B. Holst

发表

Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease.

A. Ramírez, O. Brüstle, A. Ebneth, 2021, Stem cell research.

IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

B. Brodin, L. Saaby, B. Holst, 2020, Pharmaceutics.

An advanced pluripotent stem cell test for developmental toxicity

A. Vinggaard, A. K. Rosenmai, C. Taxvig, 2021 .

Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5).

E. Shusta, B. Brodin, L. Saaby, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Scalable expansion of iPSC and their derivatives across multiple lineages.

C. Verfaillie, H. Zimmermann, A. Ebneth, 2022, Reproductive toxicology.

Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies.

B. Nielsen, A. Vinggaard, H. Zimmermann, 2022, Reproductive toxicology.

BioZoom INDUCED PLURIPOTENT STEM CELLS ( IPSC ) FOR MODELING OF ALZHEIMER ’ S DISEASE

G. Waldemar, T. Nielsen, J. Nielsen, 2015 .

Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus.

U. Mau-Holzmann, A. Ebneth, Rachel Steeg, 2021, Stem cell research.

Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies.

Juan D. Pita-Almenar, P. Shih, A. Ebneth, 2021, Stem cell research.

Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T α-synuclein levels and aggregation

R. Melki, Benjamin Schmid, B. Holst, 2021, PloS one.

Generation of an isogenic, gene-corrected iPSC line from a pre-symptomatic 28-year-old woman with an R406W mutation in the microtubule associated protein tau (MAPT) gene.

U. Mau-Holzmann, T. Nielsen, J. Nielsen, 2016, Stem cell research.

Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene.

U. Mau-Holzmann, T. Nielsen, J. Nielsen, 2016, Stem cell research.

Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1.

T. Nielsen, J. Nielsen, K. Freude, 2016, Stem cell research.

59-year-old female patient with frontotemporal dementia caused by a R 406 W mutation in microtubule associated protein tau ( MAPT )

U. Mau-Holzmann, T. Nielsen, J. Nielsen, 2016 .

A novel human pluripotent stem cell-based assay to predict developmental toxicity

A. Vinggaard, C. Taxvig, I. Meiser, 2020, Archives of Toxicology.

EBiSC best practice: How to ensure optimal generation, qualification, and distribution of iPSC lines

A. Courtney, Sabine C. Mueller, P. D. De Sousa, 2021, Stem cell reports.

Transient p53 Suppression Increases Reprogramming of Human Fibroblasts without Affecting Apoptosis and DNA Damage

Z. Tümer, M. G. Johnsen, P. Hyttel, 2014, Stem cell reports.

Low‐molecular‐weight carbohydrate Pentaisomaltose may replace dimethyl sulfoxide as a safer cryoprotectant for cryopreservation of peripheral blood stem cells

B. Holst, A. Fischer-Nielsen, E. Haastrup, 2016, Transfusion.

The positional identity of iPSC-derived neural progenitor cells along the anterior-posterior axis is controlled in a dosage-dependent manner by bFGF and EGF.

Andras Dinnyes, Susanna Cirera, Bjørn Holst, 2016, Differentiation; research in biological diversity.

Detection of lncRNA by LNA-Based In Situ Hybridization in Paraffin-Embedded Cancer Cell Spheroids.

B. Nielsen, K. Holmstrøm, J. Larsen, 2021, Methods in molecular biology.

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Anna Ochałek, A. Dinnyés, J. Nielsen, 2017, Alzheimer's Research & Therapy.

Identification of SSEA-1 expressing enhanced reprogramming (SEER) cells in porcine embryonic fibroblasts

Dong Li, T. Nielsen, K. Freude, 2017, Cell cycle.

Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene.

Ravi S Muddashetty, K. Freude, Benjamin Schmid, 2019, Stem cell research.

Lab resource: Stem cell lineGeneration of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1

G. Waldemar, T. Nielsen, J. Nielsen, 2016 .

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.

