T. Leal

发表

Identification and frequencies of cystic fibrosis mutations in central Argentina.

V. Bours, M. Wagener, X. Pepermans, 2016, Clinical biochemistry.

Impact of polymorphism of Multidrug Resistance-associated Protein 1 (ABCC1) gene on the severity of cystic fibrosis.

P. Lebecque, K. Dahan, A. Mafficini, 2011, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice

P. Lebecque, E. Marbaix, P. Wallemacq, 2010, European Respiratory Journal.

Ataluren (PTC124) Induces CFTR Protein Expression and Activity in Children with Nonsense Mutation Cystic Fibrosis

F. Vermeulen, I. Sermet-Gaudelus, T. Ajayi, 2010 .

Effects of azithromycin on glutathione S-transferases in cystic fibrosis airway cells.

B. Assael, P. Melotti, A. Corti, 2009, American journal of respiratory cell and molecular biology.

PEGylation, an approach for improving the pulmonary delivery of biopharmaceuticals

R. Vanbever, T. Leal, Marie-Julie Guichard, 2017 .

Airway delivery of low-dose miglustat normalizes nasal potential difference in F508del cystic fibrosis mice.

P. Lebecque, R. Vanbever, P. Wallemacq, 2009, American journal of respiratory and critical care medicine.

Azithromycin Attenuates Pseudomonas-Induced Lung Inflammation by Targeting Bacterial Proteins Secreted in the Cultured Medium

P. Melotti, P. Mauri, F. Huaux, 2016, Front. Immunol..

Mycobacterium xenopi and Squamous Cell Carcinoma of the Lung

G. Reychler, T. Leal, N. Audag, 2018 .

A 5.3Mb deletion in chromosome 18q12.3 as the smallest region of overlap in two patients with expressive speech delay.

L. Vallée, J. Andrieux, B. Delobel, 2011, European journal of medical genetics.

Inflammation biomarkers in sputum for clinical trials in cystic fibrosis: current understanding and gaps in knowledge.

P. Burgel, L. Dupont, I. Sermet-Gaudelus, 2021, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Ataluren (PTC124) induces cystic fibrosis transmembrane conductance regulator protein expression and activity in children with nonsense mutation cystic fibrosis.

F. Vermeulen, I. Sermet-Gaudelus, T. Ajayi, 2010, American journal of respiratory and critical care medicine.

Azithromycin fails to reduce increased expression of neutrophil-related cytokines in primary-cultured epithelial cells from cystic fibrosis mice.

P. Lebecque, D. Lison, E. Marbaix, 2009, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Influence of Tracheostomy on Lung Deposition in Spontaneously Breathing Patients.

G. Liistro, H. Reychler, L. Pitance, 2016, Journal of aerosol medicine and pulmonary drug delivery.

HLA-G expression and regulation during Pseudomonas aeruginosa infection in cystic fibrosis patients.

R. Rizzo, L. Melchiorri, B. Assael, 2016, Future microbiology.

Delivery efficacy of a vibrating mesh nebulizer and a jet nebulizer under different configurations.

G. Liistro, H. Reychler, L. Pitance, 2010, Journal of aerosol medicine and pulmonary drug delivery.

Effect of continuous positive airway pressure combined to nebulization on lung deposition measured by urinary excretion of amikacin.

G. Liistro, J. Roeseler, F. Thys, 2007, Respiratory medicine.

Aerosol delivery to the lung is more efficient using an extension with a standard jet nebulizer than an open-vent jet nebulizer.

P. Diot, G. Liistro, H. Reychler, 2013, Journal of aerosol medicine and pulmonary drug delivery.

Influence of pancreatic status and sex on polyunsaturated fatty acid profiles in cystic fibrosis.

