J. M. Borghardt

发表

Inferring pulmonary exposure based on clinical PK data: accuracy and precision of model-based deconvolution methods

S. Wicha, Anneke Himstedt, J. M. Borghardt, 2021, Journal of Pharmacokinetics and Pharmacodynamics.

Evolution of a mini-scale biphasic dissolution model: Impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics.

C. Kloft, K. Wagner, K. Frank, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Evaluating prediction methods for glomerular filtration to optimise drug doses in obese and nonobese patients

W. Huisinga, N. El-Najjar, C. Kloft, 2021, British journal of clinical pharmacology.

Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes

C. Kloft, J. M. Borghardt, Ashish Sharma, 2018, Canadian respiratory journal.

An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds.

M. Jirstrand, M. Wallman, E. Martel, 2022, Journal of pharmacological and toxicological methods.

Towards a Quantitative Mechanistic Understanding of Localized Pulmonary Tissue Retention—A Combined In Vivo/In Silico Approach Based on Four Model Drugs

S. Wicha, Anneke Himstedt, J. M. Borghardt, 2020, Pharmaceutics.

Modeling energy intake and body weight effects of a long-acting amylin analogue

Wolfgang Rist, S. Scheuerer, J. M. Borghardt, 2018, Journal of Pharmacokinetics and Pharmacodynamics.

Pharmacometric Models for Characterizing the Pharmacokinetics of Orally Inhaled Drugs

C. Kloft, A. Staab, Benjamin Weber, 2015, The AAPS Journal.

Physiologically-based pharmacokinetic modeling after drug inhalation

P. Bäckman, Anneke Himstedt, J. M. Borghardt, 2021 .

Mechanistic study on hydrodynamics in the mini‐scale biphasic dissolution model and its influence on in vitro dissolution and partitioning

K. Wagner, K. Schaefer, J. M. Borghardt, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A novel mitochondrial complex I ROS inhibitor partially improves muscle regeneration in adult but not old mice

D. Marcinek, M. Franti, Ethan L. Ostrom, 2023, Redox biology.

Model-based evaluation of pulmonary pharmacokinetics in asthmatic and COPD patients after oral olodaterol inhalation.

Alexander Staab, Charlotte Kloft, Christina Kunz, 2016, British journal of clinical pharmacology.

Understanding the suitability of established antibiotics for oral inhalation from a pharmacokinetic perspective: an integrated model-based investigation based on rifampicin, ciprofloxacin and tigecycline in vivo data.

S. Wicha, Anneke Himstedt, J. M. Borghardt, 2022, The Journal of antimicrobial chemotherapy.

Towards holistic Compound Quality Scores (CQS): Extending ligand efficiency indices with compound pharmacokinetic (PK) characteristics.

C. Tautermann, J. M. Borghardt, Roland Pfau, 2023, Drug discovery today.

Extending ligand efficacy indices with compound pharmacokinetic characteristics towards holistic Compound Quality Scores

C. Tautermann, J. M. Borghardt, Roland Pfau, 2023, bioRxiv.

Investigating pulmonary and systemic pharmacokinetics of inhaled olodaterol in healthy volunteers using a population pharmacokinetic approach.

Alexander Staab, Charlotte Kloft, Christina Kunz, 2016, British journal of clinical pharmacology.

Multi-Task ADME/PK prediction at industrial scale: leveraging large and diverse experimentaldatasets.

J. M. Borghardt, Miha Škalič, Moritz Walter, 2024, Molecular informatics.

Barriers to global pharmacometrics: educational challenges and opportunities across the globe

B. Meibohm, C. Kloft, S. Hennig, 2023, CPT: pharmacometrics & systems pharmacology.