D. Xue

发表

Dicing up chromosomes: The unexpected role of Dicer in apoptosis

B. Harry, Akihisa Nakagawa, D. Xue, 2010, Cell cycle.

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

J. Parrish, Lin Chen, D. Xue, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction

A. Palmer, N. Xia, Q. Yuan, 2012, Proceedings of the National Academy of Sciences.

Programmed cell clearance: From nematodes to humans.

B. Fadeel, D. Xue, Katharina Klöditz, 2017, Biochemical and biophysical research communications.

Cathepsin B inhibitors block multiple radiation-induced side effects in C. elegans

B. Liu, Shanshan Li, D. Xue, 2019, Cell Research.

Programmed Cell Death in C. elegans

Yi-Chun Wu, D. Xue, Monica Darland-Ransom, 2009 .

Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists.

Juan Wang, Xiaohua Liu, Gang Liu, 2016, Journal of medicinal chemistry.

Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: Validation of their authenticity via in situ chemical analysis.

H. Raja, C. Pearce, N. Oberlies, 2017, RSC advances.

The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer

N. Neamati, M. Ljungman, Amy S. Lee, 2021, Cancer Research.

Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G.

Zhe Zhang, S. Mitani, Hanna S. Yuan, 2016, Cell reports.

Identification of CED-3 substrates by a yeast-based screening method

W. Park, Daeho Park, D. Xue, 2004, Molecular biotechnology.

Fat(al) attraction: Oxidized lipids act as “eat‐me” signals

B. Fadeel, P. Quinn, V. Kagan, 2007, HFSP journal.

To live or die by the sword: the regulation of apoptosis by the proteasome.

D. Xue, J. Friedman, 2004, Developmental cell.

Discovery, structure-activity relationship study and biological evaluation of 2-thioureidothiophene-3-carboxylates as a novel class of C-X-C chemokine receptor 2 (CXCR2) antagonists.

N. Neamati, Wenmin Chen, D. Xue, 2020, European journal of medicinal chemistry.

Programmed cell clearance: molecular regulation of the elimination of apoptotic cell corpses and its role in the resolution of inflammation.

B. Fadeel, V. Kagan, D. Xue, 2010, Biochemical and biophysical research communications.

MARCKS-ED peptide as a curvature and lipid sensor.

M. Fleshner, H. Yin, E. Chapman, 2013, ACS chemical biology.

CED-1, CED-7, and TTR-52 Regulate Surface Phosphatidylserine Expression on Apoptotic and Phagocytic Cells

S. Mitani, B. Kang, D. Xue, 2012, Current Biology.

Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells

J. Espinosa, K. D. Sullivan, Kelly D. Sullivan, 2015, Cell cycle.

Human ACAP 2 is a homolog of C . elegans CNT-1 that promotes apoptosis in cancer cells

J. Espinosa, K. D. Sullivan, Kelly D. Sullivan, 2015 .

Faculty Opinions recommendation of Caspase activation inhibits proteasome function during apoptosis.

D. Xue, 2004 .

Metal-free TEMPO-promoted C(sp³)-H amination to afford multisubstituted benzimidazoles.

Y. Long, D. Xue, 2014, The Journal of organic chemistry.

EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway

B. Neumann, M. Hilliard, Rosina Giordano-Santini, 2015, Nature.

Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases.

D. Xue, D. Breckenridge, 2004, Current opinion in cell biology.

Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.

H. Yin, Subada Soti, Christina Smith, 2017, Cell chemical biology.

Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction

N. Xia, X. Mo, Q. Yuan, 2019, Nature Communications.

Characterization of aminobenzylphenols as protein disulfide isomerase inhibitors in glioblastoma cell lines.

N. Neamati, M. Ljungman, B. Shrestha, 2020, Journal of medicinal chemistry.

Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans

S. Mitani, Qinghua Zhou, B. Harry, 2012, Proceedings of the National Academy of Sciences.

A novel mechanism underlies caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease during apoptosis

H. Gong, Xinquan Wang, Xinqi Gong, 2013, Cell Research.

Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease

S. Mitani, Yong Shi, Akihisa Nakagawa, 2010, Science.

Mitochondrial Cell Death Pathways in Caenorhabiditis elegans.

