A. Horn

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Involvement of both dopaminergic and alpha-adrenergic receptors in the hypomotility induced by dibenzoyl-6,7-ADTN.

C. Sumners, J. D. de Vries, D. Dijkstra, 1981, European journal of pharmacology.

Antipsychotic phenothiazine drugs and the significance of the X‐ray structure of promazine HCl

O. Kennard, J. Rodgers, A. Horn, 1976, The Journal of pharmacy and pharmacology.

An Approach To Possible Correlations Between Activity And Conformation In Some Classes Of Psychotropic Drugs

O. Kennard, W. Motherwell, J. Rodgers, 1974 .

CONFORMATIONAL ASPECTS OF THE INHIBITION OF NEURONAL UPTAKE OF NORADRENALINE BY TRICYCLIC ANTIDEPRESSANTS

A. Horn, 1973 .

The effects of kainic acid and 6-hydroxydopamine lesions, metal ions and GTP on in vitro binding of the D-2 dopamine agonist, [3H]N-0437, to striatal membranes.

J. van der Weide, J. D. de Vries, A. Horn, 1987, European journal of pharmacology.

Chlorpromazine and dopamine: conformational similarities that correlate with the antischizophrenic activity of phenothiazine drugs.

S. Snyder, A. Horn, S. Snyder, 1971, Proceedings of the National Academy of Sciences of the United States of America.

Possible pharmacological and theoretical implications of X-ray structure of the tricyclic antidepressant imipramine

O. Kennard, M. Post, A. Horn, 1974, Nature.

A crystallographic and theoretical study of the conformation of DOET and its significance for the hallucinogenic amphetamines

O. Kennard, M. Post, L. R. Sanseverino, 1975, The Journal of pharmacy and pharmacology.

The enkephalins and opiates: structure‐activity relations

J. Rodgers, A. Horn, 1977, The Journal of pharmacy and pharmacology.

Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogues.

H. Yamamura, R. Speth, G. Peng, 1980, Journal of medicinal chemistry.

2‐Amino‐6,7‐dihydroxytetrahydronaphthalene and the receptor‐site preferred conformation of dopamine—a commentary

J. Rodgers, A. Horn, 1980, The Journal of pharmacy and pharmacology.

The effect of systemically applied cholinergic drugs on the striatal release of dopamine and its metabolites, as determined by automated brain dialysis in conscious rats

B. Westerink, G. Damsma, A. Horn, 1988, Neuroscience Letters.

Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734.

J. van der Weide, J. D. de Vries, A. Horn, 1986, European journal of pharmacology.

Structural and conformational relationships between the enkephalins and the opiates

J. Rodgers, A. Horn, 1976, Nature.

Brain and serum concentrations of dopamine analogues after peripheral administration to rats

M. Feenstra, H. Rollema, A. Horn, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Action of Neuroleptic Drugs on Dopamine-Stimulated Adenosine Cyclic 3',5'-Monophosphate Production in Rat Neostriatum and Limbic Forebrain

L. Iversen, Richard J. Miller, A. Horn, 1974 .

Desenkephalin-gamma-endorphin and neuroleptics counteract the DP-7-ATN-induced hypomotility after intra-accumbens treatment.

J. V. van Ree, F. Radhakishun, A. Horn, 1988, European journal of pharmacology.

Method for detecting dopaminergic diseases using fluorine-18 radiolabelled D2 dopamine receptor ligands

P. Jerabek, A. Horn, J. Peck, 1990 .

Affinity chromatography with the immobilized agonist N-0434 yields an active and highly purified preparation of the dopamine D-2 receptor from bovine striatum.

J. Dijk, G. Sieswerda, F. V. van Bussel, 1989, European journal of pharmacology.

Stereoselective reversal of MPTP-induced parkinsonism in the marmoset after dermal application of N-0437.

