H. Natsugari

发表

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-Butyl Ester)*

T. Iwatsubo, C. Sato, T. Kan, 2006, Journal of Biological Chemistry.

Parallel synthesis of DAPT derivatives and their γ-secretase-inhibitory activity

T. Iwatsubo, T. Kan, T. Tomita, 2004 .

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.

T. Iwatsubo, T. Kan, T. Tomita, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of new Galβ1→4Fuc segments useful for biological investigations.

Kazusa Nishiyama, Hideyo Takahashi, K. Kasai, 2011, Chemical & pharmaceutical bulletin.

Synthesis of fluorescence-labeled Galbeta1-3Fuc and Galbeta1-4Fuc as probes for the endogenous glyco-epitope recognized by galectins in Caenorhabditis elegans.

Kazusa Nishiyama, Hideyo Takahashi, K. Kasai, 2010, Chemical & pharmaceutical bulletin.

Caenorhabditis elegans galectins LEC-6 and LEC-1 recognize a chemically synthesized Galbeta1-4Fuc disaccharide unit which is present in Protostomia glycoconjugates.

Kazusa Nishiyama, Hideyo Takahashi, K. Kasai, 2009, Glycobiology.

Atropisomerism observed in indometacin derivatives.

Hideyo Takahashi, Keizō Inoue, H. Natsugari, 2011, Organic letters.

Atropisomerism in the vaptan class of vasopressin receptor ligands: the active conformation recognized by the receptor.

Hideyo Takahashi, H. Natsugari, T. Oshitari, 2011, Angewandte Chemie.

Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.

Hideyo Takahashi, Yoshiki Miyata, H. Natsugari, 2013, Bioorganic & medicinal chemistry letters.

Caenorhabditis elegans proteins captured by immobilized Galβ1-4Fuc disaccharide units: assignment of 3 annexins.

Kazusa Nishiyama, Hideyo Takahashi, K. Kasai, 2011, Carbohydrate research.

Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane.

S. Kawakami, M. Hashida, F. Yamashita, 2015, International journal of pharmaceutics.

The DC2.3 gene in Caenorhabditis elegans encodes a galectin that recognizes the galactoseβ1→4fucose disaccharide unit.

Kazusa Nishiyama, Hideyo Takahashi, K. Kasai, 2011, Biological & pharmaceutical bulletin.

Stereochemistry of N-Benzoyl-5-substituted-1-benzazepines Revisited: Synthesis of the Conformationally Biased Derivatives and Revision of the Reported Structure.

S. Ito, Hideyo Takahashi, H. Natsugari, 2016, The Journal of organic chemistry.

Synthetic studies on antascomicin A: construction of the C18–C34 fragment

H. Fuwa, Yu Okamura, H. Natsugari, 2004 .

Synthetic studies on 3-arylquinazolin-4-ones: intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines

H. Fuwa, Toshitake Kobayashi, H. Natsugari, 2005 .

In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line.

Hideyo Takahashi, Yoshiki Miyata, H. Natsugari, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis

S. Ogawa, T. Iwatsubo, M. Kurokawa, 2007, Pigment cell & melanoma research.

Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.

Hideyo Takahashi, Yoshiki Miyata, H. Natsugari, 2011, Bioorganic & medicinal chemistry letters.

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups.

T. Iwatsubo, T. Kan, T. Tomita, 2003, Chemical communications.

B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.

Hideyo Takahashi, Yoshiki Miyata, H. Natsugari, 2011, Bioorganic & medicinal chemistry.

Dual antitumor mechanisms of Notch signaling inhibitor in a T‐cell acute lymphoblastic leukemia xenograft model

S. Ogawa, T. Iwatsubo, K. Mitsumori, 2009, Cancer science.

Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo.

H. Natsugari, Y. Ikeura, N. Inatomi, 2001, The Journal of pharmacology and experimental therapeutics.

Effects of TAK-637, a tachykinin receptor antagonist, on the micturition reflex in guinea pigs.

