T. Kleyman

发表

Extracellular Zn2+ Activates Epithelial Na+ Channels by Eliminating Na+ Self-inhibition*

S. Sheng, Clint J. Perry, T. Kleyman, 2004, Journal of Biological Chemistry.

N-linked glycans are required on epithelial Na+ channel subunits for maturation and surface expression.

J. Brodsky, M. Myerburg, B. Blobner, 2018, American journal of physiology. Renal physiology.

Lack of a role of membrane-protein interactions in flow-dependent activation of ENaC.

Wen Liu, L. Satlin, T. Kleyman, 2007, American journal of physiology. Renal physiology.

Association of the Epithelial Sodium Channel with Apx and α-Spectrin in A6 Renal Epithelial Cells*

Baofeng Hu, J. Zuckerman, T. Kleyman, 1999, The Journal of Biological Chemistry.

Cell-specific regulation of L-WNK1 by dietary K.

A. Subramanya, L. Satlin, Tennille N. Webb, 2016, American journal of physiology. Renal physiology.

Transport Proteins as Regulators of Blood Pressure Homeostasis Cell-specific regulation of L-WNK 1 by dietary K

A. Subramanya, L. Satlin, Tennille N. Webb, 2015 .

Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct.

Yuan Wei, Wen Liu, L. Satlin, 2006, American journal of physiology. Renal physiology.

Epithelial Sodium Channel Inhibition by AMP-activated Protein Kinase in Oocytes and Polarized Renal Epithelial Cells*

John P. Johnson, K. Hallows, D. Neumann, 2005, Journal of Biological Chemistry.

Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae.

James Lyons-Weiler, J. Adelman, J. Brodsky, 2015, Physiological genomics.

An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.

L. Satlin, T. Kleyman, M. Carattino, 2016, American journal of physiology. Cell physiology.

Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.

M. Myerburg, J. Pilewski, R. Frizzell, 2008, American journal of physiology. Lung cellular and molecular physiology.

The mechanosensitive BKα/β1 channel localizes to cilia of principal cells in rabbit cortical collecting duct (CCD).

Wen‐Hui Wang, L. Satlin, C. Schreck, 2017, American journal of physiology. Renal physiology.

Epithelial Na(+) channels are regulated by flow.

L. Satlin, C. Woda, S. Sheng, 2001, American journal of physiology. Renal physiology.

Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects.

L. Satlin, R. Rojas, C. Woda, 2003, American journal of physiology. Renal physiology.

Urinary Plasmin(ogen) as a Prognostic Factor for Hypertension

M. Unruh, T. Orchard, T. Costacou, 2018, Kidney international reports.

Biosynthesis and cell surface delivery of the NHE1 isoform of Na+/H+ exchanger in A6 cells.

E. Chang, S. A. Ernst, P. Smith, 1996, The American journal of physiology.

Distinct Pools of Epithelial Sodium Channels Are Expressed at the Plasma Membrane*

R. Hughey, C. Kinlough, J. B. Bruns, 2004, Journal of Biological Chemistry.

Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors.

T. Kleyman, O. Kashlan, 2012, Experimental cell research.

New role for plasmin in sodium homeostasis

R. Hughey, T. Kleyman, Christopher J. Passero, 2010, Current opinion in nephrology and hypertension.

Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent

Daniel J. Shiwarski, J. Xie, D. Stolz, 2017, Molecular biology of the cell.

Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase.

A. Subramanya, Zhijian Wang, N. Pastor-Soler, 2013, American journal of physiology. Cell physiology.

Characterization of the Selectivity Filter of the Epithelial Sodium Channel*

Jinqing Li, S. Sheng, T. Kleyman, 2000, The Journal of Biological Chemistry.

An American Physiological Society cross-journal Call for Papers on "Inter-Organ Communication in Homeostasis and Disease".

H. Coller, J. Ramirez, M. Lindsey, 2021, American journal of physiology. Lung cellular and molecular physiology.

Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species.

S. Matalon, T. Kleyman, C. Fuller, 2004, American journal of physiology. Renal physiology.

Aldosterone and Epithelial Na Channels Defining an inhibitory domain in the-subunit of the epithelial sodium channel

M. Myerburg, J. Pilewski, R. Hughey, 2007 .

Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens.

M. Madaio, M. Foster, T. Kleyman, 1996, Kidney international.

Expression and localization of epithelial sodium channel in mammalian urinary bladder.

T. Kleyman, P. Weiser, Peter R. Smith, 1998, American journal of physiology. Renal physiology.

Expression and localization of epithelial sodium channel in mammalian urinary bladder.

P. Smith, T. Kleyman, P. Weiser, 1998, The American journal of physiology.

Differential arrival of newly synthesized apical and basolateral plasma membrane proteins in the epithelial cell line A6

T. Kleyman, B. Coupaye-Gerard, 1993, The Journal of Membrane Biology.

A Mechanism for Pentamidine-Induced Hyperkalemia: Inhibition of Distal Nephron Sodium Transport

T. Kleyman, B. N. Ling, C. Roberts, 1995, Annals of Internal Medicine.

The mechanosensitive BK (cid:2) / (cid:3) 1 channel localizes to cilia of principal cells in rabbit cortical collecting duct (CCD)

Wen‐Hui Wang, L. Satlin, C. Schreck, 2016 .

