S. Tsai

发表

Fatty acid biosynthesis in actinomycetes.

H. Gramajo, A. Arabolaza, L. Diacovich, 2011, FEMS microbiology reviews.

Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity.

C. Khosla, H. Gramajo, L. Diacovich, 2004, Biochemistry.

A fine balancing act of type III polyketide synthase.

S. Tsai, 2004, Chemistry & biology.

X-ray Crystallographic Structure of an Artificial β-Sheet Dimer

D. Eisenberg, M. Sawaya, J. Nowick, 2010, Journal of the American Chemical Society.

Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases.

Andrew J. Schaub, R. Luo, Shiji Zhao, 2019, Methods in enzymology.

Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC.

J. C. Milligan, Avinash B. Patel, J. Crosby, 2017, ACS chemical biology.

Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis.

Andrew J. Schaub, R. Luo, R. Müller, 2016, ACS chemical biology.

Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization.

Hung‐wen Liu, S. Tsai, Peter W. Smith, 2008, Biochemistry.

Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases.

R. Stroud, D. Cane, C. Khosla, 2002, Biochemistry.

Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis.

Pierre Baldi, S Joshua Swamidass, S. Joshua Swamidass, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Determinants of Activity and Specificity in Actinorhodin Type II Polyketide

Crosby, M. Burkart, M. Crump, 2014 .

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis

J. Vederas, Yi Tang, J. W. Li, 2012, Proceedings of the National Academy of Sciences.

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

Jason W. Labonte, C. Townsend, J. Crawford, 2010, Proceedings of the National Academy of Sciences.

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

Jason W. Labonte, C. Townsend, J. Crawford, 2009, Nature.

The type I fatty acid and polyketide synthases: a tale of two megasynthases.

Shiou-Chuan Tsai, Stuart Smith, Stuart Smith, 2007, Natural product reports.

Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase.

Chaitan Khosla, Robert M Stroud, Anang A Shelat, 2003, Structure.

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

L. Miercke, J. Krucinski, R. Stroud, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Biosynthesis of a 3,6-dideoxyhexose: crystallization and X-ray diffraction of CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase (E1) for ascarylose biosynthesis.

Hung‐wen Liu, S. Tsai, Peter W. Smith, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase.

J. C. Milligan, R. Luo, J. Crosby, 2018, Journal of the American Chemical Society.

A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes.

C. Vanderwal, S. Tsai, Ryan A. Kozlowski, 2017, Angewandte Chemie.

Stereospecific Ligand Substitutions in Manganese(I) Complexes

Shiuh-Tzung Liu, L. Yiin, S. Tsai, 1995 .

Engineered Biosynthesis of a Novel Amidated Polyketide, Using the Malonamyl-Specific Initiation Module from the Oxytetracycline Polyketide Synthase

Wenjun Zhang, Yi Tang, S. Tsai, 2006, Applied and Environmental Microbiology.

Synthesis of 2,6‐Disubstituted Fluorenones

Shiuh-Tzung Liu, S. Tsai, Shiuh‐Tzung Liu, 1991 .

Study of the effects on coordination of thioether sites. 1. Complexation study of bromopentacarbonylmanganese(I) with tripodal P3-nSn (n = 0-3) ligands

S. Peng, Shiuh-Tzung Liu, L. Yiin, 1993 .

Development of a Pantetheine Force Field Library for Molecular Modeling

Ray Luo, Shiou-Chuan Tsai, Shiji Zhao, 2021, J. Chem. Inf. Model..

Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides

Thanh Vu, Wenjun Zhang, Shiou-Chuan Tsai, 2008, Proceedings of the National Academy of Sciences.

The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases.

S. Tsai, 2018, Annual review of biochemistry.

Polyketide chain length control by chain length factor.

Shiou-Chuan Tsai, Yi Tang, Chaitan Khosla, 2003, Journal of the American Chemical Society.

Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases

C. Townsend, J. L. La Clair, M. Burkart, 2017, Proceedings of the National Academy of Sciences.

Structural basis for chain release from the enacyloxin polyketide synthase

V. Fülöp, G. Challis, Simone Kosol, 2019, Nature Chemistry.

Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

J. Mccammon, P. Markwick, S. Opella, 2013, Nature.

The Alga Ochromonas danica Produces Bromosulfolipids.

B. Duggan, C. Vanderwal, S. Tsai, 2016, Organic letters.

De novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: a cautionary note.

J. Klinman, S. Tsai, 2003, Bioorganic chemistry.

Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities.

