Sadao Hikishima

发表

Acid sphingomyelinase inhibition suppresses lipopolysaccharide‐mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium‐induced colitis in mice

R. Eyanagi, S. Shibuya, S. Soeda, 2007, Immunology.

Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice.

S. Shibuya, S. Soeda, A. Sakata, 2007, Cellular immunology.

Synthesis of 1,8-naphthyridine C-nucleosides and their base-pairing properties in oligodeoxynucleotides: thermally stable naphthyridine:imidazopyridopyrimidine base-pairing motifs.

N. Minakawa, A. Matsuda, Sadao Hikishima, 2005, Angewandte Chemie.

Antiproliferative Activity of Purine Nucleoside Phosphorylase Multisubstrate Analogue Inhibitors Containing Difluoromethylene Phosphonic Acid against Leukaemia and Lymphoma Cells

A. Bzowska, L. Glavaš-Obrovac, Mariko Hashimoto, 2010, Chemical biology & drug design.

Synthesis and Characterization of Oligodeoxynucleotides Containing Naphthyridine:Imidazopyridopyrimidine Base Pairs at their Sticky Ends. Application as Thermally Stabilized Decoy Molecules

N. Minakawa, A. Matsuda, Sadao Hikishima, 2006 .

Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs.

A. Bzowska, Mariko Hashimoto, Sadao Hikishima, 2010, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.

A. Bzowska, Mariko Hashimoto, Sadao Hikishima, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors.

S. Koyanagi, S. Shibuya, S. Soeda, 2006, Bioorganic & medicinal chemistry.

9‐Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow‐binding picomolar inhibitors of trimeric purine nucleoside phosphorylase

B. Wielgus-Kutrowska, Katarzyna Breer, A. Bzowska, 2010, The FEBS journal.

Inhibitory Properties of Nucleotides with Difluoromethylenephosphonic Acid as a Phosphate Mimic versus Calf Spleen Purine Nucleoside Phosphorylase and Effect of These Analogues on the Viability of Human Blood Lymphocytes

A. Bzowska, L. Glavaš-Obrovac, M. Suver, 2007, Nucleosides, Nucleotides & Nucleic Acids.

New base pairing motifs. The synthesis and thermal stability of oligodeoxynucleotides containing imidazopyridopyrimidine nucleosides with the ability to form four hydrogen bonds.

N. Minakawa, A. Matsuda, Takashi Sasaki, 2003, Journal of the American Chemical Society.

1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.

B. Wielgus-Kutrowska, Katarzyna Breer, A. Bzowska, 2010, Biochemical and biophysical research communications.

Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.

B. Wielgus-Kutrowska, Katarzyna Breer, A. Bzowska, 2012, Bioorganic & medicinal chemistry.

Overexpressed proteins may act as mops removing their ligands from the host cells: a case study of calf PNP.

B. Wielgus-Kutrowska, Katarzyna Breer, A. Bzowska, 2010, Biochemical and biophysical research communications.

Synthesis and characterization of oligodeoxynucleotides containing naphthyridine:imidazopyridopyrimidine base pairs at their sticky ends. Application as thermally stabilized decoy molecules.

N. Minakawa, A. Matsuda, Sadao Hikishima, 2007, Chembiochem : a European journal of chemical biology.

Deterioration after Liver Transplantation and Transthyretin Stabilizer Administration in a Patient with ATTRv Amyloidosis with a Leu58Arg (p.Leu78Arg) TTR Variant

K. Ono, K. Iwasa, M. Yamada, 2022, Internal medicine.