H. Shimeno

发表

Acid sphingomyelinase inhibition suppresses lipopolysaccharide‐mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium‐induced colitis in mice

R. Eyanagi, S. Shibuya, S. Soeda, 2007, Immunology.

Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice.

S. Shibuya, S. Soeda, A. Sakata, 2007, Cellular immunology.

Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice

S. Honda, S. Soeda, H. Shimeno, 2010, Molecular and Cellular Biochemistry.

Marine polysaccharides and angiogenesis: Modulation of angiogenesis by fucoidans

S. Soeda, H. Shimeno, Koyanagi Satoru, 2007 .

Bezafibrate Induces Plasminogen Activator Inhibitor-1 Gene Expression in a CLOCK-Dependent Circadian Manner

K. Kadota, K. Oishi, S. Ohdo, 2010, Molecular Pharmacology.

Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction

S. Soeda, H. Shimeno, M. Sakamoto, 1998, Lipids.

Inhibitory effect of oversulfated fucoidan on tube formation by human vascular endothelial cells.

S. Soeda, H. Shimeno, Y. Shibata, 1997, Biological & pharmaceutical bulletin.

Sphingomyelinase and cell-permeable ceramide analogs increase the release of plasminogen activator inhibitor-1 from cultured endothelial cells.

S. Soeda, H. Shimeno, O. Honda, 1995, Thrombosis research.

Effect of combined administration of tryptophan with putative tryptophan pyrrolase inhibitors, DL-3-pyridylalanine, allopurinol or nicotinamide, on brain serotonin concentration.

H. Shimeno, A. Nagamatsu, Y. Fukumoto, 1984, Chemical & pharmaceutical bulletin.

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells

S. Shirasawa, S. Honda, M. Yoshimitsu, 2012, International journal of cancer.

Target epitopes of HTLV‐1 recognized by class I MHC‐restricted cytotoxic T lymphocytes in patients with myelopathy and spastic paraparesis and infected patients with autoimmune disorders

K. Uozumi, S. Izumo, R. Kubota, 2011, Journal of medical virology.

Selective Inhibition by Nimesulide, a Novel Non‐steroidal Anti‐inflammatory Drug, with Prostaglandin Endoperoxide Synthase‐2 Activity In‐vitro

Tsutomu Nakamura, K. Yokoyama, H. Shimeno, 1995 .

Vasohibin induces prolyl hydroxylase‐mediated degradation of hypoxia‐inducible factor‐1α in human umbilical vein endothelial cells

S. Honda, S. Soeda, A. Sakata, 2012, FEBS letters.

Oversulfated fucoidan inhibits the basic fibroblast growth factor-induced tube formation by human umbilical vein endothelial cells: its possible mechanism of action.

S. Soeda, H. Shimeno, T. Kozako, 2000, Biochimica et biophysica acta.

Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system

S. Koyanagi, S. Soeda, H. Shimeno, 2008, Thrombosis and Haemostasis.

Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2008, Journal of pharmacological sciences.

Plasminogen activator inhibitor-1 aids survival of neurites on neurons derived from pheochromocytoma (PC-12) cells

S. Koyanagi, T. Imatoh, S. Soeda, 2004, Neuroreport.

Effect of interleukin 1β-induced fever on hepatic drug metabolism in rat

H. Shigematsu, S. Soeda, H. Shimeno, 1998 .

Liver haem metabolism in adjuvant-induced arthritic rats.

H. Shimeno, A. Toda, T. Kihara, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Effect of adjuvant-induced arthritis on hepatic drug metabolism in rats.

H. Shimeno, A. Toda, T. Kihara, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

Effects of experimental diabetes on aminopyrine metabolism in rats.

H. Shigematsu, H. Shimeno, A. Toda, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

Localization of the binding sites of porcine tissue-type plasminogen activator and plasminogen to heparin.

M. Kakiki, S. Soeda, H. Shimeno, 1987, Biochimica et biophysica acta.

An attempt to promote neo‐vascularization by employing a newly synthesized inhibitor of protein tyrosine phosphatase

S. Koyanagi, S. Shibuya, S. Soeda, 2002, FEBS letters.

PROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-α MEDIATES HIGH-FAT, DIET-ENHANCED DAILY OSCILLATION OF PLASMINOGEN ACTIVATOR INHIBITOR-1 ACTIVITY IN MICE

K. Oishi, S. Ohdo, S. Koyanagi, 2010, Chronobiology international.

Vascular endothelial cell monolayer formed on membrane filter potentiates the defense against tumor cell invasion by treatment with brefeldin A.

