Sophie M. Bertrand

发表

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.

S. Pickett, C. Chung, C. Jamieson, 2016, Journal of medicinal chemistry.

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.

S. Pickett, C. Chung, E. Nicodème, 2015, Journal of medicinal chemistry.

One-Pot Suzuki-Hydrogenolysis Protocol for the Modular Synthesis of 2,5-Diaryltetrazoles

C. Jamieson, Sophie M. Bertrand, Keith Livingstone, 2020, The Journal of organic chemistry.

Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a key off-target activity.

P. Grandi, Christina Rau, M. Bantscheff, 2019, Journal of medicinal chemistry.

Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles.

J. Bower, Sophie M. Bertrand, Tom A. Young, 2020, Journal of the American Chemical Society.

Modular Access to Eight-Membered N-Heterocycles by Directed Carbonylative C-C Bond Activation of Aminocyclopropanes.

J. Bower, O. Sokolova, Sophie M. Bertrand, 2019, Angewandte Chemie.

Transition‐Metal‐Free Coupling of 1,3‐Dipoles and Boronic Acids as a Sustainable Approach to C−C Bond Formation

C. Jamieson, A. Kennedy, Sophie M. Bertrand, 2020, Chemistry.

Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.

J. Cottom, N. Campobasso, P. Ward, 2019, Journal of medicinal chemistry.

Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site.

Yoshiaki Washio, Junya Qu, Thau Ho, 2011, Chemistry & biology.

Metal-free C–C bond formation via coupling of nitrile imines and boronic acids† †Electronic supplementary information (ESI) available: Full experimental protocols and complete compound characterization. See DOI: 10.1039/c9sc03032h

C. Jamieson, Sophie M. Bertrand, Keith Livingstone, 2019, Chemical science.

Direct small-molecule kinase activation: Novel approaches for a new era of drug discovery.

Yoshiaki Washio, Yoshiaki Washio, Graham L Simpson, 2009, Current opinion in drug discovery & development.

Optimization of Orally Bioavailable PI3K delta Inhibitors and Identification of Vps34 as a Key Selectivity Target.

P. Grandi, Birgit Dümpelfeld, M. Bantscheff, 2020 .

Structure-guided optimization of small molecule c-Abl activators

Ping Cao, Jingsong Yang, Hong Zhang, 2014, Journal of Computer-Aided Molecular Design.

UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow

L. Green, C. Jamieson, Simon Peace, 2020, Chemistry.

Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic heterocycles.

M. Barker, N. Tomkinson, Sophie M. Bertrand, 2020, Bioorganic & medicinal chemistry letters.

Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site.

M. Head, S. Moores, G. Hofmann, 2011, Chemistry & biology.

European Medicinal Chemistry Leaders in Industry (EMCL) – On the Status and Future of Medicinal Chemistry Research in Europe **

A. Torrens, M. Bossart, Michael Wagner, 2023, ChemMedChem.