K. Sugahara

发表

Enzymatic determination of urinary aspartylglycosylamine: a rapid and sensitive-method to detect aspartylclycosylaminuria (AGU).

P. Aula, K. Nishimura, K. Sugahara, 1976, Clinica chimica acta; international journal of clinical chemistry.

Characterization of a mannose‐containing glycoasparagine isolated from urine of a patient with aspartylglycosylaminuria (AGU)

P. Aula, K. Sugahara, I. Yamashina, 1976, FEBS letters.

Occurrence of a nonsulfated chondroitin proteoglycan in the dried saliva of Collocalia swiftlets (edible bird's-nest).

Su-Chen Li, Yu-Teh Li, K. Maskos, 2007, Glycobiology.

Structural studies on sulfated oligosaccharides derived from the carbohydrate-protein linkage region of chondroitin 6-sulfate proteoglycans of shark cartilage. I. Six compounds containing 0 or 1 sulfate and/or phosphate residues.

P. de Waard, J. Vliegenthart, K. Sugahara, 1992, The Journal of biological chemistry.

Structural Characterization of Heparan Sulfate and Chondroitin Sulfate of Syndecan-1 Purified from Normal Murine Mammary Gland Epithelial Cells

M. Bernfield, M. Zako, S. Yamada, 2001, The Journal of Biological Chemistry.

Determination of the Glycosaminoglycan-Protein Linkage Region Oligosaccharide Structures of Proteoglycans from Drosophila melanogaster and Caenorhabditis elegans *

Y. Hirabayashi, I. van Die, S. Yamada, 2002, The Journal of Biological Chemistry.

Heparin and Heparan Sulfate Biosynthesis

H. Kitagawa, K. Sugahara, 2002, IUBMB life.

Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Embryonic Pig Brain, Which Contain a Higher Proportion of L-Iduronic Acid than Those from Adult Pig Brain, Exhibit Neuritogenic and Growth Factor Binding Activities*

Nobuyuki Itoh, Shuhei Yamada, N. Itoh, 2004, Journal of Biological Chemistry.

Instructions for use Title Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity ofchondroitin sulfate from ray fish cartilage

Toshikazu Nakamura, Duriya Fongmoon, Shuji Mizumoto, 2017 .

Novel chondroitin sulfate oligosaccharide motifs as biomarkers: insights into their involvement in brain development.

K. Sugahara, 2015, Advances in experimental medicine and biology.

Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E Motifs in Rodent Brains*

J. Fawcett, L. Hsieh‐Wilson, E. Ehlert, 2013, The Journal of Biological Chemistry.

Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: insights into the sugar sequences with bioactivities.

P. Kongtawelert, Shuji Mizumoto, S. Yamada, 2013, Glycobiology.

Rodent Brains MotifsNets via Chondroitin Sulfate Type E Semaphorin 3 A Binds to the Perineuronal Glycobiology and Extracellular Matrices :

Linda, J. Fawcett, Arie, 2013 .

Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome.

A. Janecke, T. Müller, J. Zschocke, 2013, Human molecular genetics.

Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines

Duriya Fongmoon, Shuji Mizumoto, K. Sugahara, 2012, Glycoconjugate Journal.

ISCSM2011 chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis.

Shuji Mizumoto, K. Sugahara, 2012, Advances in experimental medicine and biology.

Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain.

A. Malmström, Shuji Mizumoto, S. Yamada, 2011, Glycobiology.

Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage.

Toshikazu Nakamura, Duriya Fongmoon, Shuji Mizumoto, 2011, Biochimica et biophysica acta.

Analysis of the structure and neuritogenic activity of chondroitin sulfate/dermatan sulfate hybrid chains from porcine fetal membranes

Shuji Mizumoto, S. Yamada, K. Sugahara, 2009, Glycoconjugate Journal.

Structural and functional changes of sulfated glycosaminoglycans in Xenopus laevis during embryogenesis.

M. Asashima, Reiko Fujinawa, Y. Tadokoro, 2009, Glycobiology.

Determination of iduronic acid and glucuronic acid in sulfated chondroitin/dermatan hybrid chains by 1H-nuclear magnetic resonance spectroscopy

Basappa, Fuchuan Li, S. Yamada, 2008, Glycoconjugate Journal.

Chondroitin/dermatan sulfate in the central nervous system.

T. Mikami, K. Sugahara, 2007, Current opinion in structural biology.

Structural determination of novel sulfated octasaccharides isolated from chondroitin sulfate of shark cartilage and their application for characterizing monoclonal antibody epitopes.

S. Yamada, K. Sugahara, S. S. Deepa, 2007, Glycobiology.

Glycosaminoglycans in Hydra magnipapillata (Hydrozoa, Cnidaria): demonstration of chondroitin in the developing nematocyst, the sting organelle, and structural characterization of glycosaminoglycans.

T. Fujisawa, S. Yamada, K. Sugahara, 2007, Glycobiology.

Functions of Chondroitin Sulfate/Dermatan Sulfate Chains in Brain Development

H. Kitagawa, A. Purushothaman, T. V. van Kuppevelt, 2007, Journal of Biological Chemistry.

Role of the sulfation pattern of chondroitin sulfate in its biological activities and in the binding of growth factors.

C. Nandini, K. Sugahara, 2006, Advances in pharmacology.

Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains in the Development of Cerebellum

Junko Fukuda, Shuji Mizumoto, T. Mikami, 2006, Journal of Biological Chemistry.

Demonstration of the Pleiotrophin-binding Oligosaccharide Sequences Isolated from Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains of Embryonic Pig Brains*

T. Muramatsu, K. Sugahara, Xingfeng Bao, 2005, Journal of Biological Chemistry.

Structural characterization of the epitopes of the monoclonal antibodies 473HD, CS-56, and MO-225 specific for chondroitin sulfate D-type using the oligosaccharide library.

A. Faissner, T. Mikami, K. Sugahara, 2005, Glycobiology.

The Engelbreth-Holm-Swarm mouse tumor produces undersulfated heparan sulfate and oversulfated galactosaminoglycans.

Y. Okumura, K. Sugahara, I. Yamashina, 1989, Biochemical and biophysical research communications.

A novel sulfated structure in the carbohydrate-protein linkage region isolated from porcine intestinal heparin.

K. Yoshida, P. de Waard, J. Vliegenthart, 1992, The Journal of biological chemistry.

Structural studies on the chondroitinase ABC-resistant sulfated tetrasaccharides isolated from various chondroitin sulfate isomers.

N. Fujii, M. Masuda, K. Sugahara, 1994, Carbohydrate research.

Structural Studies on the Hexasaccharide Alditols Isolated from the Carbohydrate-Protein Linkage Region of Dermatan Sulfate Proteoglycans of Bovine Aorta

K. Yoshida, Y. Ohkita, K. Sugahara, 1995, The Journal of Biological Chemistry.

Developmental Regulation of the Sulfation Profile of Chondroitin Sulfate Chains in the Chicken Embryo Brain*

H. Kitagawa, K. Sugahara, K. Tsutsumi, 1997, The Journal of Biological Chemistry.

Novel Tetrasaccharides Isolated from Squid Cartilage Chondroitin Sulfate E Contain Unusual Sulfated Disaccharide Units GlcA(3-O-sulfate)β1–3GalNAc(6-O-sulfate) or GlcA(3-O-sulfate)β1–3GalNAc(4,6-O-disulfate)*

A. Dell, H. Morris, S. Haslam, 1997, The Journal of Biological Chemistry.

Neuronal Cell Adhesion, Mediated by the Heparin-binding Neuroregulatory Factor Midkine, Is Specifically Inhibited by Chondroitin Sulfate E

T. Muramatsu, K. Sugahara, Issei Okazaki, 2000, The Journal of Biological Chemistry.

Structure and Function of Oversulfated Chondroitin Sulfate Variants

S. Yamada, K. Sugahara, 2000 .

Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans.

