R. Langen

发表

Identification of microRNAs in skeletal muscle associated with lung cancer cachexia

H. Woodruff, A. Dingemans, A. Harel-Bellan, 2019, Journal of cachexia, sarcopenia and muscle.

Ovarian cancer ascites induces skeletal muscle wasting in vitro and reflects sarcopenia in patients

Ruth C. R. Meex, S. Rensen, T. Van Gorp, 2021, Journal of cachexia, sarcopenia and muscle.

dysfunction in COPD The mechanisms of cachexia underlying muscle

W. Roberts, E. Wouters, P. Wagner, 2015 .

The mechanisms of cachexia underlying muscle dysfunction in COPD.

A. Schols, R. Langen, H. Gosker, 2013, Journal of applied physiology.

Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation.

E. Wouters, M. Kelders, A. Schols, 2006, American journal of respiratory cell and molecular biology.

Towards Personalized Management of Sarcopenia in COPD

A. Schols, R. Langen, H. Gosker, 2021, International journal of chronic obstructive pulmonary disease.

Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation

R. Mensink, M. Kelders, A. Schols, 2010, Cellular and Molecular Life Sciences.

Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

W. Lamers, A. Schols, C. de Theije, 2018, Endocrinology.

Hypoxia and muscle maintenance regulation: implications for chronic respiratory disease

F. Costes, C. Pison, C. D. Theije, 2011, Current opinion in clinical nutrition and metabolic care.

mouse skeletal muscle oxidative stress and impairs mitochondrial function in Acute and severe hypobaric hypoxia increases

J. Magalhães, F. Marques, W. Lamers, 2015 .

Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy.

M. Kelders, A. Schols, J. L. van der Velden, 2011, American journal of physiology. Cell physiology.

Glycogen Synthase Kinase 3β Suppresses Myogenic Differentiation through Negative Regulation of NFATc3*

M. Kelders, A. Schols, J. L. van der Velden, 2008, Journal of Biological Chemistry.

AMPK is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice

C. Henríquez-Olguín, S. Larsen, T. Jensen, 2022, bioRxiv.

Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy

H. Baarsma, A. Schols, R. Gosens, 2013, Respiratory Research.

NF-κB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy.

S. Shoelson, A. Schols, D. Gray, 2012, American journal of physiology. Lung cellular and molecular physiology.

Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure.

G. Joos, E. Wouters, A. Schols, 2009, American journal of respiratory cell and molecular biology.

ROS in the local and systemic pathogenesis of COPD.

E. Wouters, E. Wouters, R. Langen, 2003, Free radical biology & medicine.

Fatty acid induced NF‐κB activation and insulin resistance in skeletal muscle are chain length dependent

R. Mensink, A. Schols, J. Plat, 2008, American journal of physiology. Endocrinology and metabolism.

Evaluation of the Sensitivity of Metabolic Profiling by Rapid Evaporative Ionization Mass Spectrometry: Toward More Radical Oral Cavity Cancer Resections

R. Heeren, Tiffany Porta Siegel, L. Baijens, 2022, Analytical chemistry.

Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis

M. Lainscak, L. V. van Loon, L. Verdijk, 2019, Journal of cachexia, sarcopenia and muscle.

Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice

F. Verhaegen, M. Kelders, A. Schols, 2018, Scientific Reports.

Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia.

M. Lainscak, L. Verdijk, M. Kelders, 2017, Journal of the American Medical Directors Association.

Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation

F. Verhaegen, A. Schols, C. de Theije, 2017, Respiratory Research.

Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease.

A. Schols, R. Langen, H. Gosker, 2013, The international journal of biochemistry & cell biology.

Synergistic stimulation of myogenesis by glucocorticoid and IGF-I signaling.

E. Wouters, A. Schols, R. Langen, 2013, Journal of applied physiology.

Automated CT-derived skeletal muscle mass determination in lower hind limbs of mice using a 3D U-Net deep learning network.

F. Verhaegen, A. Schols, J. Theys, 2019, Journal of applied physiology.

Pre-cachexia in patients with stages I-III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system.

A. Dingemans, M. Kelders, A. Dingemans, 2012, Lung cancer.

Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer

E. Wouters, D. de Ruysscher, A. Dingemans, 2014, Journal of cachexia, sarcopenia and muscle.

Muscle atrophy in cachexia: can dietary protein tip the balance?