S. Soeda, H. Shimeno, O. Honda, 1996, Cancer letters.

LIM‐Homeodomain Transcription Factor, Lhx2, is involved in Transcriptional Control of Brain‐Specific Promoter/Exon 1f of the Mouse Aromatase Gene

N. Harada, S. Honda, S. Soeda, 2012, Journal of neuroendocrinology.

Rapid and high-yield purification of porcine heart tissue-type plasminogen activator by heparin-sepharose choromatography.

M. Kakiki, S. Soeda, H. Shimeno, 1986, Life sciences.

Aminopyrine metabolism in primary monolayer cultures of diabetic rat hepatocytes.

H. Shigematsu, H. Shimeno, A. Toda, 1988, Xenobiotica; the fate of foreign compounds in biological systems.

cDNA cloning and expression of rat leukotriene C(4) synthase: elevated expression in rat basophilic leukemia-1 cells after treatment with retinoic acid.

S. Soeda, H. Shimeno, M. Abe, 2002, Prostaglandins, leukotrienes, and essential fatty acids.

Stereoselective Reduction of Cyclopropylalkaones Possessing a Difluoromethylenephosphonate Group at the Ring: Application to Stereoselective Synthesis of Novel Cyclopropane Nucleotide Analogues

T. Yamagishi, H. Abe, S. Shibuya, 2000 .

Efficient induction of human T-cell leukemia virus-1-specific CTL by chimeric particle without adjuvant as a prophylactic for adult T-cell leukemia.

F. Lemonnier, Y. Nishimura, S. Sonoda, 2009, Molecular immunology.

Some properties of tissue-type plasminogen activator reconstituted onto phospholipid and/or glycolipid vesicles.

M. Kakiki, S. Soeda, H. Shimeno, 1987, Biochemical and biophysical research communications.

Daunorubicin attenuates tumor necrosis factor-alpha-induced biosynthesis of plasminogen activator inhibitor-1 in human umbilical vein endothelial cells.

S. Soeda, H. Shimeno, K. Iwata, 2001, Biochimica et biophysica acta.

Release of plasminogen activator inhibitor‐1 from human astrocytes is regulated by intracellular ceramide

S. Soeda, T. Ochiai, H. Shimeno, 2000, Journal of neuroscience research.

Fatty acyl-Co A: sphingosine acyltransferase in bovine brain mitochondria: its solubilization and reconstitution onto the membrane lipid liposomes.

N. Okamura, S. Soeda, H. Shimeno, 1995, Biological & pharmaceutical bulletin.

Oversulfated fucoidan and heparin suppress endotoxin induction of plasminogen activator inhibitor-1 in cultured human endothelial cells: their possible mechanism of action.

S. Soeda, H. Shimeno, N. Fujii, 1995, Biochimica et biophysica acta.

Inhibitory Effect of Oversulfated Fucoidan on Invasion through Reconstituted Basement Membrane by Murine Lewis Lung Carcinoma

S. Soeda, H. Shimeno, A. Nagamatsu, 1994, Japanese journal of cancer research : Gann.

Further characterization of the binding of plasminogen to heparin: evidence for the involvement of lysine residues.

S. Soeda, H. Shimeno, H. Ohki, 1989, Biochimica et biophysica acta.

Further characterization of the heat-stable factor in the alpha-hydroxylation and oxidation of lignoceric acid in brain: effect of acidic amino acids and hexose-phosphates on brain fatty acid metabolism.

Y. Kishimoto, N. Okamura, H. Shimeno, 1983, Archives of biochemistry and biophysics.

Tissue plasminogen activator catalyzed Lys-plasminogen activation on heparin-inserted phospholipid liposomes.

S. Soeda, H. Shimeno, A. Nagamatsu, 1990, Biochemistry.

Expression of ganglioside GM3 and H-2 antigens in clones with different metastatic and growth potentials isolated from Lewis lung carcinoma (3LL) cell line

J. Inokuchi, H. Shimeno, A. Nagamatsu, 2004, Clinical & Experimental Metastasis.

Sphingosine inhibits attachment of murine Lewis lung carcinoma cells to laminin and type IV collagen

J. Inokuchi, H. Shimeno, A. Nagamatsu, 1991, FEBS letters.

Oligomannose‐coated liposomes efficiently induce human T‐cell leukemia virus‐1‐specific cytotoxic T lymphocytes without adjuvant

F. Lemonnier, M. Yoshimitsu, S. Soeda, 2011, The FEBS journal.

Aminated fucoidan promotes the invasion of 3 LL cells through reconstituted basement membrane: its possible mechanism of action.

