J. Guillon

发表

Synthesis and Initial Results for MAO-B Inhibition by New N-Propargyl-3-pyrrol-1-ylindanamine Derivatives, Analogues of Rasagiline

Patrick Dallemagne, Sylvain Rault, Vincent Lisowski, 2003, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and evaluation of the CNS activity of new 4-alkoxyphenylimidazolidin-2-ones.

S. Rault, M. Boulouard, O. Renault, 1998, Chemical & pharmaceutical bulletin.

Synthesis and preliminary behavioural evaluation in mice of new 3‐aryl‐3‐pyrrol‐1‐ylpropanamides, analogues of FGIN‐1–27 and FGIN‐1–43

S. Rault, M. Boulouard, C. Jarry, 2001, The Journal of pharmacy and pharmacology.

CD23 Mediates Antimycobacterial Activity of Human Macrophages

Tina Kauss, D. Malvy, M. Mamani-Matsuda, 2009, Infection and Immunity.

Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II

C. Jarry, D. Thiolat, S. Massip, 2010, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents

G. Gosmann, S. Gnoatto, S. Da Nascimento, 2008 .

Design, Synthesis, and Evaluation of 2,9‐Bis[(substituted‐aminomethyl)phenyl]‐1,10‐phenanthroline Derivatives as G‐Quadruplex Ligands

J. Mergny, R. Das, A. Bourdoncle, 2017, ChemMedChem.

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

Mathieu Marchivie, Joachim Jose, Jean Guillon, 2015, Drug design, development and therapy.

Synthesis of new 4-[2-(alkylamino)ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino)ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors

C. Jarry, C. Quentin, C. Arpin, 2007, Journal of enzyme inhibition and medicinal chemistry.

Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex

J. Mergny, R. Das, V. Desplat, 2017, Molecules.

Design, synthesis, and antiproliferative effect of 2,9‐bis[4‐(pyridinylalkylaminomethyl)phenyl]‐1,10‐phenanthroline derivatives on human leukemic cells by targeting G‐quadruplex

J. Mergny, F. Gouilleux, M. Viaud-Massuard, 2021, Archiv der Pharmazie.

Structure of N-(3,4-Dimethoxyphenyl)pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4-amine, a New Inhibitor of CLK1 and DYRK1A Kinases

M. Marchivie, T. Besson, N. Pinaud, 2013 .

Crystal Structure of 1-(3-Ferrocenyl-2-methylpyrrolo[1,2-a]quinoxalin-4-yl)piperazin-4-ium Chloride

M. Marchivie, P. Sonnet, N. Pinaud, 2021, X-ray Structure Analysis Online.

Absolute Configuration and Antimalarial Activity of erythro-Mefloquine Enantiomers.

C. Cézard, M. Marchivie, S. Da Nascimento, 2013, ChemPlusChem.

Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells

G. Kroemer, É. Darbo, J. Mergny, 2020, Cancers.

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

H. Munier-Lehmann, J. Mergny, B. Raynal, 2021, Nucleic acids research.

Synthesis of a novel class of non-peptide NK-2 receptor ligand, derived from 1-phenyl-3-pyrrol-1-ylindan-2-carboxamides.

S. Rault, J. Leger, C. Jarry, 2002, Bioorganic & medicinal chemistry.

Hemisynthesis and antiproliferative properties of mono-[O-(14-benzoylaconine-8-yl)]esters and bis-[O-(14-benzoylaconine-8-yl)]esters.

J. Leger, P. Costet, J. Mérillon, 2012, European journal of medicinal chemistry.

Design, synthesis, and antiprotozoal evaluation of new 2,9‐bis[(substituted‐aminomethyl)phenyl]‐1,10‐phenanthroline derivatives

J. Mergny, R. Das, N. Azas, 2018, Chemical biology & drug design.

8-O-Azeloyl-14-benzoylaconine: a new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities.