Epithelial Sodium Channels Are Activated by Furin-dependent Proteolysis*

John P. Johnson, R. Hughey, C. Kinlough, 2004, Journal of Biological Chemistry.

Regulating ENaC's gate.

D. Eaton, T. Kleyman, 2019, American journal of physiology. Cell physiology.

Cutting it out: ENaC processing in the human nephron.

T. Kleyman, Evan C. Ray, 2015, Journal of the American Society of Nephrology : JASN.

Plasmin Activates Epithelial Na+ Channels by Cleaving the γ Subunit*

H. Rondon-Berrios, S. Tofovic, R. Hughey, 2008, Journal of Biological Chemistry.

Proteolytic Processing of the Epithelial Sodium Channel γ Subunit Has a Dominant Role in Channel Activation*

R. Hughey, T. Kleyman, M. Carattino, 2008, Journal of Biological Chemistry.

Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy.

H. W. Harris, D. Benos, M. Kashgarian, 1993, The American journal of physiology.

New insights regarding epithelial Na+ channel regulation and its role in the kidney, immune system and vasculature

Stephanie M. Mutchler, T. Kleyman, 2019, Current opinion in nephrology and hypertension.

An Increasingly Complex Relationship Between Salt and Water.

T. Kleyman, Evan C. Ray, 2017, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Regulation of the epithelial Na+ channel by paraoxonase-2

M. Chalfie, J. Brodsky, R. Hughey, 2017, The Journal of Biological Chemistry.

Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit*

G. Silverman, C. Luke, Mark T Miedel, 2016, The Journal of Biological Chemistry.

ENaC regulation by proteases and shear stress.

R. Hughey, T. Kleyman, M. Carattino, 2013, Current molecular pharmacology.

Distinct regulation of Na+ reabsorption and Cl- secretion by arginine vasopressin in the amphibian cell line A6.

T. Kleyman, B. Coupaye-Gerard, M. L. Chalfant, 1993, The American journal of physiology.

Small Heat Shock Protein αA-crystallin Regulates Epithelial Sodium Channel Expression*

J. Brodsky, R. Rubenstein, R. Hughey, 2007, Journal of Biological Chemistry.

Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activity

D. Benos, B. Rossier, J. Kraehenbuhl, 1992, The Journal of cell biology.

DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension

T. Ikizler, S. Pakala, Q. Sheng, 2022, Circulation research.

Ca2+ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct.

Wen Liu, L. Satlin, C. Woda, 2007, American journal of physiology. Renal physiology.

Ca 2 dependence of flow-stimulated K secretion in the mammalian cortical collecting duct

Wen Liu, L. Satlin, C. Woda, 2007 .

ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases*

R. Hughey, T. Kleyman, M. Carattino, 2009, The Journal of Biological Chemistry.

Demonstration of calcium-dependent chemotactic factor activatable esterase activity in human neutrophils: Relationship with chemotaxis and chemotactic deactivation

T. Kleyman, J. Mehta, B. Mandell, 1981, Inflammation.

Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD).

N. Pastor-Soler, Wen Liu, L. Satlin, 2012, American journal of physiology. Renal physiology.

Renal Epithelial Protein (Apx) Is an Actin Cytoskeleton-regulated Na+ Channel*

H. Cantiello, M. Mclaughlin, Dennis Brown, 1996, The Journal of Biological Chemistry.

Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels.

L. Suaud, R. Rubenstein, S. Goldfarb, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Biophysical approach to determine the subunit stoichiometry of the epithelial sodium channel using the Xenopus laevis oocyte expression system.

F. Kosari, S. Sheng, T. Kleyman, 2006, Methods in molecular biology.

Antiidiotypic Antibody Recognizes an Amiloride Binding Domain within the α Subunit of the Epithelial Na+ Channel*

T. Kieber‐Emmons, C. Lin, M. Foster, 1999, The Journal of Biological Chemistry.

Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD.

J. Wade, Wen Liu, L. Satlin, 2011, American journal of physiology. Renal physiology.

Regulation of the Na+/K(+)-ATPase pump in vitro after long-term exposure to cocaine: role of serotonin.

T. Kleyman, S. Mackler, X. Cha, 1998, The Journal of pharmacology and experimental therapeutics.

Regulation of the Na 1 / K 1-ATPase Pump in Vitro after Long-Term Exposure to Cocaine : Role of Serotonin 1

T. Kleyman, S. Mackler, X. Cha, 1998 .

Cell surface expression and turnover of the α-subunit of the epithelial sodium channel

Baofeng Hu, D. Eaton, B. An, 2001 .

