H. Eda

发表

Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT(4) receptor.

Keiko Suzuki, M. Sakakibara, Tomomi Matsuura, 2009, Pharmacological research.

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

J. Monahan, H. Ichijo, E. Welsh, 2010, International immunopharmacology.

Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice.

T. Sugiura, T. Dohi, H. Eda, 2013, Journal of Crohn's & colitis.

The antiproliferative activity of DMDC is modulated by inhibition of cytidine deaminase.

H. Ishitsuka, H. Eda, Y. Tanaka, 1998, Cancer research.

Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice.

H. Ishitsuka, T. Tanaka, T. Udagawa, 1990, Cancer research.

Apoptosis signal-regulating kinase 1 is crucial for oxidative stress-induced but not for osmotic stress-induced hepatocyte cell death.

K. Shinjo, H. Kusano, H. Eda, 2008, Life sciences.

Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine

H. Ishitsuka, A. Hino, Shin‐ichi Watanabe, 2004, Cancer Chemotherapy and Pharmacology.

Anticachectic activity of 5'-deoxy-5-fluorouridine in a murine tumor cachexia model, colon 26 adenocarcinoma.

H. Ishitsuka, T. Tanaka, T. Ishikawa, 1990, Cancer research.

Contribution of active and inactive states of the human 5-HT4d receptor to the functional activities of 5-HT4-receptor agonists.

T. Mikami, H. Sugimoto, T. Ohmi, 2008, Journal of pharmacological sciences.

Interleukin‐1β‐induced interleukin‐6 production in A549 cells is mediated by both phosphatidylinositol 3‐kinase and interleukin‐1 receptor‐associated kinase‐4

J. Monahan, H. Hope, H. Eda, 2011, Cell biology international.

Orally-administered caspase inhibitor PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model.

Yoshinobu Ueno, Tomomi Matsuura, T. Ohmi, 2007, Journal of pharmacological sciences.

In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT(4) receptor.

Keiko Suzuki, M. Sakakibara, T. Komada, 2009, European journal of pharmacology.

Comparative studies on the antitumor and immunosuppressive effects of the new fluorouracil derivative N4-trimethoxybenzoyl-5'-deoxy-5-fluorocytidine and its parent drug 5'-deoxy-5-fluorouridine.

H. Ishitsuka, T. Ishikawa, H. Eda, 1990, Chemical & pharmaceutical bulletin.

Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889

H. Ishitsuka, N. Shimma, T. Ishikawa, 2003, International journal of cancer.

Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.

H. Ishitsuka, I. Horii, N. Shimma, 2003, Bioorganic & medicinal chemistry letters.

5′-Deoxy-5-fluorouridine improves cachexia by a mechanism independent of its antiproliferative action in colon 26 adenocarcinoma-bearing mice

H. Ishitsuka, H. Eda, Yutaka Tanaka, 2004, Cancer Chemotherapy and Pharmacology.

Cytokines Induce Uridine Phosphorylase in Mouse Colon 26 Carcinoma Cells and Make the Cells More Susceptible to 5′‐Deoxy‐5‐fluorouridine

H. Ishitsuka, K. Tatsuno, T. Ohiwa, 1993, Japanese journal of cancer research : Gann.

Selective CB1 cannabinoid receptor antagonist, SR141716A, attenuates liver injury induced by Concanavalin A

D. Hirano, K. Shinjo, H. Eda, 2009, Hepatology research : the official journal of the Japan Society of Hepatology.

Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts

J. Monahan, H. Eda, D. Beidler, 2011, Rheumatology International.

A Nanofiber Membrane Maintains the Quiescent Phenotype of Hepatic Stellate Cells

J. Borenstein, K. Kulig, C. Neville, 2012, Digestive Diseases and Sciences.

Comparative Antitumor Activity and Intestinal Toxicity of 5′‐Deoxy‐5‐fluorouridine and Its Prodrug Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine

H. Ishitsuka, H. Eda, I. Umeda, 1990, Japanese journal of cancer research : Gann.

High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine.

H. Ishitsuka, D. Keith, H. Eda, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Involvement of human interleukin 6 in experimental cachexia induced by a human uterine cervical carcinoma xenograft.

H. Ishitsuka, H. Tokita, Takehisa Matsumoto, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.

T. Natsume, S. Iemura, Makoto Shiozaki, 2014, Bioorganic & medicinal chemistry.

Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.

J. Monahan, H. Eda, D. Beidler, 2010, Cytokine.

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

J. Monahan, H. Ichijo, E. Welsh, 2010, International immunopharmacology.