D. Philibert

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RU 3117 a steroidal compound with high affinity for sigma sites in rat testis membranes

J. Humbert, A. Bonfils, D. Philibert, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis of a fluorescent steroid derivative with high affinities for the glucocorticoid and progesterone receptors

G. Teutsch, D. Philibert, F. Bouchoux, 1994, Steroids.

Residues in the ligand binding domain that confer progestin or glucocorticoid specificity and modulate the receptor transactivation capacity.

D. Moras, J. Wurtz, D. Philibert, 2000, Molecular endocrinology.

Sequences in the ligand-binding domains of the human androgen and progesterone receptors which determine their distinct ligand identities.

H. Gronemeyer, J. Wurtz, W. Bourguet, 1997, Journal of molecular endocrinology.

RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity

G. Teutsch, D. Philibert, V. Magnien, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Exploration of the Therapeutic Potential of the Antiestrogen RU 58668 in Breast Cancer Treatment

G. Teutsch, D. Philibert, P. Velde, 1995, Annals of the New York Academy of Sciences.

Comparing the effects of unconventional and conventional crude oil exposures on zebrafish and their progeny using behavioral and genetic markers.

D. Philibert, Danielle D. Lyons, Ketih B Tierney, 2021, The Science of the total environment.

Assessment of raw and ozonated oil sands process-affected water exposure in developing zebrafish: Associating morphological changes with gene expression.

M. Gamal El-Din, Rui Qin, Rongfu Huang, 2018, Environmental pollution.

Assessing the Toxicity of Individual Aromatic Compounds and Mixtures to American Lobster (Homarus americanus) Larvae Using a Passive Dosing System

S. Marteinson, T. Parkerton, D. Philibert, 2021, Environmental toxicology and chemistry.

In vitro autoradiographic localization of [3H]corticosterone binding sites in rat hippocampus.

W. Rostène, A. Sarrieau, D. Philibert, 1984, European journal of pharmacology.

Autoradiographic localization of glucocorticosteroid and progesterone binding sites in the human post-mortem brain.

Y Agid, Y. Agid, W. Rostène, 1986, Journal of steroid biochemistry.

In vitro binding of tritiated glucocorticoids directly on unfixed rat brain sections.

B. McEwen, W. Rostène, A. Sarrieau, 1984, Journal of steroid biochemistry.

Steroid hormone receptors in human meningiomas, gliomas and brain metastases

J. Hauw, A. Buge, J. Philippon, 2004, Journal of Neuro-Oncology.

Mechanism of action of an antiprogesterone, RU486, in the rabbit endometrium. Effects of RU486 on the progesterone receptor and on the expression of the uteroglobin gene.

E. Milgrom, H. Loosfelt, D. Philibert, 1985, European journal of biochemistry.

Chapter 4 – Receptor Binding as a Tool in the Development of New Bioactive Steroids

T. Ojasoo, J. Raynaud, D. Philibert, 1979 .

Persistent and transgenerational effects of raw and ozonated oil sands process-affected water exposure on a model vertebrate, the zebrafish.

M. G. El-Din, Rui Qin, Rongfu Huang, 2019, The Science of the total environment.

Autoradiographic localization of glucocorticosteroid binding sites in rat brain after in vivo injection of [3H]RU 28362

W. Rostène, A. Sarrieau, M. Dussaillant, 1988, Neuroscience Letters.

Sex steroid receptors in human meningioma and glioma

H. Magdelenat, M. Poisson, D. Philibert, 1984 .

Cytosolie and Nuclear Sex Steroid Receptors In Meningioma

J. Philippon, M. Poisson, D. Philibert, 1984, Clinical neuropharmacology.

Progesterone Suppression of Pregnancy Lymphocytes Is not Mediated by Glucocorticoid Effect

G. Chaouat, D. Philibert, J. Szekeres-Bartho, 1990, American journal of reproductive immunology.

From RU 38486 towards Dissociated Antiglucocorticoid and Antiprogesterone

G. Teutsch, D. Philibert, M. Gaillard-Moguilewsky, 1991 .

Retinoic acid signaling regulates late stages of semicircular canal morphogenesis and otolith maintenance in the zebrafish inner ear

K. Kawakami, A. Waskiewicz, Kacey J. Mackowetzky, 2022, Developmental dynamics : an official publication of the American Association of Anatomists.

RU 58 668, a new pure antiestrogen inducing a regression of human mammary carcinoma implanted in nude mice

G. Teutsch, D. Philibert, F. Bouchoux, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

17α-Alkynyl-11β,17-dihydroxyandrostane derivatives : A new class of potent glucocorticoids.

G. Teutsch, M. Fortin, D. Philibert, 1981, Steroids.

17 alpha-alkynyl-11 beta, 17-dihydroxyandrostane derivatives : a new class of potent glucocorticoids.

G. Teutsch, M. Fortin, D. Philibert, 1981, Steroids.

Progesterone and RU486: opposing effects on human sperm.

E. Baulieu, P. Jouannet, C. Serres, 1994, Proceedings of the National Academy of Sciences of the United States of America.