Chapter 3 Subunit Stoichiometry of Heterooligomeric and Homooligomeric Epithelial Sodium Channels

F. Kosari, I. Ismailov, Jinqing Li, 1999 .

Subunit Stoichiometry of the Epithelial Sodium Channel*

F. Kosari, J. Foskett, Jinqing Li, 1998, The Journal of Biological Chemistry.

Role of Epithelial Sodium Channels and Their Regulators in Hypertension*

D. Pearce, R. Hughey, R. Soundararajan, 2010, The Journal of Biological Chemistry.

Functional Polymorphism in the Carboxyl Terminus of the α-Subunit of the Human Epithelial Sodium Channel*

F. Samaha, R. Rubenstein, D. I. Levy, 2004, Journal of Biological Chemistry.

Cys Palmitoylation of the β Subunit Modulates Gating of the Epithelial Sodium Channel*

R. Hughey, C. Kinlough, T. Kleyman, 2010, The Journal of Biological Chemistry.

Rare Variants in Genes Encoding Subunits of the Epithelial Na+ Channel Are Associated With Blood Pressure and Kidney Function

May E. Montasser, A. Reiner, S. Redline, 2022, Hypertension.

Paraoxonase 2 is an ER chaperone that regulates the epithelial Na+ channel.

J. Brodsky, T. Kleyman, Teresa M. Buck, 2021, American journal of physiology. Cell physiology.

Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel

C. Baty, R. Tan, T. Kleyman, 2020, The Journal of Biological Chemistry.

Functional cross talk between ENaC and pendrin.

R. Hughey, T. Kleyman, 2007, American journal of physiology. Renal physiology.

Clathrin-mediated Endocytosis of the Epithelial Sodium Channel

John P. Johnson, R. Frizzell, L. Traub, 2006, Journal of Biological Chemistry.

Differential Current Decay Profiles of Epithelial Sodium Channel Subunit Combinations in Polarized Renal Epithelial Cells*

John P. Johnson, Jennifer R. Bruns, O. Weisz, 2004, Journal of Biological Chemistry.

Amiloride and its analogs as tools in the study of ion transport

E. Cragoe, T. Kleyman, 1988, The Journal of Membrane Biology.

Why Diuretics Fail Failing Hearts.

T. Kleyman, Evan C. Ray, Cary R. Boyd-Shiwarski, 2017, Journal of the American Society of Nephrology : JASN.

Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia.

D. Eaton, T. Kleyman, A. E. Kemendy, 1992, The American journal of physiology.

Amiloride and Its Analogs: Unique Cation Transport Inhibitors

E. Cragoe, T. Kleyman, L. Simchowitz, 1992 .

Airway Surface Liquid Volume Regulates ENaC by Altering the Serine Protease-Protease Inhibitor Balance

M. Myerburg, J. Pilewski, R. Frizzell, 2006, Journal of Biological Chemistry.

Cation transport probes: the amiloride series.

E. Cragoe, T. Kleyman, 1990, Methods in enzymology.

Cloning and functional expression of the mouse epithelial sodium channel.

F. Kosari, Jinqing Li, T. Kleyman, 1999, American journal of physiology. Renal physiology.

Intercalated cell BKα subunit is required for flow-induced K+ secretion.

A. Subramanya, D. Kohan, Daniel Flores, 2020, JCI insight.

New amiloride analogue as hapten to raise anti-amiloride antibodies.

Q. Al-Awqati, B. Erlanger, E. Cragoe, 1986, The American journal of physiology.

Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.

Zhijian Wang, R. Rubenstein, R. Hughey, 2012, American journal of physiology. Renal physiology.

The Epithelial Na+ Channel Is Inhibited by a Peptide Derived from Proteolytic Processing of Its α Subunit*

J. Pilewski, R. Hughey, J. B. Bruns, 2006, Journal of Biological Chemistry.

Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.

R. Hughey, J. B. Bruns, S. Sheng, 2006, American journal of physiology. Renal physiology.

Opening lines of communication in the distal nephron.

K. Hallows, L. Satlin, T. Kleyman, 2013, The Journal of clinical investigation.

Isolation and properties of OSCP and an F1-ATPase binding protein from rat liver mitochondria - evidence against OSCP as the linking "stalk" between F1 and the membrane.

S. Chan, T. Kleyman, S. Kirkley, 1976, Biochemical and biophysical research communications.

Photolabile Amiloride Derivatives as Cation Site Probes of the Na,K-ATPase (*)

G. Ellis‐Davies, J. Kaplan, T. Kleyman, 1996, The Journal of Biological Chemistry.

Salt, sodium channels, and SGK1.

D. Pearce, T. Kleyman, 2007, The Journal of clinical investigation.

Effects of amiloride on acetylcholine‐dependent arterial vasodilation evolve over time in mice on a high salt diet

Stephanie M. Mutchler, T. Kleyman, 2022, Physiological reports.

Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C.

Yuan Wei, Peng Sun, Wen‐Hui Wang, 2009, American journal of physiology. Renal physiology.

