G. Budas

发表

Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic.

D. Mochly‐Rosen, T. Koyanagi, E. Churchill, 2007, Biochemical Society transactions.

Regulation and function of apoptosis signal‐regulating kinase 1 in rheumatoid arthritis

I. Mikaelian, G. Firestein, D. Hammaker, 2018, Biochemical pharmacology.

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.

M. Disatnik, D. Mochly‐Rosen, Che-Hong Chen, 2010, Journal of molecular and cellular cardiology.

The effect of corticosteroids on amyloid β precursor protein/amyloid precursor-like protein expression and processing in vivo

J. Seckl, K. Breen, G. Budas, 1999, Neuroscience Letters.

3'phosphoinositide‐dependent kinase‐1 is essential for ischemic preconditioning of the myocardium

D. Alessi, A. Jovanovic, G. Budas, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

M. Disatnik, D. Mochly‐Rosen, G. Budas, 2009, Trends in cardiovascular medicine.

Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage.

D. Mochly‐Rosen, G. Budas, Daria Mochly-Rosen, 2007, Biochemical Society transactions.

AMP‐activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP‐sensitive K+ channels

R. Tian, K. Sakamoto, A. Jovanovic, 2007, Journal of cellular physiology.

Hypoxia‐induced preconditioning in adult stimulated cardiomyocytes is mediated by the opening and trafficking of sarcolemmal KATP channels

A. Jovanovic, S. Jovanović, G. Budas, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension

W. Seeger, H. Ghofrani, N. Weissmann, 2017, American journal of respiratory and critical care medicine.

Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors

Mehar K Cheema, W. Winckler, S. Bhatia, 2021, Science Translational Medicine.

Deﬁciency of LKB1 in heart prevents ischemia-mediated activation of AMPK (cid:1) 2 but not AMPK (cid:1) 1

Anindya Dutta, A. Prescott, D. Alessi, 2006 .

Creatine kinase is physically associated with the cardiac ATP‐sensitive k+ channel in vivo

C. Botting, A. Jovanovic, G. Budas, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCε) knockout mice

M. Disatnik, D. Mochly‐Rosen, Che-Hong Chen, 2010 .

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK 2 but not AMPK 1

Anindya Dutta, A. Prescott, D. Alessi, 2006 .

Thioredoxin-2 Inhibits Mitochondrial Reactive Oxygen Species Generation and Apoptosis Stress Kinase-1 Activity to Maintain Cardiac Function

W. Min, G. Tellides, Haifeng Zhang, 2015, Circulation.

Ageing is associated with a decrease in the number of sarcolemmal ATP-sensitive K+ channels in a gender-dependent manner

A. Jovanovic, G. Budas, H. Ranki, 2002, Mechanisms of Ageing and Development.

Inhibition of Apoptosis Signal–Regulating Kinase 1 Reduces Myocardial Ischemia–Reperfusion Injury in the Mouse

N. Voelkel, A. Abbate, S. Toldo, 2012, Journal of the American Heart Association.

17β-Estradiol regulates expression of KATPchannels in heart-derived H9c2 cells

A. Davies, A. Jovanovic, G. Budas, 2002 .

Gender-specific difference in cardiac ATP-sensitive K(+) channels.

A. Jovanovic, G. Budas, H. Ranki, 2001, Journal of the American College of Cardiology.

Glyceraldehyde 3‐phosphate dehydrogenase serves as an accessory protein of the cardiac sarcolemmal KATP channel

I. Stagljar, A. Jovanovic, Q. Du, 2005 .

Glyceraldehyde 3-phosphate dehydrogenase serves as an accessory protein of the cardiac sarcolemmal K(ATP) channel.

I. Stagljar, A. Jovanovic, Q. Du, 2005, EMBO reports.

Identification of εPKC targets during cardiac ischemic injury.

J. Krieger, Julio C. B. Ferreira, D. Schechtman, 2012, Circulation journal : official journal of the Japanese Circulation Society.

The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model

M. Trauner, P. Schwabl, C. Kremoser, 2021, Biomedicines.

Mitochondrial import of PKCε is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury

M. Disatnik, D. Mochly‐Rosen, E. Churchill, 2010, Cardiovascular research.

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

M. Disatnik, D. Mochly‐Rosen, T. Hurley, 2008, Science.

Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice

R. Giffard, D. Mochly‐Rosen, Lijun Xu, 2013, Journal of neuroscience research.

Mitigation of Radiation-Induced Dermatitis by Activation of Aldehyde Dehydrogenase 2 Using Topical Alda-1 in Mice1

D. Mochly‐Rosen, Che-Hong Chen, S. Knox, 2012, Radiation research.

Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury.

