E. Weber

发表

Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin

M. Scherz, B. G. Campbell, J. Keana, 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)guanidine.

M. Kavanaugh, M. Scherz, J. Keana, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Chlorinated phenyl azides as photolabeling reagents. Synthesis of an ortho,ortho'-dichlorinated arylazido PCP receptor ligand.

K. Gee, S. Cai, J. Keana, 1993, Bioconjugate chemistry.

1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites

J. Hawkinson, S. Espitia, J. Keana, 1996 .

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.

E. R. Whittemore, J. Guastella, E. Weber, 1996, Molecular pharmacology.

In vivo Models of Cerebral Ischemia: Effects of Parenterally Administered NMDA Receptor Glycine Site Antagonists

D. Warner, J. Keana, E. Weber, 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists.

J. Hawkinson, S. Espitia, E. R. Whittemore, 2001, Bioorganic & medicinal chemistry.

Phencyclidine and psychotomimetic sigma opiates: recent insights into their biochemical and physiological sites of action

M. Sonders, J. Keana, E. Weber, 1988, Trends in Neurosciences.

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

M. Sonders, S. Mclean, S. Pou, 1986, Proceedings of the National Academy of Sciences of the United States of America.

σ Receptor ligand N,N'-di-(ortho-toIyl)guanidine inhibits release of acetylcholine in the guinea pig ileum

J. Keana, E. Weber, B. Cambell, 1991 .

Radiosynthesis of sigma receptor ligands for positron emission tomography: 11C- and 18F-labeled guanidines.

A. Wilson, R. Dannals, H. Ravert, 1991, Journal of medicinal chemistry.

Pharmacology of ACEA-1416: a potent systemically active NMDA receptor glycine site antagonist.

E. R. Whittemore, S. Cai, M. Tran, 1996, European journal of pharmacology.

Inhibition of clonic seizure-like excitatory effects induced by intrathecal morphine using two NMDA receptor antagonists: MK-801 and ACEA-1011.

J. Keana, E. Weber, K. Lutfy, 1994, European journal of pharmacology.

Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay.

S. Cai, J. Drewe, J. Guastella, 2001, Bioorganic & medicinal chemistry letters.

Antinociceptive effects of NMDA and non-NMDA receptor antagonists in the tail flick test in mice

S. Cai, E. Weber, K. Lutfy, 1997, Pain.

Synthesis and characterization of a radiolabelled derivative of the phencyclidine/N-methyl-D-aspartate receptor ligand (+) MK-801 with high specific radioactivity.

M. Sonders, M. Scherz, J. Keana, 1988, Life sciences.

Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist.

R. McBurney, S. Wong, D. L. Holmes, 1994, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor.

M. Sonders, M. Scherz, S. Wong, 1990, Journal of medicinal chemistry.

Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.

E. R. Whittemore, P. Yuen, S. Cai, 1999, Journal of medicinal chemistry.

Synthesis and Structure-Activity Relationships of 1,2,3,4- Tetrahydroquinoline-2,3,4-trione 3-Oximes: Novel and Highly Potent Antagonists for NMDA Receptor Glycine Site.

J. Hawkinson, E. R. Whittemore, S. Cai, 1996 .

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.

J. Hawkinson, E. R. Whittemore, S. Cai, 1996, Journal of medicinal chemistry.

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.

J. Hawkinson, S. Espitia, S. Cai, 1997, Journal of medicinal chemistry.

5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.

J. Hawkinson, S. Espitia, S. Cai, 1997, Journal of medicinal chemistry.

Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site.

C. Jahr, R. Lester, E. Weber, 1989, Molecular pharmacology.

Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors.

J. Hawkinson, E. R. Whittemore, S. Cai, 1996, Journal of medicinal chemistry.

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.

J. Hawkinson, S. Espitia, E. R. Whittemore, 2003, Bioorganic & medicinal chemistry.

N-methyl-D-aspartate receptor-mediated contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation: modulation by phencyclidine and glycine receptors.

B. G. Campbell, J. Keana, E. Weber, 1991, The Journal of pharmacology and experimental therapeutics.

N-(3-azidophenyl)-N-methyl-N'-([4-1H]- and [4-3H]-1-naphthyl)guanidine. A potent and selective ligand designed as a photoaffinity label for the phencyclidine site of the N-methyl-D-aspartate receptor.

K. Gee, G. J. Durant, S. Wong, 1993, Bioconjugate chemistry.

Synthesis and characterization of an affinity label for brain receptors to psychotomimetic benzomorphans: differentiation of sigma-type and phencyclidine receptors.

M. Sonders, M. Scherz, J. Keana, 1987, European journal of pharmacology.

NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin

A. Vaccarino, B. Kest, J. Liebeskind, 1993, Brain Research.

ACEA-1328, a NMDA receptor/glycine site antagonist, acutely potentiates antinociception and chronically attenuates tolerance induced by morphine.

E. Weber, K. Lutfy, P. Doan, 1999, Pharmacological research.

ACEA-1328, an NMDA receptor antagonist, increases the potency of morphine and U50,488H in the tail flick test in mice.

E. Weber, K. Lutfy, P. Doan, 1998, Pharmacological research.

Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist.