[The effects of an antiprogesterone steroid in women: interruption of the menstrual cycle and of early pregnancy].

G. Teutsch, E. Baulieu, W. Herrmann, 1982, Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie.

Switching agonistic, antagonistic, and mixed transcriptional responses to 11 beta-substituted progestins by mutation of the progesterone receptor.

P. Chambon, H. Gronemeyer, D. Philibert, 1992, Molecular endocrinology.

RU 38486: potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation.

D. Philibert, M. Moguilewsky, Daniel Philibert, 1984, Journal of steroid biochemistry.

Antiglucocorticoid properties of RU 38486 in a differentiated hepatoma cell line.

R. Barouki, J. Hanoune, M. Aggerbeck, 1983, Biochemical pharmacology.

Early-life exposure to weathered, unweathered and dispersed oil has persisting effects on ecologically relevant behaviors in sheepshead minnow.

K. Tierney, D. Philibert, Danielle D. Lyons, 2020, Ecotoxicology and environmental safety.

Comparison of Diluted Bitumen (Dilbit) and Conventional Crude Oil Toxicity to Developing Zebrafish.

K. Tierney, D. Philibert, Clara P Philibert, 2016, Environmental science & technology.

Comparison between the interaction of steroids with [35S]TBPS binding to cerebral cortical and to pituitary membranes: correlation with inhibition of prolactin release

M. Fortin, M. Vincens, D. Philibert, 1992, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacokinetics of RU 486.

J. Salmon, D. Philibert, C. Bonnat, 1985 .

Progesterone-Progestin receptors.

J. Raynaud, D. Philibert, G. Azadian-Boulanger, 1974, Basic life sciences.

Biochemical Profile of RU 486

D. Philibert, M. Moguilewsky, 1985 .

RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

C. Branche, J. Humbert, A. Bonfils, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

Free microvascular transplantation of the trapezius musculocutaneous flap in dogs.

D. Philibert, J. Fowler, J. Clapson, 1992, Veterinary surgery : VS.

The anatomic basis for a trapezius muscle flap in dogs.

D. Philibert, J. Fowler, J. Clapson, 1992, Veterinary surgery : VS.

The trapezius osteomusculocutaneous flap in dogs.

D. Philibert, J. Fowler, 1993, Veterinary surgery : VS.

Regio and stereospecific synthesis of 11β-substituted 19-norsteroids Influence of 11β-substitution on progesterone receptor affinity — (1)

G. Teutsch, A. Bélanger, D. Philibert, 1981, Steroids.

Histopharmacology of RU 486

D. Philibert, J. Secchi, C. Tournemine, 1985 .

Pharmacological Profile of RU 486 in Animals

D. Philibert, J. Secchi, M. Moguilewsky, 1985 .

11β-Amidoalkyl estradiols, a new series of pure antiestrogens

G. Teutsch, D. Philibert, P. Velde, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

A burning issue: The effect of organic ultraviolet filter exposure on the behaviour and physiology of Daphnia magna.

M. G. El-Din, T. Blewett, Z. How, 2021, The Science of the total environment.

Steroid hormone receptors and pharmacology.

J. Mornon, F. Labrie, T. Ojasoo, 1980, Journal of steroid biochemistry.

Comparative study of estrogen action.

J P Raynaud, M M Bouton, J. Raynaud, 1973, Molecular pharmacology.

Progesterone binding in the immature mouse and rat uterus.

J. Raynaud, D. Philibert, 1973, Steroids.

Progesterone binding in the immature rabbit and guinea pig uterus.

J. Raynaud, D. Philibert, 1974, Endocrinology.

Properties of the cytoplasmic progestin-binding protein in the rabbit uterus.

T Ojasoo, T. Ojasoo, J. Raynaud, 1977, Endocrinology.

Specific progesterone receptors in dimethylbenzanthracene (DMBA)-induced mammary tumors

P. Kelly, F. Labrie, J. Raynaud, 1976, Steroids.

SCREENING FOR ANTI-HORMONES BY RECEPTOR STUDIES

C. Bonne, J. Raynaud, D. Philibert, 1976 .

Steroid binding in the hypothalamus and pituitary.

J. Raynaud, D. Philibert, B. Vannier, 1976, Current topics in molecular endocrinology.

Screening for anti-hormones by receptor studies.

C. Bonne, J. Raynaud, D. Philibert, 1975, Journal of steroid biochemistry.

Binding of progesterone and R 5020, a highly potent progestin, to human endometrium and myometrium.

J. Raynaud, D. Philibert, Jean-Pierre Raynaud, 1974, Contraception.

RU 38486: a potent antiglucocorticoid in vitro and in vivo.

D. Philibert, D. Gagne, M. Pons, 1985, Journal of steroid biochemistry.

RU 38486: An Original Multifaceted Antihormone in Vivo

D. Philibert, 1984 .

Pharmacological profile of RU 58642, a potent systemic antiandrogen for the treatment of androgen-dependent disorders

M. Gaillard-Kelly, C. Branche, D. Philibert, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Field-collected crude oil, weathered oil and dispersants differentially affect the early life stages of freshwater and saltwater fishes.

