D. Winkler

发表

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.

V. Palombella, Johan A. Pradeilles, Ann M. Rowley, 2016, ACS medicinal chemistry letters.

Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an Escherichia coli expression system.

C. Walsh, E. Kitas, P. Burn, 1991, Biochemistry.

Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation.

J. Latham, E. Turcott, James C. Geoghegan, 2004, Bone.

Complement C3a, CpG Oligos, and DNA/C3a Complex Stimulate IFN-α Production in a Receptor for Advanced Glycation End Product-Dependent Manner

B. Ruan, Janet E. Paulsen, K. Nocka, 2010, The Journal of Immunology.

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

C. Walsh, J. Strominger, D. Winkler, 1993, Proceedings of the National Academy of Sciences of the United States of America.

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

M. Feldmann, A. Hill, F. Brennan, 2009, Rheumatology.

Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts.

J. Latham, James C. Geoghegan, D. Winkler, 2004, Bone.

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation

J. Kutok, D. Fruman, S. Mallya, 2017, Front. Immunol..

Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system.

C. Walsh, T. Roberts, A. Carrera, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins*

J. Latham, E. Turcott, James C. Geoghegan, 2005, Journal of Biological Chemistry.

Noggin and Sclerostin Bone Morphogenetic Protein Antagonists Form a Mutually Inhibitory Complex*

J. Latham, James C. Geoghegan, D. Winkler, 2004, Journal of Biological Chemistry.

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

John A Latham, K. Staehling-Hampton, M. Brunkow, 2003, The EMBO journal.

PI3Kγ is a molecular switch that controls immune suppression

Philippe Foubert, Kelly A. Frazer, Hongying Li, 2016, Nature.

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

J. Kutok, J. Wolchok, Sujata Sharma, 2016, Nature.

PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.

Bonnie Tillotson, James R. Porter, Pingda Ren, 2013, Chemistry & biology.

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

T. Strom, L. Turka, J. Azzi, 2017, Nature Communications.

Regulation of T cell alloimmunity by PI 3 K γ and PI 3 K δ

J. Azzi, R. Abdi, Z. Solhjou, 2017 .

Identification of Residues in the Cysteine-rich Domain of Raf-1 That Control Ras Binding and Raf-1 Activity*

Jonathan A. Cooper, D. Morrison, J. Drugan, 1998, The Journal of Biological Chemistry.

Identification and Characterization of Mutations in Ha-Ras That Selectively Decrease Binding to cRaf-1*

Jonathan A. Cooper, Jeffrey C. Johnson, A. Vojtek, 1997, The Journal of Biological Chemistry.

Corrigendum: PI3Kγ is a molecular switch that controls immune suppression

A. V. Nguyen, K. Frazer, J. Kutok, 2016, Nature.

Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

C. Walsh, J. Strominger, I. Joung, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Product-Dependent Manner Receptor for Advanced Glycation End Production in a a Complex Stimulate IFN-Complement C3a, CpG Oligos, and DNA/C3a

Janet E. Paulsen, D. Pittman, Jill F. Wright, 2010 .