A. Schols, C. M. H. Op den Kamp, R. Langen, 2009, Current opinion in clinical nutrition and metabolic care.

Interruption of Wnt Signaling Attenuates the Onset of Pressure Overload-Induced Cardiac Hypertrophy

B. Janssen, W. Blankesteijn, J. Smits, 2007, Hypertension.

Inactivation of glycogen synthase kinase 3β (GSK-3β) enhances mitochondrial biogenesis during myogenesis.

A. Schols, R. Langen, H. Gosker, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis

Simon W. Jones, M. Cooper, A. Filer, 2021, International journal of molecular sciences.

Differential sensitivity of oxidative and glycolytic muscles to hypoxia-induced muscle atrophy.

C. D. Theije, W. Lamers, A. Schols, 2015, Journal of applied physiology.

PPAR inhibits NF- B-dependent transcriptional activation in skeletal muscle

A. Russell, J.H.L. Voncken, P. Schrauwen, 2009 .

Regulation of skeletal muscle oxidative phenotype by classical NF‐κB signalling

A. Schols, R. Langen, H. Gosker, 2012, Biochimica et biophysica acta.

Recovery of muscle mass and muscle oxidative phenotype following disuse does not require GSK-3 inactivation.

M. Kelders, A. Schols, C. de Theije, 2020, Biochimica et biophysica acta. Molecular basis of disease.

NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy.

E. Wouters, S. Shoelson, H. Carlsen, 2012, American journal of respiratory cell and molecular biology.

Phase II drugs that are currently in development for the treatment of cachexia

A. Dingemans, A. Schols, J. de Vos-Geelen, 2014, Expert opinion on investigational drugs.

Systemic inflammation in chronic obstructive pulmonary disease and lung cancer: common driver of pulmonary cachexia?

A. Schols, R. Langen, J. J. Ceelen, 2014, Current opinion in supportive and palliative care.

Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

M. Kelders, A. Schols, D. Gray, 2018, Respiratory Research.

Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation

L. V. van Loon, L. Verdijk, M. Kelders, 2019, Muscle & nerve.

Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels.

L. V. van Loon, A. Schols, R. Langen, 2012, Molecular nutrition & food research.

Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta.

E. Wouters, M. Kelders, A. Schols, 2007, American journal of physiology. Cell physiology.

TNF-α-induced NF-κB activation stimulates skeletal muscle glycolytic metabolism through activation of HIF-1α.

A. Schols, R. Langen, H. Gosker, 2015, Endocrinology.

Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle

A. Schols, R. Langen, H. Gosker, 2020, BMC Pulmonary Medicine.

Trans Fatty Acid-Induced NF-κB Activation Does Not Induce Insulin Resistance in Cultured Murine Skeletal Muscle Cells

R. Mensink, A. Schols, J. Plat, 2010, Lipids.

Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways.

E. Wouters, M. Kelders, A. Schols, 2002, American journal of physiology. Cell physiology.

Tumor necrosis factor-α inhibits myogenesis through redox-dependent and -independent pathways

E. Wouters, M. Kelders, A. Schols, 2002 .

Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia

C. Jacobi, J. Ross, Alain Schilb, 2017, Journal of cachexia, sarcopenia and muscle.

Fatty Acids as a Tool to Boost Cancer Immunotherapy Efficacy

L. Dubois, J. Theys, J. van Bergenhenegouwen, 2022, Frontiers in Nutrition.

COPD_A_280540 25..40

A. Schols, R. Langen, H. Gosker, 2021 .

Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype.

A. Schols, R. Langen, H. Gosker, 2014, American journal of physiology. Endocrinology and metabolism.

Glycogen synthase kinase-3 (cid:1) is required for the induction of skeletal muscle atrophy

M. Kelders, A. Schols, R. Langen, 2011 .

Regulation of muscle atrophy by microRNAs: ‘AtromiRs’ as potential target in cachexia

J. Theys, Wouter van de Worp, A. van Helvoort, 2018, Current opinion in clinical nutrition and metabolic care.

Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesis

E. Wouters, M. Kelders, Y. Janssen-Heininger, 2003, In Vitro Cellular & Developmental Biology - Animal.

Inflammation: friend or foe of muscle remodelling in COPD?

A. Schols, R. Langen, 2007, European Respiratory Journal.

Tumor necrosis factor- (cid:1) inhibits myogenesis through redox-dependent and -independent pathways

E. Wouters, M. Kelders, A. Schols, 2002 .

Efficacy of Curosurf in a rat model of acute respiratory distress syndrome.