S. Soeda, H. Shimeno, O. Honda, 1994, Cancer letters.

Effects of D‐threo‐PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells

N. Radin, J. Inokuchi, H. Shimeno, 1989, Journal of cellular physiology.

Tumor necrosis factor-alpha-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event.

T. Tsunoda, S. Soeda, H. Shimeno, 1998, Biochimica et biophysica acta.

Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: its regulation of dimeric transcription factor formation.

R. Misasi, S. Soeda, M. Hiraiwa, 2008, Biochimica et biophysica acta.

Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders.

S. Izumo, R. Kubota, M. Yoshimitsu, 2011, Human immunology.

Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol

Y. Shoyama, Hiroyuki Tanaka, S. Soeda, 2004, Neuroscience Letters.

Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities.

Satoru Koyanagi, Hiroshi Shimeno, Noboru Tanigawa, 2003, Biochemical pharmacology.

Preparation of oversulfated fucoidan fragments and evaluation of their antithrombotic activities.

S. Soeda, H. Shimeno, Y. Ohmagari, 1993, Thrombosis research.

Fibrinolytic and anticoagulant activities of highly sulfated fucoidan.

S. Soeda, H. Shimeno, A. Nagamatsu, 1992, Biochemical pharmacology.

Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity.

J. Koizumi, Y. Tsuji, S. Shibuya, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of a difluoromethylene analogue of sphingomyelin as an inhibitor of sphingomyelinase.

S. Soeda, H. Shimeno, T. Yokomatsu, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of multisubstrate analogue inhibitors of purine nucleoside phosphorylases.

Y. Hayakawa, S. Koyanagi, S. Soeda, 2000, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acids possessing a N9-purinylmethyl functional group at the ring. a new class of inhibitors for purine nucleoside phosphorylases.

Y. Hayakawa, S. Soeda, H. Shimeno, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of α, α-difluorobenzylphosphonic acid derivatives as small molecular inhibitors of protein-tyrosine phosphatase 1B

S. Shibuya, S. Soeda, H. Shimeno, 1999 .

Synthesis of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase.

H. Abe, M. Sato, S. Soeda, 1998, Bioorganic & medicinal chemistry.

Synthesis of (2′S,3′S)-9-(4′-phosphono-4′,4′-difluoro-2′,3′-methanobutyl)guanine and its enantiomer. Evaluation of the inhibitory activity for purine nucleoside phosphorylase

H. Abe, S. Shibuya, S. Soeda, 1997 .

Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors.

S. Koyanagi, S. Shibuya, S. Soeda, 2006, Bioorganic & medicinal chemistry.

Synthesis of ceramides and cerebrosides in rat brain: comparison with synthesis of lignoceroyl-coenzyme A

Y. Kishimoto, M. Mori, H. Shimeno, 1985, Neurochemistry International.

Covalent binding of nitroso-sulfonamides to glutathione S-transferase in guinea pigs with delayed type hypersensitivity.

Y. Ishii, R. Eyanagi, S. Soeda, 2012, International immunopharmacology.

Antigenicity of sulfanilamide and its metabolites using fluorescent-labelled compounds

Y. Ishii, R. Eyanagi, H. Shigematsu, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells.

Y. Shoyama, S. Soeda, H. Tanaka, 2001, Life sciences.

Optimizing the Dosing Schedule of TNP-470 [O-(Chloroacetyl-carbamoyl) Fumagillol] Enhances Its Antitumor and Antiangiogenic Efficacies

S. Ohdo, S. Koyanagi, S. Soeda, 2003, Journal of Pharmacology and Experimental Therapeutics.

Inhibition by nimesulide of prostaglandin production in rat macrophages.

T. Nakamura, K. Yokoyama, H. Shimeno, 1998, Drugs under experimental and clinical research.

Pharmacological activities of crocin in saffron

K. Abe, H. Saito, Y. Shoyama, 2007, Journal of Natural Medicines.

Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action.

N. Radin, J. Inokuchi, H. Shimeno, 1990, Cancer research.

Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase

S. Koyanagi, S. Shibuya, S. Soeda, 2003, International journal of cancer.

Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by administration of DL-alpha-amino-beta-pyridinepropanoic acid (pyridylalanine) analogs.