C. Marsden, P. Jenner, M. Nomoto, 1989, European journal of pharmacology.

Catecholamines in the Median Eminence: New Evidence for a Major Noradrenergic Input

L. Iversen, A. Cuello, A. Horn, 1973, Nature.

N-0437: a selective D-2 dopamine receptor agonist in in vitro and in vivo models.

M. Dubocovich, D. Krause, J. van der Weide, 1988, European journal of pharmacology.

Transdermal administration of the dopamine agonist N-0437 and seven ester prodrugs: comparison with oral administration in the 6-OHDA turning model

H. Rollema, A. Horn, P. Tepper, 1990, Naunyn-Schmiedeberg's Archives of Pharmacology.

Orally Active Carbamate Prodrugs of the Selective Dopamine Agonist N‐0437: In‐vivo Activities in the 6‐OHDA Turning Model and In‐vitro Activities

P. Boer, H. Rollema, A. Horn, 1991, The Journal of pharmacy and pharmacology.

Impact of structural differences on the in vitro glucuronidation kinetics of potentially dopaminergic hydroxy-2-aminotetralins and naphthoxazines using rat and human liver microsomes.

B. Drenth, P. J. Swart, D. Dijkstra, 1991, Pharmacology & toxicology.

N,N-disubstituted 2-aminotetralins are potent D-2 dopamine receptor agonists.

J. Kebabian, A. Horn, P. Tepper, 1984, European journal of pharmacology.

The enantiomers of the D-2 dopamine receptor agonist N-0437 discriminate between pre- and postsynaptic dopamine receptors.

M. Dubocovich, J. van der Weide, J. D. de Vries, 1988, European journal of pharmacology.

A new dopaminergic prodrug

M. Feenstra, H. Rollema, D. Dijkstra, 1978, Nature.

Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.

S. Snyder, J. Coyle, A. Horn, 1971, Molecular pharmacology.

Actions of dopaminergic agonists on cyclic AMP production in rat brain homogenates.

L. Iversen, R. Miller, A. Horn, 1975, Advances in neurology.

The occurrence of tryptamine in rat brain and its pharmacological manipulation.

S. R. Snodgrass, A. Horn, S. Snodgrass, 1973, British journal of pharmacology.

A comparison of the pharmacological actions of 4-aminopyridine and two of its derivatives in the monkey.

M. Houwertjes, A. Horn, S. Ágoston, 1985, European journal of pharmacology.

The metabolic fate of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in rats after intravenous and oral administration. I. Disposition and metabolic profiling.

T. K. Gerding, B. Drenth, A. Horn, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Steric requirements for catecholamine uptake by rat brain synaptosomes: studies with rigid analogs of amphetamine.

S. Snyder, A. Horn, S. Snyder, 1972, The Journal of pharmacology and experimental therapeutics.

Uptake and release of [3H]dopamine by the median eminence: Evidence for presynaptic dopaminergic receptors and for dopaminergic feedback inhibition

D. Sarkar, G. Fink, A. Cuello, 1983, Neuroscience.

STRUCTURE‐ACTIVITY RELATIONS FOR THE INHIBITION OF 5‐HYDROXYTRYPTAMINE UPTAKE BY TRICYCLIC ANTIDEPRESSANTS INTO SYNAPTOSOMES FROM SEROTONERGIC NEURONES IN RAT BRAIN HOMOGENATES

A. Horn, R. Trace, 1974, British journal of pharmacology.

Structure‐activity relations for the inhibition of catecholamine uptake into synaptosomes from noradrenaline and dopaminergic neurones in rat brain homogenates

A. Horn, 1973, British journal of pharmacology.

The metabolism of dopamine, NN‐dialkylated dopamines and derivatives of the dopamine agonist 2−amino‐dihydroxy−1,2,3,4−tetrahydronaphthalene (ADTN) by catechol‐O‐methyltransferase

M. Raxworthy, D. Dijkstra, A. Horn, 1984, The Journal of pharmacy and pharmacology.

Pharmacological profile of non-hydroxylated and ether derivatives of the potent D2-selective agonist N-0437

J. Jansen, P. J. Swart, H. Rollema, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

A prodrug of ADTN: selectivity of dopaminergic action and brain levels of ADTN.