H. Haagsman, P. Bruijnzeel, R. Langen, 1998, The European respiratory journal.

Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies

A. Kraneveld, J. Garssen, I. van Ark, 2022, Cells.

P143 NF-kappa B (NF-κB) and activator protein-1 (AP-1) DNA binding in the quadriceps of COPD patients

M. Polkey, W. Man, N. Hopkinson, 2010, Thorax.

Peroxisome proliferator-activated receptors: a therapeutic target in COPD?

P. Schrauwen, A. Schols, R. Langen, 2008, European Respiratory Journal.

Altered Body Composition and Muscle Anabolic, Catabolic and Metabolic Gene Expression in COPD Patients with Elevated Skeletal Muscle Inflammation.

M. Polkey, E. Wouters, P. Śliwiński, 2009, ATS 2009.

Trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-κB activation.

R. Mensink, M. Kelders, A. Schols, 2010, Molecular nutrition & food research.

Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity.

A. Schols, J. L. van der Velden, R. Langen, 2007, Clinics in chest medicine.

Patient‐derived pancreatic tumour organoid implantation establishes novel pre‐cachexia mouse models

L. Dubois, R. V. van Dam, S. Rensen, 2022, JCSM Rapid Communications.

(Comex-'97)): a simulated ascent of Mount Everest Appetite at ''high altitude'' (Operation Everest III

M. Westerterp-Plantenga, K. Sunagawa, T. Ichiki, 2015 .

Effects of a nutritional intervention on impaired behavior and cognitive function in an emphysematous murine model of COPD with endotoxin-induced lung inflammation

A. Kraneveld, J. Garssen, M. Kelders, 2022, Frontiers in Nutrition.

TNF-α-induced NF-κB activation stimulates skeletal muscle glycolytic metabolism through activation of HIF-1α.

A. Schols, R. Langen, H. Gosker, 2015, Endocrinology.

PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle.

A. Russell, J. Voncken, P. Schrauwen, 2009, American journal of physiology. Endocrinology and metabolism.

Regulation of skeletal muscle plasticity by glycogen synthase kinase-3β: a potential target for the treatment of muscle wasting.

A. Schols, R. Langen, K. Verhees, 2013, Current pharmaceutical design.

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

A. Schols, R. Langen, K. Sanders, 2015, Journal of cachexia, sarcopenia and muscle.

Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium.

Y. Janssen-Heininger, N. Reynaert, M. Poynter, 2002, American journal of respiratory and critical care medicine.

Inflammatory Cytokines Inhibit Myogenic Differentiation through Activation of Nuclear Factor-␬b

E. Wouters, M. Kelders, A. Schols, 2022 .

The Modulatory Effects of Fatty Acids on Cancer Progression

L. Dubois, J. Theys, J. van Bergenhenegouwen, 2023, Biomedicines.

Regulation of mitochondrial biogenesis during myogenesis

P. Schrauwen, A. Schols, G. Schaart, 2010, Molecular and Cellular Endocrinology.

Inflammation and Skeletal Muscle Wasting During Cachexia

R. Langen, R. Hardy, J. Webster, 2020, Frontiers in Physiology.

Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology

H. Kerstjens, H. Baarsma, A. Schols, 2013, Respiratory Research.

University of Birmingham Inflammation and skeletal muscle wasting during cachexia

R. Langen, R. Hardy, J. Webster, 2020 .

Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models

A. Schols, J. Theys, Wouter van de Worp, 2020, Frontiers in Nutrition.

Decreased exercise-induced expression of nuclear factor-κB-regulated genes in muscle of patients with COPD.

E. Mercken, E. Wouters, G. Hageman, 2011, Chest.

Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia.

A. Dingemans, A. Schols, C. de Theije, 2013, The American journal of clinical nutrition.

Physical exercise at the crossroad between muscle wasting and the immune system: implications for lung cancer cachexia

D. de Ruysscher, A. Schols, Wouter van de Worp, 2022, Journal of cachexia, sarcopenia and muscle.

Tumor necrosis factor‐alpha inhibits myogenic differentiation through MyoD protein destabilization

E. Wouters, M. Kelders, A. Schols, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk

P. Olinga, S. Rensen, L. V. van Loon, 2021, Frontiers in Endocrinology.

Role of acute exacerbations in skeletal muscle impairment in COPD

S. Simons, R. Langen, H. Gosker, 2020, Expert review of respiratory medicine.

Exploring the Interface between Inflammatory and Therapeutic Glucocorticoid Induced Bone and Muscle Loss

R. Langen, R. Hardy, C. Fenton, 2019, International journal of molecular sciences.

TNF‐α impairs regulation of muscle oxidative phenotype: implications for cachexia?