I. Kamo, H. Natsugari, S. Okanishi, 2000, European journal of pharmacology.

Atropodiastereoselective 5N-Acylation of 1,5-Benzodiazepin-2-ones with (S)-2-Phenylpropanoyl and (S)-2-Phenylbutanoyl Chlorides.

H. Natsugari, T. Oshitari, H. Tabata, 2022, The Journal of organic chemistry.

Active conformation of seven-membered-ring benzolactams as new ACAT inhibitors: latent chirality at N5 in the 1,5-benzodiazepin-2-one nucleus.

Hideyo Takahashi, Yuko Takada, Tomohiro Miike, 2012, Chemistry.

Stereochemistry of 1,5-benzothiazepin-4-one S-oxide: insight into the stereogenic elements at the sulfur atom and axis.

Hideyo Takahashi, H. Natsugari, T. Yoneda, 2013, The Journal of organic chemistry.

Isolation and characterization of atropisomers of seven-membered-ring benzolactams.

Hideyo Takahashi, Yuko Takada, H. Natsugari, 2011, The Journal of organic chemistry.

Atropisomeric properties of the dibenzo[b,d]azepin-6-one nucleus.

Hideyo Takahashi, Shoukou Lee, H. Natsugari, 2008, Organic letters.

Amide-based atropisomers in tachykinin NK1-receptor antagonists: synthesis and antagonistic activity of axially chiral N-benzylcarboxamide derivatives of 2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocin-6-one

Y. Ishichi, H. Natsugari, Y. Ikeura, 2004 .

Axially chiral 1,7-naphthyridine-6-carboxamide derivatives as orally active tachykinin NK(1) receptor antagonists: synthesis, antagonistic activity, and effects on bladder functions.

A. Fujishima, T. Doi, M. Kawada, 1999, Journal of medicinal chemistry.

N-benzoyl-1,5-benzothiazepine and its S-oxide as vasopressin receptor ligands: insight into the active stereochemistry around the seven-membered ring.

Hideyo Takahashi, H. Natsugari, T. Yoneda, 2015, Journal of medicinal chemistry.

Atropisomeric Properties of N-Acyl/N-Sulfonyl 5H-Dibenzo[b,d]azepin-7(6H)-ones

Hideyo Takahashi, H. Natsugari, T. Oshitari, 2021, The Journal of organic chemistry.

Elucidation of the Active Conformation of Antiproliferative Sulfonamides, 5N-Arylsulfonyl-1,5-benzodiazepin-2-ones.

Hideyo Takahashi, H. Natsugari, K. Funaki, 2019, The Journal of organic chemistry.

Catalytic asymmetric S-oxidation of N-benzoyl-1,5-benzothiazepines

Hideyo Takahashi, H. Natsugari, T. Yoneda, 2017 .

Stereochemical properties of N-benzoylated carbazole derivatives

Hideyo Takahashi, H. Natsugari, T. Oshitari, 2015 .

N-benzoyl- and N-sulfonyl-1,5-benzodiazepines: comparison of their atropisomeric and conformational properties.

Hideyo Takahashi, H. Natsugari, T. Yoneda, 2014, The Journal of organic chemistry.

A complete gear system in N-benzoyl-carbazole derivatives.

Hideyo Takahashi, H. Natsugari, T. Oshitari, 2014, Organic letters.

Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1, 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists: determination of the absolute stereochemical requirements.

A. Fujishima, T. Doi, M. Kawada, 1998, Journal of medicinal chemistry.

ENANTIOSELECTIVE SYNTHESIS OF AN AXIALLY CHIRAL 1,7-NAPHTHYRIDINE-6-CARBOXAMIDE DERIVATIVE HAVING POTENT ANTAGONIST ACTIVITY AT THE NK1 RECEPTOR

A. Fujishima, T. Doi, H. Natsugari, 1998 .

Axial chirality and affinity at the GABA(A) receptor of pyrimido[1,2-a][1,4]benzodiazepines and related compounds.