Accessibility of ENaC extracellular domain central core residues

S. Sheng, T. Kleyman, Jingxin Chen, 2022, The Journal of biological chemistry.

Cell surface expression and turnover of the alpha-subunit of the epithelial sodium channel.

D. Eaton, P. Smith, B. An, 2001, American journal of physiology. Renal physiology.

Multiple epithelial Na+ channel domains participate in subunit assembly.

Baofeng Hu, R. Hughey, J. B. Bruns, 2003, American journal of physiology. Renal physiology.

Urea for the Treatment of Hyponatremia.

S. Weisbord, H. Rondon-Berrios, Maria K. Mor, 2018, Clinical journal of the American Society of Nephrology : CJASN.

On the Interaction between Amiloride and Its Putative α-Subunit Epithelial Na+ Channel Binding Site*

S. Sheng, T. Kleyman, O. Kashlan, 2005, Journal of Biological Chemistry.

Flow-dependent K+ secretion in the cortical collecting duct is mediated by a maxi-K channel.

L. Satlin, C. Woda, T. Kleyman, 2001, American journal of physiology. Renal physiology.

Salt-Sensitivity of Blood Pressure in Blacks and Women: A role of Inflammation, Oxidative Stress and ENaC.

Annet Kirabo, F. Elijovich, Cheryl L. Laffer, 2021, Antioxidants & redox signaling.

ENaC in Salt-Sensitive Hypertension: Kidney and Beyond

J. V. Van Beusecum, Annet Kirabo, T. Kleyman, 2020, Current Hypertension Reports.

Epithelial Na + Channels

K. Hallows, S. Sheng, T. Kleyman, 2013 .

CHAPTER 28 – Epithelial Na+ Channels

John P. Johnson, S. Sheng, T. Kleyman, 2008 .

Regulation of Epithelial Na+ Channels (ENaC) by Methylation

John P. Johnson, Clint J. Perry, T. Kleyman, 2006, Journal of Biological Chemistry.

Potassium-Retaining Diuretics: Amiloride

L. Palmer, T. Kleyman, 1995 .

Epithelial Na+ Channel Regulation by Extracellular and Intracellular Factors.

R. Hughey, T. Kleyman, O. Kashlan, 2018, Annual review of physiology.

ENaC structure and function in the wake of a resolved structure of a family member.

T. Kleyman, O. Kashlan, 2011, American journal of physiology. Renal physiology.

Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic?

J. V. Van Beusecum, M. Madhur, Annet Kirabo, 2021, Circulation research.

Mild Nephrogenic Diabetes Insipidus Caused by Foxa1 Deficiency*

K. Kaestner, J. Fulmer, R. Behr, 2004, Journal of Biological Chemistry.

The Lhs1/GRP170 Chaperones Facilitate the Endoplasmic Reticulum-associated Degradation of the Epithelial Sodium Channel*

A. Subramanya, J. Brodsky, Ankita Roy, 2013, The Journal of Biological Chemistry.

Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein.

J. Brodsky, G. Preston, T. Kleyman, 2017, The Biochemical journal.

Epithelial Sodium Channel and Salt-Sensitive Hypertension.

Annet Kirabo, Stephanie M. Mutchler, T. Kleyman, 2021, Hypertension.

The chemokine C10: immunological and functional analysis of the sequence encoded by the novel second exon.

D. Taub, M. Berger, M. Berger, 1996, Cytokine.

Photoaffinity labeling of the epithelial sodium channel.

A. Karlin, Q. Al-Awqati, D. Landry, 1986, The Journal of biological chemistry.

The cellular pool of Na+ channels in the amphibian cell line A6 is not altered by mineralocorticoids. Analysis using a new photoactive amiloride analog in combination with anti-amiloride antibodies.

J. Kraehenbuhl, E. Cragoe, T. Kleyman, 1989, The Journal of biological chemistry.

Differential modulation of a polymorphism in the COOH terminus of the α-subunit of the human epithelial sodium channel by protein kinase Cδ

Wusheng Yan, L. Suaud, R. Rubenstein, 2006 .

Plasmin and sodium retention in nephrotic syndrome.

R. Hughey, T. Kleyman, 2009, Journal of the American Society of Nephrology : JASN.

External Nickel Inhibits Epithelial Sodium Channel by Binding to Histidine Residues within the Extracellular Domains of α and γ Subunits and Reducing Channel Open Probability*

S. Sheng, Clint J. Perry, T. Kleyman, 2002, The Journal of Biological Chemistry.

Functional effects of a monoclonal antibody on mechanoelectrical transduction in outer hair cells

A. Gummer, C. Hackney, D. Furness, 2002, Hearing Research.

Characterization and localization of epithelial Na+ channels in toad urinary bladder.

D. Benos, P. Smith, T. Kleyman, 1994, The American journal of physiology.

Hydrostatic pressure-regulated ion transport in bladder uroepithelium.

John P. Johnson, John P Johnson, Thomas R Kleyman, 2003, American journal of physiology. Renal physiology.