D. Xue, M. Seervi, 2015, Current topics in developmental biology.

Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro *

H. Horvitz, T. Gilmore, M. Barkett, 1997, The Journal of Biological Chemistry.

Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro.

H. Horvitz, T. Gilmore, M. Barkett, 1997, The Journal of biological chemistry.

Cysteine protease cathepsin B mediates radiation-induced bystander effects

B. Liu, S. Mitani, Qian Liang, 2017, Nature.

Structure of the CED-4–CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans

Huilin Li, Quan Hao, Nieng Yan, 2005, Nature.

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

H. Horvitz, S. Shaham, D. Xue, 1996, Genes & development.

Cell death machinery makes life more robust CED-3, a protein that is essential for programmed cell death, also has an unexpected role in the regulation of non-apoptotic genes during normal development.

R. Zabinsky, Cristina Aguirre-Chen, C. Hammell, 2014 .

Programmed Cell Death During Caenorhabditis elegans Development

Yi-Chun Wu, B. Conradt, D. Xue, 2016, Genetics.

C. elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor

B. Liu, S. Mitani, Baohui Chen, 2010, Nature Cell Biology.

Cell death specification in C. elegans

D. Killian, D. Xue, E. Peden, 2008, Cell cycle.

The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans

Jun Qin, J. Qin, Yehua Li, 2006, Nature chemical biology.

Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?

N. Neamati, D. Xue, Yibin Xu, 2020, Journal of medicinal chemistry.

C. elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells

N. Yan, Y. Shi, D. Xue, 2009, Cell Death and Differentiation.

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3

Yigong Shi, S. Mitani, Yong Shi, 2008, Nature Structural &Molecular Biology.

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans

Min Han, Benjamin P. Weaver, R. Zabinsky, 2014, eLife.

The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease

B. Fadeel, D. Xue, 2009, Critical reviews in biochemistry and molecular biology.

Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho.

K. Gengyo-Ando, S. Mitani, D. Xue, 2007, Genes & development.

Functional genomic analysis of apoptotic DNA degradation in C. elegans.

Jay Z. Parrish, J. Parrish, D. Xue, 2003, Molecular cell.

Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor

H. Horvitz, D. Xue, 1997, Nature.

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

H. Horvitz, D. Xue, 1995, Nature.

Mitochondrial endonuclease G is important for apoptosis in C. elegans

Jay Z. Parrish, J. Parrish, Xiaodong Wang, 2001, Nature.

Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization

S. Mitani, Hanna S. Yuan, Byungho Kang, 2016, Science.

Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans

Haimin Li, Qinghua Zhou, D. Xue, 2011, Cell Research.

RNA Aptamers Targeting the Cell Death Inhibitor CED-9 Induce Cell Killing in Caenorhabditis elegans*

Nieng Yan, Yigong Shi, Yigong Shi, 2006, Journal of Biological Chemistry.

C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1

Yigong Shi, K. Gengyo-Ando, S. Mitani, 2007, Nature Cell Biology.

Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study

J. Kere, S. Katayama, V. Gogvadze, 2019, Scientific Reports.

elegans development in CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust

Min Han, Benjamin P. Weaver, R. Zabinsky, 2014 .

Crystal Structure of CRN-4: Implications for Domain Function in Apoptotic DNA Degradation

S. Mitani, Hanna S. Yuan, Akihisa Nakagawa, 2008, Molecular and Cellular Biology.

Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry

K. Gengyo-Ando, S. Mitani, D. Xue, 2008, Science.

Cell Corpse Engulfment Mediated by C. elegans Phosphatidylserine Receptor Through CED-5 and CED-12

K. Gengyo-Ando, S. Mitani, Jia-Yun Chen, 2003, Science.

Discovery of Novel 2‐N‐Aryl‐Substituted Benzenesulfonamidoacetamides: Orally Bioavailable Tubulin Polymerization Inhibitors with Marked Antitumor Activities

Long Yu, Y. Long, D. Xue, 2012, ChemMedChem.

