A. Kourounakis

发表

Effect of a novel NSAID derivative with antioxidant moiety on oxidative damage caused by liver and cerebral ischaemia‐reperfusion in rats

K. Tsiakitzis, K. Kotzampassi, A. Kourounakis, 2002, The Journal of pharmacy and pharmacology.

alpha1-Acid glycoprotein production in rat dorsal air pouch in response to inflammatory stimuli, dexamethasone and honey bee venom.

S. Petrakis, J. Papaconstantinou, A. Kourounakis, 2010, Experimental and molecular pathology.

Pharmacological characterization in vitro of EP2306 and EP2302, potent inhibitors of squalene synthase and lipid biosynthesis.

V. Manolopoulos, A. Tavridou, A. Papalois, 2006, European journal of pharmacology.

Anti‐inflammatory Properties of New Adamantane Derivatives. Design, Synthesis, and Biological Evaluation

E. Antoniadou-Vyza, A. Kourounakis, L. Hadjipetrou, 1998, Archiv der Pharmazie.

Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.

A. Kourounakis, P. Kourounakis, E. Rekka, 2008, Journal of medicinal chemistry.

Stress and Active Oxygen Species – Effect of α‐Tocopherol on Stress Response

K. Tsiakitzis, A. Kourounakis, P. Kourounakis, 2005 .

Influence of Omega-3 Fatty Acid-Rich Fish Oils on Hyperlipidemia: Effect of Eel, Sardine, Trout, and Cod Oils on Hyperlipidemic Mice

E. Polychronopoulos, V. Roussis, N. Demertzis, 2020, Journal of medicinal food.

Antihyperlipidemic morpholine derivatives with antioxidant activity: An investigation of the aromatic substitution.

Anastasios Nikitakis, A. Kourounakis, A. Matralis, 2015, Bioorganic & medicinal chemistry.

Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor.

A. IJzerman, C. Visser, A. Kourounakis, 2001, Biochemical pharmacology.

Synthesis and Evaluation of Brain‐targeted Chemical Delivery Systems for the Neurotrophomodulator 4‐Methylcatechol

J. Simpkins, N. Bodor, A. Kourounakis, 1997, The Journal of pharmacy and pharmacology.

New multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine derivatives with antioxidant, antihyperlipidemic, and antidiabetic action.

A. Kourounakis, A. Matralis, E. Ladopoulou, 2013, Journal of medicinal chemistry.

Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies

A. Kourounakis, Dimitrios Xanthopoulos, Ariadni Tzara, 2020, ChemMedChem.

Allosteric modulation of the rat adenosine A1 receptor: Differential effects on agonist and antagonist binding

A. IJzerman, C. Visser, A. Kourounakis, 2000 .

Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.

A. Kourounakis, M. Katselou, A. Matralis, 2017, European journal of medicinal chemistry.

Anti-inflammatory properties of diclofenac transition metalloelement complexes.

A. Kourounakis, M. Demertzis, D. Kovala-Demertzi, 1998, Journal of inorganic biochemistry.

Antioxidant potential of natural and synthesised polyprenylated hydroquinones.

V. Roussis, L. Tziveleka, C. Vagias, 2002, Bioorganic & medicinal chemistry.

Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias.

P. Papazafiri, A. Detsi, T. Calogeropoulou, 2001, Journal of medicinal chemistry.

Contribution of Deep Learning in the Investigation of Possible Dual LOX-3 Inhibitors/DPPH Scavengers: The Case of Recently Synthesized Compounds

G. Lambrinidis, A. Kourounakis, G. Manis, 2022, Bioengineering.

Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.

A. Kourounakis, A. Matralis, 2014, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity.

D. Galanakis, A. Kourounakis, P. Kourounakis, 2004, Bioorganic & medicinal chemistry letters.

Reduction of gastrointestinal toxicity of NSAIDs via molecular modifications leading to antioxidant anti-inflammatory drugs.