Epithelial Na+ Channels Are Fully Activated by Furin- and Prostasin-dependent Release of an Inhibitory Peptide from the γ-Subunit*

O. Weisz, J. Pilewski, R. Hughey, 2007, Journal of Biological Chemistry.

Chapter 62 – Diuretics: Mechanisms of Action

G. Gamba, M. Knepper, T. Kleyman, 2005 .

The Endoplasmic Reticulum–associated Degradation of the Epithelial Sodium Channel Requires a Unique Complement of Molecular Chaperones

J. Brodsky, T. Kleyman, Alexander R. Kolb, 2010, Molecular biology of the cell.

Arginine vasopressin and forskolin regulate apical cell surface expression of epithelial Na+ channels in A6 cells.

S. A. Ernst, T. Kleyman, B. Coupaye-Gerard, 1994, The American journal of physiology.

Maturation of the Epithelial Na+ Channel Involves Proteolytic Processing of the α- and γ-Subunits*

R. Hughey, C. Kinlough, P. Poland, 2003, Journal of Biological Chemistry.

Maturation of the epithelial Na+ channel involves proteolytic processing of the alpha- and gamma-subunits.

R. Hughey, C. Kinlough, P. Poland, 2003, The Journal of biological chemistry.

Mechanism of action of amiloride: a molecular prospective.

F. Kosari, T. Kieber‐Emmons, S. Sheng, 1999, Seminars in nephrology.

The Epithelial Sodium Channel Is a Modifier of the Long‐Term Nonprogressive Phenotype Associated with F508del CFTR Mutations

Meghan C Towne, M. Bamshad, M. Emond, 2017, American journal of respiratory cell and molecular biology.

Inhibitory Tract Traps the Epithelial Na+ Channel in a Low Activity Conformation*

B. Blobner, T. Kleyman, M. Carattino, 2012, The Journal of Biological Chemistry.

Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel.

M. Myerburg, J. Pilewski, R. Hughey, 2008, American journal of physiology. Renal physiology.

The mechanism of action of amiloride.

E. Cragoe, T. Kleyman, 1988, Seminars in nephrology.

Functional Role of Extracellular Loop Cysteine Residues of the Epithelial Na+ Channel in Na+ Self-inhibition*

R. Hughey, J. B. Bruns, S. Sheng, 2007, Journal of Biological Chemistry.

CALL FOR PAPERS Aldosterone and Epithelial Na Channels TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the -subunit distal to the furin cleavage site

M. Myerburg, R. Hughey, T. Kleyman, 2011 .

Epithelial Na+ Channels Are Activated by Laminar Shear Stress*

S. Sheng, T. Kleyman, M. Carattino, 2004, Journal of Biological Chemistry.

Extracellular intersubunit interactions modulate epithelial Na+ channel gating

S. Sheng, T. Kleyman, Jingxin Chen, 2023, The Journal of biological chemistry.

Novel Determinants of Epithelial Sodium Channel Gating within Extracellular Thumb Domains*

K. L. Winarski, S. Sheng, T. Kleyman, 2009, Journal of Biological Chemistry.

External nickel inhibits epithelial sodium channel by binding to histidine residues within the extracellular domains of alpha and gamma subunits and reducing channel open probability.

S. Sheng, Clint J. Perry, T. Kleyman, 2002, Journal of Biological Chemistry.

Subunit stoichiometry of a core conduction element in a cloned epithelial amiloride-sensitive Na+ channel.

B. Stanton, K. Karlson, B. Jovov, 1998, Biophysical journal.

Validation of commercially available antibodies directed against subunits of the epithelial Na+ channel

Stephanie M. Mutchler, T. Kleyman, Shujie Shi, 2023, Physiological reports.

Analyses of epithelial Na+ channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating

S. Sheng, T. Kleyman, Shujie Shi, 2019, The Journal of Biological Chemistry.

Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel.

M. Myerburg, R. Hughey, T. Kleyman, 2010, American journal of physiology. Renal physiology.

Intracellular trafficking of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel is modulated by casein kinase 1.

M. Rosenblatt, R. Rubenstein, L. Spruce, 2007, American journal of physiology. Renal physiology.

Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease.

R. Hughey, L. Palmer, T. Kleyman, 2014, American journal of physiology. Renal physiology.

Intracellular Na+ Regulates Epithelial Na+ Channel Maturation*

M. Myerburg, J. Pilewski, R. Hughey, 2015, The Journal of Biological Chemistry.

Extracellular Allosteric Regulatory Subdomain within the γ Subunit of the Epithelial Na+ Channel*

K. L. Winarski, S. Sheng, T. Kleyman, 2010, The Journal of Biological Chemistry.

Epithelial Sodium Channel Exit from the Endoplasmic Reticulum Is Regulated by a Signal within the Carboxyl Cytoplasmic Domain of the α Subunit*

R. Hughey, M. Aridor, J. B. Bruns, 2007, Journal of Biological Chemistry.

Epithelial Sodium Channel Pore Region

T. Kieber‐Emmons, Jinqing Li, S. Sheng, 2001, The Journal of Biological Chemistry.

Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.