H. Kitagawa, K. Sugahara, 2000, Current opinion in structural biology.

Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate.

H. Kitagawa, T. Uyama, T. Mikami, 2003, Current opinion in structural biology.

A functional dermatan sulfate epitope containing iduronate(2-O-sulfate)alpha1-3GalNAc(6-O-sulfate) disaccharide in the mouse brain: demonstration using a novel monoclonal antibody raised against dermatan sulfate of ascidian Ascidia nigra.

Kazuyuki Sugahara, Xingfeng Bao, Mauro S G Pavão, 2005, The Journal of biological chemistry.

Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [→4IdoA(2-Sulfate)β-1→3GalNAc(4-Sulfate)β-1→] motifs in dermatan sulfate on heparin cofactor II activity

T. Lotufo, K. Sugahara, E. O. Kozlowski, 2011, BMC Biochemistry.

Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas

A. Malmström, L. Massuger, A. Purushothaman, 2009, Histochemistry and Cell Biology.

Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding.

F. Sweep, R. Stan, L. Massuger, 2007, The American journal of pathology.

Appican, the Proteoglycan Form of the Amyloid Precursor Protein, Contains Chondroitin Sulfate E in the Repeating Disaccharide Region and 4-O-Sulfated Galactose in the Linkage Region*

J. Shioi, N. Robakis, S. Yamada, 2001, The Journal of Biological Chemistry.

Heparin-binding Growth Factor, Pleiotrophin, Mediates Neuritogenic Activity of Embryonic Pig Brain-derived Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains*

T. Muramatsu, A. Faissner, S. Yamada, 2005, Journal of Biological Chemistry.

Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation

J. Fawcett, T. V. van Kuppevelt, L. M. Camargo, 2008, The European journal of neuroscience.

Overexpression of Galnt3 in Chondrocytes Resulted in Dwarfism Due to the Increase of Mucin-type O-Glycans and Reduction of Glycosaminoglycans*

K. Yamana, C. Yoshida, H. Komori, 2014, The Journal of Biological Chemistry.

Handbook of Glycosyltransferases and Related Genes

Gerald W. Hart, Naoyuki Taniguchi, Hisashi Narimatsu, 2014, Springer Japan.

Molecular Characterization of Xenopus Embryo Heparan Sulfate

Y. Hirabayashi, K. Shiokawa, S. Furuya, 1998, The Journal of Biological Chemistry.

Elimination of heparan sulfate by heparitinases induces abnormal mesodermal and neural formation in Xenopus embryos

Y. Hirabayashi, K. Shiokawa, S. Furuya, 1995, Development, growth & differentiation.

Chondroitinase-mediated Degradation of Rare 3-O-Sulfated Glucuronic Acid in Functional Oversulfated Chondroitin Sulfate K and E*

Basappa, P. Kongtawelert, Duriya Fongmoon, 2007, Journal of Biological Chemistry.

Glycosaminoglycans are functional ligands for receptor for advanced glycation end‐products in tumors

Shuji Mizumoto, K. Sugahara, 2013, The FEBS journal.

A Universal Molecular Stent Method to Toughen any Hydrogels Based on Double Network Concept

T. Kurokawa, Tasuku Nakajima, J. Gong, 2012 .

9 Biosynthetic Pathways for Differential Expression of Functional Chondroitin Sulfate and Heparan Sulfate

H. Kitagawa, T. Uyama, Shuji Mizumoto, 2005 .

Investigation of Action Pattern of a Novel Chondroitin Sulfate/Dermatan Sulfate 4-O-Endosulfatase.

J. Neira, R. Daniel, Fuchuan Li, 2020, The Biochemical journal.

Specific accumulation of tumor-derived adhesion factor in tumor blood vessels and in capillary tube-like structures of cultured vascular endothelial cells.

Kazuyuki Sugahara, Y. Nagashima, H. Yasumitsu, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Shiro Ikegawa and Kazuyuki Enzymes for Sulfated Glycosaminoglycans Mutations in Genes Encoding Biosynthetic Human Genetic Disorders

S. Ikegawa, Shuji Mizumoto, K. Sugahara, 2013 .

Shuji Mizumoto , Shiro Ikegawa and Kazuyuki Sugahara Enzymes for Sulfated Glycosaminoglycans Human Genetic Disorders Caused by Mutations in Genes Encoding Biosynthetic

S. Ikegawa, Shuji Mizumoto, K. Sugahara, 2013 .

Human Genetic Disorders Caused by Mutations in Genes Encoding Biosynthetic Enzymes for Sulfated Glycosaminoglycans*

S. Ikegawa, Shuji Mizumoto, K. Sugahara, 2013, The Journal of Biological Chemistry.

Structural studies on sulfated oligosaccharides derived from the carbohydrate-protein linkage region of chondroitin sulfate proteoglycans of whale cartilage.

P. de Waard, J. Vliegenthart, K. Sugahara, 1991, European journal of biochemistry.

N-Acetylgalactosamine (GalNAc) Transfer to the Common Carbohydrate-Protein Linkage Region of Sulfated Glycosaminoglycans

H. Kitagawa, U. Lindahl, K. Sugahara, 1995, The Journal of Biological Chemistry.

Human Genetic Disorders and Knockout Mice Deficient in Glycosaminoglycan

Shuji Mizumoto, S. Yamada, K. Sugahara, 2014, BioMed research international.

Identification of Amino Acid Residues Required for the Substrate Specificity of Human and Mouse Chondroitin Sulfate Hydrolase (Conventional Hyaluronidase-4)*

Shuji Mizumoto, S. Yamada, K. Sugahara, 2012, The Journal of Biological Chemistry.

Evolution of glycosaminoglycans

S. Özbek, S. Yamada, K. Sugahara, 2011, Communicative & integrative biology.

Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.

Shuji Mizumoto, S. Yamada, K. Sugahara, 2010, Glycobiology.

Isolation and characterization of a novel chondroitin sulfate from squid liver integument rich in N-acetylgalactosamine(4,6-disulfate) and glucuronate(3-sulfate) residues.

Shuji Mizumoto, S. Yamada, K. Sugahara, 2009, Carbohydrate research.

Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish.

H. Kitagawa, Hajime Yamauchi, N. Itoh, 2009, The Biochemical journal.

Identification of Chondroitin Sulfate Glucuronyltransferase as Chondroitin Synthase-3 Involved in Chondroitin Polymerization

H. Kitagawa, K. Sugahara, J. Tamura, 2008, Journal of Biological Chemistry.

Chondroitin 4-O-Sulfotransferase-1 Regulates E Disaccharide Expression of Chondroitin Sulfate Required for Herpes Simplex Virus Infectivity*

H. Kitagawa, T. Bergström, T. Uyama, 2006, Journal of Biological Chemistry.

Embryonic Fibroblasts with a Gene Trap Mutation in Ext1 Produce Short Heparan Sulfate Chains*

W. Skarnes, M. Busse, S. Yamada, 2004, Journal of Biological Chemistry.

Molecular Cloning and Expression of Glucuronyltransferase I Involved in the Biosynthesis of the Glycosaminoglycan-Protein Linkage Region of Proteoglycans*

H. Kitagawa, T. Ogawa, S. Oka, 1998, The Journal of Biological Chemistry.

The phosphorylated and/or sulfated structure of the carbohydrate-protein-linkage region isolated from chondroitin sulfate in the hybrid proteoglycans of Engelbreth-Holm-Swarm mouse tumor.