K. Tsiakitzis, D. Galanakis, A. Kourounakis, 2000, Toxicology.

Synthesis and pharmacological evaluation of novel derivatives of anti‐inflammatory drugs with increased antioxidant and anti‐inflammatory activities

D. Galanakis, A. Kourounakis, P. Kourounakis, 1999 .

Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties

M. Pappa, A. Kourounakis, K. Pluta, 2014, Medicinal Chemistry Research.

Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules

A. Kourounakis, Dimitrios Xanthopoulos, Ariadni Tzara, 2020, Medicinal research reviews.

Novel benzoxazine and benzothiazine derivatives as multifunctional antihyperlipidemic agents.

Anastasios Nikitakis, A. Kourounakis, M. Katselou, 2011, Journal of medicinal chemistry.

Evaluation of two novel antioxidants with differential effects on curcumin-induced apoptosis in C2 skeletal myoblasts; involvement of JNKs.

M. Peleli, I. Beis, C. Gaitanaki, 2015, Bioorganic & medicinal chemistry.

Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias.

P. Papazafiri, A. Detsi, T. Calogeropoulou, 2004, Bioorganic & medicinal chemistry.

Design of Multifaceted Antioxidants: Shifting towards Anti-Inflammatory and Antihyperlipidemic Activity

G. Lambrinidis, A. Kourounakis, Ariadni Tzara, 2021, Molecules.

Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives.

A. Kourounakis, A. Matralis, 2018, ACS medicinal chemistry letters.

Design, synthesis and evaluation of antihyperlipidemic agents combining antioxidant and antiinflammatory activity

A. Kourounakis, A. Matralis, 2013 .

Design of more potent squalene synthase inhibitors with multiple activities.

Anastasios Nikitakis, A. Kourounakis, A. Matralis, 2010, Bioorganic & medicinal chemistry.

Antiatherosclerotic Properties of EP2302, a Novel Squalene Synthase Inhibitor, in the Cholesterol-fed Rabbit

V. Manolopoulos, A. Tavridou, A. Papalois, 2008, Journal of cardiovascular pharmacology.

EP2306 [2-(4-Biphenyl)-4-methyl-octahydro-1,4-benzoxazin-2-ol, hydrobromide], A Novel Squalene Synthase Inhibitor, Reduces Atherosclerosis in the Cholesterol-Fed Rabbit

V. Manolopoulos, A. Tavridou, A. Papalois, 2007, Journal of Pharmacology and Experimental Therapeutics.

EP2306 and EP2302, two novel squalene synthase inhibitors, stimulate endothelial nitric oxide synthase expression in cultured endothelial cells.

V. Manolopoulos, A. Tavridou, A. Kourounakis, 2007, Endothelium : journal of endothelial cell research.

Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.

A. Kourounakis, P. Kourounakis, E. Rekka, 2007, Bioorganic & medicinal chemistry.

Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties.

K. Tsiakitzis, P. Eleftheriou, D. Galanakis, 2006, Bioorganic & medicinal chemistry letters.

Experimental hyperlipidemia and the effect of NSAIDs.

P. Victoratos, A. Kourounakis, P. Kourounakis, 2002, Experimental and molecular pathology.

Alkannin and Shikonin: Effect on Free Radical Processes and on Inflammation ‐ A Preliminary Pharmacochemical Investigation

A. Assimopoulou, V. Papageorgiou, A. Gavalas, 2002, Archiv der Pharmazie.

Antinociceptive Properties of 1,8-Cineole and β-Pinene, from the Essential Oil of Eucalyptus camaldulensis Leaves, in Rodents

I. Chinou, G. Anifandis, C. Liapi, 2007, Planta medica.

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

H. Skaltsa, C. Barda, E. Kalpoutzakis, 2022, Molecules.

Squalene synthase inhibitors: An update on the search for new antihyperlipidemic and antiatherosclerotic agents.

A. Kourounakis, M. Katselou, A. Matralis, 2011, Current medicinal chemistry.

Anti-inflammatory and immunomodulating properties of grape melanin. Inhibitory effects on paw edema and adjuvant induced disease.

A. Kourounakis, L. Hadjipetrou, N. Avramidis, 1998, Arzneimittel-Forschung.

Synthesis and activity on free radical processes and inflammation of 9,10-dihydro-5,8-dimethoxy-triptycene-quinones.

