N. Kiguchi

发表

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.

P. W. Czoty, F. Hsu, S. Husbands, 2019, British journal of anaesthesia.

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

P. W. Czoty, P. Daga, N. Zaveri, 2018, Science Translational Medicine.

Chemokines and cytokines in neuroinflammation leading to neuropathic pain.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2012, Current opinion in pharmacology.

Possible involvement of endogenous opioid system located downstream of α7 nicotinic acetylcholine receptor in mice with physical dependence on nicotine.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2014, Journal of pharmacological sciences.

Peripheral alpha4beta2 nicotinic acetylcholine receptor signalling attenuates tactile allodynia and thermal hyperalgesia after nerve injury in mice

N. Kiguchi, S. Kishioka, F. Saika, 2015, Acta physiologica.

CC‐chemokine ligand 4/macrophage inflammatory protein‐1β participates in the induction of neuropathic pain after peripheral nerve injury

N. Kiguchi, S. Kishioka, F. Saika, 2012, European journal of pain.

CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2010, Neuroscience Letters.

HMGB1 as a potential therapeutic target for neuropathic pain.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2013, Journal of pharmacological sciences.

Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2008, Journal of pharmacological sciences.

Nociceptin/orphanin FQ peptide receptor-related ligands as novel analgesics.

H. Ding, M. Ko, N. Kiguchi, 2020, Current topics in medicinal chemistry.

Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse

H. Ding, M. Ko, N. Kiguchi, 2020, Journal of neuroscience research.

Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates.

F. Hsu, Thuy-Ai T Nguyen, H. Ding, 2020, British journal of anaesthesia.

Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2010, PAIN®.

Insufficient efferocytosis by M2-like macrophages as a possible mechanism of neuropathic pain induced by nerve injury.

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2020, Biochemical and biophysical research communications.

Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation.

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2017, Journal of pharmacological sciences.

Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2015, Pain.

Chemokine CXCL1 is responsible for cocaine‐induced reward in mice

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2018, Neuropsychopharmacology reports.

CC-chemokine ligand 2 facilitates conditioned place preference to methamphetamine through the activation of dopamine systems.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2014, Journal of pharmacological sciences.

Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation

Y. Kotake, K. Tsuga, N. Morioka, 2022, Neurochemistry International.

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

M. Nader, S. Husbands, H. Ding, 2016, Proceedings of the National Academy of Sciences.

Macrophage-T Cell Interactions Mediate Neuropathic Pain through the Glucocorticoid-induced Tumor Necrosis Factor Ligand System*

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2015, The Journal of Biological Chemistry.

Pioglitazone attenuates tactile allodynia and microglial activation in mice with peripheral nerve injury.

N. Kiguchi, S. Kishioka, T. Maeda, 2008, Drug discoveries & therapeutics.

The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice.

T. Kondo, N. Kiguchi, S. Kishioka, 2008, European journal of pharmacology.

Nicotine effects and the endogenous opioid system.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2014, Journal of pharmacological sciences.

Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation.

Akihiro Yamamoto, N. Kiguchi, S. Kishioka, 2011, Life sciences.

LPA-mediated demyelination in ex vivo culture of dorsal root

H. Ueda, R. Fujita, N. Kiguchi, 2007, Neurochemistry International.

Pharmacological studies on the NOP and opioid receptor agonist PWT2‐[Dmt1]N/OFQ(1‐13)

D. Lambert, C. Ruzza, G. Calo’, 2017, European journal of pharmacology.

Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice

J. Woods, M. Ko, N. Kiguchi, 2013, Neuroscience Letters.

Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway

M. Ikawa, S. Matsuzaki, A. Takeuchi, 2022, Frontiers in Immunology.

Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates

H. Ding, N. Kiguchi, S. Kishioka, 2022, Neuropharmacology.

Effects of NOP-Related Ligands in Nonhuman Primates.

M. Ko, N. Kiguchi, 2019, Handbook of experimental pharmacology.

Central N/OFQ-NOP Receptor System in Pain Modulation.

H. Ding, M. Ko, N. Kiguchi, 2016, Advances in pharmacology.

Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats.

K. Tohya, N. Kiguchi, S. Kishioka, 2007, Journal of pharmacological sciences.

Involvement of inflammatory mediators in neuropathic pain caused by vincristine.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2009, International review of neurobiology.

Epigenetic Regulation of Peripheral Macrophages in Neuropathic Pain

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2019, Epigenetics of Chronic Pain.

Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2021, Cells.

Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain

S. Matsuzaki, Tomoe Y. Nakamura, N. Kiguchi, 2020, Frontiers in Pharmacology.

Epigenetic regulation of CC-chemokine ligand 2 in nonresolving inflammation

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2014, Biomolecular concepts.

Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis through Histone H3 Acetylation in Injured Peripheral Nerves Elicits Neuropathic Pain

K. Tohya, N. Kiguchi, S. Kishioka, 2012, Journal of Pharmacology and Experimental Therapeutics.

Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2009, Biological & pharmaceutical bulletin.

Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2008, Neuroscience Letters.

