C. Seow

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A program for developing a comprehensive mathematical description of the crossbridge cycle of muscle.

A. Huxley, L. E. Ford, A F Huxley, 1994, Biophysical journal.

Mechanical properties of asthmatic airway smooth muscle

P. Paré, T. Hackett, Y. Bossé, 2011, European Respiratory Journal.

Exchange of ATP for ADP on high-force cross-bridges of skinned rabbit muscle fibers.

L. E. Ford, C. Seow, 1997, Biophysical journal.

effect of lung volume history Airway distensibility in healthy and asthmatic subjects

P. Paré, D. Johns, D. Sampson, 2015 .

Vitronectin Expression in the Airways of Subjects with Asthma and Chronic Obstructive Pulmonary Disease

P. Paré, T. Abraham, C. Seow, 2015, PloS one.

Mechanical Properties and Function of Airways Smooth Muscle

He Jiang, N. Stephens, C. Seow, 1994 .

Stress and strain in the contractile and cytoskeletal filaments of airway smooth muscle.

P. Paré, G. Maksym, Linhong Deng, 2009, Pulmonary pharmacology & therapeutics.

Mechanopharmacology and Synergistic Relaxation of Airway Smooth Muscle

P. Paré, P. Chitano, Lu Wang, 2019, Journal of engineering and science in medical diagnostics and therapy.

airway contraction in isolated bronchial segments Intraluminal pressure oscillation enhances subsequent

P. Paré, D. Sampson, K. Lutchen, 2015 .

Chronic activation in shortened airway smooth muscle: a synergistic combination underlying airway hyperresponsiveness?

P. Paré, Y. Bossé, C. Seow, 2010, American journal of respiratory cell and molecular biology.

Adaptation of airway smooth muscle to basal tone: relevance to airway hyperresponsiveness.

P. Paré, Y. Bossé, C. Seow, 2009, American journal of respiratory cell and molecular biology.

Airway Remodeling in Asthma: Tumor of the Airway?

S. V. van Eeden, C. Seow, 2013, Respiration.

A Role for the Hedgehog Effector Gli1 in Mediating Stent-induced Ureteral Smooth Muscle Dysfunction and Aperistalsis.

L. Fazli, D. Lange, W. Jäger, 2017, Urology.

deep inspiration and tidal oscillation Responsiveness of the human airway in vitro during

D. Sampson, J. Bates, A. Togias, 2015 .

Human airway smooth muscle is structurally and mechanically similar to that of other species

P. Paré, Y. Jiao, Y. Bossé, 2009, European Respiratory Journal.

The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics

P. Paré, J. Fredberg, M. Beckerle, 2017, PloS one.

Ultrastructure of human tracheal smooth muscle from subjects with asthma and nonasthmatic subjects. Standardized methods for comparison.

P. Paré, W. M. Elliott, T. Hackett, 2015, American journal of respiratory cell and molecular biology.

development in swine tracheal smooth muscle Effects of length oscillation on the subsequent force

P. Paré, D. Sampson, G. Donovan, 2015 .

smooth muscle to length oscillation Mechanisms for the mechanical response of airway

P. Paré, D. Sampson, J. Bates, 2015 .

its absence in asthma Potent bronchoprotective effect of deep inspiration and

P. Paré, D. Sampson, G. Donovan, 2015 .

Have we chased the wrong horse? and airway hyperresponsiveness in human asthma: Commentaries on Viewpoint: Airway smooth muscle

J. Bates, A. Togias, R. Pellegrino, 2015 .

Smooth muscle in the maintenance of increased airway resistance elicited by methacholine in humans.

P. Paré, C. Salome, C. Couture, 2014, American journal of respiratory and critical care medicine.

Commentaries on Viewpoint: Airway smooth muscle and airway hyperresponsiveness in human asthma: have we chased the wrong horse?

J. Bates, A. Togias, R. Pellegrino, 2014, Journal of applied physiology.

MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle

J. Fredberg, W. Gerthoffer, N. Dulin, 2010, European Respiratory Journal.

Airway narrowing associated with inhibition of deep inspiration during methacholine inhalation in asthmatics.

P. Paré, G. King, B. J. Moore, 2001, American journal of respiratory and critical care medicine.

Ontogeny of shortening velocity in porcine trachealis.