Y. Okumura, K. Sugahara, N. Mizuno, 1992, European journal of biochemistry.

Demonstration of the Immature Glycosaminoglycan Tetrasaccharide Sequence GlcAβ1–3Galβ1–3Galβ1–4Xyl on Recombinant Soluble Human α-Thrombomodulin

H. Kitagawa, K. Sugahara, S. Nadanaka, 1998, The Journal of Biological Chemistry.

The Tumor Suppressor EXT-like Gene EXTL2 Encodes an α1, 4-N-Acetylhexosaminyltransferase That TransfersN-Acetylgalactosamine and N-Acetylglucosamine to the Common Glycosaminoglycan-Protein Linkage Region

H. Kitagawa, K. Sugahara, H. Shimakawa, 1999, The Journal of Biological Chemistry.

Chondroitinase ABC-resistant sulfated trisaccharides isolated from digests of chondroitin/dermatan sulfate chains.

K. Khoo, A. Dell, H. Morris, 1994, Carbohydrate research.

Identification and characterization of a novel UDP-GalNAc:GlcAβ-R α1,4-N-acetylgalactosaminyltransferase from a human sarcoma cell line

H. Kitagawa, H. Okabe, K. Sugahara, 1999 .

Insight into the role of chondroitin sulfate E in angiogenesis

N. Karamanos, E. Papadimitriou, K. Sugahara, 2019, The FEBS journal.

Structural determination of novel tetra- and hexasaccharide sequences isolated from chondroitin sulfate H (oversulfated dermatan sulfate) of hagfish notochord

K. Khoo, N. Seno, K. Sugahara, 1999, Glycoconjugate Journal.

Demonstration of a novel sulfotransferase in fetal bovine serum, which transfers sulfate to the C6 position of the GalNAc residue in the sequence iduronic acidα1‐3GalNAcβ1‐4iduronic acid in dermatan sulfate

K. Sugahara, M. Fujita, S. Nadanaka, 1999, FEBS letters.

Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate.

H. Kitagawa, T. Uyama, K. Sugahara, 2002, The Journal of biological chemistry.

Molecular Cloning and Expression of a Human Chondroitin Synthase*

H. Kitagawa, T. Uyama, K. Sugahara, 2001, The Journal of Biological Chemistry.

Identification and Characterization of Three Drosophila melanogaster Glucuronyltransferases Responsible for the Synthesis of the Conserved Glycosaminoglycan-Protein Linkage Region of Proteoglycans

H. Kitagawa, M. Bernfield, J. Lincecum, 2003, The Journal of Biological Chemistry.

Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor.

H. Kitagawa, T. Uyama, K. Sugahara, 2007, The Biochemical journal.

Sequencing of chondroitin sulfate oligosaccharides using a novel exolyase from a marine bacterium that degrades hyaluronan and chondroitin sulfate/dermatan sulfate.

Wenjun Han, Fuchuan Li, K. Sugahara, 2017, The Biochemical journal.

Cloning and Characterization of a Novel Chondroitin Sulfate/Dermatan Sulfate 4-O-Endosulfatase from a Marine Bacterium*

Wenjun Han, Fuchuan Li, K. Sugahara, 2015, The Journal of Biological Chemistry.

Heparan Sulfate Polymerization in Drosophila*

H. Kitagawa, K. Sugahara, Tomomi Izumikawa, 2006, Journal of Biological Chemistry.

Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan‐protein linkage region of proteoglycans

H. Kitagawa, S. Oka, T. Kawasaki, 1999, FEBS letters.

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.

A. Purushothaman, R. Sanderson, T. Uyama, 2010, Blood.

Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype

Laurie A. Smith, Neil A. Miller, N. Miller, 2016, BMC Medical Genetics.

Microanalysis of glycosaminoglycan-derived disaccharides labeled with the fluorophore 2-aminoacridone by capillary electrophoresis and high-performance liquid chromatography.

H. Kitagawa, K. Sugahara, A. Kinoshita, 1995, Analytical biochemistry.

Structural studies of octasaccharides derived from the low-sulfated repeating disaccharide region and octasaccharide serines derived from the protein linkage region of porcine intestinal heparin.

K. Yoshida, K. Sakamoto, S. Yamada, 1999, Biochemistry.

Structural determination of five novel tetrasaccharides containing 3-O-sulfated D-glucuronic acid and two rare oligosaccharides containing a beta-D-glucose branch isolated from squid cartilage chondroitin sulfate E.

K. Khoo, A. Dell, H. Morris, 2004, Biochemistry.

Isolation and structural determination of novel sulfated hexasaccharides from squid cartilage chondroitin sulfate E that exhibits neuroregulatory activities.

A. Dell, H. Morris, S. Haslam, 2001, Biochemistry.

Chondroitin Sulfate Characterized by the E-disaccharide Unit Is a Potent Inhibitor of Herpes Simplex Virus Infectivity and Provides the Virus Binding Sites on gro2C Cells*

H. Kitagawa, T. Bergström, T. Uyama, 2005, Journal of Biological Chemistry.

Oversulfated chondroitin/dermatan sulfates containing GlcAbeta1/IdoAalpha1-3GalNAc(4,6-O-disulfate) interact with L- and P-selectin and chemokines.

M. Miyasaka, J. Hirose, S. Yamada, 2002, The Journal of biological chemistry.

Hyaluronidases Have Strong Hydrolytic Activity toward Chondroitin 4-Sulfate Comparable to that for Hyaluronan

Shuji Mizumoto, S. Yamada, K. Sugahara, 2012, Biomolecules.

Spondyloepiphyseal dysplasia, Omani type: Further definition of the phenotype

S. Robertson, H. Meijers-Heijboer, M. B. Tan-Sindhunata, 2008, American journal of medical genetics. Part A.

Clinical and Radiographic Features of the Autosomal Recessive form of Brachyolmia Caused by PAPSS2 Mutations

H. Kayserili, N. Elçioglu, H. Ohashi, 2013, Human mutation.

Identification of cell‐binding site of angiomodulin (AGM/TAF/Mac25) that interacts with heparan sulfates on cell surface

S. Hasegawa, H. Yasumitsu, K. Miyazaki, 1999, Journal of cellular biochemistry.

Fundamental biomaterial properties of tough glycosaminoglycan-containing double network hydrogels newly developed using the molecular stent method.