Hideyo Takahashi, Shoukou Lee, M. Shiro, 2008, Bioorganic & medicinal chemistry.

Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

T. Iwatsubo, T. Kan, T. Tomita, 2004 .

Novel, potent, and orally active substance P antagonists: synthesis and antagonist activity of N-benzylcarboxamide derivatives of pyrido[3,4-b]pyridine.

T. Doi, I. Kamo, Y. Ishichi, 1995, Journal of medicinal chemistry.

Stereoselective synthesis of sperabillins and related compounds

H. Natsugari, S. Hashiguchi, Akira Kawada, 1991 .

Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors.

T. Iwatsubo, T. Kan, T. Tomita, 2007, ACS chemical biology.

Synthesis and structure-activity relationships of carbapenems related to C-19393 H2.

H. Natsugari, Y. Matsushita, K. Okonogi, 1983, The Journal of antibiotics.

Synthesis of 5,6-cis-carbapenems related to C-19393 H2

H. Natsugari, Y. Matsushita, N. Tamura, 1983 .

Synthesis and antimicrobial activity of sperabillin derivatives.

S. Tsubotani, S. Harada, H. Natsugari, 1993, The Journal of antibiotics.

Polyacrylamide-based Functional Polymer-immobilized Perruthenate for Aerobic Alcohol Oxidation

Hideyo Takahashi, S. Ikegami, H. Hamamoto, 2007 .

Microbial synthesis of three metabolites of a tachykinin receptor antagonist, TAK-637.

H. Natsugari, Y. Ikeura, K. Nakahama, 2001, Journal of bioscience and bioengineering.

Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.

Yasuko Takahashi, Takeshi Iwatsubo, Makoto Sasaki, 2006, Bioorganic & medicinal chemistry letters.

Stereocontrolled synthesis of unsaturated vicinal diamines from Diels-Alder adducts of sulfur dioxide bis (imides)

S. Weinreb, H. Natsugari, R. Whittle, 1984 .

STEREOCONTROLLED SYNTHESIS OF UNSATURATED VICINAL DIAMINES FROM DIELS-ALDER ADDUCTS OF SULFUR DIOXIDE BIS(IMIDES)

S. Weinreb, H. Natsugari, R. Whittle, 1985 .

Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B2 Catalyst Under Visible Light Irradiation

H. Natsugari, T. Oshitari, H. Tabata, 2022, Pharmaceutical Research.

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Yasuko Takahashi, Takeshi Iwatsubo, Tohru Fukuyama, 2006 .

Rapid Photoracemization of Chiral Alkyl Aryl Sulfoxides

A. Inagaki, Yuki Tanaka, H. Natsugari, 2021, The Journal of organic chemistry.

Microbial synthesis of a deuterium-labelled metabolite of an NK1 receptor antagonist, TAK-637

H. Natsugari, Y. Ikeura, K. Nakahama, 2001 .

Structural basis of preferential binding of fucose-containing saccharide by the Caenorhabditis elegans galectin LEC-6.

Kazusa Nishiyama, Hideyo Takahashi, S. Wakatsuki, 2013, Glycobiology.

Effects of TAK-637, a tachykinin receptor antagonist, on lower urinary tract function in the guinea pig.

I. Kamo, H. Natsugari, S. Okanishi, 1999, European journal of pharmacology.

Diastereoselective synthesis of atropisomeric 3-(2-substituted aryl)quinazolin-4-ones and their stereochemical properties

Hideyo Takahashi, Tohru Inoue, S. Yokoshima, 2006 .

In Vivo Effects of Notch Signaling Inhibitor on Tumor Growth and Its Mechanism of Action.

S. Ogawa, T. Iwatsubo, M. Kurokawa, 2006 .

Axial chirality and affinity at the GABAA receptor of triazolobenzodiazepines.