C. Absalon, J. Bosc, C. Jarry, 2005, Bioorganic & medicinal chemistry.

New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity--Part II.

G. Déléris, J. Leger, C. Jarry, 2011, European journal of medicinal chemistry.

Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.

B. Pradines, N. Azas, M. Marchivie, 2021, European journal of medicinal chemistry.

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

S. Moukha, J. Mergny, R. Das, 2020, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives

J. Mergny, R. Das, N. Azas, 2017, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and in vitro cytostatic activity of new β-d-arabino furan[1′,2′:4,5]oxazolo- and arabino-pyrimidinone derivatives

J. Balzarini, J. Leger, J. Bosc, 2009, European Journal of Medicinal Chemistry.

New arylhexahydropyrimidinediones: Synthesis, benzodiazepine receptor affinity and anticonvulsant activity

S. Rault, M. Boulouard, P. Dallemagne, 1996 .

Derivatization of (±)-5-[(2-Methylphenoxy)methyl]-2-amino-2-oxazoline, an Imidazoline Binding Sites Ligand, with (+)- (R) -α-Methylbenzyl Isocyanate for Drug Monitoring Purposes

M. Rettori, C. Chaimbault, J. Bosc, 2002, Journal of enzyme inhibition and medicinal chemistry.

Antispasmodic and antioxidant activities of fractions and bioactive constituent davidigenin isolated from Mascarenhasia arborescens.

N. Moore, L. Goossens, C. Rivière, 2010, Journal of ethnopharmacology.

Synthesis of novel 1,3,4-benzotriazepine derivatives from 4-oxo-3,1-benzoxazine and 3,1-benzothiazine-2-carbonitriles

R. Wrigglesworth, J. Leger, V. Thiéry, 2005 .

New synthesis of isopiperitenol, previously isolated from species of Cymbopogon

J. Guillon, M. Robba, J. Rioult, 2000 .

Efficient synthesis of novel pentacyclic 6,7-dihydro-5a,7a,13,14-tetraaza-pentaphene-5,8-diones

J. Leger, C. Jarry, V. Thiéry, 2005 .

New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity.

V. Sinou, D. Parzy, C. Jarry, 2008, Bioorganic & medicinal chemistry.

Synthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives

G. Déléris, C. Jarry, D. Thiolat, 2011, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

H. Gohlke, J. Delcros, C. Gertzen, 2015, Pharmaceuticals.

Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2.

Joachim Jose, Jean Guillon, A. di Pietro, 2015, Journal of medicinal chemistry.

Crystal Structure of 7-Amino-4-iodo-3-propyl-1H-isochromen-1-one

V. Lisowski, M. Marchivie, Luisa Ronga, 2016 .

Synthesis of New Pyrrolo[1,2-a]quinoxaline Derivatives as Potential Inhibitors of Akt Kinase

C. Jarry, D. Thiolat, S. Massip, 2008, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of Omeprazole Analogues and Evaluation of These as Potential Inhibitors of the Multidrug Efflux Pump NorA of Staphylococcus aureus

C. Jarry, C. Quentin, C. Arpin, 2006, Antimicrobial Agents and Chemotherapy.

Synthesis and Cesium Binding Affinity of New 25,27-Bis(alkyloxy)calix[4]arene-crown-6 Conformers in Relation to the Alkyl Pendent Moiety

J. Leger, J. Malval, J. Monti, 2002 .

First enantioselective synthesis of 4-aminoalcohol quinoline derivatives through a regioselective SN2 epoxide opening mechanism

J. Leger, P. Sonnet, A. Dassonville-Klimpt, 2011 .

Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents.