A. Robay, L. Suaud, R. Rubenstein, 2007, American journal of physiology. Cell physiology.

Thumb domains of the three epithelial Na+ channel subunits have distinct functions

J. Brodsky, R. Hughey, A. Mukherjee, 2018, The Journal of Biological Chemistry.

Na+ Inhibits the Epithelial Na+ Channel by Binding to a Site in an Extracellular Acidic Cleft*

B. Blobner, T. Kleyman, Michael A. Tolino, 2014, The Journal of Biological Chemistry.

Role of the Wrist Domain in the Response of the Epithelial Sodium Channel to External Stimuli*

T. Kleyman, M. Carattino, Shujie Shi, 2012, The Journal of Biological Chemistry.

Base of the Thumb Domain Modulates Epithelial Sodium Channel Gating*

D. Ghosh, S. Sheng, T. Kleyman, 2011, The Journal of Biological Chemistry.

Constraint-based, Homology Model of the Extracellular Domain of the Epithelial Na+ Channel α Subunit Reveals a Mechanism of Channel Activation by Proteases*

J. Adelman, M. Grabe, B. Blobner, 2010, The Journal of Biological Chemistry.

Allosteric Inhibition of the Epithelial Na+ Channel through Peptide Binding at Peripheral Finger and Thumb Domains*

M. Grabe, C. Argyropoulos, R. Hughey, 2010, The Journal of Biological Chemistry.

Extracellular Histidine Residues Crucial for Na+ Self-inhibition of Epithelial Na+ Channels*

J. B. Bruns, S. Sheng, T. Kleyman, 2004, Journal of Biological Chemistry.

Antikaliuretic action of trimethoprim is minimized by raising urine pH.

M. Halperin, T. Kleyman, B. N. Ling, 1996, Kidney international.

K(+)-sparing diuretic actions of trimethoprim: inhibition of Na+ channels in A6 distal nephron cells.

T. Kleyman, B. N. Ling, L. Schlanger, 1994, Kidney international.

Brief report: trimethoprim-induced hyperkalemia in a patient with AIDS.

T. Kleyman, B. Coupaye-Gerard, M. Choi, 1993, The New England journal of medicine.

Application of the Amiloride Series in the Study of Ion Transport

T. Kleyman, 1991 .

Role of proteolysis in the activation of epithelial sodium channels

R. Hughey, T. Kleyman, M. Carattino, 2007, Current opinion in nephrology and hypertension.

Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain*

J. Brodsky, K. L. Winarski, R. Hughey, 2015, The Journal of Biological Chemistry.

Deletion of α-subunit exon 11 of the epithelial Na+ channel reveals a regulatory module.

S. Sheng, T. Kleyman, Jingxin Chen, 2014, American journal of physiology. Renal physiology.

Second transmembrane domain modulates epithelial sodium channel gating in response to shear stress.

T. Kleyman, M. Carattino, Shujie Shi, 2011, American journal of physiology. Renal physiology.

Asymmetric Organization of the Pore Region of the Epithelial Sodium Channel*

Jinqing Li, S. Sheng, Clint J. Perry, 2003, The Journal of Biological Chemistry.

Identification of an Amiloride Binding Domain within the α-Subunit of the Epithelial Na+ Channel*

D. Benos, T. Kieber‐Emmons, D. Eaton, 1997, The Journal of Biological Chemistry.

Cleavage state of γENaC in mouse and rat kidney.

L. Palmer, T. Kleyman, Shujie Shi, 2021, American journal of physiology. Renal physiology.

Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells

F. Jaisser, D. Warnock, H. Oberleithner, 2014, Nature Reviews Nephrology.

Cysteine Palmitoylation of the γ Subunit Has a Dominant Role in Modulating Activity of the Epithelial Sodium Channel*

Zhijian Wang, R. Hughey, A. Mukherjee, 2014, The Journal of Biological Chemistry.

Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.

T. Kleyman, Shujie Shi, 2013, American journal of physiology. Renal physiology.

Arachidonic Acid Regulates Surface Expression of Epithelial Sodium Channels*

T. Kleyman, M. Carattino, W. Hill, 2003, Journal of Biological Chemistry.

Fetal lung epithelial cells contain two populations of amiloride-sensitive Na+ channels.

S. Matalon, D. Benos, H. O'brodovich, 1993, The American journal of physiology.

Cystic Fibrosis Transmembrane Conductance Regulator Differentially Regulates Human and Mouse Epithelial Sodium Channels in Xenopus Oocytes*

F. Samaha, R. Rubenstein, T. Kleyman, 2004, Journal of Biological Chemistry.

Genistein Restores Functional Interactions between ΔF508-CFTR and ENaC in Xenopus Oocytes*

L. Suaud, R. Rubenstein, Jinqing Li, 2002, The Journal of Biological Chemistry.

Epithelial Sodium Channels Regulate Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels in XenopusOocytes*

J. Foskett, Jinqing Li, T. Kleyman, 2000, The Journal of Biological Chemistry.

Water and Electrolyte Homeostasis in a Mouse Model with Reduced ENaC Gamma Subunit Expression

Y. Barak, S. Sheng, T. Kleyman, 2021, bioRxiv.

Distinct Structural Elements in the First Membrane-spanning Segment of the Epithelial Sodium Channel*

Thomas R Kleyman, K. Blumenthal, Kenneth M Blumenthal, 2006, Journal of Biological Chemistry.