K. Ikeda, A. Leff, R. Mitchell, 1992, The American journal of physiology.

Changes in cross-bridge properties of sensitized airway smooth muscle.

N. Stephens, C. Seow, W. Kepron, 1986, Journal of applied physiology.

Passive stiffness of airway smooth muscle: the next target for improving airway distensibility and treatment for asthma?

C. Seow, 2013, Pulmonary pharmacology & therapeutics.

Selected contribution: effect of chronic passive length change on airway smooth muscle length-tension relationship.

P. Paré, Lu Wang, C. Seow, 2001, Journal of applied physiology.

recovery and adaptation in airway smooth muscle inspirations during tidal breathing attenuates force Length oscillation mimicking periodic individual deep

P. Paré, G. Donovan, A. Al-Jumaily, 2015 .

Length oscillation mimicking periodic individual deep inspirations during tidal breathing attenuates force recovery and adaptation in airway smooth muscle.

P. Paré, A. Raqeeb, C. Seow, 2010, Journal of applied physiology.

Phosphorylation of caldesmon by myosin light chain kinase increases its binding affinity for phosphorylated myosin filaments

B. Sarg, H. Lindner, A. Sobieszek, 2010, Biological chemistry.

Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility.

D. Meyerholz, R. Krishnan, M. Thompson, 2016, American journal of respiratory and critical care medicine.

airways of monkeys and rats using videomicrometry Methacholine responsiveness of proximal and distal

E. Fuchs, K. Pinkerton, S. Uhlig, 2015 .

Bronchodilatory effect of deep inspiration in freshly isolated sheep lungs.

P. Paré, Lu Wang, C. Seow, 2017, American journal of physiology. Lung cellular and molecular physiology.

Airway and parenchymal tissue resistance and elastance in ex vivo sheep lungs: Effects of bronchochallenge and deep inspiration.

P. Paré, D. Vasilescu, P. Chitano, 2022, American journal of physiology. Lung cellular and molecular physiology.

Upregulation of smooth muscle Rho-kinase protein expression in human asthma

P. Paré, P. Chitano, Lu Wang, 2019, European Respiratory Journal.

Gene expression in asthmatic airway smooth muscle: a mixed bag.

P. Paré, C. Seow, C. Pascoe, 2015, Canadian journal of physiology and pharmacology.

Myosin thick filament lability induced by mechanical strain in airway smooth muscle.

P. Paré, K. Kuo, L. E. Ford, 2001, Journal of applied physiology.

Mechanical properties of sensitized airway smooth muscle. Shortening capacity.

N. Stephens, C. Seow, S. Kong, 1991, The American review of respiratory disease.

Force-velocity curves for smooth muscle: analysis of internal factors reducing velocity.

N. Stephens, C. Seow, 1986, The American journal of physiology.

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.

P. Paré, J. Fredberg, S. Mijailovich, 2007, The European respiratory journal.

Mechanism of partial adaptation in airway smooth muscle after a step change in length.

P. Paré, C. Seow, Leslie Y. M. Chin, 2007, Journal of applied physiology.

Videomicrometry of lung slices: a glimpse of the dynamic airway–parenchyma interaction in emphysematous lungs

C. Seow, 2007, European Respiratory Journal.

responses of isolated airway segments from mature Comparison of elastic properties and contractile

P. Paré, J. Fredberg, S. Mijailovich, 2015 .

CFTR in Sarcoplasmic Reticulum of Airway Smooth Muscle: Implications for Airway Contractility

D. Meyerholz, R. Krishnan, M. Thompson, 2015 .

The importance of complete tissue homogenization for accurate stoichiometric measurement of myosin light chain phosphorylation in airway smooth muscle.

P. Paré, Lu Wang, C. Seow, 2015, Canadian journal of physiology and pharmacology.

Plasticity in smooth muscle, a hypothesis.

L. E. Ford, C. Seow, V. R. Pratusevich, 1994, Canadian journal of physiology and pharmacology.

Increased nonHDL cholesterol levels cause muscle wasting and ambulatory dysfunction in the mouse model of LGMD2B[S]

G. W. Payne, F. Rossi, P. Bernatchez, 2017, Journal of Lipid Research.

Relationship between myosin phosphorylation and contractile capability of canine airway smooth muscle.

