Masako Sasaki

发表

Design and synthesis of a monocyclic derivative as a selective ACC1 inhibitor by chemical modification of biphenyl ACC1/2 dual inhibitors.

D. Tomita, Hiroyuki Sumi, R. Mizojiri, 2021, Bioorganic & medicinal chemistry.

Design and synthesis of a novel 1H-pyrrolo[3,2-b]pyridine-3-carboxamide derivative as an orally available ACC1 inhibitor.

Moriteru Asano, Hiroyuki Sumi, R. Mizojiri, 2019, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity

H. Oki, Masanori Watanabe, Sachiko Itono, 2022, Journal of medicinal chemistry.

Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model

D. Erion, Masanori Watanabe, S. Iwasaki, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase.

Ming-Rong Zhang, J. Maeda, Yuji Nagai, 2019, Journal of medicinal chemistry.

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.

R. Nishigaki, T. Miyazaki, Naoki Tomita, 2017, Bioorganic & medicinal chemistry.

Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.

A. Mizukami, Y. Nakano, N. Amano, 2012, Bioorganic & medicinal chemistry letters.

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.

J. Yano, K. Aertgeerts, K. Takeuchi, 2011, Bioorganic & medicinal chemistry.

Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792

T. Kawamoto, Masanori Watanabe, Y. Moritoh, 2019, Pharmacology research & perspectives.

Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.

J. Yano, K. Aertgeerts, K. Takeuchi, 2011, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors.

A. Mizukami, N. Amano, K. Fukatsu, 2012, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety.

L. Qin, S. Gay, D. Dougan, 2021, Journal of medicinal chemistry.

Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors.

M. Fushimi, S. Sogabe, Kazunobu Aoyama, 2018, Journal of medicinal chemistry.

In vitro and in vivo antitumor activities of T‐3764518, a novel and orally available small molecule stearoyl‐CoA desaturase 1 inhibitor

Ikuo Miyahisa, Hiroyuki Sumi, Kazunobu Aoyama, 2017, European journal of pharmacology.

Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors.

H. Banno, D. Tomita, Moriteru Asano, 2018, Journal of medicinal chemistry.

The identification and pharmacological evaluation of potent, selective and orally available ACC1 inhibitor.

Moriteru Asano, Hiroyuki Sumi, R. Mizojiri, 2019, Bioorganic & medicinal chemistry letters.

Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model S

D. Erion, Kazunobu Aoyama, H. Yashiro, 2021 .

Corrigendum to “Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554” [Bioorg. Med. Chem. 19 (2011) 4482–4498]

J. Yano, K. Aertgeerts, K. Takeuchi, 2011 .

Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.

J. Yano, K. Aertgeerts, K. Takeuchi, 2011, Journal of medicinal chemistry.