A. Kourounakis, P. Kourounakis, S. Spyroudis, 2003, European journal of medicinal chemistry.

Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity.

A. Kourounakis, E. Rekka, M. Chrysselis, 2002, Chemical & pharmaceutical bulletin.

Antioxidant Activity of Guaiazulene and Protection Against Paracetamol Hepatotoxicity in Rats

A. Kourounakis, P. Kourounakis, E. Rekka, 1997, The Journal of pharmacy and pharmacology.

Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery

A. IJzerman, A. Kourounakis, R. de Ligt, 2000, British journal of pharmacology.

Effect of Guaiazulene on Some Cytochrome P450 Activities. Implication in the Metabolic Activation and Hepatotoxicity of Paracetamol

A. Kourounakis, P. Kourounakis, E. Rekka, 1997, Archiv der Pharmazie.

The impact of α-tocopherol on radiation-induced liver injury

K. Kotzampassi, D. Paramythiotis, N. Harlaftis, 2003 .

Multi-target drug design approaches for multifactorial diseases: from neurodegenerative to cardiovascular applications.

A. Kourounakis, M. Katselou, A. Matralis, 2014, Current medicinal chemistry.

Investigation of the effect of chamazulene on lipid peroxidation and free radical processes.

A. Kourounakis, P. Kourounakis, E. Rekka, 1996, Research Communications in Molecular Pathology and Pharmacology.

Synthesis, Antiretroviral and Antioxidant Evaluation of a Series of New Benzo[b]furan Derivatives

C. Pannecouque, A. Tsotinis, J. Neyts, 2001, Arzneimittelforschung.

5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.

A. Spek, A. IJzerman, J. K. von Frijtag Drabbe Künzel, 1999, Journal of medicinal chemistry.

Quantitative Structure Activity Relationships of Catechol Derivatives on Nerve Growth Factor Secretion in L-M Cells

N. Bodor, A. Kourounakis, 1995, Pharmaceutical Research.

New applications of squalene synthase inhibitors: Membrane cholesterol as a therapeutic target

A. Kourounakis, E. Bavavea, 2020, Archiv der Pharmazie.

Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding.

A. IJzerman, P. van der Klein, A P IJzerman, 1999, Journal of medicinal chemistry.

Suppression of Adjuvant‐Induced Disease (AID) by a Novel Analgesic‐Opioid Agonist Which Also Possesses Antioxidant Activity (Neuroimmunomodulation)

A. Kourounakis, E. Rekka, L. Hadjipetrou-Kourounakis, 1992, Annals of the New York Academy of Sciences.

Stress and active oxygen species--effect of alpha-tocopherol on stress response.

K. Tsiakitzis, A. Kourounakis, P. Kourounakis, 2005, Archiv der Pharmazie.

Antioxidant Activity of Newly Synthesized 2,7‐Diazaphenothiazines

A. Kourounakis, A. Matralis, K. Pluta, 2010, Archiv der Pharmazie.

Effects of the Novel Non-steroidal Anti-inflammatory Compound [N-(2-Thiol-ethyl)-2-{2-[N'-(2,6-dichlorophenyl) amino]phenyl} acetamide on Cytokines and Apoptosis in Ischaemic Rat Brain

K. Kotzampassi, D. Paramythiotis, A. Kourounakis, 2006, Arzneimittelforschung.

Elucidation of structure–activity relationships of 2‐amino‐3‐benzoylthiophenes: Study of their allosteric enhancing vs. antagonistic activity on adenosine A1 receptors

A. IJzerman, P. van der Klein, A. Kourounakis, 2000 .

Allosteric modulation of G protein-coupled receptors.

A. IJzerman, A. Kourounakis, Pieter A. M. van der Klein, 2001, Farmaco.

Effect of a new squalene synthase inhibitor on an ApoE-/- mouse model of atherosclerosis.

D. Perrea, L. Kaklamanis, A. Kourounakis, 2023, Bioorganic & medicinal chemistry.