P. Manning

发表

Improving Liver Graft Function Using CD47 Blockade in the Setting of Normothermic Machine Perfusion

W. Chapman, Yiing Lin, B. Banan, 2021, Transplantation.

CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation

W. Chapman, Yiing Lin, Min Xu, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Anti‐CD47 monoclonal antibody therapy reduces ischemia‐reperfusion injury of renal allografts in a porcine model of donation after cardiac death

W. Chapman, Yiing Lin, D. Nayak, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Attenuation of Ischemia-Reperfusion Injury and Improvement of Survival in Recipients of Steatotic Rat Livers Using CD47 Monoclonal Antibody

W. Chapman, Yiing Lin, T. Mohanakumar, 2016, Transplantation.

The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide.

J. Pelletier, J. Martel-Pelletier, F. Moldovan, 2002, Arthritis and rheumatism.

Normothermic extracorporeal liver perfusion for donation after cardiac death (DCD) livers.

W. Chapman, Yiing Lin, T. Mohanakumar, 2015, Surgery.

CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model

W. Chapman, Yiing Lin, T. Mohanakumar, 2015, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.

M. Currie, J. Pelletier, J. Martel-Pelletier, 1999, The Journal of rheumatology.

Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase.

M. Currie, J. Pelletier, J. Martel-Pelletier, 1998, Arthritis and rheumatism.

Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level.

M. Currie, J. Pelletier, J. Martel-Pelletier, 2000, Arthritis and rheumatism.

Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants.

M. Currie, K. Seibert, B. M. Woerner, 2002, Arthritis and rheumatism.

Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.

M. Currie, K. Seibert, P. Needleman, 1995, The Journal of clinical investigation.

Ser-Leu-Arg-Arg-atriopeptin III: the major circulating form of atrial peptide.

P. Needleman, C. E. Smith, N. Siegel, 1985, Science.

Selective iNOS Inhibitors

M. Currie, P. Manning, J. Thompson, 2001 .

MHC-specific cytotoxic T lymphocyte killing of dissociated sympathetic neuronal cultures.

C. Wilcox, J. Russell, M. Palmatier, 1987, The American journal of pathology.

Atriopeptins: circulating volume regulatory hormones with potential therapeutic role in chronic renal failure.

P. Needleman, N. Katsube, P. Manning, 1986, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Evidence for the production of peroxynitrite in inflammatory CNS demyelination

A. Cross, T. P. Misko, P. Manning, 1997, Journal of Neuroimmunology.

Peroxynitrite formation within the central nervous system in active multiple sclerosis

R. Schmidt, A. Cross, T. P. Misko, 1998, Journal of Neuroimmunology.

Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema.

M. Currie, Zhi‐qiang Wang, D. Salvemini, 1996, European journal of pharmacology.

Characterization of the Cytoprotective Action of Peroxynitrite Decomposition Catalysts*

M. Currie, A. W. Veenhuizen, D. Salvemini, 1998, The Journal of Biological Chemistry.

Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation

M. Currie, Zhi‐qiang Wang, D. Salvemini, 1996, British journal of pharmacology.

Inducible nitric oxide synthase and guinea-pig ileitis induced by adjuvant

M. Currie, M. Miller, D. Clark, 1995, Mediators of inflammation.

IL-1 produced and released endogenously within human islets inhibits beta cell function.

J. Corbett, M. Heitmeier, M. Arnush, 1998, The Journal of clinical investigation.

Enhanced immunosuppression improves early allograft function in a porcine kidney transplant model of donation after circulatory death

Yiing Lin, D. Nayak, B. Banan, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

New Therapeutic Targets for Osteoarthritis

J. Pelletier, J. Martel-Pelletier, P. Manning, 2002 .

Evaluation of the long-term pancreatic effects of constitutive nitric oxide synthase inhibition in dogs

K. Kolaja, P. Manning, R. R. Bell, 2004, InflammoPharmacology.

Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.

M. Currie, W. M. Moore, G. Jerome, 2002, Journal of medicinal chemistry.

Guanethidine-induced destruction of sympathetic neurons.

P. Manning, E. Johnson, Eugene M. Johnson, 1984, International review of neurobiology.

A 2-year randomized, double-blind, placebo-controlled, multicenter study of an oral selective iNOS inhibitor in subjects with symptomatic osteoarthritis of the knee

C. Hayes, E. Vignon, K. Brandt, 2012 .

Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase.

Sucharita Das, A. Neufeld, J. Connor, 2002, Experimental eye research.

Atrial Natriuretic Factor in Plasma of Patients with Arterial Hypertension , Heart Failure or Cirrhosis of the Liver

P. Needleman, K. Kangawa, N. Katsube, 2022 .

4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain.

A. Stevens, H. Shieh, W. M. Moore, 2003, Organic & biomolecular chemistry.

The synthesis of 6-trifluoroethyl-L-lysine: a method to introduce functionality at C-6 of L-lysine

W. M. Moore, G. Jerome, P. Manning, 2003 .

A Prodrug of a Selective Inhibitor of Inducible Nitric Oxide Synthase is Neuroprotective in the Rat Model of Glaucoma

Sucharita Das, A. Neufeld, J. Connor, 2002, Journal of glaucoma.