R. Maass-Moreno, L. E. Ford, T. Burdyga, 2001, Journal of applied physiology.

Mechanopharmacology of Rho-kinase antagonism in airway smooth muscle and potential new therapy for asthma.

P. Chitano, Lu Wang, C. Seow, 2020, Pharmacological research.

p116Rip promotes myosin phosphatase activity in airway smooth muscle cells

M. Ikebe, S. Komatsu, Lu Wang, 2020, Journal of cellular physiology.

Structural and functional changes in the airway smooth muscle of asthmatic subjects.

R. Schellenberg, C. Seow, P. Paré, 1998, American journal of respiratory and critical care medicine.

On the terminology for describing the length-force relationship and its changes in airway smooth muscle.

Keith A. Jones, J. Fredberg, S. Mijailovich, 2004, Journal of applied physiology.

Ultrastructure of airway smooth muscle

K. Kuo, C. Seow, A. M. Herrera, 2003, Respiratory Physiology & Neurobiology.

saga of a frustrated cell Historical perspective on airway smooth muscle: the

Y. Bossé, J. Fredberg, Y. Jiao, 2015 .

Ultrastructural basis of airway smooth muscle contraction.

Peter D Paré, Chun Y Seow, C. Seow, 2007, Canadian journal of physiology and pharmacology.

Myosin filament assembly in an ever-changing myofilament lattice of smooth muscle.

Chun Y Seow, C. Seow, 2005, American journal of physiology. Cell physiology.

Models of contractile units and their assembly in smooth muscle.

C. Seow, F. Ali, P. Paré, 2005, Canadian journal of physiology and pharmacology.

Myosin light chain phosphorylation facilitates in vivo myosin filament reassembly after mechanical perturbation.

K. Kuo, L. E. Ford, T. Burdyga, 2002, American journal of physiology. Cell physiology.

highlighted topics Signal Transduction in Smooth Muscle Historical perspective on airway smooth muscle: the saga of a frustrated cell

J. Fredberg, C. Seow, C. Seow, 2022 .

Plasticity in canine airway smooth muscle

L. E. Ford, C. Seow, V. R. Pratusevich, 1995, The Journal of general physiology.

Filament evanescence of myosin II and smooth muscle function

P. Chitano, Lu Wang, C. Seow, 2021, The Journal of general physiology.

Purification of Myosin from Bovine Tracheal Smooth Muscle, Filament Formation and Endogenous Association of Its Regulatory Complex

A. Sobieszek, Lu Wang, C. Seow, 2023, Cells.

Smooth muscle function and myosin polymerization

M. Ikebe, P. Chitano, Lu Wang, 2017, Journal of Cell Science.

Reply from Chun Y. Seow

C. Seow, 2015, The Journal of physiology.

Myosin filaments in smooth muscle cells do not have a constant length

J. Rottler, Lu Wang, C. Seow, 2013, The Journal of physiology.

Physical Integrity of Smooth Muscle Myosin Filaments is Enhanced by Phosphorylation of the Regulatory Myosin Light Chain

Y. Jiao, A. Sobieszek, C. Seow, 2007, Cellular Physiology and Biochemistry.

Biophysics: Fashionable cells

C. Seow, 2005, Nature.

Force maintenance and myosin filament assembly regulated by Rho-kinase in airway smooth muscle.

G. Donovan, Linhong Deng, H. Syyong, 2015, American journal of physiology. Lung cellular and molecular physiology.

Structure-function correlation in airway smooth muscle adapted to different lengths.

K. Kuo, N. Stephens, L. E. Ford, 2003, American journal of physiology. Cell physiology.

Effects of length oscillation on the subsequent force development in swine tracheal smooth muscle.

C. Seow, L. Wang, P. Paré, 2000, Journal of applied physiology.

Length adaptation of airway smooth muscle.

A. Sobieszek, Y. Bossé, C. Seow, 2008, Proceedings of the American Thoracic Society.

Rho-kinase mediated cytoskeletal stiffness in skinned smooth muscle.

Linhong Deng, Lu Wang, C. Seow, 2013, Journal of applied physiology.