Side Chain Orientation of Residues Lining the Selectivity Filter of Epithelial Na+ Channels*

S. Sheng, Clint J. Perry, T. Kleyman, 2005, Journal of Biological Chemistry.

Phosphatase inhibitors increase the open probability of ENaC in A6 cells.

A. Becchetti, D. Eaton, T. Kleyman, 2002, American journal of physiology. Renal physiology.

Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity.

D. Gu, D. Rao, Jiang He, 2016, American journal of physiology. Renal physiology.

Gain-of-function variant of the human epithelial sodium channel.

S. Sheng, T. Kleyman, Jingxin Chen, 2013, American journal of physiology. Renal physiology.

Extracellular Finger Domain Modulates the Response of the Epithelial Sodium Channel to Shear Stress*

B. Blobner, T. Kleyman, O. Kashlan, 2012, The Journal of Biological Chemistry.

Regulation of ENaCs by proteases: An increasingly complex story.

M. Myerburg, R. Hughey, T. Kleyman, 2006, Kidney international.

Characterization of an amiloride binding region in the α-subunit of ENaC

D. Eaton, T. Kleyman, N. Saxena, 2003 .

Characterization of an amiloride binding region in the alpha-subunit of ENaC.

D. Eaton, T. Kleyman, N. Saxena, 2003, American journal of physiology. Renal physiology.

Identification of an amiloride binding domain within the alpha-subunit of the epithelial Na+ channel.

D. Benos, T. Kieber‐Emmons, C. Lin, 1997, The Journal of biological chemistry.

Modeling oxidative injury response in human kidney organoids

J. Kellum, N. Hukriede, C. Baty, 2021, Stem cell research & therapy.

ATP12A promotes mucus dysfunction during Type 2 airway inflammation

S. Wenzel, T. Corcoran, M. Myerburg, 2018, Scientific Reports.

Phosphatidylinositol 4-Phosphate 5-Kinase Reduces Cell Surface Expression of the Epithelial Sodium Channel (ENaC) in Cultured Collecting Duct Cells*

John P. Johnson, P. Welling, O. Weisz, 2007, Journal of Biological Chemistry.

Expression and Distribution of PIEZO1 in the Mouse Urinary Tract.

L. Satlin, G. Apodaca, W. Ricke, 2019, American journal of physiology. Renal physiology.

Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury

D. Kohan, R. Tan, Stephanie M. Mutchler, 2021, International journal of molecular sciences.

Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.

N. Pastor-Soler, Wen Liu, L. Satlin, 2008, American journal of physiology. Renal physiology.

Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct.

Wen Liu, L. Satlin, T. Morimoto, 2005, American journal of physiology. Renal physiology.

Expression of the Cystic Fibrosis Phenotype in a Renal Amphibian Epithelial Cell Line*

D. Eaton, J. Zuckerman, R. Worrell, 1997, The Journal of Biological Chemistry.

Regulation of cation transport in the distal nephron by mechanical forces.

Wen Liu, L. Satlin, T. Kleyman, 2006, American journal of physiology. Renal physiology.

Effects of biomechanical forces on signaling in the cortical collecting duct (CCD).

Rolando Carrisoza-Gaytan, Yu Liu, Daniel Flores, 2014, American journal of physiology. Renal physiology.

8‐Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1

Dongmei Cheng, E. Jackson, Z. Mi, 2018, Journal of the American Heart Association.

Characterization and cellular localization of the epithelial Na+ channel. Studies using an anti-Na+ channel antibody raised by an antiidiotypic route.

S. A. Ernst, J. Kraehenbuhl, T. Kleyman, 1991, The Journal of biological chemistry.

Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema

L. Salkoff, A. Loewy, E. Jackson, 2015, Brain Research.

Defining topological similarities among ion transport proteins with anti-amiloride antibodies.

F. Kosari, T. Kieber‐Emmons, C. Lin, 1995, Kidney international.

Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages

A. Hanukoglu, Israel Hanukoglu, T. Kleyman, 2017, Histochemistry and Cell Biology.

Cloning and functional expression of the mouse epithelial sodium channel.

F. Kosari, Jinqing Li, T. Kleyman, 1999, American journal of physiology. Renal physiology.

Delivery of newly synthesized Na(+)-K(+)-ATPase to the plasma membrane of A6 epithelia.

S. A. Ernst, J. Zuckerman, T. Kleyman, 1997, The American journal of physiology.

An American Physiological Society cross-journal Call for Papers on "Deconstructing organs: Single-cell analyses, decellularized organs, organoids, and organ-on-a-chip models".