J. Leger, C. Jarry, M. Mamani-Matsuda, 2007, Bioorganic & medicinal chemistry.

Synthesis and PreliminaryIn Vitro Evaluation of Antimycobacterial Activity of New Pyrrolo[1,2-a]quinoxaline-carboxylic Acid Hydrazide Derivatives

R. Reynolds, J. Leger, C. Jarry, 2004, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of New 2‐(Aminomethyl)‐4‐phenylpyrrolo[1,2‐a]‐quinoxalines and their Preliminary In‐vivo Central Dopamine Antagonist Activity Evaluation in Mice

S. Rault, M. Boulouard, V. Lisowski, 2000, The Journal of pharmacy and pharmacology.

Synthesis of new pyrrolo(1,2-a)quinoxalines: potential non-peptide glucagon receptor antagonists

P. Renard, B. Pfeiffer, S. Rault, 1998 .

Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.

C. Sergheraert, J. Leger, C. Jarry, 2004, Journal of medicinal chemistry.

New aromatase inhibitors. Synthesis and biological activity of aryl-substituted pyrrolizine and indolizine derivatives.

J Guillon, S. Rault, S. Moslemi, 2000, Bioorganic & medicinal chemistry.

Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines.

F. Rossi, S. Routier, M. Marchivie, 2016, European journal of medicinal chemistry.

Synthesis and Anti-HSV-1 Activity of New 3-Amino-3-Arylpropionic Acid Esters

S. Rault, J. Boustie, P. Dallemagne, 1996 .

Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2.

J. Jose, M. Marchivie, N. Pinaud, 2013, European journal of medicinal chemistry.

Efficient Synthesis of Novel Pentacyclic 6,7‐Dihydro‐5a,7a,13,14‐tetraaza‐pentaphene‐5,8‐diones.

J. Leger, C. Jarry, V. Thiéry, 2005 .

Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents.

G. Gosmann, S. Gnoatto, P. Grellier, 2008, Bioorganic & medicinal chemistry.

Synthesis and rearrangement of cycloalkyl[1,2-e]oxazolo[3,2-a]pyrimidin-8/9-ones : an access to cycloalkyl[1,2-d]oxazolo[3,2-a]pyrimidin-5-ones

J. Leger, J. Bosc, C. Jarry, 2005 .

Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)]xanthines from 2-amino-2-oxazolines as potential A1 and A2A adenosine receptor antagonists.

C. Müller, J. Leger, J. Bosc, 2006, Bioorganic & medicinal chemistry.

Efficient one-pot microwave-assisted synthesis of 3-(thien-3-yl)imidazolidine-2,4-dione analogs

Jean Martínez, V. Lisowski, S. Massip, 2007 .

New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation

F. Gouilleux, Cécile Croix, M. Viaud-Massuard, 2021, Molecules.

Design, Synthesis and Antimalarial Activity of Some New Aminoalcoholpyrrolo[1,2-a]quinoxaline Derivatives

N. Azas, P. Sonnet, C. Mullié, 2016 .

Synthesis of new 6-(4-chlorophenyl)perhydro-1,3-diazepine-2,4-diones via ureidobutyric acids

S. Rault, M. Boulouard, P. Sonnet, 1998 .

Synthesis, Crystal Structure and Anti-leukemic Activity of 4-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-3-phenyl-3H-pyrrolo[2,3-c]quinoline

F. Rossi, M. Marchivie, N. Pinaud, 2018, Journal of Chemical Crystallography.

Synthesis and Antiproliferative Effect of Ethyl 4‐[4‐(4‐Substituted Piperidin‐1‐yl)]benzylpyrrolo[1,2‐a]quinoxalinecarboxylate Derivatives on Human Leukemia Cells

Pascal Sonnet, Sandra Rubio, Mathieu Marchivie, 2017, ChemMedChem.

Synthesis and Crystal Structure of 3-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzilimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole

F. Rossi, M. Marchivie, Luisa Ronga, 2016 .

Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents--part III.