T. Kurokawa, T. Nonoyama, J. Gong, 2016, Acta biomaterialia.

Vascular abnormalities in the placenta of Chst14−/− fetuses: implications in the pathophysiology of perinatal lethality of the murine model and vascular lesions in human CHST14/D4ST1 deficiency

S. Takeda, J. Nakayama, Kiyoshi Matsumoto, 2018, Glycobiology.

Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders

T. Kosho, Shuji Mizumoto, S. Yamada, 2017, Pharmaceuticals.

Mutations in Biosynthetic Enzymes for the Protein Linker Region of Chondroitin/Dermatan/Heparan Sulfate Cause Skeletal and Skin Dysplasias

Shuji Mizumoto, S. Yamada, K. Sugahara, 2015, BioMed research international.

promotes endothelial invasion and angiogenesis Heparanase-enhanced shedding of syndecan-1 by myeloma cells

A. Purushothaman, R. Sanderson, T. Uyama, 2011 .

Chondroitin Sulfate N‐acetylgalactosaminyltransferase‐1 (CSGalNAcT‐1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity

A. Janecke, S. Ikegawa, T. Müller, 2017, Human mutation.

Molecular Cloning of a Chondroitin Polymerizing Factor That Cooperates with Chondroitin Synthase for Chondroitin Polymerization*

H. Kitagawa, T. Uyama, K. Sugahara, 2003, Journal of Biological Chemistry.

Molecular Cloning and Expression of a Novel Chondroitin 6-O-Sulfotransferase*

H. Kitagawa, K. Sugahara, M. Fujita, 2000, The Journal of Biological Chemistry.

Heparin interaction with a receptor on hyperglycemic dividing cells prevents intracellular hyaluronan synthesis and autophagy responses in models of type 1 diabetes.

U. Desai, V. Hascall, D. Templeton, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Structural studies on sulfated glycopeptides from the carbohydrate-protein linkage region of chondroitin 4-sulfate proteoglycans of swarm rat chondrosarcoma. Demonstration of the structure Gal(4-O-sulfate)beta 1-3Gal beta 1-4XYL beta 1-O-Ser.

P. de Waard, J. Vliegenthart, H. van Halbeek, 1988, The Journal of biological chemistry.

J. Vliegenthart, H. Halbeek, P. Waard, 1988 .

Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins.

Shuji Mizumoto, S. Yamada, K. Sugahara, 2015, Current opinion in structural biology.

Structure Determination of the Octa- and Decasaccharide Sequences Isolated from the Carbohydrate-Protein Linkage Region of Porcine Intestinal Heparin (*)

K. Yoshida, J. Vliegenthart, T. de Beer, 1995, The Journal of Biological Chemistry.

Phase 1 Clinical Study of siRNA Targeting Carbohydrate Sulphotransferase 15 in Crohn’s Disease Patients with Active Mucosal Lesions

Kenji Suzuki, M. Neurath, Hiroki Sato, 2017, Journal of Crohn's & colitis.

Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis

Kenji Suzuki, M. Neurath, Hiroki Sato, 2016, PloS one.

Involvement of Human Natural Killer-1 (HNK-1) Sulfotransferase in the Biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl Tetrasaccharide Found in α-Thrombomodulin from Human Urine*

Shuji Mizumoto, S. Yamada, K. Sugahara, 2011, The Journal of Biological Chemistry.

Sulfation of the Galactose Residues in the Glycosaminoglycan-Protein Linkage Region by Recombinant Human Chondroitin 6-O-Sulfotransferase-1*

H. Kitagawa, K. Sugahara, K. Tsutsumi, 2008, Journal of Biological Chemistry.

Loss‐of‐function mutations of CHST14 in a new type of Ehlers‐Danlos syndrome

Y. Fukushima, N. Matsumoto, M. Shiina, 2010, Human mutation.

Functional expression and genomic structure of human chondroitin 6‐sulfotransferase 1

H. Kitagawa, K. Sugahara, K. Tsutsumi, 1998 .

Isolation of reducing oligosaccharide chains from the chondroitin/dermatan sulfate-protein linkage region and preparation of analytical probes by fluorescent labeling with 2-aminobenzamide.

M. Watanabe, S. Yamada, K. Sugahara, 2001, Journal of biochemistry.

Characterization of serum beta-glucuronyltransferase involved in chondroitin sulfate biosynthesis.

H. Kitagawa, T. Ogawa, K. Sugahara, 1997, Glycobiology.

Defect in dermatan sulfate in urine of patients with Ehlers-Danlos syndrome caused by a CHST14/D4ST1 deficiency.

N. Miyake, N. Okamoto, T. Kosho, 2017, Clinical biochemistry.

A response to: Loss of dermatan‐4‐sulfotransferase 1 (D4ST1/CHST14) function represents the first dermatan sulfate biosynthesis defect, “dermatan sulfate‐deficient Adducted Thumb–Clubfoot Syndrome”. Which name is appropriate, “Adducted Thumb–Clubfoot Syndrome” or “Ehlers–Danlos syndrome”?

Y. Fukushima, N. Matsumoto, N. Miyake, 2011, Human mutation.

Structural variations in the glycosaminoglycan-protein linkage region of recombinant decorin expressed in Chinese hamster ovary cells.

H. Kitagawa, Y. Yamaguchi, M. Oyama, 1997, Glycobiology.

A Non-sulfated Chondroitin Stabilizes Membrane Tubulation in Cnidarian Organelles*

Takashi Gojobori, Shuhei Yamada, T. Gojobori, 2010, The Journal of Biological Chemistry.

Identification of a Novel Chondroitin Hydrolase in Caenorhabditis elegans*

S. Mitani, Shuji Mizumoto, S. Yamada, 2008, Journal of Biological Chemistry.

Synthesis of the glycosaminoglycan-protein linkage tetraosyl peptide moieties of betaglycan, which serve as a hexosamine acceptor for enzymatic glycosyl transfer.

Shuji Mizumoto, K. Sugahara, J. Tamura, 2010, Carbohydrate research.

α4- N -Acetylhexosaminyltransferase (EXTL2)

H. Kitagawa, K. Sugahara, 2002 .

Developmental Changes in Serum UDP-GlcA:Chondroitin Glucuronyltransferase Activity (*)

H. Kitagawa, K. Sugahara, Miho Ujikawa, 1996, The Journal of Biological Chemistry.

Polydispersity in sulfation profile of oligosaccharide alditols isolated from the protein-linkage region and the repeating disaccharide region of chondroitin 4-sulfate of bovine nasal septal cartilage.

J. Vliegenthart, T. de Beer, K. Sugahara, 1996, European journal of biochemistry.

Structural analysis of unsaturated hexasaccharides isolated from shark cartilage chondroitin sulfate D that are substrates for the exolytic action of chondroitin ABC lyase.

K. Sugahara, K. Takeda, S. Nadanaka, 1996, European journal of biochemistry.

The uniform galactose 4-sulfate structure in the carbohydrate-protein linkage region of human urinary trypsin inhibitor.

M. Oyama, K. Kato, Y. Yuki, 1995, European journal of biochemistry.

Novel tetrasaccharides isolated from squid cartilage chondroitin sulfate E contain unusual sulfated disaccharide units GlcA(3-O-sulfate)beta1-3GalNAc(6-O-sulfate) or GlcA(3-O-sulfate)beta1-3GalNAc.

A. Dell, H. Morris, S. Haslam, 1997, The Journal of biological chemistry.

GAG Glucuronyltransferase-I

H. Kitagawa, K. Sugahara, 2002 .

Marine Bacteria as a Rich Source of Glycosaminoglycan‐degrading Enzymes

Qingdong Zhang, Fuchuan Li, J. Guan, 2020 .

Regulation of chondroitin sulfate biosynthesis by specific sulfation: acceptor specificity of serum beta-GalNAc transferase revealed by structurally defined oligosaccharides.

