L. Kirschner

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Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis.

S. Asa, A. Parlow, Z. Yin, 2008, Molecular endocrinology.

Molecular and Functional Analysis of PRKAR 1 A and its Locus ( 17 q 22 – 24 ) in Sporadic Adrenocortical Tumors : 17 q Losses , Somatic Mutations , and Protein Kinase A Expression and Activity 1

J. Bertherat, X. Bertagna, C. Stratakis, 2003 .

Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.

J. Bertherat, X. Bertagna, C. Stratakis, 2003, Cancer research.

Snapin mediates incretin action and augments glucose-dependent insulin secretion.

Thembi Mdluli, C. Stratakis, M. Seshadri, 2011, Cell metabolism.

A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions

S. Bornstein, C. Stratakis, D. Batista, 2004, Journal of Medical Genetics.

PRKAR1A and the evolution of pituitary tumors

L. Kirschner, 2010, Molecular and Cellular Endocrinology.

Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.

L. Kirschner, K. Nadella, 2005, Cancer research.

BRAF activates and physically interacts with PAK to regulate cell motility.

M. Saji, M. Ringel, S. Fernandez, 2014, Endocrine-related cancer.

Statistical Applications in Genetics and Molecular Biology

L. Kirschner, Soledad A. Fernandez, 2011 .

Papillary Thyroid Carcinoma: Association Between Germline DNA Variant Markers and Clinical Parameters.

Wei Li, Huiling He, S. Liyanarachchi, 2016, Thyroid : official journal of the American Thyroid Association.

A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia

I. Bossis, J. Bertherat, X. Bertagna, 2006, Nature Genetics.

Radiation hybrid mapping of chromosomal region 2p15-p16: integration of expressed and polymorphic sequences maps at the Carney complex (CNC) and Doyne honeycomb retinal dystrophy (DHRD) loci.

C. Giatzakis, C. Stratakis, L. Kirschner, 1999, Genomics.

Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype.

J. López-Barneo, K. L. La Perle, S. Jhiang, 2017, Endocrine-related cancer.

Biochemical and genetic characterization of the multidrug resistance phenotype in murine macrophage-like J774.2 cells.

D. Cohen, L. Yu, L. Greenberger, 1992, Biochemical pharmacology.

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells

D. Cohen, S. Horwitz, S. Hsu, 1990, Molecular and cellular biology.

The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.

Z. Yin, L. Kirschner, Zhirong Yin, 2009, Trends in cardiovascular medicine.

The CNC gene PRKAR1A Plays an Essential Role in Cardiac Development and Myxomagenesis

Z. Yin, L. Kirschner, Zhirong Yin, 2009 .

Knockdown of PRKAR1A, the gene responsible for Carney complex, interferes with differentiation in osteoblastic cells.

Qianben Wang, Dayong Wu, P. Manchanda, 2014, Molecular endocrinology.

2-Amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} Acetamide (OSU-03012), a Celecoxib Derivative, Directly Targets p21-Activated Kinase

S. Kulp, C. Chen, M. Saji, 2007, Molecular Pharmacology.

Adipose S14 mRNA is abnormally regulated in obese subjects.

C. Mariash, L. Kirschner, 1999, Thyroid : official journal of the American Thyroid Association.

Prkar1a in the Regulation of Insulin Secretion

C. Stratakis, M. Hussain, L. Kirschner, 2012, Hormone and Metabolic Research.

Automated MicroSPECT/MicroCT Image Analysis of the Mouse Thyroid Gland.

C. Menq, K. Powell, S. Jhiang, 2017, Thyroid : official journal of the American Thyroid Association.

PRKAR1A deficiency impedes hypertrophy and reduces heart size

C. Stratakis, Jingrui Chen, W. Bandettini, 2020, Physiological reports.

Isolated familial somatotropinomas: does the disease map to 11q13 or to 2p16?

C. Stratakis, L. Kirschner, 2000, The Journal of clinical endocrinology and metabolism.

Mouse models of endocrine tumours.

P. Manchanda, L. Kirschner, Georgette N. Jones, 2010, Best practice & research. Clinical endocrinology & metabolism.

Best Practice & Research Clinical Endocrinology & Metabolism

P. Manchanda, L. Kirschner, Georgette N. Jones, 2010 .

Metastatic Adrenocortical Carcinoma: a Single Institutional Experience

Lai Wei, M. Shah, B. Konda, 2019, Hormones and Cancer.