P. Le Pape, S. Daulouède, P. Vincendeau, 2014, European journal of medicinal chemistry.

Crystal structure of [2]benzopyrano[3,4-b]quinoxalin-5-one through spontaneous air oxidation rearrangement of 6-Chloro-isoindolo[2,1-a]quinoxaline

G. Déléris, S. Massip, V. Desplat, 2012 .

Synthesis of new 4-(E)-alkenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents by Suzuki-Miyaura cross-coupling reactions

C. Jarry, D. Thiolat, S. Massip, 2007, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, Physicochemical Studies, Molecular Dynamics Simulations, and Metal-Ion-Dependent Antiproliferative and Antiangiogenic Properties of Cone ICL670-Substituted Calix[4]arenes.

P. Cieplak, C. Cézard, E. Guillon, 2012, ChemPlusChem.

Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes. Part II

G. Lescoat, J. Leger, C. Jarry, 2011, Journal of enzyme inhibition and medicinal chemistry.

Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes

G. Lescoat, J. Leger, F. Gaboriau, 2010, Journal of enzyme inhibition and medicinal chemistry.

First Synthesis of 1,3-Alternate 25,27-Dialkyloxy-5,17-diarylcalix[4]arenes-crown-6 as New Cesium Selective Extractants by Suzuki Cross-coupling Reaction

J. Leger, C. Jarry, S. Massip, 2004 .

Modulation of cell proliferation in rat liver cell cultures by new calix[4]arenes

G. Lescoat, C. Jarry, F. Gaboriau, 2006, Journal of enzyme inhibition and medicinal chemistry.

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

Antonella Accardo, Carlo Diaferia, Diego Tesauro, 2019, Molecules.

New Synthesis and Preparative Resolution of Nornomifensine, a Useful Precursor for Positron Emission Tomography Studies

S. Rault, R. Duval, P. Dallemagne, 1997 .

Synthesis of Cone, Partial-Cone, and 1,3-Alternate 25,27-Bis[1-(2-ethyl)hexyl]- and 25,27-Bis[1-(2-tert-butoxy)ethyl]calix[4]arene-crown-6 Conformers as Potential Selective Cesium Extractants.

J. Leger, C. Jarry, P. Sonnet, 2001 .

Crystal Structure of a Fluoro Analogue of 3,4-(Methylenedioxy)amphetamine

A. Benazzouz, M. Marchivie, N. Pinaud, 2015 .

Anti-leukemia Activity of 7-hydroxy-2-substituted-methyl-5 H -oxazolo[3,2- a] pyrimidin-5-one Derivatives

J. Leger, C. Jarry, M. Mamani-Matsuda, 2002, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

R. Abagyan, R. Hartmann, S. Yee, 2020, Pharmaceuticals.

MR 20492 and MR 20494: two indolizinone derivatives that strongly inhibit human aromatase

S. Rault, S. Moslemi, G. Séralini, 1999, The Journal of Steroid Biochemistry and Molecular Biology.

Efficient synthesis of 2-aryl-6-methyl-2,3-dihydro-1H-pyridin-4-ones

S. Rault, P. Dallemagne, J. Guillon, 2000 .

Synthesis of new piperazinyl-pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of Candida albicans multidrug transporters by a Buchwald–Hartwig cross-coupling reaction

A. di Pietro, R. Prasad, M. Marchivie, 2020, RSC advances.

An easy route to 2-substituted-2,3-dihydro-5(7)H-oxazolo[3,2-a]pyrimidin-5-ones and 7-ones starting from the corresponding 2-amino-2-oxazolines

J. Leger, C. Jarry, I. Forfar, 2001 .

1H and 13C NMR assignments of bioactive indeno[1,2‐b]indole‐10‐one derivatives

J. Jose, N. Pinaud, M. Le Borgne, 2013, Magnetic resonance in chemistry : MRC.

G-quadruplexes in helminth parasites

J. Keiser, M. Fojta, Natália Bohálová, 2022, Nucleic acids research.

Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux

S. Moukha, J. Mergny, N. Azas, 2022, Pathogens.

Synthesis of new pyrrolo[1,2-a]quinoxaline derivatives as potential inhibitors of Akt kinase.

