Tsutomu Kimura

发表

Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells.

K. Kuwata, T. Murai, K. Asami, 2011, European journal of medicinal chemistry.

Synthesis of an 11C‐Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography

Siqin, Yasuyoshi Watanabe, Masaaki Suzuki, 2013, ChemMedChem.

Respiratory and cardiovascular toxicity studies of a novel antiprion compound, GN8, in rats and dogs

K. Kuwata, Tsutomu Kimura, Junji Hosokawa-Muto, 2012, Drug and chemical toxicology.

A novel consecutive reaction of lithium acetylides with 2-aryl-1-chlorovinyl p-tolyl sulfoxides leading to the formation of (Z)-enediynes

N. Ishida, T. Satoh, Tsutomu Kimura, 2013 .

Synthesis of 2-azabicyclo[2.1.0]pentanes by the intramolecular nucleophilic substitution of cyclopropylmagnesium carbenoids with magnesium anilide

T. Satoh, Tsutomu Kimura, Toshiki Nishimura, 2017 .

Synthesis of cyclopropane-fused α-chlorolactones utilizing the nucleophilicity of cyclopropylmagnesium carbenoids

J. Nishida, T. Satoh, Tsutomu Kimura, 2014 .

Recent Advances in Magnesium Carbenoid Chemistry

Tsutomu Kimura, 2017 .

Nucleophilic substitution at the alkenyl and cyclopropyl carbon atoms of magnesium carbenoids: a DFT study

T. Satoh, Tsutomu Kimura, 2013 .

Iodo-cyclization of N-Homoallyl Thioamides Leading to 2,4-Diaryl-5,6-dihydro-4H-1,3-thiazines

F. Shibahara, T. Murai, Tsutomu Kimura, 2004 .

Iodo-Cyclization of N-Homoallyl Thioamides Leading to 2,4-Diaryl-5,6-dihydro-4H-1,3-thiazines.

F. Shibahara, T. Murai, Tsutomu Kimura, 2004 .

Syntheses and Properties of Phosphinoselenoic Chlorides, Acids, and Their Salts

T. Murai, Tsutomu Kimura, 2006 .

Phosphinoselenothioic acids and their salts: synthesis, characterization, and reaction with electrophiles.

T. Murai, Tsutomu Kimura, S. Kato, 2005, Journal of Organic Chemistry.

P-chiral phosphinoselenoic chlorides and phosphinochalcogenoselenoic acid esters: synthesis, characterization, and conformational studies.

T. Murai, Tsutomu Kimura, 2005, The Journal of organic chemistry.

Selenothiophosphinic Acid Salts: Efficient Synthesis, Structure and Reactivity

T. Murai, Tsutomu Kimura, S. Kato, 2002 .

New synthesis of multi-substituted α-chlorocyclobutanones from 1-chloro-3-cyanoalkyl p -tolyl sulfoxides by 4- Exo-Dig nucleophilic ring closure of magnesium carbenoids to nitrile group as the key reaction

N. Ishida, T. Satoh, H. Saitoh, 2012 .

Fritsch–Buttenberg–Wiechell rearrangement of magnesium alkylidene carbenoids leading to the formation of alkynes

Tsutomu Kimura, Akane Ando, Kotohiko Sekiguchi, 2021, Beilstein journal of organic chemistry.

Synthesis of Spiro[2.6]nonadienones and Spiro[3.6]decadienones by the Reaction of Cyclopropyl- and Cyclobutylmagnesium Carbenoids with Lithium Phenolates and Naphtholates

T. Satoh, Tsutomu Kimura, Yuki Sasaki, 2012 .

Synthesis, Structures, and Some Reactions of [(Thioacyl)thio]‐ and (Acylseleno)antimony and ‐bismuth Derivatives ((RCSS)xMR$\rm{_{{\bf 3 - }{\bf x}}^{\bf 1} }$ and (RCOSe)xMR$\rm{_{{\bf 3 - }{\bf x}}^{\bf 1} }$ with M = Sb, Bi and x = 1–3)

M. Kimura, Kazuki Yamada, Tsutomu Kimura, 2006 .

Enantiomerically pure P-chiral phosphinoselenoic chlorides: inversion of configuration at the P-chirogenic center in the synthesis and reaction of these substances.

T. Murai, Tsutomu Kimura, 2005, Chemical communications.

Optically active P-chiral phosphinoselenoic amides: stereochemical outcome at the P-stereogenic center in the synthesis of these substances and their characterization

T. Murai, Tsutomu Kimura, 2005 .

Selenothiophosphinic Acid Salt: Efficient Synthesis, Structure and Reactivity.

T. Murai, Tsutomu Kimura, S. Kato, 2003 .

Selenophilic reaction of organolithium and magnesium reagents with phosphinoselenoic chlorides

T. Murai, Tsutomu Kimura, Noriko Mizuhata, 2005 .

Synthesis of GN8 derivatives and evaluation of their antiprion activity in TSE-infected cells.