P. Lebecque, P. Wallemacq, T. Coste, 2008, Clinical chemistry.

PEGylation of Recombinant Human Deoxyribonuclease I Provides a Long‐Acting Version of the Mucolytic for Patients with Cystic Fibrosis

E. Marbaix, K. Vanvarenberg, R. Vanbever, 2020 .

CFTR biomarkers: time for promotion to surrogate end-point

M. Amaral, N. Derichs, M. Proesmans, 2012, European Respiratory Journal.

In Vitro and In Vivo Comparison of Two Nebulizers Used for Inhaled Pentamidine Delivery.

G. Liistro, G. Reychler, T. Leal, 2017, Archivos de bronconeumologia.

Lung immunoglobulin A immunity dysregulation in cystic fibrosis

S. Verleden, P. Burgel, C. Bouzin, 2020, EBioMedicine.

Sweat Proteomics in Cystic Fibrosis: Discovering Companion Biomarkers for Precision Medicine and Therapeutic Development

D. Baiwir, G. Mazzucchelli, G. Eppe, 2022, Cells.

Impact of MIF Gene Promoter Polymorphism on F508del Cystic Fibrosis Patients

P. Lebecque, A. Mafficini, B. Assael, 2014, PloS one.

A randomized placebo-controlled trial of miglustat in cystic fibrosis based on nasal potential difference.

P. Lebecque, J. Dingemanse, T. Leal, 2012, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Comparative Variability of Nasal Potential Difference Measurements in Human and Mice

P. Lebecque, P. Wallemacq, T. Leal, 2012 .

Early referral to cystic fibrosis specialist centre impacts on respiratory outcome.

P. Lebecque, F. De Baets, K. Desager, 2009, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

A specific database for providing local and national level of integration of clinical data in cystic fibrosis.

P. Lebecque, J. Gigi, P. Mailleux, 2007, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Towards zero prevalence of chronic Pseudomonas aeruginosa infection in children with cystic fibrosis.

P. Lebecque, X. Bossuyt, G. Reychler, 2006, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice.

E. Marbaix, F. Huaux, P. Wallemacq, 2012, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Congenital tracheal malformation in cystic fibrosis transmembrane conductance regulator‐deficient mice

J. Bernaudin, A. Clément, E. Bonvin, 2008, The Journal of physiology.

In vitro evaluation of efficacy of 5 methods of disinfection on mouthpieces and facemasks contaminated by strains of cystic fibrosis patients.

P. Lebecque, J. Gigi, G. Reychler, 2005, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Emerging Roles of microRNAs in Cystic Fibrosis — From Pathogenesis to Development of New Therapies

T. Leal, Sabrina Noël, 2015 .

SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation1

V. Villella, V. Raia, L. Maiuri, 2009, The Journal of Immunology.

ABPA in adulthood: a CFTR-related disorder

P. Lebecque, E. Marchand, X. Pepermans, 2010, Thorax.

Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent’s disease

F. Jouret, O. Devuyst, Sara Terryn, 2011, Pflügers Archiv - European Journal of Physiology.

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

P. Lebecque, D. Lison, E. Marbaix, 2013, PloS one.

Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency.

M. Bolomini-Vittori, A. Montresor, B. Rossi, 2016, American journal of respiratory and critical care medicine.

Impact of PEGylation on the mucolytic activity of recombinant human deoxyribonuclease I in cystic fibrosis sputum.

P. Lebecque, F. Vermeulen, R. Vanbever, 2018, Clinical science.

Needle-free iontophoresis-driven β-adrenergic sweat rate test.

P. Lebecque, F. Vermeulen, A. Mottais, 2021, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Vardenafil reduces macrophage pro-inflammatory overresponses in cystic fibrosis through PDE5- and CFTR-dependent mechanisms.

F. Huaux, Nadtha Panin, S. Noel, 2017, Clinical science.

This information is current as Inflammation Link between Oxidative Stress and SUMOylation of Tissue Transglutaminase as

V. Villella, V. Raia, L. Maiuri, 2009 .

and ciliated epithelium Ion transport across CF and normal murine olfactory

Seiko F. Okada, P. Lebecque, L. Ostrowski, 2011 .