Inflammatory Macrophages in the Sciatic Nerves Facilitate Neuropathic Pain Associated with Type 2 Diabetes Mellitus

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation

N. Kiguchi, S. Kishioka, T. Maeda, 2009, Proceedings of the National Academy of Sciences.

Activation of nicotinic acetylcholine receptors on bone marrow-derived cells relieves neuropathic pain accompanied by peripheral neuroinflammation

Jun Nakamura, N. Kiguchi, S. Kishioka, 2012, Neurochemistry International.

Activation of Extracellular Signal-Regulated Kinase in Sciatic Nerve Contributes to Neuropathic Pain After Partial Sciatic Nerve Ligation in Mice

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2009, Anesthesia and analgesia.

Pharmacological Regulation of Neuropathic Pain Driven by Inflammatory Macrophages

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2017, International journal of molecular sciences.

[The role of CC-chemokine ligand 2 in the development of psychic dependence on methamphetamine].

N. Kiguchi, S. Kishioka, F. Saika, 2015, Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence.

Peroxisome Proliferator-Activated Receptor Gamma Activation Relieves Expression of Behavioral Sensitization to Methamphetamine in Mice

Akihiro Yamamoto, N. Kiguchi, S. Kishioka, 2007, Neuropsychopharmacology.

Chemogenetic activation of central gastrin‐releasing peptide‐expressing neurons elicits itch‐related scratching behavior in male and female mice

D. Uta, Tomoe Y. Nakamura, M. Ko, 2021, Pharmacology research & perspectives.

Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.

Y. Shiozawa, S. H. Park, H. Ding, 2022, Biochemical pharmacology.

Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys

T. Ma, H. Ding, M. Ko, 2018, Journal of diabetes.

Vascular endothelial growth factor signaling in injured nerves underlies peripheral sensitization in neuropathic pain

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2014, Journal of neurochemistry.

Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates

G. Calo’, C. Trapella, H. Ding, 2021, Anesthesiology.

Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice

Ken-ichi Tanaka, H. Ding, M. Ko, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Epigenetic upregulation of CCL2 and CCL3 via histone modifications in infiltrating macrophages after peripheral nerve injury.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2013, Cytokine.

GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn

K. Sakimura, D. Uta, M. Abe, 2020, Neuropharmacology.

Potential therapeutic targets for the treatment of opioid abuse and pain.

M. Ko, N. Kiguchi, 2022, Advances in pharmacology.

Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms.

N. Kiguchi, S. Kishioka, K. Ueno, 2012, Drug discoveries & therapeutics.

Involvement of spinal Met–enkephalin in nicotine-induced antinociception in mice

Akihiro Yamamoto, N. Kiguchi, S. Kishioka, 2008, Brain Research.

Availability of serum corticosterone level for quantitative evaluation of morphine withdrawal in mice.

N. Kiguchi, S. Kishioka, K. Ueno, 2011, Drug discoveries & therapeutics.

Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2018, Journal of Neuroinflammation.

Leptin enhances CC-chemokine ligand expression in cultured murine macrophage.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2009, Biochemical and biophysical research communications.

Upregulation of CCL7 and CCL2 in reward system mediated through dopamine D1 receptor signaling underlies methamphetamine-induced place preference in mice

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2018, Neuroscience Letters.

Critical role of GRP receptor–expressing neurons in the spinal transmission of imiquimod‐induced psoriatic itch

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2020, Neuropsychopharmacology reports.

Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics

E. Romero-Sandoval, H. Ding, N. Kiguchi, 2023, Drugs.

Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.

J. Cline, N. Kock, H. Ding, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2018, Journal of Neuroinflammation.

TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages.

M. Ko, N. Kiguchi, S. Kishioka, 2015, Journal of pharmacological sciences.

Negative relationship between morphine analgesia and P-glycoprotein expression levels in the brain.

S. Tokuyama, W. Hamabe, N. Kiguchi, 2007, Journal of pharmacological sciences.

Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation.

N. Kiguchi, S. Kishioka, Yuka Kobayashi, 2010, Pain.

Histone modifications in the injured sciatic nerve regulate neuropathic pain

N. Kiguchi, S. Kishioka, 2014 .

Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis through Histone H3 Acetylation in Injured Peripheral Nerves Elicits Neuropathic Pain

K. Tohya, N. Kiguchi, S. Kishioka, 2012, Journal of Pharmacology and Experimental Therapeutics.

Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation

N. Kiguchi, S. Kishioka, T. Maeda, 2009, Proceedings of the National Academy of Sciences.

Sexually dimorphic effects of pexidartinib on nerve injury-induced neuropathic pain in mice

N. Kiguchi, S. Kishioka, F. Saika, 2023, bioRxiv.

Central N/OFQ-NOP Receptor System in Pain Modulation.

H. Ding, M. Ko, N. Kiguchi, 2016, Advances in pharmacology.

Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation.

S. Matsuzaki, N. Kiguchi, S. Kishioka, 2017, Journal of pharmacological sciences.

Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice

J. Woods, M. Ko, N. Kiguchi, 2013, Neuroscience Letters.

Sexually dimorphic effects of pexidartinib on nerve injury‐induced neuropathic pain in mice

Yuko Hino, N. Kiguchi, S. Kishioka, 2024, Glia.

Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice

Ken-ichi Tanaka, H. Ding, M. Ko, 2016, The Journal of Pharmacology and Experimental Therapeutics.