K. Otsubo

发表

Multiple gene polymorphisms and warfarin sensitivity

H. Takane, I. Ieiri, E. Shikata, 2006, European Journal of Clinical Pharmacology.

Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy

E. Shimizu, N. Burioka, M. Miyata, 2006, Journal of Human Genetics.

Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy

S. Higuchi, H. Takane, I. Ieiri, 2006, Expert opinion on drug metabolism & toxicology.

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

Y. Sugiyama, I. Ieiri, Hiroshi Suzuki, 2004, Pharmacogenetics.

CYP2C19 polymorphism effect on phenobarbitone

E. Yukawa, S. Higuchi, N. Tashiro, 2000, European Journal of Clinical Pharmacology.

Pharmacokineties in Japanese patients with epilepsy: analysis by population pharmacokinetics

E. Yukawa, S. Higuchi, N. Tashiro, 2000 .

Life-threatening toxicities in a patient with UGT1A1*6/*28 and SLCO1B1*15/*15 genotypes after irinotecan-based chemotherapy

S. Higuchi, H. Takane, I. Ieiri, 2009, Cancer Chemotherapy and Pharmacology.

Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele.

E. Shimizu, N. Burioka, Y. Fukuoka, 2007, Therapeutic drug monitoring.

The Antiplatelet Aggregation Effects of Aspirin Suppositories

K. Nakashima, I. Ieiri, K. Otsubo, 2003, Cerebrovascular Diseases.

Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis.

S. Higuchi, N. Tashiro, I. Ieiri, 2000, Therapeutic drug monitoring.

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene.

J. Kigawa, Y. Kanamori, Masakuni Takahashi, 2001, The Journal of pharmacology and experimental therapeutics.

Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects.

Y. Sugiyama, S. Higuchi, H. Takane, 2004, Hepatology research : the official journal of the Japan Society of Hepatology.

Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues.

Eiji Shimizu, Kenji Otsubo, Hiroshige Nakamura, 2012, Lung cancer.

Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele

T. Kubota, S. Higuchi, K. Chiba, 2000, European Journal of Clinical Pharmacology.

SmI2-induced reductive cross-coupling of carbonyl compounds with (α,β-unsaturated esters

J. Inanaga, M. Yamaguchi, K. Otsubo, 1986 .

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.

S. Higuchi, I. Ieiri, A. Suzuki, 2001, Pharmacogenetics.

Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy.

E. Shimizu, A. Yamasaki, S. Higuchi, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis of N-Acetylhemiaminal metabolites of opc-21268, vasopressin V1 receptor antagonist

S. Morita, K. Otsubo, M. Uchida, 1993 .

Interindividual differences in placental expression of the SLC22A2 (OCT2) gene: relationship to epigenetic variations in the 5'-upstream regulatory region.

I. Ieiri, K. Otsubo, Takeshi Hirota, 2011, Journal of pharmaceutical sciences.

Interaction magnitude, pharmacokinetics and pharmacodynamics of ticlopidine in relation to CYP2C19 genotypic status

T. Ishizaki, I. Ieiri, A. Urae, 2005, Pharmacogenetics and genomics.

Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism

T. Ishizaki, I. Ieiri, K. Nakagawa, 2001, European Journal of Clinical Pharmacology.

P-Hydroxylation of Phenobarbital: Relationship to (s)-Mephenytoin Hydroxylation (CYP2C19) Polymorphism

S. Higuchi, N. Tashiro, I. Ieiri, 2001, Therapeutic drug monitoring.

CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics.

E. Yukawa, S. Higuchi, N. Tashiro, 2000, European journal of clinical pharmacology.

An efficient synthesis of optically active metabolites of platelet adhesion inhibitor OPC-29030 by lipase-catalyzed enantioselective transesterification

S. Morita, K. Otsubo, Y. Kawano, 1999 .

Synthesis of a key intermediate, (S)-2-[(3-hydroxypropyl)sulfinyl]-1-(o-tolyl)imidazole, for the platelet aggregation inhibitor, OPC-29030 via lipase-catalyzed enantioselective transesterification

S. Morita, K. Otsubo, Y. Kawano, 1997 .

Synthesis and antiulcer activity of optical isomers of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid (rebamipide).