J. E. Huettner, M. Tran, J. Guastella, 1995, The Journal of pharmacology and experimental therapeutics.

In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites.

J. E. Huettner, J. Guastella, J. Keana, 1995, Molecular pharmacology.

Blockade of morphine tolerance by ACEA-1328, a novel NMDA receptor/glycine site antagonist.

S. Cai, K. Shen, J. Keana, 1995, European journal of pharmacology.

The N-methyl-d-aspartate (NMDA) receptor glycine site antagonist ACEA 1021 does not produce pathological changes in rat brain

J. Hawkinson, M. J. Whitehouse, P. Sahota, 1997, Brain Research.

Inhibition of morphine tolerance by NMDA receptor antagonists in the formalin test

K. Shen, E. Weber, K. Lutfy, 1996, Brain Research.

Synthesis and Structure‐Activity Relationships of Substituted 1,4‐ Dihydroquinoxaline‐2,3‐diones: Antagonists of N‐Methyl‐D‐aspartate ( NMDA) Receptor Glycine Sites and Non‐NMDA Glutamate Receptors.

S. Cai, S. Kher, J. Guastella, 1996 .

Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.

J. Hawkinson, J. E. Huettner, S. Espitia, 1996, Journal of medicinal chemistry.

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.

J. Hawkinson, S. Espitia, L. Wise, 1999, Journal of medicinal chemistry.

Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance.

E. Weber, K. Lutfy, P. Doan, 1999, European journal of pharmacology.

Behavioral pharmacology of two novel substituted quinoxalinedione glutamate antagonists

J. Wiley, K. Nicholson, R. Mansbach, 1995, Behavioural pharmacology.

Regiospecific Oxidative Nitration of 3,4-Dihydro-6,7-disubstituted Quinoxaline-2(1H)-ones Gives 1,4-Dihydro-5-nitro-6,7-disubstituted Quinoxaline-2,3-diones, Potent Antagonists at the NMDA/Glycine Site

S. Cai, S. Kher, J. Keana, 1995 .

Synthesis and Structure‐Activity Studies of N,N′‐Diarylguanidine Derivatives. N‐(1‐Naphthyl)‐N′‐(3‐ethylphenyl)‐N′‐methylguanidine: A New, Selective Noncompetitive NMDA Receptor Antagonist.

Scott T. Wong, R. McBurney, D. L. Holmes, 1994 .

Morphine analgesia and tolerance in mice selectively bred for divergent swim stress-induced analgesia.

E. Weber, K. Lutfy, B. Sadowski, 1994, European journal of pharmacology.

Methyl-o-aspartate Receptor-Associated Glycine Binding Site

C. Jahr, R. Lester, E. Weber, 2012 .

(+)‐[3H]MK‐801 Binding Sites in Postmortem Human Brain

J. Keana, E. Weber, M. Quarum, 1990, Journal of neurochemistry.

Tolerance develops to the antinociceptive and motor impairing effects of ACEA-1416, a NMDA receptor antagonist, in the formalin and rotarod test in mice.

E. Weber, K. Lutfy, 1998, Pharmacological research.

Synthesis of 7,8-(methylenedioxy)-1-phenyl-3,5-dihydro-4H-2, 3-benzodiazepin-4-ones as novel and potent noncompetitive AMPA receptor antagonists.

R. B. Carter, S. Cai, Y. Wang, 1998, Journal of Medicinal Chemistry.

6,7,8,9-tetrahydro-3-hydroxy-1H-1-benzazepine-2,5-diones via a diels-alder reaction:antagonists with a non-planar hydrophobic region for NMDA receptor glycine sites

J. Hawkinson, J. Keana, E. Weber, 1995 .

Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.

E. R. Whittemore, S. Cai, J. Drewe, 1998, Journal of medicinal chemistry.

10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands.

K. Gee, R. McBurney, P. Barmettler, 1993, Journal of medicinal chemistry.

Solubilization and Characterization of σ‐Receptors from Guinea Pig Brain Membranes

M. Kavanaugh, J. Keana, E. Weber, 1989, Journal of neurochemistry.

Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.

E. R. Whittemore, S. Cai, Jin-Cheng Huang, 1998, Journal of medicinal chemistry.

Solubilization and characterization of sigma-receptors from guinea pig brain membranes.

M. Kavanaugh, J. Keana, E. Weber, 1989, Journal of Neurochemistry.

A novel photoaffinity ligand for the phencyclidine site of the N-methyl-D-aspartate receptor labels a Mr 120,000 polypeptide.

P. Barmettler, M. Sonders, J. Keana, 1990, The Journal of biological chemistry.

N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype.

E. R. Whittemore, P. Yuen, S. Cai, 1998, Bioorganic & Medicinal Chemistry Letters.

N‐(2‐(4‐Hydroxyphenyl)ethyl)‐4‐chlorocinnamide: A Novel Antagonist at the 1A/2B NMDA Receptor Subtype.

E. R. Whittemore, S. Cai, J. Keana, 2010 .

Attenuation of nociceptive responses by ACEA-1021, a competitive NMDA receptor/glycine site antagonist, in the mice

E. Weber, K. Lutfy, 1996, Brain Research.