Yusuke Tominari

发表

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-Butyl Ester)*

T. Iwatsubo, C. Sato, T. Kan, 2006, Journal of Biological Chemistry.

Parallel synthesis of DAPT derivatives and their γ-secretase-inhibitory activity

T. Iwatsubo, T. Kan, T. Tomita, 2004 .

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.

T. Iwatsubo, T. Kan, T. Tomita, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.

H. Oki, S. Iwasaki, S. Morimoto, 2022, European journal of medicinal chemistry.

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups.

T. Iwatsubo, T. Kan, T. Tomita, 2003, Chemical communications.

Ligand-induced genetic degradation as a tool for target validation.

Masato T. Kanemaki, Yusuke Tominari, Aisha Yesbolatova, 2019, Drug discovery today. Technologies.

The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice

Ken-ichiro Hayashi, Y. Saga, Haruki Takeuchi, 2020, Nature Communications.

Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation*

T. Iwatsubo, T. Kan, T. Tomita, 2003, The Journal of Biological Chemistry.

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.

T. Iwatsubo, T. Kan, T. Tomita, 2003, The Journal of biological chemistry.

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

M. Okaniwa, M. Yabuki, Terufumi Takagi, 2017, PloS one.