H. Kitagawa, K. Sugahara, J. Tamura, 1997, Glycobiology.

Developmental changes in glycosaminoglycan sulfotransferase activities in animal sera.

M. Nakamura, S. Shibamoto, K. Sugahara, 1987, Archives of biochemistry and biophysics.

Glycosaminoglycan chain analysis and characterization (glycosylation/epimerization).

Shuji Mizumoto, K. Sugahara, 2012, Methods in molecular biology.

Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage

P. Kongtawelert, Duriya Fongmoon, J. Jacquinet, 2010, Glycoconjugate Journal.

Structure of Oligosaccharides Isolated from Heparan Sulfate/Heparin and Substrate Specificities of the Degrading Enzymes of Bacterial Origin

S. Yamada, K. Sugahara, 1998 .

Structural Recognition by Recombinant Human Heparanase That Plays Critical Roles in Tumor Metastasis

M. Nakajima, S. Yamada, K. Sugahara, 2002, The Journal of Biological Chemistry.

Structural Requirements of Heparan Sulfate for the Binding to the Tumor-derived Adhesion Factor/Angiomodulin That Induces Cord-like Structures to ECV-304 Human Carcinoma Cells*

K. Miyazaki, S. Yamada, K. Sugahara, 2000, The Journal of Biological Chemistry.

Preparation of oligosaccharides from sulfated glycosaminoglycans using bacterial enzymes.

S. Yamada, K. Sugahara, 2003, Methods in molecular biology.

Characterization of heparinase from an oral bacterium Prevotella heparinolytica.

M. Watanabe, S. Yamada, K. Sugahara, 1998, Journal of biochemistry.

Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection.

Eunmi Kim, H. Sawa, Takashi Kimura, 2011, Biochemical and biophysical research communications.

Purification and characterization of fetal bovine serum beta-N-acetyl-D-galactosaminyltransferase and beta-D-glucuronyltransferase involved in chondroitin sulfate biosynthesis.

H. Kitagawa, U. Lindahl, T. Lind, 1999, European journal of biochemistry.

Involvement of the core protein in the first beta-N-acetylgalactosamine transfer to the glycosaminoglycan-protein linkage-region tetrasaccharide and in the subsequent polymerization: the critical determining step for chondroitin sulphate biosynthesis.

H. Kitagawa, K. Sugahara, J. Tamura, 1999, The Biochemical journal.

Conversion of N-sulfated glucosamine to N-sulfated mannosamine in an unsaturated heparin disaccharide by non-enzymatic, base-catalyzed C-2 epimerization during enzymatic oligosaccharide preparation.

M. Watanabe, S. Yamada, K. Sugahara, 1998, Carbohydrate research.

A Major Common Trisulfated Hexasaccharide Core Sequence, Hexuronic Acid(2-Sulfate)-Glucosamine(N-Sulfate)-Iduronic Acid-N-Acetylglucosamine-Glucuronic Acid-Glucosamine(N-Sulfate), Isolated from the Low Sulfated Irregular Region of Porcine Intestinal Heparin*

K. Yoshida, S. Yamada, Y. Yamane, 1998, The Journal of Biological Chemistry.

Structures of Five Sulfated Hexasaccharides Prepared from Porcine Intestinal Heparin Using Bacterial Heparinase

J. Hopwood, S. Yamada, K. Sugahara, 1996, The Journal of Biological Chemistry.

Isolation of the porcine heparin tetrasaccharides with glucuronate 2-O-sulfate. Heparinase cleaves glucuronate 2-O-sulfate-containing disaccharides in highly sulfated blocks in heparin.

K. Yoshida, T. Murakami, S. Yamada, 1995, The Journal of biological chemistry.

Structural studies on the oligosaccharides isolated from bovine kidney heparan sulphate and characterization of bacterial heparitinases used as substrates.

K. Khoo, A. Dell, H. Morris, 1994, Glycobiology.

Structural studies on the tri- and tetrasaccharides isolated from porcine intestinal heparin and characterization of heparinase/heparitinases using them as substrates.

K. Khoo, A. Dell, H. Morris, 1994, Glycobiology.

Structural studies on the bacterial lyase-resistant tetrasaccharides derived from the antithrombin III-binding site of porcine intestinal heparin.

K. Khoo, A. Dell, H. Morris, 1993, The Journal of biological chemistry.

One- and two-dimensional 1H-NMR characterization of two series of sulfated disaccharides prepared from chondroitin sulfate and heparan sulfate/heparin by bacterial eliminase digestion.

K. Yoshida, S. Yamada, K. Sugahara, 1992, Journal of biochemistry.

Pseudodiastrophic dysplasia expands the known phenotypic spectrum of defects in proteoglycan biosynthesis

H. Scott, A. Schreiber, C. Barnett, 2020, Journal of Medical Genetics.

Anti-tumor and anti-angiogenic activity of novel hydantoin derivatives: Inhibition of VEGF secretion in liver metastatic osteosarcoma cells.

Basappa, K. Rangappa, C. Ananda Kumar, 2009, Bioorganic & medicinal chemistry.

Specific Molecular Interactions of Oversulfated Chondroitin Sulfate E with Various Heparin-binding Growth Factors

Nobuyuki Itoh, S. Higashiyama, N. Itoh, 2002, The Journal of Biological Chemistry.

Novel Sulfated Oligosaccharides Containing 3-O-Sulfated Glucuronic Acid from King Crab Cartilage Chondroitin Sulfate K

H. Kitagawa, A. Dell, H. Morris, 1996, The Journal of Biological Chemistry.

Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement.

S. Mundlos, H. Kitagawa, M. Sakano, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Biodiversity of CS-proteoglycan sulphation motifs: chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis.

J. Melrose, B. Farrugia, B. Caterson, 2018, The Biochemical journal.

Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells.

Basappa, Shuhei Yamada, K. Sugahara, 2009, Glycobiology.

Involvement of Highly Sulfated Chondroitin Sulfate in the Metastasis of the Lewis Lung Carcinoma Cells*

Fuchuan Li, T. V. van Kuppevelt, G. T. ten Dam, 2008, Journal of Biological Chemistry.

Raised serum chondroitin sulfate epitope level in ovarian epithelial cancer.

T. Hardingham, P. Kongtawelert, Jitwadee Supabandhu, 2006, Journal of biochemistry.

Heparan/Chondroitin Sulfate Biosynthesis

T. Darden, H. Kitagawa, L. Pedersen, 2000, The Journal of Biological Chemistry.

Purification of -mannosidase from a snail, Achatina fulica, and its action on glycopeptides.

T. Okumura, K. Sugahara, I. Yamashina, 1972, Biochimica et biophysica acta.

Paper disk assay for glycosaminoglycan sulfotransferases.

T. Ishii, K. Sugahara, I. Yamashina, 1987, Analytical biochemistry.

Nematode Chondroitin Polymerizing Factor Showing Cell-/Organ-specific Expression Is Indispensable for Chondroitin Synthesis and Embryonic Cell Division*

H. Kitagawa, K. Gengyo-Ando, S. Mitani, 2004, Journal of Biological Chemistry.

Structural studies on sulfated oligosaccharides derived from the carbohydrate-protein linkage region of chondroitin 6-sulfate proteoglycans of shark cartilage. II. Seven compounds containing 2 or 3 sulfate residues.