S. Morita, K. Otsubo, T. Shimizu, 1991, Chemical & pharmaceutical bulletin.

SmI2-Induced highly regioselective reduction of α,β-epoxy esters and γ,δ-epoxy-α,β-unsaturated esters. An efficient route to optically active β-hydroxy and δ-hydroxy esters

J. Inanaga, M. Yamaguchi, K. Otsubo, 1987 .

A facile reductive dimerization of conjugated acid derivatives with samarium diiodide

T. Hanamoto, J. Inanaga, K. Otsubo, 1991 .

An efficient synthesis of a key intermediate towards (S)-(−)-nadifloxacin

S. Morita, K. Otsubo, M. Uchida, 1995 .

Practical Synthesis of Both Enantiomers of Vasopressin V2 Receptor Antagonist OPC-41061 Using the Catalytic Asymmetric Hydrogenation

H. Yamashita, S. Morita, K. Otsubo, 2002 .

Tandem Michael-Horner-Wadsworth-Emmons reaction of α,β-unsaturated 2,6-di-tert-butyl-4-methylphenyl esters as a convenient method for the preparation of δ-B ranched aliene carboxylates

K. Fuji, Kiyoshi Tanaka, K. Otsubo, 1995 .

SmI2-Induced Highly Regioselective Reduction of α,β-Epoxy Esters and γ,δ-Epoxy-α,β-Unsaturated Esters. An Efficient Route to Optically Active β-Hydroxy and δ-Hydroxy Esters.

J. Inanaga, M. Yamaguchi, K. Otsubo, 1988 .

A highly stereoselective conversion of α,β-epoxy esters to α-hydroxy esters: an efficient route to optically active α-hydroxyesters

J. Inanaga, M. Yamaguchi, K. Otsubo, 1987 .

A direct synthesis of γ-, δ-, and ε-lactones utilizing SmI2-induced Barbier-type reaction in the presence of hexamethylphosphoric triamide (HMPA)

J. Inanaga, M. Yamaguchi, K. Otsubo, 1987 .

Enantioselective preparation of allenecarboxylates by asymmetric horner-wadsworth-emmons reaction

K. Fuji, Kiyoshi Tanaka, K. Otsubo, 1996 .

Practical application of the palladium-catalyzed amination in phenylpiperazine synthesis: An efficient synthesis of a metabolite of the antipsychotic agent aripiprazole

S. Morita, K. Otsubo, Y. Kawano, 1998 .

Synthesis and antibacterial activity of the metabolites of 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H- benzo[i,j]quinolizine-2-carboxylic acid (OPC-7251).

K. Otsubo, T. Shimizu, M. Uchida, 1990, Chemical & pharmaceutical bulletin.

FUNCTIONAL ASSESSMENT OF ABCG2 (BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA

M. Oshimura, Y. Sugiyama, J. Kigawa, 2005, Drug Metabolism and Disposition.

Population Pharmacokinetic and Pharmacodynamic Analysis of Linezolid and a Hematologic Side Effect, Thrombocytopenia, in Japanese Patients

S. Higuchi, H. Takane, I. Ieiri, 2011, Antimicrobial Agents and Chemotherapy.

Examination of Preparation Method and Storage Conditions for CMC-Na Solution.

M. Nakano, K. Otsubo, Y. Nakao, 1996 .

Urodynamic effects and safety of modified intravesical oxybutynin chloride in patients with neurogenic detrusor overactivity: 3 years experience

M. Saito, K. Satoh, K. Otsubo, 2004, International journal of urology : official journal of the Japanese Urological Association.

Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.

M. Oshimura, E. Nanba, S. Higuchi, 2004, Human molecular genetics.

Instability of standard calibrators may be involved in overestimating vancomycin concentrations determined by fluorescence polarization immunoassay.

I. Ieiri, K. Otsubo, H. Shuto, 1996, Therapeutic drug monitoring.

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein

Miyuki Kimura, Kenji Otsubo, Shun Higuchi, 2002, Clinical pharmacology and therapeutics.

Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Yuichi Sugiyama, Miyuki Kimura, Kenji Otsubo, 2003, Clinical pharmacology and therapeutics.

The MDR1 (ABCB1) Gene Polymorphism and its Clinical Implications

H. Takane, I. Ieiri, K. Otsubo, 2004, Clinical pharmacokinetics.

Haplotype-Oriented Genetic Analysis and Functional Assessment of Promoter Variants in the MDR1 (ABCB1) Gene

J. Kigawa, N. Terakawa, H. Takane, 2004, Journal of Pharmacology and Experimental Therapeutics.

Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

Keizo Sugimachi, Kenji Otsubo, Atsushi Yamauchi, 2002, Transplantation.

Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans

M. Ritchie, I. Ieiri, H. Echizen, 2006, Pharmacogenetics and genomics.

The Effects of Genetic Polymorphisms of CYP2C9 and CYP2C 19 on Phenytoin Metabolism in Japanese Adult Patients with Epilepsy: Studies in Stereoselective Hydroxylation and Population Pharmacokinetics

E. Yukawa, S. Higuchi, N. Tashiro, 1998, Epilepsia.

Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin

H. Takane, I. Ieiri, C. Shigemasa, 2006, Journal of Human Genetics.

Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy.

S. Higuchi, I. Ieiri, A. Urae, 1999, British journal of clinical pharmacology.

Genetic polymorphisms and functional characterization of the 5′‐flanking region of the human CYP2C9 gene: In vitro and in vivo studies

S. Higuchi, N. Tashiro, I. Ieiri, 2001, Clinical pharmacology and therapeutics.

Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivity.

I. Ieiri, Kazuko Inoue, E. Shikata, 2003, Blood.

Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril

K. Maeda, H. Kusuhara, Y. Sugiyama, 2006, Clinical pharmacology and therapeutics.

5'-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients.

I. Ieiri, H. Echizen, G. Wilkinson, 2004, Blood.

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus.

E. Nanba, S. Higuchi, Y. Fukumaki, 2000, Pharmacogenetics.

Effect of Food Thickener and Deglutition Aid Jelly on Pharmacokinetics of Drugs

H. Takane, I. Ieiri, K. Otsubo, 2011 .

Polymorphism in human organic cation transporters and metformin action.

S. Higuchi, H. Takane, I. Ieiri, 2008, Pharmacogenomics.

Acute Hypotension after Loxoprofen Sodium Co-administration in Two Acute Myeloid Leukemia Patients Undergoing Chemotherapy Treatment.

I. Ieiri, K. Otsubo, K. Ishiga, 2003 .

A CYP2D6 phenotype-genotype mismatch in Japanese psychiatric patients.

S. Higuchi, N. Tashiro, I. Ieiri, 2004, Pharmacopsychiatry.

Hepatotoxicity of Voriconazole: A Retrospective Study

H. Takane, K. Otsubo, K. Ogawa, 2009 .

Efficacy of emetic and United State pharmacopoeia ipecac syrup in prevention of drug absorption.

S. Higuchi, K. Otsubo, T. Aoyama, 1990, Chemical & pharmaceutical bulletin.

Enantioselective Synthesis of the Metabolites of Vasopressin V2 Receptor Antagonist OPC-31260 via Lipase-Catalyzed Transesterification

K. Otsubo, M. Kido, F. Tabusa, 2000 .

Simultaneous determination of carbamate pesticides in human serum and urine by automatic reversed-phase HPLC combined with on-line column enrichment

I. Ieiri, K. Otsubo, Y. Fujii, 2004 .

An Efficient Synthesis of Optical Isomers of Vasopressin V2 Receptor Antagonist OPC-41061 by Lipase-catalyzed Enantioselective Transesterification

H. Yamashita, S. Morita, K. Otsubo, 2001 .

Suitable blending method of lipiodol-cisplatin in transcatheter arterial embolization for hepatocellular carcinoma: evaluation of sustained release and accumulation nature.

T. Ogawa, T. Kaminou, K. Otsubo, 2008, Hepato-gastroenterology.