Josephine C. Adams, J. Ramirez, A. Marette, 2020, American journal of physiology. Lung cellular and molecular physiology.

Hypertension

J. V. Van Beusecum, M. Madhur, Annet Kirabo, 2021, Circulation Research.

An aldosterone regulated chicken intestine protein with high affinity to amiloride.

H. Garty, C. Asher, E. Cragoe, 1997, Comparative biochemistry and physiology. Part A, Physiology.

Biochemical evidence for the presence of an amiloride binding protein in adult alveolar type II pneumocytes.

S. Matalon, D. Benos, T. Kleyman, 1992, Journal of Biological Chemistry.

Mutations in the Pore Region Modify Epithelial Sodium Channel Gating by Shear Stress*

S. Sheng, T. Kleyman, M. Carattino, 2005, Journal of Biological Chemistry.

Distinct epitopes on amiloride. II. Variably restricted epitopes defined by monoclonal anti-amiloride antibodies.

T. Kleyman, J. Zebrowitz, 1991, The American journal of physiology.

Distinct epitopes on amiloride.

D. Warnock, B. Rossier, J. Kraehenbuhl, 1989, The American journal of physiology.

Pore-lining residues of MEC-4 and MEC-10 channel subunits tune the Caenorhabditis elegans degenerin channel's response to shear stress

B. Blobner, Stephanie M. Mutchler, T. Kleyman, 2018, The Journal of Biological Chemistry.

5-(N-Ethyl-N-isopropyl)amiloride sensitive Na+ currents in intact fetal distal lung epithelial cells.

X. Wang, H. O'brodovich, H. Tohda, 1993, Canadian Journal of Physiology and Pharmacology.

The epithelial sodium channel in inflammation and blood pressure modulation

Annet Kirabo, T. Kleyman, L. Ertuglu, 2023, Frontiers in Cardiovascular Medicine.

Second Transmembrane Domains of ENaC Subunits Contribute to Ion Permeation and Selectivity*

S. Sheng, T. Kleyman, K. McNulty, 2001, The Journal of Biological Chemistry.

Profound hyponatremia and dehydration: A case of cisplatin induced renal salt wasting syndrome

T. Kleyman, Thomas Powell, T. B. George, 2023, Physiological reports.

L-WNK1 is required for BK channel activation in intercalated cells

A. Subramanya, Daniel Flores, Wen‐Hui Wang, 2021, bioRxiv.

in mammalian urinary bladder Expression and localization of epithelial sodium channel

Qing Yang, J. Wade, Jie Liu, 2011 .

Editor's Note: AJP-Cell and AJP-Renal article series to honor the work of Dale Benos.

P. Insel, T. Kleyman, Martin Frank, 2011, American journal of physiology. Cell physiology.

Regulation of mitochondrial cAMP-dependent protein kinase activity in yeast.

A. Hudson, T. Kleyman, C. McEntee, 1994, Biochemistry and molecular biology international.

Luminal sodium entrythrough amiloride-sensitive, highly-selective sodium channels (ENaC) in the apical membrane of distal nephron epithelial cells is the rate-limiting step for hormonally

A. Becchetti, D. Eaton, T. Kleyman, 2002 .

ATP12A promotes mucus dysfunction during Type 2 airway inflammation

S. Wenzel, T. Corcoran, M. Myerburg, 2018, Scientific Reports.

Specific Palmitoyltransferases Associate with and Activate the Epithelial Sodium Channel*

Zhijian Wang, M. Butterworth, R. Hughey, 2017, The Journal of Biological Chemistry.

Genistein Improves Regulatory Interactions between G551D-Cystic Fibrosis Transmembrane Conductance Regulator and the Epithelial Sodium Channel in Xenopus Oocytes*

L. Suaud, R. Rubenstein, T. Kleyman, 2002, The Journal of Biological Chemistry.

Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7.

C. Kozak, T. Kleyman, D. Brooker, 1995, Genomics.

Aldosterone does not alter apical cell-surface expression of epithelial Na+ channels in the amphibian cell line A6.

S. A. Ernst, T. Kleyman, B. Coupaye-Gerard, 1992, Journal of Biological Chemistry.

Characterization of an amiloride binding region in the (cid:1) -subunit of ENaC

D. Eaton, T. Kleyman, N. Saxena, 2003 .

Role of Epithelial Sodium Channels and Their Regulators in Hypertension*

D. Pearce, R. Hughey, R. Soundararajan, 2010, The Journal of Biological Chemistry.

Epithelial Sodium Channels Regulate Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels in XenopusOocytes*

J. Foskett, Jinqing Li, T. Kleyman, 2000, The Journal of Biological Chemistry.

Proteases, ENaCs and cystic fibrosis

M. Myerburg, T. Kleyman, 2014, Journal of Physiology.

The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice

A. Subramanya, D. Nguyen, L. Hendershot, 2022, JCI insight.

TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site.

M. Myerburg, R. Hughey, T. Kleyman, 2012, American journal of physiology. Renal physiology.