H. Natsugari, T. Oshitari, H. Tabata, 2022, Bioorganic & medicinal chemistry.

Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation*

T. Iwatsubo, T. Kan, T. Tomita, 2003, The Journal of Biological Chemistry.

β-galactosidases from jack bean and Streptococcus have different cleaving abilities towards fucose-containing sugars.

Kazusa Nishiyama, Hideyo Takahashi, K. Kasai, 2011, Biological & pharmaceutical bulletin.

Incompatibility between Meropenem Injection and Amino Acid Infusions caused by L-Cysteine

Hideyo Takahashi, Machiko Watanabe, C. Kudo, 2013 .

Design and Synthesis of DDR1 Inhibitors with a Desired Pharmacophore Using Deep Generative Models

M. Neya, Yasunobu Asawa, A. Yoshimori, 2020, ChemMedChem.

Leaching of the plasticizer, acetyl tributyl citrate: (ATBC) from plastic kitchen wrap.

Kazusa Nishiyama, Hideyo Takahashi, K. Nara, 2009 .

Synthesis of γ-lactam analogues of carbapenems with substituted-thio groups at the C-3 position

H. Natsugari, S. Hashiguchi, M. Ochiai, 1988 .

Synthesis of γ-Lactam Analogues of Carbapenems with Substituted Thio Groups at the C-3 Position.

H. Natsugari, S. Hashiguchi, M. Ochiai, 1988 .

Elucidation of the E-Amide Preference of N-Acyl Azoles.

Hideyo Takahashi, S. Inagaki, T. Ohwada, 2017, Journal of Organic Chemistry.

4-Substituted carbamazepine derivatives: Conformational analysis and sodium channel-blocking properties.

Hideyo Takahashi, T. Yoshinaga, H. Natsugari, 2018, Bioorganic & medicinal chemistry.

Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active Form.

Hideyo Takahashi, H. Natsugari, T. Yoneda, 2017, Journal of medicinal chemistry.

Isolation of Atropisomers of N-Benzoylated Pyrroles and Imidazoles

Hideyo Takahashi, H. Natsugari, T. Oshitari, 2015, Synthesis.

Conformation and atropisomeric properties of indometacin derivatives.

Hideyo Takahashi, I. Azumaya, Takeyuki Tanaka, 2013, Chemistry.

Conversion of Racemic Alkyl Aryl Sulfoxides into Pure Enantiomers Using a Recycle Photoreactor: Tandem Use of Chromatography on Chiral Support and Photoracemization on Solid Support

A. Inagaki, Yuki Tanaka, H. Natsugari, 2023, The Journal of organic chemistry.

Mammalian galectins bind galactoseβ1-4fucose disaccharide, a unique structural component of protostomial N-type glycoproteins.

J. Hirabayashi, Kazusa Nishiyama, Hideyo Takahashi, 2013, Biochemical and biophysical research communications.

Preparation of a polyclonal antibody that recognizes a unique galactoseβ1-4fucose disaccharide epitope.

Kazusa Nishiyama, Hideyo Takahashi, S. Nishihara, 2015, Carbohydrate research.

Purification of galectin-1 mutants using an immobilized Galactoseβ1-4Fucose affinity adsorbent.

Kazusa Nishiyama, Hideyo Takahashi, H. Natsugari, 2015, Protein expression and purification.

Sugar-binding properties of the two lectin domains of LEC-1 with respect to the Galβ1-4Fuc disaccharide unit present in protostomia glycoconjugates.

Kazusa Nishiyama, Hideyo Takahashi, K. Kasai, 2011, Biological & pharmaceutical bulletin.

Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent acyl-CoA: cholesterol acyltransferase inhibitors.

H. Natsugari, E. Ishikawa, K. Meguro, 1995, Chemical & pharmaceutical bulletin.

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.