P. de Waard, J. Vliegenthart, K. Sugahara, 1992, The Journal of biological chemistry.

Recognition of glycosaminoglycans by midkine.

T. Muramatsu, Kazuyuki Sugahara, Takashi Muramatsu, 2003, Methods in enzymology.

Chondroitin Sulfate Chains on Syndecan-1 and Syndecan-4 from Normal Murine Mammary Gland Epithelial Cells Are Structurally and Functionally Distinct and Cooperate with Heparan Sulfate Chains to Bind Growth Factors

Shuhei Yamada, O. Goldberger, Kazuyuki Sugahara, 2004, Journal of Biological Chemistry.

Characterization of one neutral and two acidic glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU).

S. Funakoshi, K. Sugahara, I. Yamashina, 1976, Journal of biochemistry.

Glycosaminoglycan modification of neuropilin‐1 modulates VEGFR2 signaling

M. Hori, Y. Liao, S. Takashima, 2006, The EMBO journal.

Structural studies of glycoasparagines from urine of a patient with aspartylglycosylaminuria (AGU)

P. Aula, K. Sugahara, I. Yamashina, 1977, FEBS letters.

Recent Advances in the Structural Study of Functional Chondroitin Sulfate and Dermatan Sulfate in Health and Disease

Kazuyuki Sugahara, Shuji Mizumoto, Nikos Karamanos, 2008, Connective tissue research.

The unusual tetrasaccharide sequence GlcAβ-3GalNAc(4-sulfate)(β1–4GlcA(2-sulfate)β1–3GalNAc(6-sulfate) found in the hexasaccharides prepared by testicular hyaluronidase digestion of shark cartilage chondroitin sulfate D

K. Sugahara, S. Nadanaka, 1997 .

EXTL2, a Member of the EXT Family of Tumor Suppressors, Controls Glycosaminoglycan Biosynthesis in a Xylose Kinase-dependent Manner*

H. Kitagawa, M. Asano, Kazuyuki Sugahara, 2013, The Journal of Biological Chemistry.

Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells

N. Iwasaki, Shuji Mizumoto, T. Funakoshi, 2014, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines

Duriya Fongmoon, Shuji Mizumoto, K. Sugahara, 2013, Glycoconjugate Journal.

Potential therapeutic application of chondroitin sulfate/dermatan sulfate.

Shuhei Yamada, Kazuyuki Sugahara, S. Yamada, 2008, Current drug discovery technologies.

Specificities of Three Distinct Human Chondroitin/Dermatan N-Acetylgalactosamine 4-O-Sulfotransferases Demonstrated Using Partially Desulfated Dermatan Sulfate as an Acceptor

H. Kitagawa, Shuji Mizumoto, T. Mikami, 2003, Journal of Biological Chemistry.

Oversulfated Chondroitin/Dermatan Sulfates Containing GlcAβ1/IdoAα1–3GalNAc(4,6-O-disulfate) Interact with L- and P-selectin and Chemokines*

Shuhei Yamada, M. Miyasaka, Kazuyuki Sugahara, 2002, The Journal of Biological Chemistry.

Structural and Functional Characterization of Oversulfated Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from the Notochord of Hagfish

Nobuyuki Itoh, Mitsuhiro Ohta, N. Itoh, 2004, Journal of Biological Chemistry.

Characteristic Hexasaccharide Sequences in Octasaccharides Derived from Shark Cartilage Chondroitin Sulfate D with a Neurite Outgrowth Promoting Activity*

A. Faissner, K. Sugahara, S. Nadanaka, 1998, The Journal of Biological Chemistry.

Roles of glycosaminoglycans and glycanmimetics in tumor progression and metastasis

Basappa, K. Rangappa, K. Sugahara, 2014, Glycoconjugate Journal.

Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives

Basappa, G. Sethi, K. Rangappa, 2012, BMC chemical biology.

Anti-Tumor Activity of a Novel HS-Mimetic-Vascular Endothelial Growth Factor Binding Small Molecule

P. Houghton, K. N. Thimmaiah, K. Rangappa, 2012, PloS one.

Receptor for Advanced Glycation End Products (RAGE) Functions as Receptor for Specific Sulfated Glycosaminoglycans, and Anti-RAGE Antibody or Sulfated Glycosaminoglycans Delivered in Vivo Inhibit Pulmonary Metastasis of Tumor Cells*

Kazuyuki Sugahara, Shuji Mizumoto, Jun Takahashi, 2012, The Journal of Biological Chemistry.

A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-α.

Basappa, C. Kavitha, K. Rangappa, 2010, Cancer letters.

Novel sulfated octa- and decasaccharides from squid cartilage chondroitin sulfate E: sequencing and application for determination of the epitope structure of the monoclonal antibody MO-225.

P. Kongtawelert, S. Yamada, T. Mikami, 2007, Biochemistry.

Biosynthesis of Heparin and Heparan Sulfate

H. Kitagawa, Shuji Mizumoto, K. Sugahara, 2005 .

De Novo Mutations in SLC35A2 Encoding a UDP‐Galactose Transporter Cause Early‐Onset Epileptic Encephalopathy

Y. Wada, N. Matsumoto, Y. Maegaki, 2013, Human mutation.

Composition of Perineuronal Net Extracellular Matrix in Rat Brain

J. Fawcett, C. Galtrey, D. Carulli, 2006, Journal of Biological Chemistry.

C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans.

H. Kitagawa, P. Okkema, Kazuyuki Sugahara, 2006, Developmental biology.

A Novel Eliminase from a Marine Bacterium That Degrades Hyaluronan and Chondroitin Sulfate*

Wenjun Han, Fuchuan Li, K. Sugahara, 2014, The Journal of Biological Chemistry.

Chondroitin Sulfate Bacterium That Degrades Hyaluronan and A Novel Eliminase from a Marine

E. Matrices, Wenjun Han, Fuchuan Li, 2014 .

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis

H. Kitagawa, U. Lindahl, T. Lind, 2000, EMBO reports.

Neuritogenic Activity of Chondroitin/Dermatan Sulfate Hybrid Chains of Embryonic Pig Brain and Their Mimicry from Shark Liver

Fuchuan Li, Kazuyuki Sugahara, Fuchuan Li, 2007, Journal of Biological Chemistry.

Identification of the reaction products of the purified hyaluronidase from stonefish (Synanceja horrida) venom.

C. H. Poh, H. Khoo, K. Sugahara, 1992, The Biochemical journal.

Molecular Cloning and Expression of a Second Chondroitin N-Acetylgalactosaminyltransferase Involved in the Initiation and Elongation of Chondroitin/Dermatan Sulfate*

H. Kitagawa, T. Uyama, K. Sugahara, 2003, The Journal of Biological Chemistry.

Mass preparation of oligosaccharides by the hydrolysis of chondroitin sulfate polysaccharides with a subcritical water microreaction system.

S. Yamada, K. Sugahara, H. Ura, 2013, Carbohydrate research.

Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons

A. Faissner, K. Sugahara, A. Clement, 1999, Neuroscience Letters.

The DSD-1 Carbohydrate Epitope Depends on Sulfation, Correlates with Chondroitin Sulfate D Motifs, and Is Sufficient to Promote Neurite Outgrowth*

A. Faissner, C. Mandl, K. Sugahara, 1998, The Journal of Biological Chemistry.

Demonstration of glycosaminoglycans in Caenorhabditis elegans

H. Kitagawa, D. H. van den Eijnden, I. van Die, 1999, FEBS letters.

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica

S. Mundlos, C. Ott, U. Kornak, 2018, PLoS genetics.

Proteoglycans and Glycosaminoglycans Improve Toughness of Biocompatible Double Network Hydrogels

Jian Ping Gong, Takayuki Kurokawa, Kazunori Yasuda, 2014, Advanced materials.

