P. Guzzo

发表

Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.

R. N. Davis, Shuang Liu, A. Mhyre, 2016, Journal of medicinal chemistry.

Synthesis and structure-activity relationship of substitutions at the C-1 position of Delta9-tetrahydrocannabinol.

Bernard Paul, M. Wolf, P. Guzzo, 2010, Bioorganic & medicinal chemistry letters.

Bifidenone: Structure-Activity Relationship and Advanced Preclinical Candidate.

M. O'Neil-Johnson, C. Starks, Russell B Williams, 2018, Journal of medicinal chemistry.

The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.

D. Kitchen, Shuang Liu, A. Mhyre, 2014, Bioorganic & medicinal chemistry.

Inhibitors of Glycine Transporter-1: Potential Therapeutics for the Treatment of CNS Disorders.

C. Cioffi, P. Guzzo, 2016, Current topics in medicinal chemistry.

The preparation of optically active α-amino 4H-[1,2,4]oxadiazol-5-ones from optically active α-amino acids

T. Belliotti, M. Stier, Matthew R. Johnson, 2009 .

5-Functionalized indazoles as glucocorticoid receptor agonists.

D. Kitchen, A. Usyatinsky, Denise Peace, 2010, Bioorganic & medicinal chemistry letters.

Effects of (2R)‐(3‐amino‐2‐fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxation in dogs and mechanism of hypothermic effects in mice

J. Jensen, B. Olsson, J. Mattsson, 2005, British journal of pharmacology.

From preclinical to clinical development: The example of a novel treatment for obesity

N. Moore, B. Sargent, P. Guzzo, 2014, Neurobiology of Disease.

Preparation of 8-Amido-2-dimethylamino-1,2,3,4-tetrahydro-2-dibenzofurans and several fluorinated derivatives via [3,3]-sigmatropic rearrangement of O-aryloximes.

Sean R. Dinn, A. Kiefer, Steven W. Tregay, 2003, The Journal of organic chemistry.

Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.

Shuang Liu, A. Mhyre, J. Maeng, 2013, Bioorganic & medicinal chemistry letters.

5-(pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists.

Mark Hadden, S. Cheetham, Y. Khmelnitsky, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives.

K. Nacro, Denise Peace, T. Friedrich, 2007, Bioorganic & medicinal chemistry.

Nucleophilic Addition to the α-Carbon of β-Lactams

P. Guzzo, Marvin J Miller, 1997 .

Catalytic, Asymmetric Synthesis of the Carbacephem Framework

P. Guzzo, Marvin J Miller, 1994 .

Initial Process Development and Scale-Up of the Synthesis of a Triple Reuptake Inhibitor ALB 109780

Qiang Yang, Shuang Liu, P. Guzzo, 2012 .

Novel Cyclopropyl β-Amino Acid Analogues of Pregabalin and Gabapentin That Target the α2-δ Protein

A. Thorpe, S. Donevan, A. El‐Kattan, 2005 .

ASYMMETRIC ORGANIC SYNTHESIS. RADICAL CYCLIZATIONS OF CHIRAL ENAMIDES

P. Guzzo, A. Schultz, D. Nowak, 1995 .

An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 antagonist

M. M. Hsia, K. Nacro, B. Shimpukade, 2012 .

Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.

J. Macor, Shuang Liu, T. Molski, 2014, ACS medicinal chemistry letters.

Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.

M. Reitman, J. Metzger, Mark Hadden, 2010, Bioorganic & medicinal chemistry letters.

The Solution Conformations of Lidocaine Analogues

P. Guzzo, E. Byrnes, P. McMaster, 1991, Pharmaceutical Research.

Partial agonism of 5-HT3 receptors: a novel approach to the symptomatic treatment of IBS-D.

David D. Manning, N. Moore, B. Sargent, 2013, ACS chemical neuroscience.

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.

M. Reitman, J. Metzger, Mark Hadden, 2010, Bioorganic & medicinal chemistry letters.

A facile synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines

Shuang Liu, K. Nacro, P. Guzzo, 2012 .

Process Development and Pilot-Scale Synthesis of New Cyclization Conditions of Substituted Phenylacetamides to Tetrahydroisoquinoline-2-ones Using Eaton’s Reagent

Qiang Yang, P. Guzzo, L. Ulysse, 2010 .

Tetrahydrocarboline analogs as MCH-1 antagonists.

Mark Hadden, S. Cheetham, Y. Khmelnitsky, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity.

Mark Hadden, S. Cheetham, Y. Khmelnitsky, 2010, Bioorganic & medicinal chemistry letters.

Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.

M. Reitman, J. Metzger, O. Palyha, 2011, ACS medicinal chemistry letters.

Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors.

Christer Alstermark, Ola Fjellström, Karolina Nilsson, 2008, Journal of medicinal chemistry.

Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists.

J. Metzger, Mark Hadden, O. Palyha, 2010, Bioorganic & Medicinal Chemistry Letters.

Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.

M. Reitman, J. Metzger, Mark Hadden, 2010, Bioorganic & medicinal chemistry letters.

Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.

David D. Manning, N. Barnes, C. Brady, 2011, Bioorganic & medicinal chemistry letters.

The discovery of diazepinone-based 5-HT3 receptor partial agonists.

David D. Manning, N. Barnes, C. Brady, 2014, Bioorganic & medicinal chemistry letters.

CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome

David D. Manning, A. Cooper, K. Brock, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists.

K. Nacro, R. Pathak, Animesh Ghosh, 2012, Bioorganic & medicinal chemistry letters.

Preparation of 8-Amido-2-dimethylamino-1,2,3,4-tetrahydro-2-dibenzofurans and several fluorinated derivatives via [3,3]-sigmatropic rearrangement of O-aryloximes.

Sean R. Dinn, A. Kiefer, Steven W. Tregay, 2003, The Journal of organic chemistry.

Synthesis of a conformationally constrained threonine–valine dipeptide mimetic: design of a potential inhibitor of plasminogen activator inhibitor-1

T. Inghardt, M. Trova, M. Linschoten, 2002 .

The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.

D. Kitchen, Shuang Liu, A. Mhyre, 2014, Bioorganic & medicinal chemistry.

Reactions of N-chloro β-lactams

P. Guzzo, Marvin J Miller, Peter R. Guzzo, 1994 .

Synthesis and Characterization of Novel Bi- and Tricyclic α-Amino Acids

M. Stier, Jolicia F. Gauuan, Matthew R. Johnson, 2011 .