D. Dijkstra, A. Horn, B. Westerink, 1979, European journal of pharmacology.

Simultaneous demonstration of the activation of presynaptic dopamine autoreceptors and postsynaptic dopamine receptors in vitro by N,N-dipropyl-5,6-ADTN

J. C. Stoof, A. H. Mulder, A. Horn, 1980, Brain Research.

The action of some new aminopyridines on mammalian non-myelinated nerve fibres.

J. van den Akker, A. Horn, S. Ágoston, 1983, European journal of pharmacology.

OCTOPAMINE IN MAMMALIAN BRAIN: RAPID POST MORTEM INCREASE AND EFFECTS OF DRUGS

A. Harmar, A. Horn, A. J. Harmar, 1976, Journal of neurochemistry.

Structure activity relationships for agonist and antagonist drugs at pre- and postsynaptic receptor sites in rat brain.

L. Iversen, R. Miller, A. Horn, 1975, Psychopharmacology bulletin.

N-0434, A very potent and specific new D-2 dopamine receptor agonist.

J. Kebabian, P. Beart, A. Horn, 1984, European journal of pharmacology.

Effect of butaclamol on dopamine‐sensitive adenylate cyclase in the rat striatum

L. Iversen, R. Miller, Richard J. Miller, 1975, The Journal of pharmacy and pharmacology.

Enantiomers of monohydroxy-2-aminotetralin derivatives and their activity at dopamine autoreceptors as studied by brain dialysis.

B. Westerink, W. Timmerman, D. Dijkstra, 1991, European journal of pharmacology.

The enantiomers of the dopamine agonist N-0437: in vivo and in vitro effects on the release of striatal dopamine.

M. Dubocovich, W. Timmerman, J. D. de Vries, 1989, European journal of pharmacology.

Synthesis and pharmacological evaluation of 5,6,7,8‐tetrahydro‐6‐[propyl[2‐(2‐thienyl)ethyl]amino]‐1,2‐naphthalenediol: A novel non‐selective dopamine‐receptor agonist

D. Dijkstra, A. Horn, J. Vries, 2010 .

2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.

M. Dubocovich, A. Horn, P. Tepper, 1993, Journal of medicinal chemistry.

A noradren aline sensitive adenylate cyclase in the rat limbic forebrain: preparation, properties and the effects of agonists, adrenolytics and neuroleptic drugs.

O. Phillipson, A. Horn, 1976, European journal of pharmacology.

Abstracts of Dutch doctoral theses

R. A. Zeeuw, G. J. Jong, M. J. M. Zeeland, 2005, Pharmaceutisch Weekblad.

The metabolic fate of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in rats after intravenous and oral administration. II. Isolation and identification of metabolites.

T. K. Gerding, B. Drenth, A. Horn, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Determination of enantiomeric purity of the new D-2 dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin (N-0437) by reversed-phase high-performance liquid chromatography after pre-column derivatization with D(+)-glucuronic acid.

T. K. Gerding, B. Drenth, A. Horn, 1989, Journal of chromatography.

Structure-Activity Relations for Neurotransmitter Receptor Agonists and Antagonists

A. Horn, 1975 .

Continuous production of the pharmaceutical 7,8-dihydroxy N-di-n-propyl 2-aminotetralin using a phenoloxidase from cell cultures of Mucuna pruriens

N. Pras, D. Dijkstra, A. Horn, 1990, Plant Cell, Tissue and Organ Culture.

Bioconversion of bi- and tri-cyclic monophenols by alginate-entrapped cells of Mucuna pruriens L. and by the partially purified Mucuna-phenoloxidase

N. Pras, D. Dijkstra, A. Horn, 1990, Plant Cell, Tissue and Organ Culture.

Effects of dopamine-like drugs on rat striatal adenyl cyclase have implications for CNS dopamine receptor topography