Biological variability of the sweat chloride in diagnostic sweat tests: A retrospective analysis.

P. Lebecque, F. Vermeulen, K. De Boeck, 2016, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Sweat potassium concentration may help to identify falsification of sweat test: a case report.

P. Lebecque, P. Wallemacq, T. Leal, 2008, Clinical biochemistry.

Exophiala (Wangiella) dermatitidis and cystic fibrosis - Prevalence and risk factors.

P. Lebecque, F. Symoens, G. Reychler, 2010, Medical mycology.

Exophiala (Wangiella) dermatitidis and cystic fi brosis – Prevalence and risk factors , prevalence , selective media ,

P. Lebecque, F. Symoens, T. Leal, 2010 .

Clinical and Morphological Characteristics of Sporadic Genetically Determined Pancreatitis as Compared to Idiopathic Pancreatitis: Higher Risk of Pancreatic Cancer in CFTR Variants

B. Weynand, A. Geubel, A. Jouret-Mourin, 2013, Digestion.

Basic protocol for transepithelial nasal potential difference measurements.

Michael R Knowles, Jean Lebacq, Patrick Lebecque, 2004, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Cystic fibrosis: insight into CFTR pathophysiology and pharmacotherapy.

S. Noel, T. Leal, B. Lubamba, 2012, Clinical biochemistry.

PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis

S. Noel, T. Leal, B. Dhooghe, 2012, Front. Pharmacol..

Pharmacological Potential of PDE5 Inhibitors for the Treatment of Cystic Fibrosis

T. Leal, B. Lubamba, Sabrina Noël, 2012 .

Pharmacological Potential of PDE 5 Inhibitors for the Treatment of Cystic Fibrosis

T. Leal, B. Lubamba, Sabrina Noël, 2012 .

Correction of Chloride Transport and Mislocalization of CFTR Protein by Vardenafil in the Gastrointestinal Tract of Cystic Fibrosis Mice

C. Bouzin, T. Leal, Sabrina Noël, 2013, PloS one.

Array-CGH detection of a de novo 0.8Mb deletion in 19q13.32 associated with mental retardation, cardiac malformation, cleft lip and palate, hearing loss and multiple dysmorphic features.

J. Andrieux, B. Delobel, S. Bouquillon, 2009, European journal of medical genetics.

Lung inflammation in cystic fibrosis: pathogenesis and novel therapies.

F. Huaux, T. Leal, Sabrina Noël, 2014, Clinical biochemistry.

On the Corner of Models and Cure: Gene Editing in Cystic Fibrosis

M. Ensinck, M. Carlon, A. Mottais, 2021, Frontiers in Pharmacology.

Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells

A. Mottais, C. Bouzin, E. Hermans, 2020, Biology Open.

Resveratrol increases F508del-CFTR dependent salivary secretion in cystic fibrosis mice

A. Capron, P. Wallemacq, S. Noel, 2015, Biology Open.

An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis.

P. Lebecque, M. Armand, P. Wallemacq, 2007, Clinical biochemistry.

Cystic fibrosis is associated with a defect in apical receptor-mediated endocytosis in mouse and human kidney.

P. Lebecque, P. Courtoy, C. Hermans, 2007, Journal of the American Society of Nephrology : JASN.

Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population

T. Leal, L. Higa, M. V. M. Peixoto, 2015, Journal of clinical medicine research.

Mutations of the cystic fibrosis gene and intermediate sweat chloride levels in children.

P. Lebecque, J. Cassiman, H. Cuppens, 2002, American journal of respiratory and critical care medicine.

Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives

S. Noel, T. Leal, Jérémy Haaf, 2016, Clinical pharmacology : advances and applications.

Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid.

P. Lebecque, M. Armand, P. Wallemacq, 2009, The Journal of nutrition.

Azithromycin reduces spontaneous and induced inflammation in ΔF508 cystic fibrosis mice

P. Lebecque, D. Lison, E. Marbaix, 2006, Respiratory research.

Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis.

