Taichi Ohshiro

发表

Molecular analysis of a novel LCAT mutation (Gly179 → Arg) found in a patient with complete LCAT deficiency.

S. Ishibashi, J. Osuga, H. Yagyu, 2011, Journal of atherosclerosis and thrombosis.

Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity

I. Goldberg, S. Ishibashi, J. Osuga, 2013, Journal of Lipid Research.

Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.

H. Tomoda, H. Kawagishi, Taichi Ohshiro, 2020, Bioorganic & medicinal chemistry letters.

New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produced by Verticillium sp. FKI-2679

H. Tomoda, R. Masuma, R. Uchida, 2012, The Journal of Antibiotics.

Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells

T. Doi, L. Rudel, H. Tomoda, 2017, Scientific Reports.

PRD125, a Potent and Selective Inhibitor of Sterol O-Acyltransferase 2 Markedly Reduces Hepatic Cholesteryl Ester Accumulation and Improves Liver Function in Lysosomal Acid Lipase-Deficient Mice

L. Rudel, H. Tomoda, J. Chuang, 2015, The Journal of Pharmacology and Experimental Therapeutics.

A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction

S. Ohte, H. Tomoda, Taichi Ohshiro, 2018, Scientific Reports.

Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis

Taku Tanaka, Kenta Yamamoto, Takanori Ito, 2021, Scientific Reports.

The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice.

T. Doi, S. Ishibashi, H. Tomoda, 2020, Biological & pharmaceutical bulletin.

Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.

H. Yamazaki, M. Namikoshi, D. Sumilat, 2018, Bioorganic & medicinal chemistry letters.

Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.

A. Iwasaki, K. Suenaga, H. Tomoda, 2017, Journal of natural products.

Anti-atherosclerotic Activity of Triacsin C, an Acyl-CoA Synthetase Inhibitor

S. Ōmura, S. Ishibashi, H. Tomoda, 2008, The Journal of Antibiotics.

Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages[S]

A. Honda, S. Ishibashi, H. Tomoda, 2014, Journal of Lipid Research.

Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages[S]

S. Ishibashi, Motohiro Sekiya, H. Okazaki, 2014, Journal of Lipid Research.

The mechanism of action of bufalin in inhibition of lipid droplet accumulation in mouse macrophages.

B. Hong, H. Tomoda, Wei Jiang, 2013, Biological & pharmaceutical bulletin.

The molecular target of rubimaillin in the inhibition of lipid droplet accumulation in macrophages.

B. Hong, H. Tomoda, Wei Jiang, 2009, Biological & pharmaceutical bulletin.

Synthesis and biological evaluation of a focused library of beauveriolides.

S. Ōmura, T. Doi, H. Tomoda, 2008, Bioorganic & medicinal chemistry letters.

Inhibition of lipid droplet accumulation in macrophages by triterpenoids produced from Torametes orientaris.

H. Tomoda, H. Kawagishi, Taichi Ohshiro, 2005, Biological & pharmaceutical bulletin.

Spylidone, a Novel Inhibitor of Lipid Droplet Accumulation in Mouse Macrophages Produced by Phoma sp. FKI-1840

S. Ōmura, H. Tomoda, R. Masuma, 2005, The Journal of Antibiotics.

Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice.

S. Ishibashi, Masafumi Takahashi, A. Nishiyama, 2012, Biochemical and biophysical research communications.

Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages.

H. Tomoda, R. Obata, S. Nishiyama, 2005, Bioorganic & medicinal chemistry letters.

Discovery of SOAT2 inhibitors from synthetic small molecules.

F. Tanaka, H. Tomoda, H. Cui, 2016, Bioorganic & medicinal chemistry letters.

Acyltransferase inhibitors: a patent review (2010–present)

H. Tomoda, Taichi Ohshiro, 2015, Expert opinion on therapeutic patents.

Discovery of prescopranone, a key intermediate in scopranone biosynthesis

H. Ikeda, K. Shin‐ya, S. Ohte, 2022, The Journal of Antibiotics.

Pyripyropene A, an Acyl–Coenzyme A: Cholesterol Acyltransferase 2–Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia

Hiroshi Tomoda, Satoshi Omura, S. Ōmura, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Total synthesis of amidepsine B and revision of its absolute configuration

S. Ōmura, H. Tomoda, T. Nagamitsu, 2009, The Journal of Antibiotics.

Design and Synthesis of A‐Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors

S. Ōmura, H. Tomoda, T. Nagamitsu, 2018, ChemMedChem.

Design, Synthesis, and Biological Evaluation of Beauveriolide Analogues Bearing Photoreactive Amino Acids.

T. Doi, Masahito Yoshida, H. Tomoda, 2016, Chemical & pharmaceutical bulletin.

DISCOVERY AND DEVELOPMENT OF ISOZYME‐SELECTIVE INHIBITORS INVOLVED IN LIPID METABOLISM

H. Tomoda, Taichi Ohshiro, 2013 .

Selectivity of Microbial Acyl-CoA : cholesterol Acyltransferase Inhibitors toward Isozymes

Hiroshi Tomoda, S. Ōmura, L. Rudel, 2007, The Journal of Antibiotics.