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

Jay Z. Parrish, David J. Chen, J. Parrish, 2005, EMBO reports.

CRN‐1, a Caenorhabditis elegans FEN‐1 homologue, cooperates with CPS‐6/EndoG to promote apoptotic DNA degradation

Jay Z. Parrish, J. Parrish, Chonglin Yang, 2003, The EMBO journal.

Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors.

N. Neamati, J. Stuckey, Yong Wu, 2019, Journal of medicinal chemistry.

Programmed cell death.

B. Conradt, D. Xue, 2005, WormBook : the online review of C. elegans biology.

Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans

Yigong Shi, Yigong Shi, J. Chai, 2002, Science.

Kinetics and specificity of paternal mitochondrial elimination in Caenorhabditis elegans

Qian Liang, Xiao-Ming Yin, B. Kang, 2016, Nature Communications.

Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.

S. Mitani, L. Staehelin, B. Kang, 2008, Molecular cell.

Cuts can kill: the roles of apoptotic nucleases in cell death and animal development

Jay Z. Parrish, J. Parrish, D. Xue, 2006, Chromosoma.

Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors.

N. Neamati, Duxin Sun, Lipeng Dai, 2022, Journal of medicinal chemistry.

The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.

Annika L. A. Nichols, D. Hall, B. Neumann, 2016, Cell reports.

Somatic sex determination in Caenorhabditis elegans is modulated by SUP-26 repression of tra-2 translation

Jau-Song Yu, Jeng-Ting Chen, D. Xue, 2010, Proceedings of the National Academy of Sciences.

Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.

Yigong Shi, J. Chai, N. Yan, 2004, Molecular cell.

A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells

M. Driscoll, Qian Liang, Xiaohui Wang, 2014, Nature Communications.

Structure and function analysis of the C. elegans aminophospholipid translocase TAT-1

S. Mitani, B. Fadeel, A. Hall, 2019, Journal of Cell Science.

Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway

Kelly D. Sullivan, Akihisa Nakagawa, D. Xue, 2014, Nature Structural &Molecular Biology.

Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14

Hongyan Guo, B. Harry, Akihisa Nakagawa, 2016, Nature Structural &Molecular Biology.

A Class of Benzenoid Chemicals Suppresses Apoptosis in C. elegans

D. Kokel, D. Xue, 2006, Chembiochem : a European journal of chemical biology.

Caspase protocols in Caenorhabditis elegans.

D. Xue, E. Lee, 2014, Methods in molecular biology.

Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalisation

D. Xue, Yu-Zen Chen, James H. Mapes, 2013, Nature Communications.

Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study

J. Kere, S. Katayama, V. Gogvadze, 2019, Scientific Reports.

Methods for studying programmed cell death in C. elegans.

Yi-Chun Wu, D. Xue, Xiaochen Wang, 2012, Methods in cell biology.

Analysis of programmed cell death in the nematode Caenorhabditis elegans.

M. Driscoll, D. Xue, Y. C. Wu, 2000, Methods in enzymology.

The Roles and Acting Mechanism of Caenorhabditis elegans DNase II Genes in Apoptotic DNA Degradation and Development

S. Mitani, S. Lo, D. Xue, 2009, PloS one.

Bcl-2 Proteins EGL-1 and CED-9 Do Not Regulate Mitochondrial Fission or Fusion in Caenorhabditis elegans

B. Kang, D. Xue, D. Breckenridge, 2009, Current Biology.

SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans.

S. Mitani, D. Killian, D. Xue, 2008, Developmental biology.

Structural Insights into Apoptotic DNA Degradation by CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans*

C. Lin, Hanna S. Yuan, Yi-Ting Wang, 2012, The Journal of Biological Chemistry.

Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in C. elegans

D. Xue, N. Sridhar, A. K. Fajrial, 2023, Science advances.

First-in-Class NADH/Ubiquinone Oxidoreductase Core Subunit S7 (NDUFS7) Antagonist for the Treatment of Pancreatic Cancer.

N. Neamati, M. Ljungman, D. Xue, 2023, ACS pharmacology & translational science.