Novel 70-kDa Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains with a Unique Heterogenous Sulfation Pattern from Shark Skin, Which Exhibit Neuritogenic Activity and Binding Activities for Growth Factors and Neurotrophic Factors*

Nobuyuki Itoh, N. Itoh, C. Nandini, 2005, Journal of Biological Chemistry.

CSGALNACT1‐congenital disorder of glycosylation: A mild skeletal dysplasia with advanced bone age

N. Katsanis, M. McDonald, G. Povysil, 2019, Human mutation.

Substrate specificity studies of Flavobacterium chondroitinase C and heparitinases towards the glycosaminoglycan--protein linkage region. Use of a sensitive analytical method developed by chromophore-labeling of linkage glycoserines using dimethylaminoazobenzenesulfonyl chloride.

K. Yoshida, S. Yamada, K. Morikawa, 1999, European journal of biochemistry.

Expression of Multiple Chondroitin/Dermatan Sulfotransferases in the Neurogenic Regions of the Embryonic and Adult Central Nervous System Implies That Complex Chondroitin Sulfates Have a Role in Neural Stem Cell Maintenance

A. Faissner, A. von Holst, K. Akita, 2008, Stem cells.

Essential Roles of 3′-Phosphoadenosine 5′-Phoshosulfate Synthase in Embryonic and Larval Development of the Nematode Caenorhabditis elegans*

H. Kitagawa, K. Gengyo-Ando, S. Mitani, 2006, Journal of Biological Chemistry.

2-O-Phosphorylation of Xylose and 6-O-Sulfation of Galactose in the Protein Linkage Region of Glycosaminoglycans Influence the Glucuronyltransferase-I Activity Involved in the Linkage Region Synthesis*

H. Kitagawa, L. Pedersen, M. Negishi, 2008, Journal of Biological Chemistry.

Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus.

Eunmi Kim, Takashi Kimura, Yasuo Suzuki, 2011, Biochemical and biophysical research communications.

Structure of Pleiotrophin- and Hepatocyte Growth Factor-binding Sulfated Hexasaccharide Determined by Biochemical and Computational Approaches*

Toshikazu Nakamura, Fuchuan Li, C. Nandini, 2010, The Journal of Biological Chemistry.

Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex

L. Roncali, F. Girolamo, M. Mucignat, 2009, Journal of cellular and molecular medicine.

Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin‐binding neuroregulatory factors

Shuhei Yamada, J. Shioi, N. Robakis, 2004, FEBS letters.

Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor

V. Megalooikonomou, N. Kieffer, E. Papadimitriou, 2015, Molecular Cancer.

Oversulfated Dermatan Sulfate Exhibits Neurite Outgrowth-promoting Activity toward Embryonic Mouse Hippocampal Neurons

A. Faissner, T. Mikami, K. Sugahara, 2003, Journal of Biological Chemistry.

Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis

H. Kitagawa, U. Lindahl, Toshiyuki Saito, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization.

H. Kitagawa, K. Sugahara, Y. Tone, 2001, The Biochemical journal.

Preparation of a series of sulfated tetrasaccharides from shark cartilage chondroitin sulfate D using testicular hyaluronidase and structure determination by 500 MHz1H NMR spectroscopy

S. Yamada, K. Sugahara, Yukako Tanaka, 1996, Glycoconjugate Journal.

Impairment of Embryonic Cell Division and Glycosaminoglycan Biosynthesis in Glucuronyltransferase-I-deficient Mice*

H. Kitagawa, M. Sakano, Yukiko Watamoto, 2010, The Journal of Biological Chemistry.

Expression of rib-1, a Caenorhabditis elegans Homolog of the Human Tumor Suppressor EXT Genes, Is Indispensable for Heparan Sulfate Synthesis and Embryonic Morphogenesis*

H. Kitagawa, K. Gengyo-Ando, S. Mitani, 2007, Journal of Biological Chemistry.

Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans

H. Kitagawa, K. Gengyo-Ando, S. Mitani, 2003, Nature.

Functional expression and genomic structure of human chondroitin 6-sulfotransferase.

H. Kitagawa, K. Sugahara, K. Tsutsumi, 1998, FEBS letters.

Faulty initiation of proteoglycan synthesis causes cardiac and joint defects.

D. Seelow, D. Horn, S. Mundlos, 2011, American journal of human genetics.

Chondroitin Sulfate “Wobble Motifs” Modulate Maintenance and Differentiation of Neural Stem Cells and Their Progeny*

A. Purushothaman, A. Faissner, K. Sugahara, 2011, The Journal of Biological Chemistry.

Heterogeneity of the Chondroitin Sulfate Portion of Phosphacan/6B4 Proteoglycan Regulates Its Binding Affinity for Pleiotrophin/Heparin Binding Growth-associated Molecule*

Nobuaki Maeda, Kazuyuki Sugahara, Tadahisa Mikami, 2003, Journal of Biological Chemistry.

Specificity studies of bacterial sulfatases by means of structurally defined sulfated oligosaccharides isolated from shark cartilage chondroitin sulfate D.

K. Sugahara, T. Kojima, Takeshi Kojima, 1996, European journal of biochemistry.

Microanalysis of glycosaminoglycan-derived oligosaccharides labeled with a fluorophore 2-aminobenzamide by high-performance liquid chromatography: application to disaccharide composition analysis and exosequencing of oligosaccharides.

A Kinoshita, K Sugahara, K. Sugahara, 1999, Analytical biochemistry.

Demonstration of the immature glycosaminoglycan tetrasaccharide sequence GlcAbeta1-3Galbeta1-3Galbeta1-4Xyl on recombinant soluble human alpha-thrombomodulin. An oligosaccharide structure on a "part-time" proteoglycan.

H. Kitagawa, K. Sugahara, S. Nadanaka, 1998, The Journal of biological chemistry.

The sulphated carbohydrate-protein linkage region isolated from chondroitin 4-sulphate chains of inter-alpha-trypsin inhibitor in human plasma.

K. Khoo, A. Dell, H. Morris, 1995, Glycobiology.

Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence.

H. Kitagawa, K. Sugahara, H. Sakaguchi, 2000, Biochimica et biophysica acta.

A sulfated glycosaminoglycan array for molecular interactions between glycosaminoglycans and growth factors or anti-glycosaminoglycan antibodies.

P. Kongtawelert, P. Pothacharoen, W. Takada, 2013, Analytical biochemistry.

Specific interaction of the envelope glycoproteins E1 and E2 with liver heparan sulfate involved in the tissue tropismatic infection by hepatitis C virus

Y. Matsuura, Chikako Kataoka, S. Taguwa, 2012, Glycoconjugate Journal.

Important role of heparan sulfate in postnatal islet growth and insulin secretion.