Fungal isobisvertinol, a new inhibitor of lipid droplet accumulation in mouse macrophages.

S. Ōmura, H. Tomoda, Nobuhiro Koyama, 2007, Organic letters.

Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440

H. Tomoda, R. Uchida, Taichi Ohshiro, 2020, The Journal of Antibiotics.

Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.

Y. Furukawa, T. Kadowaki, N. Yahagi, 2009, Cell metabolism.

A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction

S. Ohte, H. Tomoda, Taichi Ohshiro, 2018, Scientific Reports.

Isoform-specific inhibitors of ACATs: recent advances and promising developments.

Hiroshi Tomoda, H. Tomoda, Taichi Ohshiro, 2011, Future medicinal chemistry.

New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440

H. Tomoda, Taichi Ohshiro, Elyza Aiman Azizah Nur, 2020, Molecules.

Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440

H. Tomoda, R. Uchida, Taichi Ohshiro, 2020, The Journal of Antibiotics.

Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307

T. Fukuda, H. Tomoda, R. Uchida, 2018, The Journal of Antibiotics.

7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007

C. Imada, H. Tomoda, T. Terahara, 2016, The Journal of Antibiotics.

In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites

H. Yamazaki, H. Tomoda, T. Nagamitsu, 2014, The Journal of Antibiotics.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.

S. Ōmura, S. Ohte, L. Rudel, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.

S. Ōmura, L. Rudel, H. Yamazaki, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.

S. Ōmura, S. Ohte, L. Rudel, 2013, Bioorganic & medicinal chemistry letters.

The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA: cholesterol acyltransferase.

Hiroshi Tomoda, Satoshi Omura, Takayuki Doi, 2009, Chemical & pharmaceutical bulletin.

Selective Inhibition of Acyl-CoA:cholesterol Acyltransferase 2 Isozyme by Flavasperone and Sterigmatocystin from Aspergillus Species

Hiroshi Tomoda, S. Ohte, L. Rudel, 2008, The Journal of Antibiotics.

Selectivity of Pyripyropene Derivatives in Inhibition toward Acyl-CoA:cholesterol Acyltransferase 2 Isozyme

Hiroshi Tomoda, Toshiaki Sunazuka, S. Ōmura, 2008, The Journal of Antibiotics.

Molecular target of decursins in the inhibition of lipid droplet accumulation in macrophages.

Hiroshi Tomoda, Ichiji Namatame, Hirokazu Kawagishi, 2006, Biological & pharmaceutical bulletin.

New Pyripyropene A Derivatives, Highly SOAT2-Selective Inhibitors, Improve Hypercholesterolemia and Atherosclerosis in Atherogenic Mouse Models

S. Ishibashi, L. Rudel, H. Tomoda, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers.

S. Ōmura, T. Doi, L. Rudel, 2006, Journal of Organic Chemistry.

Conformationally restricted analog and biotin-labeled probe based on beauveriolide III.

S. Ōmura, T. Doi, Masahito Yoshida, 2012, Bioorganic & medicinal chemistry letters.

Spylidone, a Novel Inhibitor of Lipid Droplet Accumulation in Mouse Macrophages Produced by Phoma sp. FKI-1840.

S. Ōmura, H. Tomoda, R. Masuma, 2005 .

Discovery of a Fungal Multicopper Oxidase That Catalyzes the Regioselective Coupling of a Tricyclic Naphthopyranone To Produce Atropisomers.

S. Ohte, H. Tomoda, I. Fujii, 2018, Angewandte Chemie.

Monapinone Coupling Enzyme Produces Non-Natural Heterodimers

S. Ohte, H. Tomoda, I. Fujii, 2021, Catalysts.

Liver-Specific Deletion of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Causes Hepatic Steatosis and Death

S. Ishibashi, Motohiro Sekiya, K. Ohashi, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Total synthesis of tanzawaic acid A

S. Ohte, H. Tomoda, T. Nagamitsu, 2023, Tetrahedron.

Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells

T. Doi, L. Rudel, H. Tomoda, 2017, Scientific Reports.

Liver-Specific Deletion of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Causes Hepatic Steatosis and Death

S. Ishibashi, Motohiro Sekiya, K. Ohashi, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.

H. Yamazaki, M. Namikoshi, D. Sumilat, 2018, Bioorganic & medicinal chemistry letters.

Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity

I. Goldberg, S. Ishibashi, J. Osuga, 2013, Journal of Lipid Research.

Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells.

H. Tomoda, Taichi Ohshiro, Elyza Aiman Azizah Nur, 2022, Drug discoveries & therapeutics.

Antibiotic production by an endophytic Streptomyces isolated from the medicinal plant Poikilospermum suaveolens

Taichi Ohshiro, Elyza Aiman Azizah Nur, Keisuke Kobayashi, 2024, Biodiversitas Journal of Biological Diversity.