G. Tian

发表

Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines*

B. Greenberg, Xiaodong Liu, C. Birr, 2002, The Journal of Biological Chemistry.

Mechanism of γ-secretase cleavage activation: Is γ-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Clay W Scott, B. Greenberg, C. Scott, 2004 .

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Clay W Scott, B. Greenberg, C. Scott, 2004, Biochemistry.

Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies.

S. Frye, R. Mook, M. Moss, 1995, Biochemistry.

Inhibition of human steroid 5alpha reductases type I and II by 6-aza-steroids: structural determinants of one-step vs two-step mechanism.

J. D. Stuart, S. Frye, P. Kuzmič, 1996 .

Inhibition of human steroid 5alpha reductases type I and II by 6-aza-steroids: structural determinants of one-step vs two-step mechanism.

J. D. Stuart, S. Frye, P. Kuzmič, 1996, Biochemistry.

The Mechanism of γ-Secretase

B. Greenberg, Xiaodong Liu, D. Aharony, 2003, Journal of Biological Chemistry.

Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.

Clay W Scott, S. Geschwindner, N. Dekker, 2016, Bioorganic & medicinal chemistry letters.

In Vivo Time-Dependent Inhibition of Human Steroid 5a-Reductase by Finasteride

G. Tian, 1996 .

Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

J. Briand, S. Thrall, W. Rumsey, 2022, Scientific Reports.

Linear Relationships between the Ligand Binding Energy and the Activation Energy of Time-dependent Inhibition of Steroid 5α-Reductase by Δ1-4-Azasteroids*

C. Haffner, G. Tian, 2001, The Journal of Biological Chemistry.

17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase 1.

J. D. Stuart, T. Kost, R. Mook, 1994, Biochemistry.

Chemical Mechanism of the Covalent Modification of 5.alpha.-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

K. Facchine, Shiang-yuan Chen, G. Tian, 1995 .

New Probes of Oxygen Binding and Activation: Application to Dopamine β-Monooxygenase

J. Klinman, J. Berry, G. Tian, 1992 .

Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1.

C. Alhambra, J. Albert, D. Wilkins, 2010, Bioorganic & medicinal chemistry letters.

Oxygen isotope effect on activated bleomycin stability

K. Drlica, R. Burger, G. Tian, 1995 .

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.

Gianni Chessari, Mark Sylvester, Rutger H A Folmer, 2007, Journal of medicinal chemistry.

Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor

P. Bonaventure, T. Lovenberg, P. Connolly, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Discrimination between 16O and 18O in oxygen binding to the reversible oxygen carriers hemoglobin, myoglobin, hemerythrin, and hemocyanin: a new probe for oxygen binding and reductive activation by proteins

J. Klinman, G. Tian, 1993 .

Oxygen-18 kinetic isotope effects in the dopamine beta-monooxygenase reaction: evidence for a new chemical mechanism in non-heme metallomonooxygenases.

J. Klinman, J. Berry, G. Tian, 1994, Biochemistry.

Modulation of cyclin-dependent kinase 4 by binding of magnesium (II) and manganese (II).

W. Holmes, S. T. Davis, G. Tian, 2002, Biophysical chemistry.

Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1.

C. Alhambra, W. Frietze, J. Albert, 2018, Bioorganic & medicinal chemistry letters.

6-Azasteroids: Potent Dual Inhibitors of Human Type 1 and 2 Steroid 5. alpha.-Reductase.

M. K. James, S. Frye, T. Tippin, 1994 .

Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.

Shefali R Patel, K. Bachman, V. Pande, 2021, Journal of medicinal chemistry.

Biological Regulation by Protein Phosphorylation

Clay W Scott, R. Bhat, C. Scott, 2006 .

Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines.

G. Tian, M. Cory, A. A. Smith, 2001, Biochemistry.

Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

J. Briand, S. Thrall, W. Rumsey, 2022, Scientific Reports.

Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency.

Clay W Scott, C. Scott, G. Tian, 2011, Biochemistry.

Potent Phenylpyridine and Oxodihydrofuran Inhibitors of Cyclooxygenase-2: Optimization toward a Long Residence Time with Balanced Internal Energetics.

P. Connolly, Zhuming Zhang, Kay Ahn, 2021, Biochemistry.

Oxygen-18 kinetic isotope effect studies of the tyrosine hydroxylase reaction: Evidence of rate limiting oxygen activation

J. Klinman, G. Tian, W. A. Francisco, 1998 .

Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase.

Clay W Scott, Xiao Hong Yu, P. Edwards, 2011, European journal of pharmacology.

The Mechanism of -Secretase MULTIPLE INHIBITOR BINDING SITES FOR TRANSITION STATE ANALOGS AND SMALL MOLECULE INHIBITORS*

B. Greenberg, D. Aharony, G. Tian, 2003 .

Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities.

W. Rocque, W. Holmes, W. C. Clay, 1997, Biochemistry.

Effective rate constants and general isotope effect equations for steady state enzymatic reactions with multiple isotope-sensitive steps☆

G. Tian, 1992 .