Tony Burdett, Helen Parkinson, Heiko Zimmermann, 2017, Stem cell research.

Generation of two isogenic iPSC lines with either a heterozygous or a homozygous E280A mutation in the PSEN1 gene.

U. Mau-Holzmann, K. Freude, Benjamin Schmid, 2019, Stem cell research.

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

L. Bolund, Xin Liu, Fengping Xu, 2022 .

Gene expression changes in rat prostate after activation or blocking of the androgen and estrogen receptor

M. Dalgaard, A. Vinggaard, C. Nellemann, 2005, Molecular and Cellular Endocrinology.

Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line.

U. Mau-Holzmann, A. Ebneth, Ravi S Muddashetty, 2019, Stem cell research.

APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis

G. Gouras, S. Chakraborty, Ravi S Muddashetty, 2020, The Journal of Neuroscience.

Selecting optimal spectral bands for improved detection of autofluorescent biomarkers in multiphoton microscopy

Dominik Marti, Peter Andersen, Björn-Ole Meyer, 2020, Journal of biomedical optics.

Molecular Switch Controlling Expression of the Mannose-Specific Adhesin, Msa, in Lactobacillus plantarum

K. Holmstrøm, S. Ahrné, Jacob Glenting, 2019, Applied and Environmental Microbiology.

Genetic Protection Modifications: Moving Beyond the Binary Distinction Between Therapy and Enhancement for Human Genome Editing.

P. Sandøe, Yonglun Luo, M. Gjerris, 2019, The CRISPR journal.

Creating a human-induced pluripotent stem cell-based NKX2.5 reporter gene assay for developmental toxicity testing

A. Vinggaard, C. Taxvig, Andreas Frederik Treschow, 2021, Archives of Toxicology.

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

L. Bolund, Fengping Xu, Yonglun Luo, 2017, Stem cell reports.

Generation of two patient specific GABRD variants and their isogenic controls for modeling epilepsy.

B. Holst, M. Kamand, Methi Wathikthinnakon, 2024, Stem cell research.

Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder.

T. Michel, Å. Fex Svenningsen, M. Thomassen, 2020, Stem cell research.

Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases.

T. Gasser, U. Mau-Holzmann, T. Kluba, 2016, Stem cell research.

Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1.

Tong Li, A. Dinnyés, T. Nielsen, 2016, Stem cell research.

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B.

T. Nielsen, J. Nielsen, K. Freude, 2016, Stem cell research.

Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H196.

T. Nielsen, J. Nielsen, P. Hyttel, 2016, Stem cell research.

Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT).

G. Waldemar, J. Nielsen, L. Hasholt, 2016, Stem cell research.

Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H271.

T. Nielsen, J. Nielsen, P. Hyttel, 2016, Stem cell research.

Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H266.

T. Nielsen, J. Nielsen, P. Hyttel, 2016, Stem cell research.

Lab resource: Stem cell lineGeneration of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1

G. Waldemar, T. Nielsen, J. Nielsen, 2016 .

Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H196.

U. Mau-Holzmann, Alexander F Engelbrecht, T. Nielsen, 2016, Stem cell research.

Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H271.

U. Mau-Holzmann, Alexander F Engelbrecht, T. Nielsen, 2016, Stem cell research.

Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia.

G. Waldemar, J. Nielsen, L. Hasholt, 2016, Stem cell research.

Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266.

U. Mau-Holzmann, Alexander F Engelbrecht, T. Nielsen, 2016, Stem cell research.

Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT).

G. Waldemar, J. Nielsen, L. Hasholt, 2016, Stem cell research.

Lab resource : Stem cell line Induced pluripotent stem cells ( iPSCs ) derived from a patient with frontotemporal dementia caused by a R 406 W mutation in microtubule-associated protein tau ( MAPT )

G. Waldemar, J. Nielsen, L. Hasholt, 2015 .