Development of a pituitary‐specific cre line targeted to the Pit‐1 lineage

S. Asa, Z. Yin, L. Williams-Simons, 2008, Genesis.

Novel targeted therapies in adrenocortical carcinoma

B. Konda, L. Kirschner, 2016, Current opinion in endocrinology, diabetes, and obesity.

Inhibition of IGF-1R in adrenocortical carcinoma.

L. Kirschner, 2015, The Lancet. Oncology.

Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16.

K. Csaky, J. Bellingham, K. Gregory-Evans, 1999, Biochemical and biophysical research communications.

Mutations in regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes.

J. Bertherat, X. Bertagna, C. Stratakis, 2009, The Journal of clinical endocrinology and metabolism.

Sequence analysis of the PRKAR1A gene in sporadic somatotroph and other pituitary tumours

S. Czirják, C. Stratakis, M. Korbonits, 2002, Clinical endocrinology.

Gaining traction in the treatment of adrenocortical carcinoma.

L. Kirschner, Lawrence S Kirschner, 2013, The Journal of clinical endocrinology and metabolism.

Neurosurgical implications of Carney complex.

E. Oldfield, C. Stratakis, J. Carney, 2000, Journal of neurosurgery.

Structural Analysis of the Mouse mdr1a (P-Glycoprotein) Promoter Reveals the Basis for Differential Transcript Heterogeneity in Multidrug-Resistant J774.2 Cells

D. Cohen, S. Horwitz, S. Hsu, 1990 .

Protein Kinase A Activation Enhances β-Catenin Transcriptional Activity through Nuclear Localization to PML Bodies

R. Davuluri, T. Zuo, P. Manchanda, 2014, PloS one.

Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors.

C. Stratakis, A. Lacroix, M. Nesterova, 2009, The Journal of clinical endocrinology and metabolism.

PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex

J. Bertherat, W. Farrell, R. Clayton, 2002, Journal of medical genetics.

The next generation of therapies for adrenocortical cancers

L. Kirschner, 2012, Trends in Endocrinology & Metabolism.

Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex.

S. Bornstein, S. Brauer, C. Stratakis, 1999, The Journal of clinical endocrinology and metabolism.

Intraoperative Prediction of Long-Term Remission in Acromegaly

R. Carrau, L. Prevedello, M. Zachariah, 2022, Operative neurosurgery.

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors

Lianbo Yu, K. L. La Perle, P. Manchanda, 2012, Oncogene.

Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification.

K. Powell, K. L. La Perle, M. Weinstein, 2010, Molecular endocrinology.

Use of mouse models to understand the molecular basis of tissue‐specific tumorigenesis in the Carney complex

L. Kirschner, 2009, Journal of internal medicine.

Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.

G. Kay, P. Schmalbrock, A. Stemmer-Rachamimov, 2008, Neoplasia.

Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.

C. Stratakis, G. Leone, L. Kirschner, 2008, Cancer research.

A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.

C. Stratakis, D. Kusewitt, H. Westphal, 2005, Cancer research.

Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.

K. L. La Perle, Amruta Ashtekar, L. Kirschner, 2018, Thyroid : official journal of the American Thyroid Association.

Cushing's Syndrome and Fetal Features Resurgence in Adrenal Cortex–Specific Prkar1a Knockout Mice

J. Bertherat, C. Stratakis, F. Tissier, 2010, PLoS genetics.

Nivolumab in metastatic adrenocortical carcinoma: results of a phase II trial.

S. Abdulkadir, D. Mahalingam, B. Carneiro, 2019, The Journal of clinical endocrinology and metabolism.

Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation.

C. Stratakis, J. Carney, L. Kirschner, 2001, The Journal of clinical endocrinology and metabolism.

Carney complex: diagnosis and management of the complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas.

J. Carney, C. Stratakis, L. Kirschner, 1998, American journal of medical genetics.

Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors

C. Stratakis, F. Weinberg, Y. Cho‐Chung, 2004, Cancer Research.

Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex

C. Stratakis, Y. Cho‐Chung, Y. Cho, 2000, Nature Genetics.

Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex.

C. Stratakis, J. Carney, L. Kirschner, 2000, Human molecular genetics.

Identification of a novel genetic locus for familial cardiac myxomas and Carney complex.

B. Korf, C. Basson, C. Stratakis, 1998, Circulation.

The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.

