T. Lu

发表

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.

Kaixian Chen, Hualiang Jiang, C. Luo, 2019, European journal of medicinal chemistry.

Discovery of High-Affinity Inhibitors of the BPTF Bromodomain.

Kaixian Chen, Hualiang Jiang, Bo Li, 2021, Journal of medicinal chemistry.

Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening.

Kaixian Chen, Hualiang Jiang, C. Luo, 2019, Bioorganic chemistry.

A patent review of BRD4 inhibitors (2013-2019)

C. Luo, Wenchao Lu, T. Lu, 2019, Expert opinion on therapeutic patents.

Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors.

Kaixian Chen, Hualiang Jiang, C. Luo, 2020, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain.

Kaixian Chen, Hualiang Jiang, Hao Jiang, 2020, Bioorganic chemistry.

Transition-Metal-Free Synthesis of 1,3-Butadiene-Containing π-Conjugated Polymers.

T. Lu, Yonghai Chai, Xuediao Cai, 2016, Macromolecular rapid communications.

Cyclization strategy leads to highly potent Bromodomain and extra-terminal (BET) Bromodomain inhibitors for the treatment of acute liver injury.

Kaixian Chen, C. Luo, Yuanyuan Zhang, 2022, European journal of medicinal chemistry.

Discovery and characterization of a novel glucose-6-phosphate dehydrogenase (G6PD) inhibitor via high-throughput screening.

Kaixian Chen, Hualiang Jiang, C. Luo, 2021, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of novel triazoloquinazolinone derivatives as SHP2 protein inhibitors

T. Lu, Zhongyuan Wang, Zhixu Zhou, 2021, Journal of enzyme inhibition and medicinal chemistry.

Non-peptidic phenyl-based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines.

B. Tomczuk, F. Salemme, R. Bone, 2000, Bioorganic & medicinal chemistry letters.

Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.

B. Tomczuk, J. Spurlino, C. Illig, 2000, Bioorganic & medicinal chemistry letters.

In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors.

B. Tomczuk, J. Spurlino, C. Illig, 1998, Bioorganic & medicinal chemistry letters.

Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor.

B. Tomczuk, J. Spurlino, C. Illig, 2000, Bioorganic & medicinal chemistry letters.

In vitro Evaluation and Crystallographic Analysis of a New Class of Selective, Non‐Amide‐Based Thrombin Inhibitors.

B. Tomczuk, J. Spurlino, C. Illig, 1998 .

Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.

J. Spurlino, C. Illig, R. Bone, 1998, Journal of medicinal chemistry.

Amidinohydrazones as Guanidine Bioisosteres: Application to a New Class of Potent, Selective and Orally Bioavailable, Non‐amide‐based Small‐Molecule Thrombin Inhibitors.

B. Tomczuk, J. Spurlino, C. Illig, 2000 .

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors.

Kaixian Chen, Hualiang Jiang, C. Luo, 2019, European journal of medicinal chemistry.

Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening

C. Luo, Chuan-peng Liu, Dan Zhang, 2019, Acta Pharmacologica Sinica.

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Hao Jiang, C. Luo, H. Ding, 2018, Acta Pharmacologica Sinica.

Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis

Yvonne Ying-Ya Wen, Hu Zhou, J. Mao, 2022, Advanced science.

Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3

Kaixian Chen, Hualiang Jiang, C. Luo, 2021, Acta pharmaceutica Sinica. B.

Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.

Z. Chen, Kaixian Chen, Hualiang Jiang, 2018, Bioorganic & medicinal chemistry.

Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-terminal (BET) Bromodomain Inhibitors.

Hualiang Jiang, C. Luo, Shijie Chen, 2020, Journal of medicinal chemistry.

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Hao Jiang, C. Luo, H. Ding, 2018, Acta Pharmacologica Sinica.

Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold.

Kaixian Chen, Hualiang Jiang, Bo Li, 2022, Bioorganic chemistry.

Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate.

M. Cushman, Wei Song, A. Treston, 2007, Journal of medicinal chemistry.