P. Lebecque, D. Lison, B. Scholte, 2009, American journal of respiratory cell and molecular biology.

Production and characterization of a PEGylated derivative of recombinant human deoxyribonuclease I for cystic fibrosis therapy.

R. Vanbever, R. Wattiez, Harshad P. Patil, 2017, International journal of pharmaceutics.

Strategies in early clinical development for the treatment of basic defects of cystic fibrosis

S. Noel, T. Leal, B. Dhooghe, 2016, Expert opinion on investigational drugs.

Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis.

P. Lebecque, P. Wallemacq, J. Lebacq, 2008, American journal of respiratory and critical care medicine.

Nasal potential difference measurements in diagnosis of cystic fibrosis: an international survey.

B. Tümmler, N. Derichs, M. Ballmann, 2014, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

41 Corrector effect of resveratrol on refractory adrenergic pathway in saliva secretion of cystic fibrosis mice

P. Lebecque, P. Wallemacq, T. Leal, 2012 .

63 Resveratrol improves chloride secretion in cystic fibrosis mice homozygous for the F508del mutation

P. Lebecque, P. Wallemacq, T. Leal, 2011 .

BIO010967 929..936

A. Capron, P. Wallemacq, S. Noel, 2015 .

Vancomycin Penetration of Uninfected Pleural Fluid Exudate after Continuous or Intermittent Infusion

B. Byl, F. Jacobs, J. Thys, 2003, Antimicrobial Agents and Chemotherapy.

Characterization of the Human Eccrine Sweat Proteome—A Focus on the Biological Variability of Individual Sweat Protein Profiles

D. Baiwir, G. Mazzucchelli, G. Eppe, 2021, International journal of molecular sciences.

Nasal potential difference in suspected cystic fibrosis patients with 5T polymorphism.

N. Derichs, P. Melotti, K. De Boeck, 2020, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Evaluation of eluforsen, a novel RNA oligonucleotide for restoration of CFTR function in in vitro and murine models of p.Phe508del cystic fibrosis

T. Ritsema, W. Beumer, Patricia Biasutto, 2019, PloS one.

Vardenafil increases intracellular accumulation of the most prevalent mutant CFTR in human bronchial epithelial cells.

A. Mottais, C. Bouzin, E. Hermans, 2020, Biology open.

Miglustat effects on the basal nasal potential differences in cystic fibrosis.

P. Lebecque, J. Dingemanse, T. Leal, 2013, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Airway ion transport impacts on disease presentation and severity in cystic fibrosis.

P. Lebecque, J. Dall'ava, I. Fajac, 2008, Clinical biochemistry.

[Mucoviscidosis: CFTR mutation-specific therapy: a ray of sunshine in a cloudy sky].

P. Lebecque, T. Leal, A. Leonard, 2013, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

Modified Method to Measure Nasal Potential Difference

P. Lebecque, P. Wallemacq, J. Lebacq, 2003, Clinical chemistry and laboratory medicine.

Correction: SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation

V. Villella, V. Raia, L. Maiuri, 2014, Journal of Immunology.

SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation1

V. Villella, V. Raia, L. Maiuri, 2009, Journal of Immunology.

Early referral to cystic fibrosis specialist centre impacts on respiratory outcome.

P. Lebecque, A. Malfroot, T. Leal, 2009, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

P. Lebecque, D. Lison, E. Marbaix, 2013, PloS one.

Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice.

E. Marbaix, F. Huaux, P. Wallemacq, 2012, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Ratiometric sweat secretion optical test in cystic fibrosis, carriers and healthy subjects.

S. Ceri, F. Bianchi, B. Assael, 2017, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Influence of perfusate temperature on nasal potential difference

F. Vermeulen, P. Melotti, K. De Boeck, 2012, European Respiratory Journal.