G. Chrousos, C. Mitsiades, C. Stratakis, 1998, The Journal of clinical endocrinology and metabolism.

Chromosome 2 (2p16) abnormalities in Carney complex tumours

J. Carney, S. Pack, E. Pak, 2003, Journal of medical genetics.

Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes.

C. Stratakis, L. Kirschner, 2000, Biochemical and biophysical research communications.

The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Ovarian Lesions in Carney Complex: Clinical Genetics and Possible Predisposition to Malignancy

C. Stratakis, J. Carney, S. Pack, 2022 .

Genomic mapping of chromosomal region 2p15-p21 (D2S378-D2S391): integration of Genemap'98 within a framework of yeast and bacterial artificial chromosomes.

B. Pike, S. Chandrasekharappa, S. Pack, 1999, Genomics.

Mouse models of altered protein kinase A signaling.

Z. Yin, L. Kirschner, Georgette N. Jones, 2009, Endocrine-related cancer.

Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators

S. Libutti, C. Stratakis, S. Antonini, 2004, Oncogene.

The regulatory 1α subunit of protein kinase A modulates renal cystogenesis.

M. Irazabal, V. Torres, P. Harris, 2017, American journal of physiology. Renal physiology.

Abnormal Fibroblasts Drive Pigmentary Skin Lesions in a Mouse Model of Carney Complex.

L. Kirschner, S. Priya, 2022, The Journal of investigative dermatology.

PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer

V. Vasko, L. Kirschner, S. Priya, 2019, Front. Endocrinol..

Mouse models of thyroid cancer: A 2015 update

Amruta Ashtekar, L. Kirschner, Zahida Qamri, 2016, Molecular and Cellular Endocrinology.

5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer

C. Stratakis, L. Kirschner, 2016, Hormones and Cancer.

A unified cause for adrenal Cushing's syndrome

L. Kirschner, 2014, Science.

PKA signaling drives mammary tumorigenesis through Src

M. Pujana, S. Molyneux, R. Khokha, 2014, Oncogene.

The Protein Kinase A Regulatory Subunit R1A (Prkar1a) Plays Critical Roles in Peripheral Nerve Development

N. Ratner, T. Rizvi, L. Kirschner, 2013, The Journal of Neuroscience.

Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.

Kimberly M. Kelly, Z. Yin, L. Kirschner, 2011, Molecular endocrinology.

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.

T. Triche, P. Hu, S. Molyneux, 2010, The Journal of clinical investigation.

Regulation of actin function by protein kinase A‐mediated phosphorylation of Limk1

M. Saji, M. Ringel, Motoyasu Saji, 2009, EMBO reports.

Mouse model for bilateral adrenal hyperplasia.

J. Bertherat, C. Stratakis, G. Marceau, 2009, Annales d'endocrinologie.

Heart-Specific Ablation of Prkar1a Causes Failure of Heart Development and Myxomagenesis

P. Binkley, D. Jarjoura, E. Abel, 2008, Circulation.

Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.

L. Kirschner, K. Nadella, William H. Towns, 2008, Molecular endocrinology.

Emerging treatment strategies for adrenocortical carcinoma: a new hope.

L. Kirschner, 2006, The Journal of clinical endocrinology and metabolism.

A Mouse Model for Carney Complex

S. Bornstein, C. Stratakis, F. Weinberg, 2004, Endocrine research.

Regulatory subunit type I‐α of protein kinase A (PRKAR1A): A tumor‐suppressor gene for sporadic thyroid cancer

C. Stratakis, O. Gimm, N. Sarlis, 2002, Genes, chromosomes & cancer.

Adrenal disease in childhood: caught at an awkward age

L. Kirschner, 2002, Trends in Endocrinology & Metabolism.

Genetic analysis of Carney complex: current understanding and future questions

C. Stratakis, L. Kirschner, 2002 .

Signaling Pathways in Adrenocortical Cancer

LAWRENCE S. KIRSCHNER, L. Kirschner, 2002, Annals of the New York Academy of Sciences.

Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticotropin.

C. Stratakis, S. Lyonnet, C. Bourdony, 2001, The Journal of clinical endocrinology and metabolism.

Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Carney Complex, Peutz-Jeghers Syndrome, Cowden Disease, and Bannayan-Zonana Syndrome Share Cutaneous and Endocrine Manifestations, But Not Genetic

I. Tomlinson, C. Basson, C. Eng, 2022 .

Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas" (Carney complex).