M. Polkey, E. Wouters, P. Śliwiński, 2010 .

TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?

M. Polkey, E. Wouters, P. Śliwiński, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

diseaseexercise in chronic obstructive pulmonary Quadriceps metabolism during constant workrate

A. Russell, F. Maltais, M. Kelders, 2015 .

Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB.

E. Wouters, M. Kelders, Y. Janssen-Heininger, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

diaphragm: coexpression patterns and effect of COPD Developmental myosin heavy chains in the adult human

F. Maltais, S. Powers, J. Shrager, 2013 .

Nuclear transcription factor kB activation and protein turnover adaptations in skeletal muscle of patients with progressive stages

A. Dingemans, A. Schols, R. Langen, 2013 .

Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly

C. Jacobi, J. Ross, Alain Schilb, 2016, Aging.

Inflammatory signaling in skeletal muscle insulin resistance: green signal for nutritional intervention?

R. Mensink, A. Schols, J. Plat, 2010, Current opinion in clinical nutrition and metabolic care.

Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse

L. V. van Loon, L. Verdijk, A. Schols, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Muscle-specific GSK-3β ablation accelerates regeneration of disuse-atrophied skeletal muscle.

M. Kelders, A. Schols, C. de Theije, 2015, Biochimica et biophysica acta.

Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation.

E. Wouters, M. Kelders, A. Schols, 2006, American journal of physiology. Cell physiology.

Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression.

M. Polkey, P. Śliwiński, A. Schols, 2014, Biochimica et biophysica acta.

Distinct responses of protein turnover regulatory pathways in hypoxia- and semistarvation-induced muscle atrophy.

W. Lamers, A. Schols, C. de Theije, 2013, American journal of physiology. Lung cellular and molecular physiology.

Preserved muscle oxidative metabolic phenotype in newly diagnosed non-small cell lung cancer cachexia

A. Dingemans, A. Schols, S. Lagarde, 2015, Journal of cachexia, sarcopenia and muscle.

Inactivation of glycogen synthase kinase-3β (GSK-3β) enhances skeletal muscle oxidative metabolism.

A. Schols, R. Langen, H. Gosker, 2017, Biochimica et biophysica acta. Molecular basis of disease.

A novel orthotopic mouse model replicates human lung cancer cachexia

F. Verhaegen, A. Schols, J. Theys, 2023, Journal of cachexia, sarcopenia and muscle.

Deep Learning Based Automated Orthotopic Lung Tumor Segmentation in Whole-Body Mouse CT-Scans

F. Verhaegen, A. Schols, J. Theys, 2021, Cancers.

Regulation of PGC-1α expression by a GSK-3β-TFEB signaling axis in skeletal muscle.

A. Schols, R. Langen, H. Gosker, 2019, Biochimica et biophysica acta. Molecular cell research.

Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3β

M. Kelders, A. Schols, J. L. van der Velden, 2010, Cellular and Molecular Life Sciences.

Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy

C. D. Theije, W. Lamers, A. Schols, 2018, PloS one.

Human pancreatic tumour organoid‐derived factors enhance myogenic differentiation

S. Rensen, S. O. Olde Damink, R. Langen, 2022, Journal of cachexia, sarcopenia and muscle.

A novel in vitro model for the assessment of postnatal myonuclear accretion

L. V. van Loon, L. Verdijk, A. Schols, 2018, Skeletal Muscle.

An optimization and refinement of the whole‐gut transit assay in mice

W. Boesmans, V. Melotte, Saskia Seeldrayers, 2023, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Adenosine monophosphate-activated protein kinase is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice.

C. Henríquez-Olguín, S. Larsen, T. Jensen, 2023, Journal of cachexia, sarcopenia and muscle.

Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice

F. Verhaegen, M. Kelders, A. Schols, 2018, Scientific Reports.

Precision Medicine for More Oxygen (P4O2)—Study Design and First Results of the Long COVID-19 Extension

R. Vermeulen, P. Skipp, J. Charbonnier, 2023, Journal of personalized medicine.

Differential sensitivity of oxidative and glycolytic muscles to 1 hypoxia-induced muscle atrophy 2 3

C. D. Theije, W. Lamers, R. Langen, 2014 .

Angiotensin II is associated with activation of NF- B- mediated genes and downregulation of PPARs

S. Kihara, T. Funahashi, I. Shimomura, 2002 .

Unbiased analysis of skeletal muscle molecular responses upon pulmonary rehabilitation in advanced COPD

L. Verdijk, A. Schols, R. Haast, 2018, Rehabilitation and Chronic Care.