L. Haataja

发表

“Register-shift” insulin analogs uncover constraints of proteotoxicity in protein evolution

Brian J. Smith, F. Ismail-Beigi, P. Arvan, 2020, The Journal of Biological Chemistry.

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes

P. Arvan, Anoop Arunagiri, Ming Liu, 2018, Annals of the New York Academy of Sciences.

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

Teresa L. Mastracci, L. Dimeglio, W. Qian, 2018, Diabetes Care.

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac

N. Heisterkamp, J. Groffen, S. Kweon, 2010, BMC Biochemistry.

Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes

P. Arvan, Anoop Arunagiri, J. Kappler, 2021, Diabetes.

Evidence for distinct actions of oligomers and fibrils of hIAPP

S. Jayasinghe, Chia-yu Lin, R. Kayed, 2006 .

Sox17 Regulates Insulin Secretion in the Normal and Pathologic Mouse β Cell

P. Arvan, J. Wells, J. Spence, 2014, PloS one.

Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants.

J. Voncken, N. Heisterkamp, J. Groffen, 2000, Blood.

Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants.

J. Voncken, N. Heisterkamp, J. Groffen, 2000 .

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

W. Hsueh, Chia-yu Lin, P. Butler, 2005, The Journal of clinical endocrinology and metabolism.

Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3′-kinase-dependent pathway

W. Hsueh, Chia-yu Lin, P. Butler, 2005 .

Impaired NH2-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death

D. Steiner, P. Halban, C. Rhodes, 2006, Diabetes.

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

P. Arvan, Ming Liu, Billy Tsai, 2016, Diabetes.

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

P. Arvan, Ming Liu, L. Haataja, 2010, Trends in Endocrinology & Metabolism.

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones

P. Arvan, Anoop Arunagiri, Billy Tsai, 2021, Nature Communications.

Brief description of insulin mRNA quantity and quality

R. Kaufman, P. Arvan, Anoop Arunagiri, 2021 .

Pancreatic beta-cells secrete insulin in fast- and slow-release forms.

R. Chow, D. Michael, R. Ritzel, 2006, Diabetes.

Autophagy is a major regulator of beta cell insulin homeostasis

Erol Cerasi, P. Arvan, J. Wikstrom, 2016, Diabetologia.

UCP-2 and UCP-3 Proteins Are Differentially Regulated in Pancreatic Beta-Cells

K. Maedler, L. Haataja, L. Shu, 2008, PloS one.

Cellular interactions of CRKL, and SH2-SH3 adaptor protein.

T. Fioretos, V. Kaartinen, J. Voncken, 1994, Cancer research.

Distinct states of proinsulin misfolding in MIDY

Ming Liu, P. Arvan, M. Weiss, 2021, Cellular and Molecular Life Sciences.

Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations

Ming Liu, P. Arvan, C. Bellanné-Chantelot, 2020, Molecular and Cellular Endocrinology.

Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes

P. Arvan, Ming Liu, F. Barbetti, 2012, Diabetes.

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity

M. Low, P. Arvan, G. Kim, 2018, The Journal of clinical investigation.

In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes

P. Arvan, Ming Liu, L. Haataja, 2011, Diabetes.

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

B. Marsh, P. Arvan, A. Noske, 2015, Diabetes.

Proteasomal degradation of WT proinsulin in pancreatic beta cells

P. Arvan, Anoop Arunagiri, Billy Tsai, 2022, The Journal of biological chemistry.

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

Stephen C. J. Parker, L. Sussel, Nathan Lawlor, 2024, bioRxiv.

Altered b -Cell Prohormone Processing and Secretion in Type 1 Diabetes

S. Richardson, M. Atkinson, P. Arvan, 2021 .

Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.

P. Arvan, L. Satin, E. Bernal-Mizrachi, 2015, Cell reports.

Many Commercially Available Antibodies for Detection of CHOP Expression as a Marker of Endoplasmic Reticulum Stress Fail Specificity Evaluation

P. Butler, T. Gurlo, L. Haataja, 2008, Cell Biochemistry and Biophysics.

High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes

R. Rizza, Chia-yu Lin, P. Butler, 2007, Diabetes.

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

W. Soeller, P. Butler, T. Gurlo, 2007, American journal of physiology. Endocrinology and metabolism.

Pancreatic β-Cells Secrete Insulin in Fast- and Slow-Release Forms

Robert H. Chow, R. Chow, D. Michael, 2006 .

Spatial organization of ABR and CRK genes on human chromosome band 17p13.3.