Emergence of airway smooth muscle functions related to structural malleability.

J. Fredberg, C. Seow, 2011, Journal of applied physiology.

`Sarcomeres' of smooth muscle: functional characteristics and ultrastructural evidence

C. Seow, A. M. Herrera, B. McParland, 2005, Journal of Cell Science.

Length‐dependent filament formation assessed from birefringence increases during activation of porcine tracheal muscle

L. E. Ford, Chun Y Seow, Alexander V Smolensky, 2005, The Journal of physiology.

Mathematical description of geometric and kinematic aspects of smooth muscle plasticity and some related morphometrics.

R. Lambert, C. Seow, P. Paré, 2004, Journal of applied physiology.

High ionic strength and low pH detain activated skinned rabbit skeletal muscle crossbridges in a low force state

L. E. Ford, C. Seow, 1993, The Journal of general physiology.

airway smooth muscle Series-to-parallel transition in the filament lattice of

B. Brook, A. Al-Jumaily, J. Speich, 2015 .

Series-to-parallel transition in the filament lattice of airway smooth muscle.

L. E. Ford, C. Seow, V. R. Pratusevich, 2000, Journal of applied physiology.

cutting-edge report Series-to-parallel transition in the filament lattice of airway smooth muscle

L. E. Ford, C. Seow, V. R. Pratusevich, 2000 .

Lung resistance and elastance are different in ex vivo sheep lungs ventilated by positive and negative pressures.

H. Coxson, D. Vasilescu, P. Chitano, 2022, American journal of physiology. Lung cellular and molecular physiology.

Gene expression analysis in asthma using a targeted multiplex array

M. Obeidat, T. Hackett, Stephanie M. Warner, 2017, BMC Pulmonary Medicine.

Airway Smooth Muscle and Related Extracellular Matrix in Normal and Asthmatic Lung

R. Schellenberg, C. Seow, 2009 .

Peripheral airway smooth muscle mechanics in obstructive airways disease.

A. O. Opazo Saez, C. Seow, P. Paré, 2000, American journal of respiratory and critical care medicine.

Point:Counterpoint Comments

Chun Y. Seow, C. Seow, 2007 .

human asthma: Have we chased the wrong horse? Commentaries on Viewpoint: Airway smooth muscle and airway hyperresponsiveness in

J. Bates, A. Togias, R. Pellegrino, 2015 .

Airway narrowing and internal structural constraints.

P D Paré, C Y Seow, L Wang, 2000, Journal of applied physiology.

Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and nonasthmatics.

G. Donovan, T. Hackett, C. Seow, 2017, American journal of physiology. Lung cellular and molecular physiology.

nonasthmatic subjects Deep inspirations protect against airway closure in

D. Sampson, G. Donovan, C. Salome, 2015 .

Adaptation to chronic length change in explanted airway smooth muscle.

Lu Wang, C. Seow, P. Paré, 2003, Journal of applied physiology.

Response of arterial smooth muscle to length perturbation.

C Y Seow, C. Seow, C. Seow, 2000, Journal of applied physiology.

The mechanics of exaggerated airway narrowing in asthma: the role of smooth muscle.

G. King, C. Seow, P. Paré, 1999, Respiration physiology.

Development and maintenance of force and stiffness in airway smooth muscle.

Linhong Deng, C. Seow, Brandon A. Norris, 2015, Canadian journal of physiology and pharmacology.

The biophysics and biochemistry of smooth muscle contraction.

A. Halayko, N. Stephens, C. Seow, 1992, Canadian journal of physiology and pharmacology.

Biophysical and biochemical properties of "asthmatic" airway smooth muscle.

N. Stephens, C. Seow, J. A. He, 1991, Advances in experimental medicine and biology.

hypertensiondysfunction during acute pulmonary Pulmonary artery smooth muscle activation attenuates

R. Armentano, J. Barra, D. Bia, 2012 .

to structural malleability Emergence of airway smooth muscle functions related

J. Fredberg, R. Pellegrino, B. Brook, 2015 .

Airway diameter at different transpulmonary pressures in ex vivo sheep lungs: Implications for deep-inspiration-induced bronchodilation and bronchoprotection.