D. Mochly‐Rosen, E. Churchill, G. Budas, 2007, Pharmacological research.

Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.

Jin Yang, C. Chang, S. Viatchenko‐Karpinski, 2014, Journal of molecular and cellular cardiology.

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

C. Ponting, S. Teichmann, J. Marioni, 2019, Cell reports.

Combination of an FXR agonist and an ACC inhibitor increases anti-fibrotic efficacy in rodent models of NASH

I. Mikaelian, A. Ray, D. Newstrom, 2018 .

Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia

A. Clelland, Victoria Murray-Tait, Q. Du, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ASK1 contributes to fibrosis and dysfunction in models of kidney disease

Melanie H. Wong, S. Wise, D. French, 2018, The Journal of clinical investigation.

Explorer Deficiency of PDK 1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

C. Kahn, D. Alessi, L. Bertrand, 2017 .

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

D. Alessi, L. Bertrand, A. Mora, 2003, The EMBO journal.

17Beta-estradiol regulates expression of K(ATP) channels in heart-derived H9c2 cells.

A. Davies, A. Jovanovic, G. Budas, 2002, Journal of the American College of Cardiology.

Activation of PKCε-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice

D. Mochly‐Rosen, V. Zambelli, Che-Hong Chen, 2021, Biomolecules.

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

A. Ashworth, Anindya Dutta, A. Prescott, 2006, American journal of physiology. Endocrinology and metabolism.

ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model.

I. Mikaelian, A. Wree, A. Feldstein, 2020, JCI insight.

Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.

D. Bernstein, S. Palaniyandi, M. Disatnik, 2011, Journal of molecular and cellular cardiology.

PKC isozymes in chronic cardiac disease: possible therapeutic targets?

D. Mochly‐Rosen, T. Koyanagi, A. Vallentin, 2008, Annual review of pharmacology and toxicology.

Chronic Mild Hypoxia Protects Heart-derived H9c2 Cells against Acute Hypoxia/Reoxygenation by Regulating Expression of the SUR2A Subunit of the ATP-sensitive K+ Channel*

Kevin A. Robertson, R. Wenger, A. Davies, 2003, Journal of Biological Chemistry.

Ethanol for cardiac ischemia: the role of protein kinase c

M. Disatnik, D. Mochly‐Rosen, E. Churchill, 2008, Therapeutic advances in cardiovascular disease.

M‐LDH serves as a sarcolemmal KATP channel subunit essential for cell protection against ischemia

T. J. Wilson, A. Jovanovic, G. Budas, 2002, The EMBO journal.

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.

S. Viatchenko‐Karpinski, J. Shryock, S. Rajamani, 2011, American journal of physiology. Cell physiology.

Year : 2003 Chronic mild hypoxia protects heart-derived H 9 c 2 cells against acute hypoxia / reoxygenation by regulating expression of the SUR 2 A subunit of the ATP-sensitive K + channel

R. Wenger, A. Davies, A. Jovanovic, 2007 .

Reduction of Liver Steatosis and Fibrosis with an Ask1 Inhibitor in a Murine Model of Nash is Accompanied by Improvements in Cholesterol, Bile Acid and Lipid Metabolism

S. Watkins, D. Tumas, G. Budas, 2016 .

Apoptosis signal-regulating kinase 1 inhibition in in vivo and in vitro models of pulmonary hypertension

D. Welsh, A. Peacock, A. C. Church, 2020, Pulmonary circulation.

to the Heart Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage

M. Disatnik, D. Mochly‐Rosen, T. Hurley, 2014 .

Non-steroidal FXR agonist cilofexor improves cholestatic liver injury in the Mdr2-/- mouse model of sclerosing cholangitis

H. Scharnagl, M. Trauner, T. Stojaković, 2023, JHEP reports : innovation in hepatology.

Thioredoxin-2 Inhibits Mitochondrial ROS Generation and ASK1 Activity to Maintain Cardiac Function

W. Min, G. Tellides, Qunhua Huang, 2015 .

Mitochondrial Ca 2 + Accumulation Docosahexaenoic Acid and Butyrate Synergistically Induce Colonocyte Apoptosis by Enhancing

J. Lupton, S. Cortassa, M. Aon, 2005 .

Identification of εPKC targets during cardiac ischemic injury.

D. Schechtman, D. Mochly‐Rosen, J. Perales, 2012, Circulation journal : official journal of the Japanese Circulation Society.

Peroxisomes, Refsum's disease and the α- and ω-oxidation of phytanic acid

J. Trimmer, M. Bootman, M. Taussig, 2007 .