L. Iversen, Richard J. Miller, A. Horn, 1974, Nature.

DOPAMINE IN THE MESOLIMBIC SYSTEM OF THE RAT BRAIN: ENDOGENOUS LEVELS AND THE EFFECTS OF DRUGS ON THE UPTAKE MECHANISM AND STIMULATION OF ADENYLATE CYCLASE ACTIVITY

R. Miller, A. Horn, A. Cuello, 1974, Journal of neurochemistry.

3,4-Disubstituted phenyliminoimidazolidines as potential prodrugs of the purported dopamine agonist 3,4-dihydroxyphenylimino-2-imidazolidine (DPI)

H. Houwing, A. Horn, J. C. Oene, 1983, Pharmaceutisch Weekblad.

Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin

J. Wiechers, D. Dijkstra, A. Horn, 1987, Naunyn-Schmiedeberg's Archives of Pharmacology.

The effectiveness of yohimbine in blocking rat central dopamine autoreceptors in vivo

A. Horn, J. Vries, J. C. Oene, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

A comparison of the potencies of various dopamine receptor agonists in models for pre- and postsynaptic receptor activity

M. Feenstra, C. Sumners, H. Rollema, 1983, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacological profile of a chromanamine analogue (DP‐6OH‐3CA) of the selective presynaptic dopamine agonist N, N‐dipropyl‐7‐hydroxy‐2‐aminotetralin

N. Vermue, A. Horn, Durk Dukstra, 1988, The Journal of pharmacy and pharmacology.

In‐vitro and in‐vivo metabolism of the presynaptic dopamine agonist 3‐PPP to a catecholic analogue in rats *

H. Rollema, A. Horn, D. Mastebroek, 1985, The Journal of pharmacy and pharmacology.

In vivo dopamine autoreceptor selectivity appears to be critically dependent upon the aromatic hydroxyl position in a series of N,N-disubstituted 2-aminotetralins.

J. D. de Vries, D. Dijkstra, A. Horn, 1984, European journal of pharmacology.

trans-N-n-Propyl-7-hydroxy-octahydrobenzo(f)quinoline, a rigid 3-PPP analogue with greater potency but lack of selectivity for dopamine autoreceptors.

H. Houwing, D. Dijkstra, A. Horn, 1983, European journal of pharmacology.

Is TL-99 a selective presynaptic dopamine receptor agonist?

A. H. Mulder, J. D. de Vries, D. Dijkstra, 1982, European journal of pharmacology.

Evidence that the purported dopaminergic agonist (3,4-dihydroxyphenylimino)-2-imidazolidine (DPI) may reduce rat striatal dopamine turnover by an alpha 2-adrenergic mechanism.

H. Houwing, A. Horn, J. V. van Oene, 1982, European journal of pharmacology.

Behavioural and neurochemical studies on apomorphine-induced hypomotility in mice

C. Sumners, A. Horn, J. Vries, 1981, Neuropharmacology.

The significance of COMT activity in controlling dopamine agonist levels in brain and serum: studies with a prodrug and a metabolite of 6,7-ADTN.

M. Feenstra, H. Rollema, D. Dijkstra, 1980, European journal of pharmacology.

The neuropharmacological profile of N-methyl-N-propargyl-2-aminotetralin: a potent monoamine oxidase inhibitor

D. Dijkstra, A. Horn, W. Jong, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain.

F. Artaud, M. Hamon, S. Bourgoin, 1984, European journal of pharmacology.

A COMPARISON OF THE FACILITATORY ACTIONS OF 4‐AMINOPYRI‐DINE METHIODIDE AND 4‐AMINOPYRIDINE ON NEUROMUSCULAR TRANSMISSION

