Li Wu

发表

The analgesic tropane analogue (±)-SM 21 has a high affinity for σ2 receptors

R. Mach, S. Childers, Li Wu, 1999 .

Suramin Derivatives as Inhibitors and Activators of Protein-tyrosine Phosphatases*

A. Kreimeyer, Zhon-Yin Zhang, M. Kassack, 2004, Journal of Biological Chemistry.

Thermodynamic Study of Ligand Binding to Protein-tyrosine Phosphatase 1B and Its Substrate-trapping Mutants*

Terrence R. Burke, T. Burke, Z. Yao, 2000, The Journal of Biological Chemistry.

Crystal Structure of the Yersinia Protein-tyrosine Phosphatase YopH Complexed with a Specific Small Molecule Inhibitor*

A. Fedorov, S. Almo, Zhon-Yin Zhang, 2003, Journal of Biological Chemistry.

Suramin Is an Active Site-directed, Reversible, and Tight-binding Inhibitor of Protein-tyrosine Phosphatases*

Y. Keng, Y. Zhao, Zhon-Yin Zhang, 1998, The Journal of Biological Chemistry.

Derivatives of Salicylic Acid as Inhibitors of YopH in Yersinia pestis

Chung F. Wong, Zunnan Huang, Zhon-Yin Zhang, 2010, Chemical biology & drug design.

The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors

C. V. Vander Kooi, Matthew S. Gentry, Robert D. Murphy, 2022, The Journal of biological chemistry.

N‐[18F]4′‐fluorobenzylpiperidin‐4yl‐(2‐fluorophenyl) acetamide ([18F]FBFPA): A potential fluorine‐18 labeled PET radiotracer for imaging sigma‐1 receptors in the CNS

Robert H Mach, N. Buchheimer, R. Ehrenkaufer, 2005, Synapse.

Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases.

Sanjai Kumar, Bo Zhou, Zhon-Yin Zhang, 2008, Journal of the American Chemical Society.

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.

Zhon-Yin Zhang, Shizhen Chen, Xin Zhou, 2016, MedChemComm.

Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta.

Zhon-Yin Zhang, Yunpeng Bai, A. Gunawan, 2014, Antioxidants & redox signaling.

Conformationally-flexible benzamide analogues as dopamine D3 and σ2 receptor ligands

R. Mach, S. Vangveravong, R. Luedtke, 2004 .

Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors.

K. No, Ky-Youb Nam, Zhon-Yin Zhang, 2005, Bioorganic & medicinal chemistry letters.

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

C. Wells, R. Chan, Zhon-Yin Zhang, 2014, Journal of medicinal chemistry.

Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.

Jie Xu, Zhon-Yin Zhang, Zhong-Yin Zhang, 2013, Journal of medicinal chemistry.

A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis.

Chung F. Wong, Zhon-Yin Zhang, Li Wu, 2014, Bioorganic & medicinal chemistry.

Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).

R. Chan, Zhon-Yin Zhang, Zhihong Yu, 2010, Journal of medicinal chemistry.

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids.

A. Adibekian, Zhon-Yin Zhang, D. Abegg, 2018, Journal of the American Chemical Society.

Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.

Zhon-Yin Zhang, Yunpeng Bai, A. Gunawan, 2014, MedChemComm.

Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase.

R. Callender, Mazdak Khajehpour, Zhon-Yin Zhang, 2007, Biochemistry.

Acquisition of a Specific and Potent PTP1B Inhibitor from a Novel Combinatorial Library and Screening Procedure*

D. Lawrence, Y. Keng, Zhon-Yin Zhang, 2001, The Journal of Biological Chemistry.

Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations

Zhon-Yin Zhang, S. Zhang, Li Wu, 2014, Biochemistry.

Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.

Zhon-Yin Zhang, Li Wu, Sijiu Liu, 2011, Bioorganic & medicinal chemistry letters.

Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations*

Shenmin Zhang, Jie Xu, Zhon-Yin Zhang, 2013, The Journal of Biological Chemistry.

The Purification and Characterization of a Human Dual-specific Protein Tyrosine Phosphatase (*)

J. Dixon, J. Denu, Gaochao Zhou, 1995, The Journal of Biological Chemistry.

Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2

S. Zhang, Zhon-Yin Zhang, Li Wu, 2020, The Journal of Biological Chemistry.

Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2*

D. Lawrence, Bo Zhou, Zhon-Yin Zhang, 2001, The Journal of Biological Chemistry.

SHP2 is a target of the immunosuppressant tautomycetin.

B. Shen, R. Chan, Zhon-Yin Zhang, 2011, Chemistry & biology.

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.

Jun O. Liu, C. Wells, J. Shim, 2015, ACS medicinal chemistry letters.

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.

J. Dixon, Zhon-Yin Zhang, Yan Zhang, 2015, Bioorganic & medicinal chemistry.

Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.

R. Mach, S. Vangveravong, R. Luedtke, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of n-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as sigma-2 receptor ligands

R. Mach, S. Vangveravong, Li Wu, 2002 .

Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed Reaction

K. Guan, S. Noh, Y. Zhao, 1998, The Journal of Biological Chemistry.

Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.

Zhon-Yin Zhang, Y. Long, Zhong-Yin Zhang, 2008, Journal of the American Chemical Society.

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.

Zhon-Yin Zhang, Jifeng Wang, R. He, 2016, Journal of medicinal chemistry.

A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.

Nunzio Bottini, N. Bottini, Zhon-Yin Zhang, 2013, Journal of medicinal chemistry.

Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis.

Zhon-Yin Zhang, A. Gunawan, Yantao He, 2013, Chemical communications.