C. Khosla, Abhirup Das, S. Tsai, 2011, Biochemistry.

The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase.

M. Burkart, T. Korman, J. Crosby, 2013, Chemistry & biology.

ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria.

D. Kurth, Ting-Wan Lin, H. Gramajo, 2009, Microbiology.

2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase .

Yate-Ching Yuan, Y. Yen, Bingsen Zhou, 2009, Biochemistry.

Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI.

Ming-Yue Lee, S. Tsai, B. Ames, 2012, Biochemistry.

Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway.

C. Moody, Ming-Yue Lee, Wenjun Zhang, 2011, Biochemistry.

Structural Enzymology of Polyketide Synthase: The Structure–Sequence–Function Correlation

T. Korman, S. Tsai, B. Ames, 2010 .

Structural enzymology of polyketide synthases.

Brian Douglas Ames, Shiou-Chuan Sheryl Tsai, S. Tsai, 2009, Methods in enzymology.

Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase.

J. Wong, Yu-Hong Tan, R. Luo, 2008, Biochemistry.

Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.

J. Rohr, Hung‐wen Liu, E. Sasaki, 2016, ACS chemical biology.

Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases

Hung‐wen Liu, E. Sasaki, Avinash B. Patel, 2015, Proceedings of the National Academy of Sciences.

Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase.

T. Korman, Gaurav Shakya, S. Tsai, 2011, Biochemistry.

Structural Analysis of Actinorhodin Polyketide Ketoreductase: Cofactor Binding and Substrate Specificity

Shiou-Chuan Tsai, T. Korman, Tyler Paz Korman, 2004, Biochemistry.

Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers.

C. Townsend, Nathan Mih, M. Burkart, 2013, Chemistry and Biology.

Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis.

R. Stroud, C. Khosla, Kenji Watanabe, 2003, Journal of molecular biology.

Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.

Ana Arabolaza, Hugo Gramajo, Ting-Wan Lin, 2010, Biochemistry.

Biochemical and Structural Characterization of an Essential Acyl Coenzyme A Carboxylase from Mycobacterium tuberculosis

D. Kurth, H. Gramajo, L. Diacovich, 2006, Journal of bacteriology.

Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain.

C. Townsend, J. Meier, M. Burkart, 2016, Angewandte Chemie.

Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA.

M. Burkart, C. Nguyen, S. Tsai, 2015, Chemistry & biology.

Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway.

Chaitan Khosla, Robert M Stroud, L. Miercke, 2002, Structure.

The Type I Fatty Acid and Polyketide Synthases: A Tale of Two Megasynthases

Shiou-Chuan Tsai, Stuart Smith, Stuart Smith, 2008 .

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units

Shunji Takahashi, Hiroyuki Osada, Shiou-Chuan Tsai, 2016, Nature Communications.

Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase.

D. Cane, C. Khosla, Hongxiang Lu, 2002, Biochemistry.

Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures.

J. Klinman, S. Tsai, 2001, Biochemistry.

Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis.

S. Brady, S. Tsai, D. R. Jackson, 2016, ACS chemical biology.

Molecular basis for interactions between an acyl carrier protein and a ketosynthase

Andrew J. Schaub, R. Luo, M. Burkart, 2019, Nature Chemical Biology.

Influence Relevance Voting: An Accurate And Interpretable Virtual High Throughput Screening Method

Pierre Baldi, Sanjay Joshua Swamidass, Chloé-Agathe Azencott, 2009, J. Chem. Inf. Model..

Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols.

Ray Luo, Jay D Keasling, Shiou-Chuan Tsai, 2015, Chemistry & biology.

Modeling Linear and Cyclic PKS Intermediates through Atom Replacement

Andrew J. Schaub, J. L. La Clair, M. Jaremko, 2014, Journal of the American Chemical Society.

Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE)

L. Miercke, J. Krucinski, R. Stroud, 2002 .

Influence Relevance Voting: An Accurate And Interpretable Virtual High Throughput Screening Method

S. Joshua Swamidass, P. Baldi, Chloé-Agathe Azencott, 2009, J. Chem. Inf. Model..

ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria.

D. Kurth, Ting-Wan Lin, H. Gramajo, 2009, Microbiology.

Polyketide Synthase: Sequence, Structure, and Function

M. Burkart, J. Beld, S. Tsai, 2014 .

A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes.

C. Vanderwal, S. Tsai, A. R. White, 2017, Angewandte Chemie.

Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases

Hung‐wen Liu, E. Sasaki, Avinash B. Patel, 2015, Proceedings of the National Academy of Sciences.