J. Lambert, A. Horn, I. G. Marshall, 1979, British journal of pharmacology.

STRUCTURE ACTIVITY RELATIONS FOR THE INHIBITION OF 5‐HT UPTAKE INTO RAT HYPOTHALAMIC HOMOGENATES BY SEROTONIN AND TRYPTAMINE ANALOGUES

A. Horn, 1973, Journal of neurochemistry.

The pharmacological characterization of 3,4‐dihydroxyphenylimino‐2‐imidazolidine (DPI) as a potent mixed α1/α2‐adrenoceptor agonist rather than as a dopamine receptor agonist

A. Horn, J. C. Oene, 1985, The Journal of pharmacy and pharmacology.

The purported dopamine agonist (3,4-dihydroxyphenylimino)-2-imidazolidine (DPI) acts as a nonselective alpha-adrenoceptor agonist in inducing hypertension, hypomotility and hypothermia in the rat.

H. Houwing, A. Horn, J. V. van Oene, 1982, European journal of pharmacology.

PHARMACOKINETICS AND PHARMACODYNAMICS OF 2,4‐DIAMINOPYRIDINE IN THE CAT

M. Houwertjes, A. Horn, A. Scaf, 1988, Fundamental & clinical pharmacology.

Comparison of the pharmacological actions of some new 4-aminopyridine derivatives.

A. Horn, S. Ágoston, P. Biessels, 1984, European journal of pharmacology.

Improvement of the oral bioavailability of the selective dopamine agonist N-0437 in rats: the in vitro and in vivo activity of eight ester prodrugs

A. Horn, P. Tepper, I. Daas, 1990, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effect of dihydroxy-2-aminotetralin derivatives on dopamine metabolism in the rat striatum

B. Westerink, M. Feenstra, H. Rollema, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Facile syntheses of potent dopaminergic argonists and their effect on neurotransmitter release.

A. H. Mulder, D. Dijkstra, A. Horn, 1978, Journal of medicinal chemistry.

Inhibition of rat brain monoamine oxidase type A by 2- aminotetralin and tetrahydroisoquinoline analogues of dopamine

O. Hommes, M. Feenstra, D. Dijkstra, 1983, Pharmaceutisch Weekblad.

Neurochemical and behavioural profiles of five dopamine analogues

C. Sumners, D. Dijkstra, A. Horn, 1981, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effect of non-catecholic 2-aminotetralin derivatives on dopamine metabolism in the rat striatum

B. Westerink, M. Feenstra, H. Rollema, 1980, Naunyn-Schmiedeberg's Archives of Pharmacology.

FACILE SYNTHESES OF POTENT DOPAMINERGIC AGONISTS AND THEIR EFFECTS ON NEUROTRANSMITTER RELEASE

A. H. Mulder, D. Dijkstra, A. Horn, 1978 .

PRODRUGS OF SOME DOPAMINERGIC 2-AMINOTETRALINS - A REVIEW OF THEIR SYNTHESES AND NEUROCHEMICAL PROFILES

B. Westerink, M. Feenstra, H. Rollema, 1981 .

(1S,3R,4S)-1-Methyl-3-(4-methoxyphenoxymethyl)-4-phenylpiperidinium chloride (FG4963): a selective inhibitor of serotonin uptake

A. Horn, P. Jones, T. P. Singh, 1979 .

Stereoselective blockade of the dopamine receptor and the X-ray structures of α and β-flupenthixol

M. Post, A. Horn, T. P. Singh, 1975, Nature.

The purported dopamine agonist DPI inhibits [3H]noradrenaline release from rat cortical slices but not [3H]dopamine and [14C]acetylcholine release from rat striatal slices in‐vitro

P. Sminia, A. H. Mulder, A. Horn, 1983, The Journal of pharmacy and pharmacology.

The tricyclic antidepressants: imipramine hydrochloride. The crystal and molecular structure of 5‐(3‐dimethylaminopropyl)‐10,1l‐dihydro‐5H‐dibenz[b,f]azepine hydrochloride

M. Post, A. Horn, T. P. Singh, 1975 .

AN ASSAY PROCEDURE FOR TRYPTAMINE IN BRAIN AND SPINAL CORD USING ITS [3H]DANSYL DERIVATIVE

S. R. Snodgrass, A. Horn, S. Snodgrass, 1973, Journal of neurochemistry.

Dopamine receptor blockade and the neuroleptics, a crystallographic study

O Kennard, M. Post, M L Post, 1975, The Journal of pharmacy and pharmacology.