T. Iwatsubo, T. Kan, T. Tomita, 2006, Bioorganic & Medicinal Chemistry Letters.

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.

T. Iwatsubo, T. Kan, T. Tomita, 2003, The Journal of biological chemistry.

Atropisomeric properties of 7-, 8-, and 9-membered-ring dibenzolactams: conformation, thermal stability, and chemical reactivity.

Hideyo Takahashi, H. Natsugari, H. Tabata, 2010, The Journal of organic chemistry.

Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones

H. Natsugari, T. Oshitari, H. Tabata, 2023, Molecules.

Atropisomeric Properties of N-Alkyl/Aryl 5H-Dibenz[b,f]azepines.

H. Natsugari, T. Oshitari, H. Tabata, 2022, Chemical & pharmaceutical bulletin.

Atropisomeric Properties of 9-Methyl-1,4-benzodiazepin-2-ones

H. Natsugari, T. Oshitari, H. Tabata, 2021, Synthesis.

Freezing the Butterfly Motion of Carbamazepine Derivatives

Hideyo Takahashi, H. Natsugari, T. Oshitari, 2015, Synthesis.

Atropisomeric and Conformational Properties of 6N-Benzoyl- and 6N-p-Tosyl-1,6-Benzodiazocines: Comparison with Those of 1,5-Benzodiazepines

Hideyo Takahashi, H. Natsugari, K. Funaki, 2019, HETEROCYCLES.

Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device.

K. Sakaguchi, F. Sugawara, Yuki Matsumoto, 2009, Bioorganic & medicinal chemistry.

Heterocycles. XIV. Reactions of 2-amino-5-phenyl-1,4-benzodiazepines and 2-amino-6-phenyl-1,5-benzodiazocines with diketene.

H. Natsugari, K. Meguro, Y. Kuwada, 1979 .

Heterocycles. XII. Synthesis of 2-amino-5-phenyl-1,4-benzodiazepine 1-oxides and 2-amino-6-phenyl-1,5-benzodiazocine 1-oxides and their reactions with acylating agents.

H. Natsugari, K. Meguro, Y. Kuwada, 1979 .

Heterocycles. X. Synthesis and Reactions of 1, 4, 5-Benzotriazocinium Salts

H. Natsugari, K. Meguro, Y. Kuwada, 1979 .

Atropisomerism in the 2,3,4,5-Tetrahydro-1H-1,5-benzodiazepine Nucleus: Effects of Central Chirality at C3 on the N-Mesylation Reaction

Hideyo Takahashi, H. Natsugari, T. Yoneda, 2018, Synlett.

HETEROCYCLES PART 4, REACTIONS OF 2-AMINO-3H-1,4-BENZODIAZEPINES WITH PRIMARY AMINES AND HYDROXYLAMINES

H. Natsugari, K. Meguro, H. Tawada, 1974 .

Synthesis of lactivicin and its derivatives

H. Natsugari, A. Morimoto, Y. Kawano, 1987 .

Synthesis of Lactivicin and Its Derivatives.

H. Natsugari, A. Morimoto, Y. Kawano, 1987 .

Potent NK1 receptor antagonists: synthesis and antagonistic activity of various heterocycles with an N-[3,5-bis(trifluoromethyl)benzyl]-N-methylcarbamoyl substituent.

T. Doi, S. Morimoto, M. Ogino, 1997, Chemical & pharmaceutical bulletin.

Mammalian galectins bind galactoseβ1-4fucose disaccharide, a unique structural component of protostomial N-type glycoproteins.

J. Hirabayashi, Kazusa Nishiyama, Hideyo Takahashi, 2013, Biochemical and biophysical research communications.

Caenorhabditis elegans proteins captured by immobilized Galβ1-4Fuc disaccharide units: assignment of 3 annexins.

Kazusa Nishiyama, Hideyo Takahashi, K. Kasai, 2011, Carbohydrate research.