, 2005 .

Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.

K. Rex, J. Canon, B. Herberich, 2019, Journal of medicinal chemistry.

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.

K. Rex, B. Herberich, Matthew R. Lee, 2016, Journal of medicinal chemistry.

Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists.

P. Chakrabarti, E. Doherty, A. Bannon, 2008, Journal of medicinal chemistry.

TRPV1 modulator that does not cause hyperthermia in rats

J. Louis, B. H. Manning, N. Gavva, 2008 .

Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding.

J. Cheetham, K. Stark, C. Fotsch, 2003, Journal of medicinal chemistry.

Synthesis of Benzo[b]carbazoloquinones by Coupling of Organostannanes with Bromoquinones.

A. Echavarren, Ó. D. Frutos, N. Tamayo, 1998 .