J. Rullas

发表

X-ray-based virtual slicing of TB-infected lungs

J. Vaquero, A. Muñoz-Barrutia, A. Ortega-Gil, 2019, Scientific Reports.

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).

David Barros, J. Plattner, Esther Pérez-Herrán, 2017, Journal of medicinal chemistry.

The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis

G. Drewes, Pablo Gamallo, Markus Boesche, 2022, Science Translational Medicine.

Mycobacterium tuberculosis Gyrase Inhibitors as a New Class of Antitubercular Drugs

J. Lavandera, David Barros, Lluís Ballell, 2015, Antimicrobial Agents and Chemotherapy.

Chemokine expression by systemic sclerosis fibroblasts: abnormal regulation of monocyte chemoattractant protein 1 expression.

J. Alcamí, J. Pablos, B. Santiago, 2001, Arthritis and rheumatism.

Fas activation of a proinflammatory program in rheumatoid synoviocytes and its regulation by FLIP and caspase 8 signaling.

J. Ramírez, J. Alcamí, J. Pablos, 2006, Arthritis and rheumatism.

The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-κB activation

M. Esteban, J. Alcamí, J. Gil, 2001, Oncogene.

Basal shuttle of NF-κB/IκBα in resting T lymphocytes regulates HIV-1 LTR dependent expression

J. Alcamí, M. Mittelbrunn, M. López-Huertas, 2007, Retrovirology.

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

Robert H Bates, M. Botta, V. L. La Rosa, 2013, PloS one.

Exploring the SAR of the β-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.

Robert H Bates, Fraser Cunningham, C. Chung, 2020, ACS infectious diseases.

Prostratin Induces HIV Activation and Downregulates HIV Receptors in Peripheral Blood Lymphocytes

J. Alcamí, Stephen J Brown, M. Hezareh, 2004, Antiviral therapy.

Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis.

Robert H Bates, T. Ioerger, E. Rubin, 2019, ACS medicinal chemistry letters.

Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions

Robert H Bates, M. Vieth, P. Hipskind, 2022, ACS infectious diseases.

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

A. Diacon, J. Lelièvre, J. Mckinney, 2015, Antimicrobial Agents and Chemotherapy.

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

A. Korkegian, K. Read, P. Hipskind, 2018, Journal of medicinal chemistry.

The Hepatitis B Virus X Protein Induces HIV-1 Replication and Transcription in Synergy with T-cell Activation Signals

B. Berkhout, J. Aramburu, E. Lara-Pezzi, 2001, The Journal of Biological Chemistry.

Sialoadhesin expression by bone marrow macrophages derived from Ehrlich-tumor-bearing mice

S. Kusmartsev, J. Rullas, M. G. Danilets, 1999, Cancer Immunology, Immunotherapy.

A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

P. Rosenthal, J. Regadera, D. Pompliano, 2008, PloS one.

TRAF Family Proteins Link PKR with NF-κB Activation

H. Nakano, P. Gómez-Puertas, Susana Guerra, 2004, Molecular and Cellular Biology.

Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, G. Drewes, 2016, Nature Communications.

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

G. Drewes, M. Bantscheff, G. Besra, 2016, Nature Microbiology.

MC159L protein from the poxvirus molluscum contagiosum virus inhibits NF-kappaB activation and apoptosis induced by PKR.

M. Esteban, J. Alcamí, J. Gil, 2001, The Journal of general virology.

Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA.

Hongfang Yang, William McDowell, Paolo A Centrella, 2014, Journal of medicinal chemistry.

Fast Standardized Therapeutic-Efficacy Assay for Drug Discovery against Tuberculosis

P. Cardona, Iñigo Angulo-Barturen, J. Rullas, 2010, Antimicrobial Agents and Chemotherapy.

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

N. Loman, C. Constantinidou, M. Pallen, 2013, PloS one.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Christopher B. Cooper, Lisa K. Woolhiser, J. Sacchettini, 2016, Antimicrobial Agents and Chemotherapy.

A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

D. Sherman, Gonzalo Colmenarejo, Anuradha Kumar, 2015, ACS infectious diseases.

Early myeloid cells are high producers of nitric oxide upon CD40 plus IFN‐γ stimulation through a mechanism dependent on endogenous TNF‐α and IL‐1α

M. Howard, M. Muñoz-Fernández, A. Heath, 2000 .

Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection

F. Gleeson, J. Vaquero, L. Alameda, 2022, Pharmaceutics.

Improvement of detection specificity of Plasmodium‐infected murine erythrocytes by flow cytometry using autofluorescence and YOYO‐1

M. Jiménez-Díaz, Iñigo Angulo-Barturen, D. Gargallo‐Viola, 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

N‐Benzyl‐4‐((heteroaryl)methyl)benzamides: A New Class of Direct NADH‐Dependent 2‐trans Enoyl–Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity

J. Sacchettini, M. Convery, Delia Blanco, 2016, ChemMedChem.

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis.

Katrina A. Badiola, M. Todd, P. Rutledge, 2018, Journal of medicinal chemistry.

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

N. Loman, G. Besra, David Barros, 2017, Scientific Reports.

The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model

L. Alameda, Iñigo Angulo-Barturen, S. Ferrer, 2017, Journal of Pharmacokinetics and Pharmacodynamics.

TRAF family proteins link PKR with NF-kappa B activation.

H. Nakano, P. Gómez-Puertas, Susana Guerra, 2004, Molecular and cellular biology.

University of Birmingham Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, G. Drewes, 2016 .

Small-molecule SMARt751 hypersensitizes M. tuberculosis resistant to ethionamide by upregulating the mymA operon

G. Drewes, Markus Boesche, R. Wintjens, 2022 .

Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection

J. Lelièvre, M. Zimmerman, T. Dick, 2023, Antimicrobial Agents and Chemotherapy.

Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, M. Bantscheff, 2016, Nature Communications.