A. Thurkauf

发表

Drug specificity of pharmacological dystonia

W. Bowen, J. Walker, K. Rice, 1990, Pharmacology Biochemistry and Behavior.

Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.

A. Newman, S. Husbands, A. Thurkauf, 2001, Journal of medicinal chemistry.

Identification and Characterization of NDT 9513727 [N,N-bis(1,3-Benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a Novel, Orally Bioavailable C5a Receptor Inverse Agonist

J. Krause, M. E. Buck, R. Brodbeck, 2008, Journal of Pharmacology and Experimental Therapeutics.

Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists.

H. Zhao, A. Thurkauf, A. Kieltyka, 2000, Bioorganic & medicinal chemistry letters.

Comparison of the effects of the uncompetitive N-methyl-D-aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine (ADCI) with its structural analogs dizocilpine (MK-801) and carbamazepine on ethanol withdrawal seizures.

K. Grant, M. Rogawski, L. Snell, 1992, The Journal of pharmacology and experimental therapeutics.

Anticonvulsant activity of the low-affinity uncompetitive N-methyl-D- aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (ADCI): comparison with the structural analogs dizocilpine (MK-801) and carbamazepine.

M. Rogawski, S. Yamaguchi, S. M. Jones, 1991, The Journal of pharmacology and experimental therapeutics.

Identification and characterization of NDT 9513727, a novel, orally bioavailable C5a receptor inverse agonist

J. Krause, M. E. Buck, R. Brodbeck, 2008 .

Anticonvulsant 1‐Phenylcycloalkylamines: Two Analogues with Low Motor Toxicity When Orally Administered

M. Rogawski, P. Blake, S. Yamaguchi, 1992, Epilepsia.

1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands.

W. Greenlee, Suoming Zhang, A. Ganguly, 2003, Bioorganic & medicinal chemistry letters.

Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.

K. Hodgetts, R. Brodbeck, S. Rachwał, 2002, Bioorganic & medicinal chemistry letters.

The synthesis of tritiated 2‐phenyl‐4‐[4‐(2‐pyrimidyl)piperazinyl]methylimidazole ([3H] NGD 94‐1), a ligand selective for the dopamine D4 receptor subtype

A. Thurkauf, 1997 .

NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.

J. Yuan, R. Brodbeck, A. Thurkauf, 1998, Bioorganic & medicinal chemistry letters.

6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D(4) receptors.

K. Hodgetts, R. Brodbeck, A. Thurkauf, 2001, Bioorganic & medicinal chemistry.

Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.

J. Chandrasekhar, K. Hodgetts, R. Brodbeck, 2003, Bioorganic & medicinal chemistry letters.

A PRACTICAL AND CONVENIENT SYNTHESIS OF METHYL 5-FORMYL-3-METHOXYBENZOATE

A. Thurkauf, He Zhao, 2001 .

An improved procedure for the preparation of acetals from diaryl ketones

A. E. Jacobson, A. Thurkauf, Kenner C. Riee, 1988 .

2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors.

A Thurkauf, D K Jones-Hertzog, D. Hoffman, 1997, Journal of medicinal chemistry.

Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.

He Zhao, D. Hoffman, R. Brodbeck, 2002, Bioorganic & medicinal chemistry letters.

Treatment of N-Boc Derivatives of β-Amino Alcohols with N,N-Diethylaminosulfur Trifluoride Leads to Chiral Oxazolidinones: An Unexpected Intramolecular Cyclization

A. Thurkauf, He Zhao, 1999 .

I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor.

J. Tallman, D. Gallager, R. Brodbeck, 1997, The Journal of pharmacology and experimental therapeutics.

Aromatic Annelation. II. Synthesis of phenols.

M. Tius, A. Thurkauf, Joel W. Truesdell, 1982 .

An electrophilic affinity ligand based on (+)-MK801 distinguishes PCP site 1 from PCP site 2

J. Linders, K. Rice, R. Rothman, 1994, Neurochemical Research.

Synthesis of [3H]‐1‐[1‐(3‐isothiocyanatophenyl) cyclohexyl]piperidine (METAPHIT), an acylating agent for phencyclidine receptors

K. Rice, R. Highet, A. E. Jacobson, 1989 .

Synthesis of tritium labelled (–)–U50,488, a selective kappa opioid agonist

K. Rice, A. Thurkauf, Brian De Gosta, 1989 .

II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1.

J. Tallman, A. Thurkauf, R. Primus, 1997, The Journal of pharmacology and experimental therapeutics.

MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO

T. Kameyama, T. Nabeshima, K. Rice, 1990, Neuroscience Letters.

A Practical and Convenient Synthesis of Methyl 5-Formyl-3-methoxybenzoate.

A. Thurkauf, He Zhao, 2001 .

Aromatic annelation. I. Synthesis of pyridines.

M. Tius, A. Thurkauf, Joel W. Truesdell, 1982 .

GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine

N. Greig, K. Rice, A. Mele, 1991, Pharmacology Biochemistry and Behavior.

Synthesis and evaluation of optically pure [3H]‐(+)‐pentazocine, a highly potent and selective radioligand for σ receptors

W. Bowen, K. Rice, B. de Costa, 1989 .

An efficient synthesis of optically pure (S)-(-)-3-methylcyclohexanone

K. Rice, A. E. Jacobson, A. Thurkauf, 1987 .

Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist.

C. George, K. Rice, S. Mascarella, 1988, Journal of medicinal chemistry.

Evaluation of ADCI against convulsant and locomotor stimulant effects of cocaine: Comparison with structural analogs dizocilpine and carbamazepine

J. Witkin, A. Thurkauf, B. K. Seidleck, 1994, Pharmacology Biochemistry and Behavior.

trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents.

D. Hoffman, H. Zhao, K. Hodgetts, 2000, Journal of medicinal chemistry.

Atypical antipsychotic-like effects of the dopamine D3 receptor agonist, (+)-PD 128,907.

H. Wikström, J. Yuan, J. Witkin, 1998, European journal of pharmacology.

Indoline and Piperazine Containing Derivatives as a Novel Class of Mixed D2/D4 Receptor Antagonists. Part 2. Asymmetric Synthesis and Biological Evaluation.

D. Hoffman, R. Brodbeck, A. Thurkauf, 2003 .

[3H]1‐[2‐(2‐thienyl)cyclohexyl]piperidine labels two high‐affinity binding sites in human cortex: Further evidence for phencyclidine binding sites associated with the biogenic amine reuptake complex

K. Rice, M. Heyes, R. Rothman, 1991, Synapse.

Synthesis of tritium labelled 4-fluoro-1-[1–(2-thienyl)]cyclohexylpiperidine ([3H]-FTCP); a tool for autoradiographic study of the phencyclidine binding site

K. Rice, D. Kiesewetter, B. Costa, 1989 .

Etoxadrol‐meta‐isothiocyanate: A potent, enantioselective, electrophilic affinity ligand for the phencyclidine‐binding site

K. Rice, P. Huguenin, M. Mattson, 1988, FEBS letters.

Tight binding dopamine reuptake inhibitors as cocaine antagonists

N. Greig, K. Rice, A. Mele, 1989, FEBS letters.

1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding.

J. Yuan, A. Thurkauf, R. Meade, 1996, Journal of medicinal chemistry.

2-Phenyl-4-(aminomethyl)imidazoles as potential antipsychotic agents. Synthesis and dopamine D2 receptor binding.

A. Thurkauf, R. Meade, K. Gerber, 1995, Journal of medicinal chemistry.