C. Stratakis, J. Carney, S. Pack, 2000, The Journal of clinical endocrinology and metabolism.

Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing’s disease

N. Lehman, A. Joehlin-Price, D. Prevedello, 2017, Diagnostic Pathology.

Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.

Lianbo Yu, D. Jarjoura, K. L. La Perle, 2012, Endocrine-related cancer.

Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone

C. Cheadle, C. Stratakis, M. Collins, 2010, Proceedings of the National Academy of Sciences.

New Strategies for the Treatment of Adrenocortical Carcinoma

L. Kirschner, 2009 .

Localization of sequences that influence basal and cell type-specific activity of the murine mdr2 promoter.

L. Yu, S. Horwitz, C. Yang, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Biological Evaluation of a Fluorescent‐Imaging Agent for Medullary Thyroid Cancer in an Orthotopic Model

M. Tweedle, M. Saji, M. Ringel, 2017, The Journal of clinical endocrinology and metabolism.

De novo generation of simple sequence during gene amplification.

L. Kirschner, 1996, Nucleic acids research.

Emerging drugs for the treatment of adrenocortical carcinoma

M. Shah, B. Konda, M. Husain, 2021, Expert opinion on emerging drugs.

Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression

K. L. La Perle, Amruta Ashtekar, L. Boucai, 2018, The Journal of clinical endocrinology and metabolism.

Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.

K. Powell, M. Weinstein, L. Kirschner, 2007, The International journal of developmental biology.

Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.

Lianbo Yu, D. Jarjoura, K. L. La Perle, 2014, The Journal of clinical endocrinology and metabolism.

Large-scale preparation of sequence-ready bacterial artificial chromosome DNA using QIAGEN columns.

C. Stratakis, L. Kirschner, 1999, BioTechniques.

Predictors of Postoperative Diabetes Insipidus Following Endoscopic Resection of Pituitary Adenomas

D. Prevedello, L. Kirschner, A. Montaser, 2018, Journal of the Endocrine Society.

Intraoperative Predictor of Remission in Cushing Disease

R. Carrau, M. Zachariah, R. Lonser, 2022, Operative neurosurgery.

Clinical and Genetic Analysis of Primary Bilateral Adrenal Diseases (Micro- and Macronodular Disease) Leading to Cushing Syndrome

C. Stratakis, L. Kirschner, 1998, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Response to Letter to the Editor: “Predictors of Postoperative Diabetes Insipidus Following Endoscopic Resection of Pituitary Adenomas”

D. Prevedello, L. Kirschner, Pratima Nayak, 2019, Journal of the Endocrine Society.

P450arom gene expression in peripheral blood lymphocytes: Identification of a cryptic splice site for exon-1 afterEpstein–Barr virus transformation

C. Stratakis, W. Yue, A. Brodie, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Targeted Therapies for Adrenocortical Carcinoma: IGF and Beyond

K. Bussey, M. Demeure, Michael J Demeure, 2011, Hormones & cancer.

Combination therapy with capecitabine and temozolomide in patients with low and high grade neuroendocrine tumors, with an exploratory analysis of O6-methylguanine DNA methyltransferase as a biomarker for response

M. Dillhoff, Lai Wei, M. Shah, 2017, Oncotarget.

Amplification of the murine mdr2 gene and a reconsideration of the structure of the murine mdr gene locus.

L. Kirschner, 1995, DNA and cell biology.

Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline.

A. Tabarin, M. Murad, L. Nieman, 2015, The Journal of clinical endocrinology and metabolism.

Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion

R. Nelson, K. Russart, L. Kirschner, 2018, Hormones and Behavior.

Paradoxical Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular Adrenocortical Disease

D. Papanicolaou, J. Doppman, G. Chrousos, 1999, Annals of Internal Medicine.

Genetic evaluation of patients and families with concern for hereditary endocrine tumor syndromes

R. Pilarski, Jennifer L. Anderson, P. Brock, 2021, Familial cancer.

2-Amino-N- Acetamide (OSU-03012), a Celecoxib Derivative, Directly Targets p21-Activated Kinase

S. Kulp, M. Saji, M. Ringel, 2007 .

Improved Acromegaly Patient Satisfaction With Oral Octreotide Capsules Compared With Injectable Somatostatin Receptor Ligands in the MPOWERED Trial

P. Chanson, S. Melmed, M. Fleseriu, 2021, Journal of the Endocrine Society.