Analysis of the dopamine agonist N-0437 in rat serum using reversed-phase high-performance liquid chromatography with electrochemical detection.

H. Rollema, J. D. de Vries, A. Horn, 1989, Journal of chromatography.

Octopamine-sensitive adenylate cyclase in cockroach brain: effects of agonists, antagonists, and guanylyl nucleotides.

A. Harmar, A. Horn, 1977, Molecular pharmacology.

Evidence concerning the anatomical location of the dopamine stimulated adenylate cyclase in the substantia nigra

T. Jessell, P. Emson, O. Phillipson, 1977, Brain Research.

In vitro binding of the very potent and selective D-2 dopamine agonist, [3H]N-0437 to calf caudate membranes.

J. van der Weide, J. D. de Vries, A. Horn, 1987, European journal of pharmacology.

Substantia nigra of the rat contains a dopamine sensitive adenylate cyclase

O. Phillipson, A. Horn, 1976, Nature.

Effects of ADTN and various other 2-aminotetralin derivatives on the efflux of 3H-dopamine from rat striatal slices.

B. Braakhuis, A. H. Mulder, D. Dijkstra, 1980, European journal of pharmacology.

Abstracts of papers

Spencer R. Wijn, O. Zuiderveld, J. Brussee, 2005, Pharmaceutisch Weekblad.

STUDIES ON THE NEUROTOXIC PROPERTIES OF HYDROXYLATED TRYPTAMINES

A. Horn, H. Baumgarten, A. Björklund, 1974 .

The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: Interaction with autoreceptor responses

P. Boer, B. Westerink, A. Horn, 1990, Neuroscience Letters.

Pharmacological implications of the X‐ray structure of a rigid analogue of the tricyclic antidepressants

J. Rodgers, A. Horn, T. P. Singh, 1975, The Journal of pharmacy and pharmacology.

2‐Chloro‐9‐(ω‐dimethylaminopropylidene)thioxanthene

M. Post, A. Horn, T. P. Singh, 1974 .

Proceedings: Noradrenaline-sensitive adenylate cyclase in rat limbic forebrain homogenates: effects of agonists and antagonists.

O. Phillipson, A. Horn, 1975, British journal of pharmacology.

Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D2 dopamine receptor agonist

P. Seeman, J. Weide, D. Grigoriadis, 1985, Pharmaceutisch Weekblad.

Neurotoxicity of hydroxylated tryptamines: structure-activity relationships. 2. In vitro studies on monoamine uptake inhibition and uptake impairment.

A. Björklund, A. Nobin, A. Horn, 1975, Acta Physiologica Scandinavica Supplementum.

STRUCTURE‐ACTIVITY RELATIONSHIPS OF SEROTONIN NEUROTOXINS: EFFECTS ON SEROTONIN UPTAKE

A. Horn, 1978, Annals of the New York Academy of Sciences.

Possible anomalous behaviour of apomorphine in relation to other dopamine receptor agonists

M. Feenstra, H. Rollema, A. Horn, 1983, The Journal of pharmacy and pharmacology.

Failure to detect 6-hydroxydopamine in rat striatum after the dopamine releasing drugs dexamphetamine, methylamphetamine and MPTP.

B. Westerink, H. Rollema, J. D. de Vries, 1986, European journal of pharmacology.

Autoradiographic localization of dopamine D2 receptors in the rat brain using the new agonist [3H]N-0437

J. Palacios, M. Camps, J. Weide, 1987, Neuroscience Letters.