Comparative Kinetic Analysis and Substrate Specificity of the Tandem Catalytic Domains of the Receptor-like Protein-tyrosine Phosphatase α*

J. den Hertog, A. Buist, Zhon-Yin Zhang, 1997, The Journal of Biological Chemistry.

Determinants of Substrate Recognition in the Protein-tyrosine Phosphatase, PTP1 (*)

D. Mcnamara, W. Miller, A. Walsh, 1996, The Journal of Biological Chemistry.

Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.

T. Burke, Z. Yao, Zhon-Yin Zhang, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of N(1-benzylpiperidin-4-yl)arylacetamide analogues as potent σ1 receptor ligands

R. Mach, Li Wu, P. Hammond, 2001 .

Walden-Inversion-Enforced Transition-State Stabilization in a Protein Tyrosine Phosphatase

Jiali Gao, Jiali Gao, C. Alhambra, 1998 .

Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis.

Zhon-Yin Zhang, A. Gunawan, R. He, 2015, ACS medicinal chemistry letters.

Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.

Yuehong Wang, Sheng Zhang, S. Zhang, 2010, ACS medicinal chemistry letters.

A Facile Hydroxyindole Carboxylic Acid Based Focused Library Approach for Potent and Selective Inhibitors of Mycobacterium Protein Tyrosine Phosphatase B

Jie Xu, Zhon-Yin Zhang, A. Gunawan, 2013, ChemMedChem.

[18F]N-4′-Fluorobenzyl-4-(3-bromophenyl) acetamide for imaging the sigma receptor status of tumors: comparison with [18F]FDG and [125I]IUDR

N. Buchheimer, R. Ehrenkaufer, T. Morton, 2001 .

Environmental effects on phosphoryl group bonding probed by vibrational spectroscopy: implications for understanding phosphoryl transfer and enzymatic catalysis.

D. Herschlag, R. Callender, P. O'Brien, 2002, Journal of the American Chemical Society.

Double Click Reaction for the Acquisition of a Highly Potent and Selective mPTPB Inhibitor

Jie Xu, Zhon-Yin Zhang, Zhihong Yu, 2010, ChemMedChem.

Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.

Zhon-Yin Zhang, Chun Hu, Zhiyan Xiao, 2013, Bioorganic & medicinal chemistry letters.

Highly Potent and Selective N-aryl Oxamic Acid Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (mPTPB).

Zhon-Yin Zhang, Congwei Niu, Li Wu, 2020, Journal of medicinal chemistry.

Enantioselective Synthesis of Nonphosphorus-Containing Phosphotyrosyl Mimetics and Their Use in the Preparation of Tyrosine Phosphatase Inhibitory Peptides

G. Milne, Z. Yao, J. Voigt, 1998 .

Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.

T. Burke, M. Nicklaus, J. Voigt, 2003, Bioorganic & medicinal chemistry letters.

Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.

N. Noinaj, Zhon-Yin Zhang, M. Michael, 2022, Journal of medicinal chemistry.

Restoration of potent protein-tyrosine phosphatase activity into the membrane-distal domain of receptor protein-tyrosine phosphatase alpha.

J. den Hertog, Y. Keng, Z. Zhang, 1999, Biochemistry.

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.

D S Lawrence, S. Almo, D. Lawrence, 2000, Biochemistry.

The catalytic role of Cys124 in the dual specificity phosphatase VHR.

G. Zhou, J. Dixon, J. Denu, 1994, The Journal of biological chemistry.

The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.

E. Fauman, J. Dixon, L. Wu, 1994, Biochemistry.

Synthesis of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors.

R. Mach, R. Luedtke, Li Wu, 2003, Bioorganic & medicinal chemistry.

An affinity-based fluorescence polarization assay for protein tyrosine phosphatases.

D. Lawrence, Sanjai Kumar, Zhon-Yin Zhang, 2007, Methods.

Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction.

L. Wu, A. Hengge, Z. Zhang, 1995, Biochemistry.

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.

C. Moxham, Z. Zhang, J. Sredy, 1999, Journal of medicinal chemistry.

Probing the function of the conserved tryptophan in the flexible loop of the Yersinia protein-tyrosine phosphatase.

L. Wu, Y. Keng, Z. Zhang, 2008, European journal of biochemistry.

Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.

Zhon-Yin Zhang, Y. Long, A. Gunawan, 2008, Journal of the American Chemical Society.

Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases.

Sanjai Kumar, Bo Zhou, Zhon-Yin Zhang, 2008, Journal of the American Chemical Society.

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.

Jun O. Liu, C. Wells, J. Shim, 2015, ACS medicinal chemistry letters.

Impaired transition state complementarity in the hydrolysis of O-arylphosphorothioates by protein-tyrosine phosphatases.

D. Herschlag, F. Hollfelder, Y. Keng, 1999, Biochemistry.

Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases.

Zhon-Yin Zhang, L. Andrade, Li Wu, 2011, Organic & biomolecular chemistry.

Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.

Bo Zhou, Zhon-Yin Zhang, S. Knapp, 2008, Journal of the American Chemical Society.

Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta.

Zhon-Yin Zhang, Yunpeng Bai, A. Gunawan, 2014, Antioxidants & redox signaling.

SHP2 is a target of the immunosuppressant tautomycetin.

B. Shen, R. Chan, Zhon-Yin Zhang, 2011, Chemistry & biology.

Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif.

L. Wu, Y. Zhao, Y. Zhao, 1995, Biochemistry.

Structure-based design and synthesis of small molecule protein-tyrosine phosphatase 1B inhibitors.

L. Wu, T. Burke, Z. Zhang, 1998, Bioorganic & medicinal chemistry.

Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains.

Dajun Yang, T. Burke, Li Wu, 2000, Bioorganic & medicinal chemistry letters.