A. Sugawara, N. Noguchi, S. Takasawa, 2009, Biochemical and biophysical research communications.

T. Hardingham, P. Kongtawelert, P. Pothacharoen, 2007, Journal of Biological Chemistry.

In Vitro Heparan Sulfate Polymerization

H. Kitagawa, K. Sugahara, J. Tamura, 2003, Journal of Biological Chemistry.

Instructions for use Title Expression of N-Acetylgalactosamine 4-Sulfate 6O-Sulfotransferase Involved in Chondroitin Sulfate Synthesis

Shuji Mizumoto, S. Yamada, K. Sugahara, 2019 .

Expression of N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase Involved in Chondroitin Sulfate Synthesis Is Responsible for Pulmonary Metastasis

Shuji Mizumoto, S. Yamada, K. Sugahara, 2013, BioMed research international.

Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria

Fuchuan Li, K. Sugahara, Shumin Wang, 2016, Glycoconjugate Journal.

Chondroitin 6‐sulphate synthesis is up‐regulated in injured CNS, induced by injury‐related cytokines and enhanced in axon‐growth inhibitory glia

H. M. Geller, J. Fawcett, T. V. van Kuppevelt, 2005, The European journal of neuroscience.

In Vitro Heparan Sulfate Polymerization CRUCIAL ROLES OF CORE PROTEIN MOIETIES OF PRIMER SUBSTRATES IN ADDITION TO THE EXT1-EXT2 INTERACTION*

H. Kitagawa, K. Sugahara, J. Tamura, 2003 .

rib-2, a Caenorhabditis elegansHomolog of the Human Tumor Suppressor EXT Genes Encodes a Novel α1,4-N-Acetylglucosaminyltransferase Involved in the Biosynthetic Initiation and Elongation of Heparan Sulfate*

H. Kitagawa, U. Lindahl, K. Sugahara, 2001, The Journal of Biological Chemistry.

Crystal Structure of an α1,4-N-Acetylhexosaminyltransferase (EXTL2), a Member of the Exostosin Gene Family Involved in Heparan Sulfate Biosynthesis*

Fumiyasu Taniguchi, Jian Dong, L. Pedersen, 2003, The Journal of Biological Chemistry.

Demonstration of a Novel Gene DEXT3 ofDrosophila melanogaster as the EssentialN-Acetylglucosamine Transferase in the Heparan Sulfate Biosynthesis

H. Kitagawa, U. Lindahl, K. Sugahara, 2002, The Journal of Biological Chemistry.

Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3

F. Rüschendorf, C. Becker, P. Nürnberg, 2015, Human Genetics.

Mutations in B3GALT6, which encodes a glycosaminoglycan linker region enzyme, cause a spectrum of skeletal and connective tissue disorders.

D. Chitayat, N. Matsumoto, Hironori Ito, 2013, American journal of human genetics.

Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype*

A. Purushothaman, R. Sanderson, C. Pisano, 2011, The Journal of Biological Chemistry.

Correction: Anti-Tumor Activity of a Novel HS-Mimetic-Vascular Endothelial Growth Factor Binding Small Molecule

P. Houghton, K. N. Thimmaiah, K. Rangappa, 2012, PLoS ONE.

Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture

P. Kongtawelert, P. Pothacharoen, Shuji Mizumoto, 2013, Glycoconjugate Journal.

A novel pentasaccharide sequence GlcA(3-sulfate)(beta1-3)GalNAc(4-sulfate)(beta1-4)(Fuc alpha1-3)GlcA(beta1-3)GalNAc(4-sulfate) in the oligosaccharides isolated from king crab cartilage chondroitin sulfate K and its differential susceptibility to chondroitinases and hyaluronidase.

H. Kitagawa, A. Dell, H. Morris, 1997, Biochemistry.

Glycosaminoglycans and Glycomimetics in the Central Nervous System

J. Kwok, K. Sugahara, D. Rowlands, 2015, Molecules.

A Functional Dermatan Sulfate Epitope Containing Iduronate(2-O-sulfate)α1–3GalNAc(6-O-sulfate) Disaccharide in the Mouse Brain

K. Sugahara, M. S. Pavão, Xingfeng Bao, 2005, Journal of Biological Chemistry.

Assessment of glycosaminoglycan-protein linkage tetrasaccharides as acceptors for GalNAc- and GlcNAc-transferases from mouse mastocytoma

H. Kitagawa, U. Lindahl, K. Sugahara, 1997, Glycoconjugate Journal.

Conformational studies on five octasaccharides isolated from chondroitin sulfate using NMR spectroscopy and molecular modeling.

Basappa, Anne Imberty, Johannis P Kamerling, 2007, Biochemistry.

Detection and characterization of UDP-GalNAc: chondroitin N-acetylgalactosaminyltransferase in bovine serum using a simple assay method.

H. Kitagawa, K. Sugahara, K. Tsuchida, 1995, Journal of biochemistry.

Chondroitin 4-O-Sulfotransferase-1 Regulates E Disaccharide Expression of Chondroitin Sulfate Required for Herpes Simplex Virus Infectivity*

H. Kitagawa, T. Bergström, T. Uyama, 2006, Journal of Biological Chemistry.

Carbohydrate ( N -Acetylgalactosamine 4- O ) Sulfotransferase 14 (CHST14)

T. Kosho, Shuji Mizumoto, K. Sugahara, 2014 .

Involvement of Human Natural Killer-1 (HNK-1) Sulfotransferase in the Biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl Tetrasaccharide Found in α-Thrombomodulin from Human Urine*

Shuji Mizumoto, S. Yamada, K. Sugahara, 2011, The Journal of Biological Chemistry.

Overexpression of Galnt3 in Chondrocytes Resulted in Dwarfism Due to the Increase of Mucin-type O-Glycans and Reduction of Glycosaminoglycans*

K. Yamana, C. Yoshida, T. Komori, 2014, The Journal of Biological Chemistry.

Synthesis of the glycosaminoglycan-protein linkage tetraosyl peptide moieties of betaglycan, which serve as a hexosamine acceptor for enzymatic glycosyl transfer.

Shuji Mizumoto, K. Sugahara, J. Tamura, 2010, Carbohydrate research.

A Novel Eliminase from a Marine Bacterium That Degrades Hyaluronan and Chondroitin Sulfate*

Wenjun Han, Fuchuan Li, K. Sugahara, 2014, The Journal of Biological Chemistry.

Instructions for use

Shuji Mizumoto, S. Yamada, K. Sugahara, 2022 .

Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish.

H. Kitagawa, Hajime Yamauchi, N. Itoh, 2009, The Biochemical journal.

The Biological Importance of Specific Sulfation of Chondroitin Sulfate/Dermatan Sulfate in Their Functional Expression

T. Mikami, K. Sugahara, 2006 .

Human Genetic Disorders Caused by Mutations in Genes Encoding Biosynthetic Enzymes for Sulfated Glycosaminoglycans*

S. Ikegawa, Shuji Mizumoto, K. Sugahara, 2013, The Journal of Biological Chemistry.

Structure and Function of Oversulfated Chondroitin Sulfate Variants: Unique Sulfation Patterns and Neuroregulatory Activities

K. Sugahara, 2009 .

De Novo Mutations in SLC35A2 Encoding a UDP‐Galactose Transporter Cause Early‐Onset Epileptic Encephalopathy

Y. Wada, N. Matsumoto, Y. Maegaki, 2013, Human mutation.

Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage.

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Clinical and Radiographic Features of the Autosomal Recessive form of Brachyolmia Caused by PAPSS2 Mutations

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