D. Ledbetter, N. Heisterkamp, J. Groffen, 1995, Oncogene.

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.

P. Butler, T. Gurlo, Tatyana Gurlo, 2008, Endocrine reviews.

Calcium-activated Calpain-2 Is a Mediator of Beta Cell Dysfunction and Apoptosis in Type 2 Diabetes*

P. Butler, T. Gurlo, S. Costes, 2009, The Journal of Biological Chemistry.

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

Ralf Langen, S. Jayasinghe, Chia-yu Lin, 2006, American journal of physiology. Endocrinology and metabolism.

Characterization of RAC3, a Novel Member of the Rho Family*

N. Heisterkamp, J. Groffen, L. Haataja, 1997, The Journal of Biological Chemistry.

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

K. Kaestner, T. LaFramboise, C. Mathews, 2021, bioRxiv.

Proinsulin misfolding is an early event in the progression to type 2 diabetes

R. Kaufman, P. Arvan, Anoop Arunagiri, 2019, eLife.

Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro

Gopika G. Nair, P. Arvan, R. Blelloch, 2015, The EMBO journal.

Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.

E. Bonifacio, M. Atkinson, P. Arvan, 2017, Cell Metabolism.

Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size

D. Egli, Yurong Xin, Jinrang Kim, 2021, JCI insight.

Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells

D. Egli, Yurong Xin, Jinrang Kim, 2020 .

BCR/ABL-induced Leukemogenesis Causes Phosphorylation of Hef1 and Its Association with Crkl*

N. Heisterkamp, J. Groffen, R. de Jong, 1997, The Journal of Biological Chemistry.

Tyrosine phosphorylation of murine Crkl.

J. Voncken, N. Heisterkamp, J. Groffen, 1995, Oncogene.

Inhibition of Bcr serine kinase by tyrosine phosphorylation

N. Heisterkamp, J. Groffen, Y. Wu, 1996, Molecular and cellular biology.

The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours

N. Heisterkamp, J. Groffen, C. Morris, 2000, Cytogenetic and Genome Research.

Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia

V. Kaartinen, N. Heisterkamp, J. Groffen, 2005, Molecular and Cellular Biology.

Abnormal function of astroglia lacking Abr and Bcr RacGAPs.

V. Kaartinen, J. Voncken, N. Heisterkamp, 2001, Development.

Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.

R. Kaufman, P. Arvan, Anoop Arunagiri, 2021, The Journal of clinical investigation.

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

R. Strieter, K. Maedler, J. Oberholzer, 2009, Cell metabolism.

The Small GTPase Rac3 Interacts with the Integrin-binding Protein CIB and Promotes Integrin αIIbβ3-mediated Adhesion and Spreading*

V. Kaartinen, N. Heisterkamp, J. Groffen, 2002, The Journal of Biological Chemistry.

Integration of ER protein quality control mechanisms defines β cell function and ER architecture

P. Arvan, Billy Tsai, Yu-Jie Chen, 2022, The Journal of clinical investigation.

Evolution of insulin at the edge of foldability and its medical implications

F. Ismail-Beigi, P. Arvan, M. Weiss, 2020, Proceedings of the National Academy of Sciences.

Requirement for TRanslocon-Associated Protein (TRAP) α in insulin biogenesis

S. Flibotte, Ming Liu, P. Arvan, 2019, bioRxiv.

Biosynthesis, structure, and folding of the insulin precursor protein

R. Kaufman, P. Arvan, Anoop Arunagiri, 2018, Diabetes, obesity & metabolism.

Proinsulin Intermolecular Interactions during Secretory Trafficking in Pancreatic β Cells*

E. Snapp, P. Arvan, M. Wheeler, 2012, The Journal of Biological Chemistry.

Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress*

P. Arvan, M. Weiss, Ming Liu, 2013, The Journal of Biological Chemistry.

Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

P. Arvan, M. Weiss, Ming Liu, 2010, PloS one.

Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes

N. Morgan, S. Richardson, W. Qian, 2021, Diabetes.

Scambio, a novel guanine nucleotide exchange factor for Rho

N. Heisterkamp, J. Groffen, B. Hemmeryckx, 2004, Molecular Cancer.

Toxic Human Islet Amyloid Polypeptide (h-IAPP) Oligomers Are Intracellular, and Vaccination to Induce Anti-Toxic Oligomer Antibodies Does Not Prevent h-IAPP–Induced β-Cell Apoptosis in h-IAPP Transgenic Mice

Chia-yu Lin, R. Kayed, C. Glabe, 2007, Diabetes.

phosphorylation.of Bcr serine kinase by tyrosine

N. Heisterkamp, J. Groffen, Yun Wu, 2013 .

Correction: Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

P. Arvan, M. Weiss, F. Barbetti, 2010, PLoS ONE.

Toxic Human IAPP Oligomers are Intracellular , and Vaccination to Induce Anti-toxic Oligomer Antibodies Does not Prevent Human IAPP Induced Beta-Cell Apoptosis in Human IAPP Transgenic Mice

Chia-yu Lin, R. Kayed, C. Glabe, 2007 .

Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?

P. Arvan, S. Bernardini, C. Cras-Méneur, 2016, Clinical Diabetes and Endocrinology.

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

A. Kong, G. Rutter, D. Wigley, 2020, bioRxiv.

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo

P. Arvan, R. Kennedy, Shusheng Lu, 2015, Diabetes.

Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells

L. Groop, P. Arvan, R. Prasad, 2018, Molecular and Cellular Endocrinology.

Monitoring C-peptide Storage and Secretion in Islet Beta Cells in vitro and in vivo

P. Arvan, R. Kennedy, Shusheng Lu, 2015 .

Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes*

P. Arvan, Ming Liu, P. Witkowski, 2014, The Journal of Biological Chemistry.

Piotr Witkowski , and Late-onset Diabetes Cell Failure β Contributes to Pancreatic Inefficient Translocation of Preproinsulin Molecular Bases of Disease

P. Arvan, P. Witkowski, S. Shan, 2014 .

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258–264

Teresa L. Mastracci, L. Dimeglio, W. Qian, 2019, Diabetes Care.

Abnormalities in Proinsulin Processing in Islets from Individuals with Longstanding T1D

Teresa L. Mastracci, P. Arvan, J. Nyalwidhe, 2019, bioRxiv.

Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth

R. Kaufman, P. Arvan, M. Weiss, 2020, Diabetes.

Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth

R. Kaufman, P. Arvan, M. Weiss, 2019, bioRxiv.

Dominant protein interactions that influence the pathogenesis of conformational diseases.

P. Arvan, Ming Liu, L. Haataja, 2013, The Journal of clinical investigation.

TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis.

V. Kaartinen, N. Heisterkamp, J. Groffen, 2002, International journal of molecular medicine.

Identification of a novel Rac3-interacting protein C1D.

N. Heisterkamp, J. Groffen, L. Haataja, 1998, International journal of molecular medicine.

The small GTPase Rac interacts with ubiquitination complex proteins Cullin-1 and CDC23.

N. Heisterkamp, J. Groffen, D. Senadheera, 2001, International journal of molecular medicine.

Phosphorylation substrates and altered signalling in leukemias caused by BCR/ABL

V. Kaartinen, N. Heisterkamp, J. Groffen, 1999, Leukemia.

The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.

V. Kaartinen, N. Heisterkamp, J. Groffen, 2002, The Journal of biological chemistry.

Deletion within the D17S34 locus in a primitive neuroectodermal tumor.

D. Ledbetter, A. Tanigami, N. Heisterkamp, 1997, Cancer research.

Binding of the strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) to bovine serum albumin.

T. Vartiainen, J. Tuomisto, S. Lötjönen, 1991, Toxicology letters.

Requirement for translocon-associated protein (TRAP) α in insulin biogenesis

S. Flibotte, P. Arvan, Jialu Xu, 2019, Science Advances.

Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.

N. Heisterkamp, J. Groffen, S. D. De Langhe, 2002, International journal of molecular medicine.

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

P. Arvan, B. Tyrberg, T. Mandrup-Poulsen, 2019, Diabetes.

Altered enzyme activities of xenobiotic biotransformation in kidneys after subchronic administration of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) to rats.

T. Vartiainen, H. Komulainen, S. Vaittinen, 1995, Toxicology.

Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity

P. Arvan, R. Leibel, F. Barbetti, 2023, bioRxiv.

Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis

M. Cnop, P. Arvan, Vaibhav Sidarala, 2024, Protein science : a publication of the Protein Society.

Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.

E. Bonifacio, M. Atkinson, P. Arvan, 2017, Cell metabolism.

Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity

P. Arvan, R. Leibel, L. Haataja, 2024, Molecular metabolism.

Permanent Neonatal diabetes-causing Insulin mutations have dominant effects on proinsulin processing and beta cell identity

P. Arvan, R. Leibel, L. Haataja, 2023 .

Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes

P. Arvan, S. Shan, Huan Guo, 2012, Diabetes.

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

K. Kaestner, T. LaFramboise, C. Mathews, 2022, Nature Communications.