M. Chappell

发表

Synthesis of CMP-sialic acid conjugates: Substrates for the enzymatic synthesis of natural and designed sialyl oligosaccharides

R. Halcomb, M. Chappell, 1997 .

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.

J. F. Soriano, P. Ornstein, M. Blanco, 2016, Bioorganic & medicinal chemistry letters.

Mild oxidation of cytidine-sialic acid phosphite derivatives using dimethyldioxirane

R. Halcomb, M. Chappell, 1999 .

Angiotensins: From Endocrine to Intracrine Functions

M. Chappell, 2009 .

En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B.

S. Stachel, S. Danishefsky, M. Chappell, 2000, Organic letters.

RECENT DEVELOPMENTS IN TECHNOLOGY FOR GLYCOSYLATION WITH SIALIC ACID

R. Halcomb, M. Chappell, 2002 .

Synthesis of a six-carbon sialic acid using an indium-mediated coupling.

R. Halcomb, M. Chappell, 2000, Organic letters.

On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones.

T. Chou, S. Stachel, W. Bornmann, 2001, The Journal of organic chemistry.

Enzyme-Catalyzed Synthesis of Oligosaccharides That Contain Functionalized Sialic Acids

R. Halcomb, M. Chappell, 1997 .

Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.

T. Chou, S. Danishefsky, W. Tong, 2002, Journal of the American Chemical Society.

Metabotropic Glutamate Receptor

J. F. Soriano, P. Ornstein, S. Atwell, 2016 .

Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F.

T. Chou, S. Stachel, S. Danishefsky, 2001, Journal of the American Chemical Society.

The Interactivity of Complex Synthesis and Tumor Pharmacology in the Discovery Process: Total Synthesis and Comparative in vivo Evaluations of the 15-Aza Epothilones.

T. Chou, S. Stachel, W. Bornmann, 2001 .

Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B.

T. Chou, S. Kuduk, S. Stachel, 2002, The Journal of organic chemistry.

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

J. F. Soriano, P. Ornstein, S. Atwell, 2016, Journal of medicinal chemistry.

On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments.

T. Chou, S. Stachel, S. Danishefsky, 2000, Organic letters.

Total synthesis and antitumor activity of 12,13-desoxyepothilone F: an unexpected solvolysis problem at C15, mediated by remote substitution at C21.

T. Chou, S. Kuduk, S. Stachel, 2000, The Journal of organic chemistry.