C. Jarry, D. Thiolat, S. Massip, 2008, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, Crystal Structure and Anti-Leukemic Activity

M. Marchivie, N. Pinaud, V. Desplat, 2020 .

First synthesis of segetalins B and G: two cyclopentapeptides with estrogen-like activity

J. Rochette, P. Sonnet, N. Franceschini, 2003 .

1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole

V. Desplat, J. Guillon, Solène Savrimoutou, 2018, Molbank.

Synthesis and CNS Activity of New 3-Amino-3-arylpropionic Acid Derivatives

S. Rault, M. Boulouard, O. Renault, 1999 .

Crystal structure and identification of a pyrimido[6,1-b][1,3]oxazin-6-one derivative from the reaction of acrolein with 5-(phenoxymethyl)-2-amino-2-oxazoline

M. Marchivie, P. Sonnet, F. Hallé, 2018, Comptes Rendus Chimie.

Antitumor activity of semisynthetic derivatives of Aconitum alkaloids

P. Costet, L. Lartigue, J. Bosc, 2014, Investigational New Drugs.

Design and synthesis of a new type of non steroidal human aromatase inhibitors.

J Guillon, S. Moslemi, G. Séralini, 1998, Bioorganic & medicinal chemistry letters.

First synthesis of segetalin A and analogous cyclohexapeptides

J. Rochette, P. Sonnet, J. Brion, 2001 .

SYNTHESIS OF NEW PHENYLPYRROLIZINONES VIA A MANNICH REACTION

S. Rault, P. Sonnet, P. Dallemagne, 1999 .

Basis of a FTIR spectroscopy methodology for automated evaluation of Akt kinase inhibitor on leukemic cell lines used as model

G. Déléris, Adrian Travo, V. Desplat, 2012, Analytical and Bioanalytical Chemistry.

Enantiopure substituted pyridines as promising antimalarial drug candidates

M. Marchivie, P. Sonnet, C. Mullié, 2020 .

Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[ 1,2-a]quinoxalines.

N. Azas, P. Sonnet, C. Mullié, 2017, Medicinal chemistry.

Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles.

S. Costantini, L. Portella, S. Scala, 2015, Molecular bioSystems.

Synthesis, Crystal Structure and Anti-Leukemic Activity of (E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

V. Baylot, N. Pinaud, V. Desplat, 2023, Molbank.

Synthesis, Crystal Structure and Anti-Leukemic Activity of 1,3-Dihydro-1-{1-[4-(4-phenylpyrrolo[1,2-a]quinoxalin-3-yl)benzyl]piperidin-4-yl}-2H-benzimidazol-2-one

N. Pinaud, V. Desplat, J. Guillon, 2022, Molbank.

1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity

M. Marchivie, N. Pinaud, V. Desplat, 2020, Molbank.

Diminished oligomerization in the synthesis of new anti‐angiogenic cyclic peptide using solution instead of solid‐phase cyclization

F. Rossi, J. Clarhaut, S. Papot, 2016, Biopolymers.

Structural elucidation of two photolytic degradation products of tetrabenazine.

H. Fessi, N. Pinaud, N. Cartiser, 2014, Journal of pharmaceutical and biomedical analysis.

Conformational Ensembles Explored Dynamically from Disordered Peptides Targeting Chemokine Receptor CXCR4

S. Costantini, L. Portella, S. Scala, 2015, International journal of molecular sciences.

First Synthesis of 1-Phenyl-3-pyrrol-1-ylindan-2-carboxylic Acid, a New Scaffold of Potential Non-peptide Endothelin Receptor Antagonists

S. Rault, P. Dallemagne, J. Guillon, 1999 .

New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity.

V. Sinou, D. Parzy, C. Jarry, 2008, Bioorganic & medicinal chemistry.