Wohn-Jenn Leu

发表

Antileukemic Natural Product Induced Both Apoptotic and Pyroptotic Programmed Cell Death and Differentiation Effect

J. Guh, I. Chen, Hsun-Shuo Chang, 2021, International journal of molecular sciences.

Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways

J. Guh, Shih-Ping Liu, Chia-Chun Yu, 2016, Oncotarget.

Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

C. Chen, J. Guh, Wei‐Ling Chang, 2015, Oncotarget.

Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy

J. Guh, S. P. Swain, Wohn-Jenn Leu, 2020, International journal of molecular sciences.

Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

J. Guh, Chia-Chun Yu, Wei‐Ling Chang, 2015, Oncotarget.

Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

N. Zhong, J. Guh, Shih-Ping Liu, 2018, Front. Pharmacol..

The Combination of a Novel GLUT1 Inhibitor and Cisplatin Synergistically Inhibits Breast Cancer Cell Growth By Enhancing the DNA Damaging Effect and Modulating the Akt/mTOR and MAPK Signaling Pathways

J. Guh, L. Hsu, F. Kung, 2022, Frontiers in Pharmacology.

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

J. Guh, L. Hsu, Wohn-Jenn Leu, 2020, Molecules.

Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades.

C. Chen, J. Guh, T. Hwang, 2013, Biochemical pharmacology.

Synthesis, characterization and cancer cell growth inhibition activity of ruthenium(II) complexes bearing bidentate pyrrole-imine ligands

J. Guh, Chia‐Her Lin, Jui‐Hsien Huang, 2018, Journal of Organometallic Chemistry.

Catalytic transfer hydrogenation and anticancer activity of arene-ruthenium compounds incorporating bi-dentate precursors.

Yu-Hsiang Chang, J. Guh, Chia‐Her Lin, 2015, Dalton transactions.

Ruthenium (II) complexes containing dehydroacetic acid and its imine derivative ligands. Synthesis, characterization and cancer cell growth anti-proliferation activity (GI50) study

J. Guh, Chia‐Her Lin, Yong-Jie Li, 2018, Journal of Organometallic Chemistry.

Asymmetric synthesis of (-)-brevipolide H through cyclopropanation of the α,β-unsaturated ketone.

Wen-Jung Chang, Wohn-Jenn Leu, She-Hung Chan, 2014, Organic letters.

Synthesis and characterization of ruthenium compounds incorporating keto-amine ligands. The applications of catalytic transfer hydrogenation and cancer cell inhibition

J. Guh, Chia‐Her Lin, Jui‐Hsien Huang, 2016 .

Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells

J. Guh, D. Perrone, E. Marchesi, 2020, Frontiers in Pharmacology.

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

J. Guh, Wei-Jan Huang, L. Hsu, 2020, Molecules.

Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways.

J. Guh, S. Bräse, Shih-Ping Liu, 2017, Oncotarget.

Reevesioside A, a Cardenolide Glycoside, Induces Anticancer Activity against Human Hormone-Refractory Prostate Cancers through Suppression of c-myc Expression and Induction of G1 Arrest of the Cell Cycle

J. Guh, Chia-Chun Yu, I. Chen, 2014, PloS one.

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

J. Guh, Shih-Ping Liu, L. Hsu, 2020, Frontiers in Oncology.

Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems

J. Guh, Shih-Ping Liu, Chia-Chun Yu, 2019, Front. Oncol..

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

J. Guh, Y. Ho, Chia-Chun Yu, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Extract From Plectranthus amboinicus Inhibit Maturation and Release of Interleukin 1β Through Inhibition of NF-κB Nuclear Translocation and NLRP3 Inflammasome Activation

J. Guh, Wohn-Jenn Leu, Jui-Ching Chen, 2019, Front. Pharmacol..

Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death against Human Non-Small Cell Lung Cancers

J. Guh, L. Hsu, Wohn-Jenn Leu, 2020, International journal of molecular sciences.

Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer.

S. Pan, J. Guh, Wohn-Jenn Leu, 2014, The Journal of urology.

Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer

N. Zhong, J. Guh, Wohn-Jenn Leu, 2021, Molecules.

The Prostate

J. Guh, I. Chen, Hsun-Shuo Chang, 2020 .

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

J. Guh, Y. Ho, Chia-Chun Yu, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin‐induced apoptosis in castration‐resistant prostate cancer

J. Guh, L. Hsu, Wohn-Jenn Leu, 2024, The Prostate.

Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism.

J. Guh, L. Hsu, Wohn-Jenn Leu, 2024, Naunyn-Schmiedeberg's archives of pharmacology.

Mechanistic study of dual‐function inhibitors targeting topoisomerase II and Rad51‐mediated DNA repair pathway against castration‐resistant prostate cancer

J. Guh, Hsu-Shan Huang, L. Hsu, 2023, The Prostate.