R. Czerwinski

发表

Enzymatically inactive macrophage migration inhibitory factor inhibits monocyte chemotaxis and random migration.

W. Hanlon, S. Wright, C. P. Whitman, 1999, Biochemistry.

Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase.

T. Harris, M. Massiah, A. Mildvan, 1999, Biochemistry.

Inactivation of 4-oxalocrotonate tautomerase by 2-oxo-3-pentynoate.

M. Fitzgerald, W. Johnson, C. P. Whitman, 1997, Biochemistry.

Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4 A resolution: analysis and implications for the mechanism of inactivation and catalysis.

Alexander B. Taylor, W. Johnson, C. P. Whitman, 1998, Biochemistry.

Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the pKa values of active site residues and on the pH dependence of catalysis.

T. Harris, A. Mildvan, J. Stivers, 1999, Biochemistry.

Identification and characterization of acidic mammalian chitinase inhibitors.

D. Joseph-McCarthy, J. Ellingboe, Jaison Jacob, 2010, Journal of medicinal chemistry.

Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner

J. Casanova, C. Picard, V. Rao, 2014, The Journal of Biological Chemistry.

Manner Controls Cytokine Induction in a Cell 1 Receptor-associated Kinase 4 and Autophosphorylation Activates Interleukin Interleukin 1 / Toll-like Receptor-induced Immunology :

J. Casanova, C. Picard, V. Rao, 2014 .

Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions.

W. Johnson, C. P. Whitman, Susan C Wang, 2007, Biochemistry.

Kinetic characterization of recombinant human acidic mammalian chitinase.

Yi‐Te Chou, L. Fitz, A. Aulabaugh, 2006, Biochemistry.

PKA controls a level of topoisomerase I mRNA in mouse L5178Y lymphoma cells treated with db-cAMP

B. Sochanowicz, K. Starón, R. Czerwinski, 1994, Molecular Biology Reports.

EC-Delayed Fission Properties of 234

R. Chadwick, K. Gregorich, R. Czerwinski, 2013 .

Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820.

Paul M Wehn, D. Nijhawan, Xinlin Du, 2019, Structure.

A kinetic and stereochemical investigation of the role of lysine-32 in the phenylpyruvate tautomerase activity catalyzed by macrophage migration inhibitory factor.

W. Johnson, C. P. Whitman, R. Czerwinski, 1999, Biochemistry.

The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization.

T. Maurer, J. Telliez, M. Kuhn, 2020, Bioorganic & medicinal chemistry.

Effects of fluorodeoxyuridine and nalidixic acid on the activity of topoisomerase I in plasmodia of Physarum polycephalum.

K. Starón, R. Czerwinski, B. Kowalska-Loth, 1992, The International journal of biochemistry.

Topoisomerase I in actively growing plasmodia and during differentiation of the slime mold Physarum polycephalum.

K. Starón, R. Czerwinski, B. Kowalska-Loth, 1991, Biochimica et biophysica acta.

Topoisomerase I is differently phosphorylated in two sublines of L5178Y mouse lymphoma cells.

K. Starón, R. Czerwinski, B. Kowalska-Loth, 1995, Biochimica et biophysica acta.

Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.

P. A. Golubkov, M. Person, W. Johnson, 2006, Bioorganic chemistry.

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.

Bin Wang, Rui Xu, Zhaodan Cao, 2016, Cancer research.

Catalytic Domain Crystal Structure of Protein Kinase C-θ (PKCθ)*♦

Rita Greco, Diane Joseph-McCarthy, L. Mosyak, 2004, Journal of Biological Chemistry.

3-[(1 S,2 S,3 R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma.

Paul M Wehn, Keshi Wang, G. Han, 2019, Journal of medicinal chemistry.

Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity.

R. Kriz, M. Stahl, Paul W. Wu, 2009, Biochemistry.

Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.

K. Parris, L. Mosyak, J. Telliez, 2003, Structure.

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.

J. Bauman, J. Telliez, J. Chrencik, 2018, Journal of medicinal chemistry.

The structural basis for the perturbed pKa of the catalytic base in 4-oxalocrotonate tautomerase: kinetic and structural effects of mutations of Phe-50.

T. Harris, M. Massiah, A. Mildvan, 2001, Biochemistry.

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.

M. Hegen, J. Telliez, J. Chrencik, 2017, Journal of medicinal chemistry.

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.

Jason M. Edmonds, David R. Anderson, R. Kurumbail, 2014, The Biochemical journal.

Regulatory changes in the control of carbamoyl phosphate synthetase induced by truncation and mutagenesis of the allosteric binding domain.

F. Raushel, R. Czerwinski, S. Mareya, 1995, Biochemistry.

cDNA cloning of Physarum polycephalum DNA topoisomerase I and expression analysis in plasmodia treated with cAMP.

K. Starón, R. Czerwinski, A. Lipniacki, 1998, Gene.

ATP-mediated kinome selectivity: the missing link in understanding the contribution of individual JAK Kinase isoforms to cellular signaling.

J. Telliez, A. Thorarensen, A. Casimiro-Garcia, 2014, ACS chemical biology.

Triad of polar residues implicated in pH specificity of acidic mammalian chitinase

L. Mosyak, D. Joseph-McCarthy, W. Somers, 2009, Protein science : a publication of the Protein Society.

Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism.

R. Kriz, M. Stahl, A. Aulabaugh, 2005, Biochemistry.

Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay.

David R. Anderson, R. Kurumbail, S. Shakya, 2012, Journal of medicinal chemistry.

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).

Z. Cao, Tzuling Cheng, Paul M Wehn, 2018, Journal of medicinal chemistry.

Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.

W. Johnson, C. P. Whitman, M. Hackert, 1999, Biochemistry.

The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity.

A. Murzin, A. Kern, W. Johnson, 2002, Biochemistry.

Kinetic and structural characterization of DmpI from Helicobacter pylori and Archaeoglobus fulgidus, two 4-oxalocrotonate tautomerase family members.

A. Kern, R. Dasgupta, C. P. Whitman, 2010, Bioorganic chemistry.

THE CONTRIBUTION OF THE SUBSTRATE'S CARBOXYLATE GROUP TO THE MECHANISM OF 4-OXALOCROTONATE TAUTOMERASE

W. Johnson, C. P. Whitman, R. Czerwinski, 1998 .

Identification, Characterization, and Crystal Structure ofBacillus subtilis Nicotinic Acid Mononucleotide Adenylyltransferase*

W. Somers, M. Stahl, R. Chopra, 2002, The Journal of Biological Chemistry.

Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.

D. Joseph-McCarthy, A. Wissner, J. Ellingboe, 2008, Journal of medicinal chemistry.

Kinetic and structural effects of mutations of the catalytic amino-terminal proline in 4-oxalocrotonate tautomerase.

T. Harris, A. Mildvan, C. P. Whitman, 1997, Biochemistry.

Structural basis of recruitment of RBM39 to DCAF15 by a sulfonamide molecular glue E7820

D. Nijhawan, Xinlin Du, O. Volkov, 2019, bioRxiv.

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.

Z. Cao, Tzuling Cheng, Keshi Wang, 2016, Cancer research.