Pauline Johnson

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CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and phosphatidylinositol-3 kinase.

N. Wong, Jacqueline C Y Lai, N. Maeshima, 2011, Cellular signalling.

Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation

J. Boucher, N. Van Rooijen, P. Murray, 2014, European journal of immunology.

Differential Use of Chondroitin Sulfate to Regulate Hyaluronan Binding by Receptor CD44 in Inflammatory and Interleukin 4-activated Macrophages*

K. Brown, B. Ruffell, Pauline Johnson, 2011, The Journal of Biological Chemistry.

Innate Immune Cell CD45 Regulates Lymphopenia-Induced T Cell Proliferation

Pauline Johnson, A. Saunders, Y. Shim, 2014, The Journal of Immunology.

Phosphatase-Associated Phosphoprotein Association with Leukocyte Independent of Its Phosphatase Activity and Apoptosis Mediated Through CD45 Is

B. Schraven, I. Ding, P. Hugo, 2002 .

Apoptosis Mediated Through CD45 Is Independent of Its Phosphatase Activity and Association with Leukocyte Phosphatase-Associated Phosphoprotein1

B. Schraven, I. Ding, P. Hugo, 2002, The Journal of Immunology.

Demonstration of a Direct Interaction between p56 and the Cytoplasmic Domain of CD45 in Vitro(*)

R. Aebersold, J. Watts, Pauline Johnson, 1996, The Journal of Biological Chemistry.

Characterization of the Interaction between CD45 and CD45-AP (*)

A. Maiti, K. Kitamura, Pauline Johnson, 1995, The Journal of Biological Chemistry.

Hyaluronan Induces Cell Death in Activated T Cells through CD441

B. Ruffell, Pauline Johnson, 2008, The Journal of Immunology.

A human homolog of the mouse CD8 molecule, Lyt-3: genomic sequence and expression

Pauline Johnson, 2004, Immunogenetics.

Splenic erythroid progenitors decrease TNF‐α production by macrophages and reduce systemic inflammation in a mouse model of T cell‐induced colitis

M. Dosanjh, Pauline Johnson, Y. Shim, 2020, European journal of immunology.

CD44 interacts directly with Lck in a zinc-dependent manner.

J. Ford, J. Cross, Jacqueline C Y Lai, 2010, Molecular immunology.

CD 45 Down-Regulates Lck-Mediated CD 44 Signaling and Modulates Actin Rearrangement in T Cells 1

A. Shaw, N. Wong, Jacqueline C Y Lai, 2008 .

CD45 Down-Regulates Lck-Mediated CD44 Signaling and Modulates Actin Rearrangement in T Cells1

A. Shaw, N. Wong, Jacqueline C Y Lai, 2008, The Journal of Immunology.

Differential Function of PTPα and PTPα Y789F in T Cells and Regulation of PTPα Phosphorylation at Tyr-789 by CD45*

C. Pallen, N. Wong, Pauline Johnson, 2007, Journal of Biological Chemistry.

The noncatalytic domains of Lck regulate its dephosphorylation by CD45.

J. Cross, Pauline Johnson, J. Felberg, 2003, Biochimica et biophysica acta.

CD44-initiated Cell Spreading Induces Pyk2 Phosphorylation, Is Mediated by Src Family Kinases, and Is Negatively Regulated by CD45*

N. Wong, Pauline Johnson, Ruihong Li, 2001, The Journal of Biological Chemistry.

Expression of N-acetylglucosamine 6-O-sulfotransferases (GlcNAc6STs)-1 and -4 in human monocytes: GlcNAc6ST-1 is implicated in the generation of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is induced by TNF-alpha.

R. Kannagi, K. Brown, Pauline Johnson, 2005, Glycobiology.

Temporal stability of the mouse gut microbiota in relation to innate and adaptive immunity.

M. Hartmann, P. Dimitriu, W. Mohn, 2013, Environmental microbiology reports.

Association of 75/80-kDa Phosphoproteins and the Tyrosine Kinases Lyn, Fyn, and Lck with the B Cell Molecule CD20

G. Schieven, J. Ledbetter, J. Bolen, 1995, The Journal of Biological Chemistry.

H2-M3-Restricted T Cells Participate in the Priming of Antigen-Specific CD4+ T Cells1

Salim Dhanji, H. Teh, M. Chow, 2006, The Journal of Immunology.

Rearrangement in T Cells Signaling and Modulates Actin CD45 Down-Regulates Lck-Mediated CD44

A. Shaw, Pauline Johnson, 2013 .

Chondroitin sulfate addition to CD44H negatively regulates hyaluronan binding.

B. Ruffell, Pauline Johnson, 2005, Biochemical and biophysical research communications.

CD8B, the human equivalent of the mouse Ly-3 gene is localized on chromosome 2

P. Goodfellow, N. Spurr, Pauline Johnson, 2004, Immunogenetics.

Hyaluronan binding identifies the most proliferative activated and memory T cells

M. Dosanjh, J. Cross, N. Maeshima, 2011, European journal of immunology.

Use of CD 44 by CD 4 Th 1 and Th 2 lymphocytes to roll and adhere

Stephen R. Clark, P. Kubes, M. Norman, 2006 .