K. Tierney, D. Philibert, Danielle D. Lyons, 2019, The Science of the total environment.

Non-steroidal antiandrogens: Synthesis and biological profile of high-affinity ligands for the androgen receptor

G. Teutsch, M. Gaillard-Kelly, A. Bonfils, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

History and perspectives of antiprogestins from the chemist's point of view.

G. Teutsch, D. Philibert, 1994, Human reproduction.

Growth and recovery of zebrafish embryos after developmental exposure to raw and ozonated oil sands process-affected water.

M. Gamal El-Din, K. Tierney, D. Philibert, 2018, Chemosphere.

9. Regional- and stereo-specific synthesis of 11β-substituted 19-nor-steroids

G. Teutsch, A. Bélanger, D. Philibert, 1978 .

New analogues of mifepristone with more dissociated antiprogesterone activities.

D. Philibert, M. Gaillard-Moguilewsky, C. Tournemine, 1989, Journal of steroid biochemistry.

Synthesis of 11β-vinyl-19-norsteroids as potent progestins

G. Teutsch, A. Bélanger, D. Philibert, 1982, Steroids.

Contragestion by antiprogestin RU 486: A review

E. Baulieu, A. Ulmann, D. Philibert, 2004, Archives of Gynecology and Obstetrics.

Design of ligands for the glucocorticoid and progestin receptors.

G. Teutsch, G. Lemoine, D. Philibert, 1991, Biochemical Society transactions.

204. RU 38486 — A potent antiprogesterone

G. Teutsch, D. Philibert, C. Tournemine, 1982 .

General Structure‐Activity Correlations of Antihormones

G. Teutsch, G. Lemoine, D. Philibert, 1995, Annals of the New York Academy of Sciences.

The pharmacological profile of a novel norpregnance progestin (trimegestone).

D. Philibert, F. Bouchoux, D. Lecaque, 1999, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

Fertility control with RU 486.

A. Ulmann, D. Philibert, C. Dubois, 1987, Hormone research.

Synthesis and evaluation of a new series of mechanism-based aromatase inhibitors.

D. Lesuisse, D. Philibert, C. Hartmann, 1992, Journal of medicinal chemistry.

Paradoxical involvement of glucocorticoid receptors in the aldosterone-induced impairment of ACTH secretion from perifused pituitary glands.

M. Sakly, D. Philibert, B. Koch, 1984, Journal of Steroid Biochemistry.

A progesterone metabolite enhances the activity of the GABAA receptor complex at the pituitary level.

M. Vincens, D. Philibert, M. Moguilewsky, 1989, European journal of pharmacology.

11β-Amidoalkoxyphenyl estradiols, a new series of pure antiestrogens

G. Teutsch, D. Philibert, M. Hardy, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes.

S. Kirkiacharian, D. Philibert, F. Bouchoux, 1999, Farmaco.

Corticosteroid receptors in rat hippocampal sections: effect of adrenalectomy and corticosterone replacement.

B. McEwen, W. Rostène, A. Sarrieau, 1986, Journal of steroid biochemistry.

80. Potent antiglucocorticoid activity of RU38486 on acth secretion in vitro and in vivo in the rat

D. Philibert, J. Cǒté, R. Deraedt, 1982 .

Self-inhibition of steroid secretion by amphibian adrenocortical cells is not mediated through glucocorticoid receptors.

M. Feuilloley, H. Vaudry, F. Leboulenger, 1991, Journal of Molecular Endocrinology.

Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

C. Branche, D. Philibert, B. Bergaud, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

Structure-activity relationships of a new family of steroidal aromatase inhibitors. 1. Synthesis and evaluation of a series of analogs related to 19-[(methylthio)methyl]androstenedione (RU54115).

G. Teutsch, D. Mansuy, D. Philibert, 1996, Journal of medicinal chemistry.

Effects of the Antiprogesterone Agent RU 486 on the Natural Cycle and Gestation in Intact Cynomolgus Monkeys

E. Baulieu, G. Germain, D. Philibert, 1985 .

Synthesis of 11 beta-vinyl-19-norsteroids as potent progestins.

G. Teutsch, A. Bélanger, D. Philibert, 1982, Steroids.

Regio and stereospecific synthesis of 11 beta-substituted 19-norsteroids. Influence of 11 beta-substitution on progesterone receptor affinity - (1).

G. Teutsch, A. Bélanger, D. Philibert, 1981, Steroids.

Control of birth in rats by RU 486, an antiprogesterone compound.

E. Baulieu, G. Germain, D. Philibert, 1987, Journal of Reproduction and Fertility.

The Use of the Antiprogesterone Compound RU 486 to Control Timing of Parturition in Rats

E. Baulieu, G. Germain, D. Philibert, 1985 .

Changes in Temperature Alter the Toxicity of Polycyclic Aromatic Compounds to American Lobster (Homarus americanus) Larvae

S. Marteinson, D. Philibert, B. D. de Jourdan, 2023, Environmental toxicology and chemistry.