CD47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model

W. Chapman, Yiing Lin, T. Mohanakumar, 2014, Transplantation.

2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.

M. Currie, T. P. Misko, W. M. Moore, 1996, Journal of medicinal chemistry.

Immunosuppressive agents prevent guanethidine-induced destruction of rat sympathetic neurons

Eugene M. Johnson, J. Russell, P. Manning, 1982, Brain Research.

2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.

M. Currie, W. M. Moore, G. Jerome, 1998, Journal of medicinal chemistry.

2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).

M. Currie, T. P. Misko, W. M. Moore, 1998, Journal of medicinal chemistry.

Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase.

G. Gilkeson, C. Reilly, F. Hutchison, 2002, Kidney international.

3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.

W. M. Moore, G. Jerome, J. Connor, 2002, Bioorganic & medicinal chemistry letters.

A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics

M. Currie, S. Kharitonov, L. Donnelly, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor.

M. Currie, J. Pelletier, J. Martel-Pelletier, 1999, Osteoarthritis and cartilage.

Syntheses of new racemic NG‐(1‐iminoethyl)phosphalysine derivatives as potential inhibitors of nitric oxide synthase

W. M. Moore, G. Jerome, J. Sikorski, 2000 .

5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.

A. Stevens, H. Shieh, W. M. Moore, 2004, Journal of medicinal chemistry.

Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

M. Currie, M. Toth, W. M. Moore, 1998, Journal of medicinal chemistry.

Syntheses of new conformationally constrained S‐[2‐[(1‐iminoethyl)amino] ethyl]homocysteine derivatives as potential nitric oxide synthase inhibitors

M. Toth, W. M. Moore, G. Jerome, 2002 .

Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.

M. Toth, W. M. Moore, S. Metz, 2001, Bioorganic & medicinal chemistry letters.

Interactions between the inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) pathways: implications for therapeutic intervention in osteoarthritis.

P. Needleman, P. Manning, 1999, Osteoarthritis and cartilage.

Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma.

Shin Lin, W. Chapman, Yiing Lin, 2015, Cancer letters.

L-N6-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo.

C. Bogdan, M. Röllinghoff, S. Stenger, 1995, European journal of pharmacology.

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

K. Seibert, P. Isakson, J. Masferrer, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Guanethidine-induced destruction of peripheral sympathetic neurons occurs by an immune-mediated mechanism

R. Schmidt, P. Manning, C. Powers, 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience.

The Biology of Nerve Growth Factor in Vivo

C. Wilcox, P. Manning, E. Johnson, 1988 .

Species and structural specificity of the lipopigment accumulation and neuronal destruction induced by N-(2-guanidinoethyl)-4-methyl-1,2,5,6-tetrahydropyridine (guanacline)

R. Rydel, M. Palmatier, P. Manning, 1986, Brain Research.

Protection from guanethidine-induced neuronal destruction by nerve growth factor: Effect of NGF on immune function

Eugene M. Johnson, J. Russell, P. Manning, 1985, Brain Research.

Guanethidine-Induced Destruction of Sympathetic Neurons: An Autoimmune "Disease" Prevented by Nerve Growth Factor

P. Manning, E. Johnson, 1984 .

Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis

A. Cross, S. Goorha, T. P. Misko, 1996, Journal of Neuroimmunology.

Vasopressin-stimulated release of atriopeptin: endocrine antagonists in fluid homeostasis.

P. Needleman, P T Manning, N. Katsube, 1985, Science.

Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding

R. Karr, Benjamin J. Capoccia, M. Bouchlaka, 2019, Molecular Cancer Therapeutics.

Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.

C. Rao, Bandaru S. Reddy, J. Connor, 2002, Cancer research.

Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase.

M. Currie, W. M. Moore, G. Jerome, 1995, European journal of pharmacology.

Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase

J. Williamson, R. Tilton, T. Lin, 1995, The Journal of experimental medicine.

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

C. Hayes, E. Vignon, K. Brandt, 2012, Annals of the rheumatic diseases.

Selective Cyclooxygenase-2 Inhibitor Administered Alone or in Combination with Celecoxib , a Oxide Synthase Inhibitor in Colon Carcinogenesis , Chemopreventive Properties of a Selective Inducible Nitric Updated

V. Rao, Bandaru S. Reddy, J. Connor, 2001 .

Procedes destines au traitement et a la prevention de troubles gastro-intestinaux

J. Connor, P. Manning, 2003 .

The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey.

M. Currie, P. Didier, D. Clark, 1997, The Journal of pharmacology and experimental therapeutics.

Phase 1-2 study of TI-061 alone and in combination with other anti-cancer agents in patients with advanced malignancies.

R. Karr, A. Italiano, A. Bexon, 2017 .

Inhibition of Nitric Oxide Synthase and Prospects For Therapy in Inflammatory Diseases

M. Currie, J. Connor, P. Manning, 1998, Current Pharmaceutical Design.

Specific inhibitors of inducible nitric oxide synthase: Efficacy in a rodent model of sepsis

M. Currie, G. Jerome, D. Widomski, 1999, Inflammation Research.

Temporal relationships of cytokine production in mouse non-lethal sepsis: Effect of nitric oxide synthase inhibitors

M. Currie, J. Connor, D. Widomski, 1997, Inflammation Research.