CD45 Regulates Migration, Proliferation, and Progression of Double Negative 1 Thymocytes

N. Abraham, M. Wlodarska, Jacqueline C Y Lai, 2010, The Journal of Immunology.

Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages

R. Midura, K. Brown, V. Hascall, 2016, Scientific Reports.

Hyaluronan and Its Interactions With Immune Cells in the Healthy and Inflamed Lung

Pauline Johnson, Yifei Dong, A. Arif, 2018, Front. Immunol..

ATG Genes Influence the Virulence of Cryptococcus neoformans through Contributions beyond Core Autophagy Functions

J. Kronstad, G. Hu, M. Caza, 2018, Infection and Immunity.

TNF-alpha increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans.

R. Kannagi, Pauline Johnson, M. Delcommenne, 2002, Glycobiology.

Differential expression of the alternatively spliced exons of murine CD45 in Th1 and Th2 cell clones

M. Luqman, I. Trowbridge, K. Bottomly, 1991, European journal of immunology.

T Cells through CD44 Hyaluronan Induces Cell Death in Activated

B. Ruffell, Pauline Johnson, 2022 .

Regulation of CD71+TER119+ erythroid progenitor cells by CD45.

M. Dosanjh, Pauline Johnson, Y. Shim, 2020, Experimental hematology.

Hyaluronan Binding Identifies a Functionally Distinct Alveolar Macrophage–like Population in Bone Marrow–Derived Dendritic Cell Cultures

M. Dosanjh, Pauline Johnson, Christophe M. Deeg, 2015, The Journal of Immunology.

Protective Effect of Killed Trypanosome Vaccines with Incorporated Adjuvants

D. Gall, Pauline Johnson, R. Neal, 1963, Nature.

TNF-α Induction of CD44-Mediated Leukocyte Adhesion by Sulfation

A. Maiti, G. Maki, Pauline Johnson, 1998 .

Immunoglobulin-Related Structures Associated with Vertebrate Cell Surfaces

A. Barclay, G. McCaughan, Alan F. Williams, 1988 .

Alan F. Williams, Pauline Johnson, 1986, Nature.

Purification of Membrane Glycoproteins with Monoclonal Antibody Affinity Columns

Alan F. Williams, G. Woollett, Pauline Johnson, 1985 .

Galectin-3 and Galectin-1 Bind Distinct Cell Surface Glycoprotein Receptors to Induce T Cell Death1

D. Hsu, Fu-Tong Liu, L. Baum, 2006, The Journal of Immunology.

Inflammation-Induced Metastatic Colonization of the Lung Is Facilitated by Hepatocyte Growth Factor-Secreting Monocyte-Derived Macrophages

Kimberly C. Wiegand, M. Gold, C. Roskelley, 2021, Molecular Cancer Research.

CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

C. Roskelley, T. Huan, M. Dosanjh, 2020, Frontiers in Immunology.

RNA sequencing and lipidomic analysis of alveolar macrophages from normal and CD44 deficient mice

C. Roskelley, T. Huan, M. Dosanjh, 2019, bioRxiv.

CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment

C. Maxwell, L. Sanderson, M. Dosanjh, 2018, PloS one.

The amoebicidal activity and toxicity of natural emetine, (±)-2-dehydroemetine and (−)-2-dehydroemetine

Pauline Johnson, R. Neal, 1968 .

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

Josef M. Penninger, Pauline Johnson, Christopher D. Richardson, 2001, Nature.

CD45 Regulates TLR-Induced Proinflammatory Cytokine and IFN-β Secretion in Dendritic Cells1

T. Miletić, J. Cross, K. Kott, 2008, The Journal of Immunology.

Generation and Identification of GM-CSF Derived Alveolar-like Macrophages and Dendritic Cells From Mouse Bone Marrow.

M. Dosanjh, Pauline Johnson, Grace F. T. Poon, 2016, Journal of visualized experiments : JoVE.

The Where, When, How, and Why of Hyaluronan Binding by Immune Cells

K. Brown, Pauline Johnson, Yifei Dong, 2015, Front. Immunol..

CD44 and its role in inflammation and inflammatory diseases.

B. Ruffell, Pauline Johnson, 2009, Inflammation & allergy drug targets.

Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance.

C. Eaves, Jing Wang, A. Astanehe, 2010, Cancer research.

Inflammation-Induced Metastatic Colonization of the Lung Is Facilitated by Hepatocyte Growth Factor-Secreting Monocyte-Derived Macrophages

Kimberly C. Wiegand, M. Gold, C. Roskelley, 2021, Molecular Cancer Research.

Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells

W. Jefferies, S. Rothenberger, Pauline Johnson, 1995, European journal of immunology.

Chimeric CD4/CD44 molecules associate with CD44 via the transmembrane region and reduce hyaluronan binding in T cell lines

J. Walker, Pauline Johnson, Ruihong Li, 1998, European journal of immunology.

Subdomain X of the Kinase Domain of Lck Binds CD45 and Facilitates Dephosphorylation*

J. Cross, Pauline Johnson, D. Ng, 2004, Journal of Biological Chemistry.

Regulation of hyaluronan binding by F-actin and colocalization of CD44 and phosphorylated ezrin/radixin/moesin (ERM) proteins in myeloid cells.

K. Brown, Jacqueline C Y Lai, Pauline Johnson, 2005, Experimental cell research.

CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts

C. Nguyen, A. Hammann, R. Filomenko, 2016, Oncotarget.

CD45-Mediated Fodrin Cleavage during Galectin-1 T Cell Death Promotes Phagocytic Clearance of Dying Cells1

L. Baum, M. Pang, Pauline Johnson, 2009, The Journal of Immunology.

Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

R. Hancock, K. Brown, A. Karlsson, 2011, The Journal of Immunology.

Role of CD44 and Hyaluronan in Neutrophil Recruitment1

Adil I. Khan, B. Heit, P. Kubes, 2004, The Journal of Immunology.

Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement

K. Jaqaman, S. Grinstein, C. Bertozzi, 2018, Cell.

Hyaluronan‐binding by CD44 reduces the memory potential of activated murine CD8 T cells

C. Maxwell, M. Dosanjh, N. Maeshima, 2018, European journal of immunology.

Dendritic Cell Cultures Derived - Population in Bone Marrow like - Distinct Alveolar Macrophage Hyaluronan Binding Identifies a Functionally

M. Dosanjh, Pauline Johnson, Christophe M. Deeg, 2015 .

ResponsesReduces Proinflammatory Macrophage Host Defense Peptide LL-37 Selectively

R. Hancock, K. Brown, R. Falsafi, 2011 .

The immunophilin protein FKBPL and its peptide derivatives are novel regulators of vascular integrity and inflammation via NF-κB signaling

G. Cavalleri, A. Kissenpfennig, I. Tikhonova, 2021, bioRxiv.

Secretion in Dendritic Cells Proinflammatory Cytokine and IFN-CD45 Regulates TLR-Induced

T. Miletić, J. Cross, K. Kott, 2008 .

Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere.

Stephen R. Clark, P. Kubes, M. Norman, 2006, Blood.

Expression of CD45 Lacking the Catalytic Protein Tyrosine Phosphatase Domain Modulates Lck Phosphorylation and T Cell Activation*

Pauline Johnson, Yanni Wang, 2005, Journal of Biological Chemistry.

Characterization of Recombinant CD45 Cytoplasmic Domain Proteins

P. Johnson, Pauline Johnson, J. Felberg, 1998, The Journal of Biological Chemistry.

A cell death pathway induced by antibody-mediated cross-linking of CD45 on lymphocytes.

P. Hugo, S. Lesage, Pauline Johnson, 2003, Critical reviews in immunology.

Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.

C. Pallen, N. Wong, Pauline Johnson, 2007, The Journal of biological chemistry.

Tyrosine phosphorylation in immune cells: direct and indirect effects on toll-like receptor-induced proinflammatory cytokine production.

J. Cross, Pauline Johnson, 2009, Critical reviews in immunology.

The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV‐1 without producing a T cell response

I. Sadowski, Pauline Johnson, A. Saunders, 2011, FEBS letters.

Role of Sulfation in CD44-Mediated Hyaluronan Binding Induced by Inflammatory Mediators in Human CD14+ Peripheral Blood Monocytes1

K. Brown, A. Maiti, Pauline Johnson, 2001, The Journal of Immunology.

Peripheral Blood Monocytes + Inflammatory Mediators in Human CD 14 Hyaluronan Binding Induced by Role of Sulfation in CD 44-Mediated

K. Brown, A. Maiti, Pauline Johnson, 2001 .

Recruitmentof CD44 and Hyaluronan in Neutrophil

Bryan Heit, Lixin Liu, Pauline Johnson, 2012 .

Clearance of Dying Cells Galectin-1 T Cell Death Promotes Phagocytic CD 45-Mediated Fodrin Cleavage during

L. Baum, M. Pang, Pauline Johnson, 2009 .

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

P. Johnson, H. Ostergaard, I. Trowbridge, 1989, Proceedings of the National Academy of Sciences of the United States of America.

The survival of fetal and bone marrow monocyte-derived alveolar macrophages is promoted by CD44 and its interaction with hyaluronan

P. Johnson, M. Dosanjh, Pauline Johnson, 2017, Mucosal Immunology.

Protein tyrosine phosphorylation in Mycobacterium tuberculosis.

P. Johnson, R. Stokes, Pauline Johnson, 1994, FEMS microbiology letters.

CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and phosphatidylinositol-3 kinase.

N. Wong, Jacqueline C Y Lai, N. Maeshima, 2011, Cellular Signalling.