N. Harada, H. Shimeno, A. Toda, 1987, Journal of enzyme inhibition.

An inhibitor of proline endopeptidase: purification from rat brain and characterization.

S. Soeda, H. Shimeno, A. Nagamatsu, 1985, Chemical & pharmaceutical bulletin.

Preparation of aminated fucoidan and its evaluation as an antithrombotic and antilipemic agent.

S. Soeda, H. Shimeno, Y. Ohmagari, 1994, Biological & pharmaceutical bulletin.

Synthesis of taurine- and/or acetyl group-conjugated poly(D-Glu, D-Lys) derivatives and their effects on fibrinolysis.

S. Soeda, H. Shimeno, H. Ohki, 1988, Thrombosis research.

A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells.

Satoru Koyanagi, Hiroshi Shimeno, H. Aramaki, 2003, Cancer research.

Two molecular species of proline endopeptidase in human plasma: isolation and characterization.

S. Soeda, H. Shimeno, A. Nagamatsu, 1984, Chemical & pharmaceutical bulletin.

Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo.

Y. Shoyama, Hiroyuki Tanaka, R. Eyanagi, 2007, Biochimica et biophysica acta.

Inhibition of proline endopeptidase activity by acyl-coenzyme A esters.

S. Soeda, H. Shimeno, A. Nagamatsu, 1990, Biochimica et biophysica acta.

Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress

Y. Tsuji, S. Shibuya, S. Soeda, 2004, Neurochemistry International.

An enzyme-linked immunosorbent assay for the detection of plasminogen activator-induced fribrin clot lysis in a circulating plasma system.

S. Soeda, H. Shimeno, A. Nagamatsu, 1992, Chemical and pharmaceutical bulletin.

Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis

Y. Shoyama, Hiroyuki Tanaka, S. Soeda, 2004, Neurochemistry International.

Promising pharmacological actions of croon in crocus sativus on the central nervous system

H. Saito, S. Morimoto, Y. Shoyama, 2003 .

Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathways

S. Koyanagi, R. Eyanagi, S. Soeda, 2006, Neuroscience.

The stimulatory effects of caffeine with oseltamivir (Tamiflu®) on light–dark behavior and open-field behavior in mice

Shigenori Watanabe, Satoko Nishimura, R. Eyanagi, 2010, Neuroscience Letters.

Cytochrome P-450 in liver microsomes of streptozotocin-induced diabetic rats: purification and characterization.

S. Ogata, H. Shimeno, A. Toda, 1993, Biochimica et biophysica acta.

24-Hour Oscillation of Mouse Methionine Aminopeptidase2, a Regulator of Tumor Progression, Is Regulated by Clock Gene Proteins

S. Higuchi, S. Ohdo, S. Koyanagi, 2004, Cancer Research.

Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues.

H. Okamura, S. Ohdo, S. Koyanagi, 2006, Molecular endocrinology.

Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver.

S. Higuchi, S. Ohdo, H. Takane, 2006, Endocrinology.

Purification and Characterization of the Heat‐Stable Factors Essential for the Conversion of Lignoceric Acid to Cerebronic Acid and Glutamic Acid: Identification of N‐Acetyl‐l‐Aspartic Acid

C. Fenselau, L. Kan, Y. Kishimoto, 1983, Journal of neurochemistry.

Biochemistry and neurobiology of prosaposin: a potential therapeutic neuro-effector.

T. Inuzuka, I. Hozumi, R. Misasi, 2009, Central nervous system agents in medicinal chemistry.

Improved inhibitors of glucosylceramide synthase.

A. Abe, N. Radin, J. Shayman, 1992, The Journal of biological chemistry.

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells

S. Shirasawa, S. Honda, M. Yoshimitsu, 2012, International journal of cancer.

Bezafibrate Induces Plasminogen Activator Inhibitor-1 Gene Expression in a CLOCK-Dependent Circadian Manner

K. Kadota, K. Oishi, S. Ohdo, 2010, Molecular Pharmacology.

Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2010 .

Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner

K. Oishi, S. Ohdo, S. Koyanagi, 2010 .

Deficient release of plasminogen activator inhibitor-1 from astrocytes triggers apoptosis in neuronal cells.

S. Soeda, T. Ochiai, H. Shimeno, 2001, Brain research. Molecular brain research.

S. Izumo, R. Kubota, M. Yoshimitsu, 2011, Human immunology.