E. Hughes

发表

Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function.

D. Middleton, E. Hughes, Rachel Edwards, 2010, Biochemical and biophysical research communications.

Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR.

Naomi E. Stanhope, D. Middleton, J. Griffin, 2019, Chemical communications.

Novel stereoselective bufadienolides reveal new insights into the requirements for Na+, K+-ATPase inhibition by cardiotonic steroids

D. Middleton, R. Jiang, T. Chung, 2016, Scientific Reports.

Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?

D. Middleton, J. Clayton, E. Hughes, 2009, Biochimica et biophysica acta.

Solid-state NMR and Functional Measurements Indicate That the Conserved Tyrosine Residues of Sarcolipin Are Involved Directly in the Inhibition of SERCA1*

D. Middleton, A. Kitmitto, J. Clayton, 2007, Journal of Biological Chemistry.

Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin

Geoffrey R Akien, S. Radford, D. Middleton, 2018, The Journal of Biological Chemistry.

Comparison of the Structure and Function of Phospholamban and the Arginine-14 Deficient Mutant Associated with Dilated Cardiomyopathy

D. Middleton, E. Hughes, 2014, PloS one.

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils.

Geoffrey R Akien, S. Radford, S. Hung, 2016, Journal of the American Chemical Society.

The conformation of ATP within the Na,K-ATPase nucleotide site: a statistically constrained analysis of REDOR solid-state NMR data.

D. Middleton, M. Esmann, E. Hughes, 2011, Angewandte Chemie.

Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation.

A. Doig, E. Hughes, R. Burke, 2000, The Journal of biological chemistry.

Average orientation of a fluoroaromatic molecule in lipid bilayers from DFT-informed NMR measurements of 1H–19F dipolar couplings† †Electronic supplementary information (ESI) available. CCDC 1584785. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8cp01064a

D. Middleton, J. Griffin, M. Coogan, 2018, Physical chemistry chemical physics : PCCP.

Inhibition of Toxicity in the β-Amyloid Peptide Fragment β-(25–35) Using N-Methylated Derivatives

A. Doig, E. Hughes, R. Burke, 2000, The Journal of Biological Chemistry.

Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils

S. Radford, E. Yates, D. Middleton, 2017, Journal of molecular biology.

Heparin and Methionine Oxidation Promote the Formation of Apolipoprotein A-I Amyloid Comprising α-Helical and β-Sheet Structures.

D. Middleton, G. Siligardi, R. Hussain, 2017, Biochemistry.

A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain.

D. Middleton, I. Barsukov, M. Esmann, 2011, Biochimica et biophysica acta.

Solid-state NMR Reveals Structural Changes in Phospholamban Accompanying the Functional Regulation of Ca2+-ATPase*

D. Middleton, E. Hughes, 2003, Journal of Biological Chemistry.

The cytoplasmic domains of phospholamban and phospholemman associate with phospholipid membrane surfaces.

D. Middleton, J. Clayton, E. Hughes, 2005, Biochemistry.

Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicity.

D. Middleton, J. Madine, E. Hughes, 2013, Biochemistry.

Side-chain structures in the first turn of the alpha-helix.

A. Doig, S. Penel, E. Hughes, 1999, Journal of molecular biology.

Solid-state NMR measurements of the kinetics of the interaction between phospholamban and Ca2 + -ATPase in lipid bilayers

D. Middleton, E. Hughes, 2005, Molecular membrane biology.

The effects of α-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy

Jillian Madine, A. Doig, D. Middleton, 2008, Molecular membrane biology.

Circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation in vitro.

N. Fullwood, D. Middleton, G. Siligardi, 2020, ACS chemical neuroscience.

Orientation of a Diagnostic Ligand Bound to Macroscopically Aligned Amyloid-β Fibrils Determined by Solid-State NMR.

S. Radford, D. Middleton, J. Griffin, 2018, The journal of physical chemistry letters.

Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function.

D. Middleton, E. Hughes, Rachel Edwards, 2010, Biochemical and biophysical research communications.

Probing the oligomeric state of phospholamban variants in phospholipid bilayers from solid-state NMR measurements of rotational diffusion rates.

D. Middleton, J. Clayton, E. Hughes, 2005, Biochemistry.