H. Coxson, P. Chitano, Lu Wang, 2021, American journal of physiology. Lung cellular and molecular physiology.

Time course of increased airway narrowing caused by inhibition of deep inspiration during methacholine challenge.

G. King, B. J. Moore, C. Seow, 1999, American journal of respiratory and critical care medicine.

Mechanical alterations in sensitized canine saphenous vein.

N. Stephens, C. Seow, W. Kepron, 1990, Journal of applied physiology.

Changes of tracheal smooth muscle stiffness during an isotonic contraction.

N. Stephens, C. Seow, N. L. Stephens, 1989, The American journal of physiology.

Increase in passive stiffness at reduced airway smooth muscle length: potential impact on airway responsiveness.

Kevin Lian, Y. Bossé, C. Seow, 2010, American journal of physiology. Lung cellular and molecular physiology.

Molecular Events of the Crossbridge Cycle Reflected in the Force–Velocity Relationship of Activated Muscle

C. Seow, Kathryn N. Seow, 2022, Frontiers in Physiology.

Contribution of damped passive recoil to the measured shortening velocity of skinned rabbit and sheep muscle fibres

L. E. Ford, C. Seow, 1992, Journal of Muscle Research & Cell Motility.

Shortening velocity and power output of skinned muscle fibers from mammals having a 25,000-fold range of body mass

L. E. Ford, C. Seow, Chun Y. Seow, 1991, The Journal of general physiology.

soleus single muscle fibers when CTP replaces ATP Peak power output is maintained in rabbit psoas and rat

K. McDonald, G. Sieck, W. Zhan, 2015 .

immature rabbit lungs Comparison of the shear modulus of mature and

J. Bates, B. Wiggs, S. Gunst, 2015 .

The role of airway smooth muscle during an attack of asthma simulated in vitro.

C. Seow, B. McParland, Ross Tait, 2005, American journal of respiratory cell and molecular biology.

Effects of substituting uridine triphosphate for ATP on the crossbridge cycle of rabbit muscle

L. E. Ford, H. White, C. Seow, 2001, The Journal of physiology.

The Huxley crossbridge model as the basic mechanism for airway smooth muscle contraction.

P. Chitano, Lu Wang, C. Seow, 2019, American journal of physiology. Lung cellular and molecular physiology.

Are you pulling my airway?

C. Seow, 2005, European Respiratory Journal.

Structural basis for exaggerated airway narrowing.

C. Seow, B. McParland, P. Paré, 2007, Canadian journal of physiology and pharmacology.

Airway smooth muscle tone increases airway responsiveness in healthy young adults.

L. Boulet, C. Couture, G. King, 2017, American journal of physiology. Lung cellular and molecular physiology.

Adaptive response of pulmonary arterial smooth muscle to length change.

K. Kuo, H. Syyong, C. Seow, 2008, Journal of applied physiology.

Time course of isotonic shortening and the underlying contraction mechanism in airway smooth muscle.

H. Syyong, A. Raqeeb, C. Seow, 2011, Journal of applied physiology.

morphometricsof smooth muscle plasticity and some related Mathematical description of geometric and kinematic

S. Cairns, G. Sieck, A. Al-Jumaily, 2015 .

Hyperresponsiveness: Relating the Intact Airway to the Whole Lung.

K. Lutchen, C. Seow, P. Paré, 2017, Physiology.

Airway wall remodeling in asthma: From the epithelial layer to the adventitia

Y. Bossé, C. Seow, P. Paré, 2008, Current allergy and asthma reports.

Stress and strain in the contractile and cytoskeletal filaments of airway smooth muscle.

Nathan J. Brown, G. Maksym, Linhong Deng, 2009, Pulmonary pharmacology & therapeutics.

Detachment of low‐force bridges contributes to the rapid tension transients of skinned rabbit skeletal muscle fibres

S. Shroff, L. E. Ford, C. Seow, 1997, The Journal of physiology.

Myosin filaments in smooth muscle cells do not have a constant length

J. Rottler, Lu Wang, C. Seow, 2013, The Journal of physiology.

Adaptive response of pulmonary arterial smooth muscle to length change.

K. Kuo, H. Syyong, C. Seow, 2008, Journal of applied physiology.