R. Ayyad

发表

Discovery of novel triazolophthalazine derivatives as DNA intercalators and topoisomerase II inhibitors

M. M. Khalifa, H. A. Mahdy, Helmy M. Sakr, 2021, Archiv der Pharmazie.

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2020, Molecules.

Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds.

C. Supuran, M. Ceruso, A. Abdel-Aziz, 2016, Bioorganic & medicinal chemistry.

Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR‐2 Inhibitors

Mamdouh M. Ali, Khaled El-Adl, Abdel-Ghany A. El-Helby, 2017, Archiv der Pharmazie.

Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones.

L. Abou-zeid, M. A. El-Sayed, A. Abdel-Aziz, 2016, European journal of medicinal chemistry.

Some Novel Anticonvulsant Agents Derived from Phthalazinedione

R. Ayyad, M. Zayed, 2012, Arzneimittelforschung/Drug Research.

Design and synthesis of new benzylidene-quinazolinone hybrids as potential anti-diabetic agents: In vitro α-glucosidase inhibition, and docking studies

A. Mansour, M. M. Khalifa, Helmy M. Sakr, 2021, Journal of Molecular Structure.

Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors.

M. Elsohly, M. M. Khalifa, M. Radwan, 2020, Bioorganic & medicinal chemistry.

Development of 2-oindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

R. Ahmad, H. Abdel‐Aziz, T. Al-Warhi, 2020, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies

A. Alanazi, M. Al-agamy, A. Abdel-Aziz, 2016, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors.

M. Elsohly, M. M. Khalifa, M. Radwan, 2020, Bioorganic chemistry.

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives.

Mamdouh M. Ali, Wagdy M. Eldehna, S. M. Abou-Seri, 2016, European journal of medicinal chemistry.

Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies

A. Alanazi, Y. Asiri, A. Abdel-Aziz, 2016, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, molecular modeling and biological evaluation of novel 2,3-dihydrophthalazine-1,4-dione derivatives as potential anticonvulsant agents

Farag F. Sherbiny, M. M. Khalifa, I. Eissa, 2017 .

Design, Synthesis of Analgesics and Anticancer of Some New Derivatives of Benzimidazole

A. Mansour, Helmy M. Sakr, R. Ayyad, 2021, International Journal of Organic Chemistry.

Phthalazine-1,4-dione derivatives as non-competitive AMPA receptor antagonists: design, synthesis, anticonvulsant evaluation, ADMET profile and molecular docking

Khaled El-Adl, Abdel-Ghany A. El-Helby, R. Ayyad, 2018, Molecular Diversity.

Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5‐[(4‐chloro/2,4‐dichloro)benzylidene]thiazolidine‐2,4‐dione derivatives as VEGFR‐2 inhibitors

Khaled El-Adl, Abdel-Ghany A. El-Helby, Helmy M. Sakr, 2020, Archiv der Pharmazie.

Synthesis and antitumor evaluation of trimethoxyanilides based on 4(3H)-quinazolinone scaffolds.

M. Mohamed, A. Abdel-Aziz, A. El-Azab, 2016, European journal of medicinal chemistry.

Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors

M. Elsohly, M. Radwan, I. Eissa, 2019, Archiv der Pharmazie.

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer

R. Ahmad, H. Abdel‐Aziz, T. Al-Warhi, 2021, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of some novel quinoxaline derivatives as anticonvulsant agents

R. Ayyad, M. Zayed, Abdelghany Aly Elhelby, 2011, Arzneimittelforschung.

Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies.

L. Abou-zeid, A. Abdel-Aziz, A. El-Azab, 2016, European journal of medicinal chemistry.

New pyrimidine-5-carbonitrile derivatives as EGFR inhibitors with anticancer and apoptotic activity: Design, molecular modeling and synthesis

R. Ayyad, H. Mahdy, I. A. Osman, 2022, New Journal of Chemistry.

1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights

T. Al-Warhi, Wagdy M. Eldehna, Mahmoud A. El Hassab, 2023, Molecules.

Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity.

F. M. Abdelrazek, R. Ayyad, A. F. El-Farargy, 2016, Mini reviews in medicinal chemistry.

Design, synthesis, in silico ADMET profile and GABA‐A docking of novel phthalazines as potent anticonvulsants

Khaled El-Adl, Abdel-Ghany A. El-Helby, Hamada S. Abulkhair, 2019, Archiv der Pharmazie.

Design and synthesis of some novel 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-(substituted)phenyl)acetamide derivatives for biological evaluation as anticonvulsant agents

A. Mansour, I. Eissa, M. Ibrahim, 2013 .

Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues

A. Alanazi, M. Mohamed, M. A. El-Sayed, 2016, Journal of enzyme inhibition and medicinal chemistry.

Design, Synthesis, In‐Vivo Anti‐Diabetic Activity, In‐Vitro α‐Glucosidase Inhibitory Activity and Molecular Docking Studies of Some Quinazolinone Derivatives

M. M. Khalifa, Helmy M. Sakr, R. Ayyad, 2022, ChemistrySelect.