K. Kuwata, Y. Kamatari, Tsutomu Kimura, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of 3-azabicyclo[3.1.0]hexanes by insertion of cyclopropylmagnesium carbenoids into an intramolecular C–H bond adjacent to a nitrogen atom

T. Satoh, Tsutomu Kimura, Natsumi Wada, 2015 .

PCP Pincer Palladium Complexes and Their Catalytic Properties: Synthesis via the Electrophilic Ligand Introduction Route

Y. Uozumi, Tsutomu Kimura, 2006 .

Synthesis of [2,6-Bis(2-oxazolinyl)phenyl]palladium Complexes via the Ligand Introduction Route

Y. Uozumi, Tsutomu Kimura, 2008 .

Mechanism of magnesium carbenoid 1,3-C-H insertion: A DFT study

T. Satoh, Tsutomu Kimura, 2015 .

Quantum chemical characterization of magnesium carbenoids

T. Satoh, Tsutomu Kimura, 2012 .

Synthesis, including asymmetric synthesis, of 3-oxabicyclo[3.1.0]hexanes and bicyclo[3.1.0]hexanes by the 1,5-CH insertion of cyclopropylmagnesium carbenoids as the key reaction

T. Satoh, Tsutomu Kimura, Toshifumi Miyagawa, 2012 .

Synthesis of small ring-containing conjugated dienes via the coupling reaction of cyclopropyl- and cyclobutylmagnesium carbenoids with α-sulfonylallyllithiums

T. Satoh, Tsutomu Kimura, M. Inumaru, 2013 .

Degree of vinylidene character of α-heteroatom-substituted vinylmagnesium chlorides: a DFT study to discern the role of the halogen atom in magnesium alkylidene carbenoid chemistry

T. Satoh, Tsutomu Kimura, 2013 .

Efficient Synthesis of Cyclopropanecarboxylic Acid Esters Starting from the Conjugate Addition of Lithium Ester Enolates to 1-Chlorovinyl p-Tolyl Sulfoxides

Y. Hattori, T. Satoh, Tsutomu Kimura, 2013 .

Effects of Chelated and Non-chelated Transition Metal Ions on the Photoreactions of Pyridinecarboxylic Acids in Aqueous Solutions

Tsutomu Kimura, A. Sugimori, J. Kamimura, 1981 .

Configurational Stability of Optically Active Dichloromethyl p-Tolyl Sulfoxide and Its Anionic Species: Experimental and Theoretical Study

T. Satoh, Tsutomu Kimura, Hitoshi Momochi, 2013 .

Heck reaction in water with amphiphilic resin-supported palladium-phosphine complexes

Y. Uozumi, Tsutomu Kimura, 2002 .

Heck Reaction in Water with Amphiphilic Resin‐Supported Palladium‐Phosphine Complexes.

Y. Uozumi, Tsutomu Kimura, 2003 .

Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats

A. Sanbuissho, T. Kawada, K. Mori, 2013, Journal of immunotoxicology.

A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques

Y. Matsuyama, F. Ono, Takeshi Ishikawa, 2019, Nature Biomedical Engineering.

Fundamental Toxicological Sciences

K. Kuwata, Tsutomu Kimura, Junji Hosokawa-Muto, 2019 .

Oral toxicity study of an antiprion compound N,N’-[(cyclohexylmethylene)di-4,1-phenylene]bis[2-(1-pyrrolidinyl)acetamide] in rats and cynomolgus monkeys

K. Kuwata, Tsutomu Kimura, Junji Hosokawa-Muto, 2019, Fundamental Toxicological Sciences.

Discovery of a multipotent chaperone, 1-(2,6-Difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol with the inhibitory effects on the proliferation of prion, cancer as well as influenza virus

K. Kuwata, Ryo Honda, Tsutomu Kimura, 2020, Prion.

Consecutive reaction of 1-chlorovinyl p-tolyl sulfoxides with [chloro(p-tolylsulfinyl)methyl]lithium leading to the formation of multi-functionalized methylenecyclopropanes

T. Satoh, Tsutomu Kimura, Hitoshi Momochi, 2017 .

Efficient one-pot synthesis of 1-chlorovinyl p-tolyl sulfoxides from aldehydes and ketones by the Horner-Wadsworth-Emmons reaction

T. Satoh, Tsutomu Kimura, Genki Kobayashi, 2017 .

Through-Bond Interaction in the Trifluoroethanolysis of 4-Oxo-2eq-adamantyl Triflate and Its Essential Vanishing in the Corresponding 2-Phenyl Substituted Trifluoroacetate

K. Takeuchi, K. Yanagi, Tsutomu Kimura, 1992 .

New synthesis of multisubstituted cyanocyclopropanes by the intramolecular SN2 alkylation and 1,3-CC insertion reaction of magnesium carbenoids as the key reactions

T. Satoh, H. Saitoh, Tsutomu Kimura, 2012 .

A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques

Y. Matsuyama, F. Ono, Takeshi Ishikawa, 2019, Nature Biomedical Engineering.