J. Sousa

发表

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

D. Caridha, L. Walker, C. Ockenhouse, 2013, Malaria Journal.

An LC–MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model

L. Walker, X. Jin, B. Pybus, 2014, European Journal of Drug Metabolism and Pharmacokinetics.

Ethosuximide and phenytoin dose-dependently attenuate acute nonconvulsive seizures after traumatic brain injury in rats.

F. Tortella, X. Lu, D. Shear, 2013, Journal of neurotrauma.

Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants

R. Paris, Qigui Li, M. Hickman, 2016, Malaria Journal.

Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

B. Tekwani, R. Paris, L. Walker, 2015, Antimicrobial Agents and Chemotherapy.

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

D. Caridha, L. Walker, Q. Zeng, 2014, Malaria Journal.

Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines

W. Milhous, T. Shearer, Kirsten S. Smith, 2008, Drug Metabolism and Disposition.

Improving Relative Bioavailability of Oral Imidazolidinedione by Reducing Particle Size Using Homogenization and Ultra-Sonication.

Q. Zeng, Qigui Li, Chad C. Black, 2019, Military medicine.

Comparison of Anti-Xa Activity in Patients Receiving Apixaban or Rivaroxaban

B. Pybus, S. Marcsisin, J. Sousa, 2018, The Annals of pharmacotherapy.

Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites

D. Caridha, Q. Zeng, Qigui Li, 2017, Malaria research and treatment.

Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs

B. Tekwani, Brice Campo, L. Walker, 2016, Antimicrobial Agents and Chemotherapy.

Evaluation of Blast Overpressure Exposure Effects on Concentration of Antibiotics in Mice.

J. Long, S. Tyner, D. Zurawski, 2020, Military medicine.

An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

P. Waterman, J. Moon, J. Livezey, 2020, Malaria Journal.

An Open Label Study of the Safety and Efficacy of a Single Dose of Weekly Chloroquine and Azithromycin Administered for Malaria Prophylaxis in Healthy Adults Challenged with 7G8 Chloroquine-Resistant Plasmodium falciparum in a Controlled Human Malaria Infection (CHMI) Model

P. Waterman, J. Moon, J. Livezey, 2020 .

Developmental differences in stress responding after repeated underwater trauma exposures in rats

S. Marcsisin, J. Sousa, V. Zottig, 2018, Stress.

Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum.

L. Gerena, D. Caridha, P. Wipf, 2010, Bioorganic & medicinal chemistry letters.

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

Richard J Sciotti, L. Walker, Robert E. Christian, 2012, Malaria Journal.

Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.

John C. Tan, D. Caridha, Q. Zeng, 2019, Journal of medicinal chemistry.

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.

Ping Zhang, Jing Zhang, Lisa Xie, 2014, Journal of pharmacological and toxicological methods.

Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum

S. Norval, K. Read, Q. Zeng, 2011, European Journal of Drug Metabolism and Pharmacokinetics.

Prolonged protection provided by a single dose of atovaquone-proguanil for the chemoprophylaxis of Plasmodium falciparum malaria in a human challenge model.

J. Dumler, A. Magill, Bryan L. Smith, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

D. Caridha, L. Walker, C. Ockenhouse, 2013, Malaria Journal.

CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

B. Tekwani, G. Shanks, B. Pybus, 2013, Malaria Journal.

Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly

J. Rayner, T. Otto, A. Blagborough, 2021, JCI insight.

Controlled human malaria infection with PvW1: a new clone of Plasmodium vivax with high quality genome assembly

J. Rayner, T. Otto, A. Blagborough, 2021, medRxiv.

Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria.

W. Mccarthy, C. Ockenhouse, J. Bennett, 2013, The New England journal of medicine.

Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants

R. Paris, Qigui Li, M. Hickman, 2016, Malaria Journal.

Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

L. Gerena, D. Caridha, P. Wipf, 2010, Malaria Journal.

Saccharomyces boulardii CNCM I-745 probiotic does not alter the pharmacokinetics of amoxicillin

Qigui Li, J. Livezey, Ken Nguyen, 2020, Drug metabolism and personalized therapy.

An LC–MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model

L. Walker, X. Jin, B. Pybus, 2014, European Journal of Drug Metabolism and Pharmacokinetics.

A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

J. Kublin, S. Kappe, Y. Fong, 2018, The Journal of infectious diseases.

Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics

B. Tekwani, R. Paris, L. Walker, 2015, Antimicrobial Agents and Chemotherapy.

Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

N. Waters, W. Mccarthy, Qigui Li, 2019, The Journal of infectious diseases.

Functional and Molecular Correlates after Single and Repeated Rat Closed-Head Concussion: Indices of Vulnerability after Brain Injury.

F. Tortella, A. Yarnell, D. Shear, 2017, Journal of neurotrauma.

Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum.

L. Gerena, D. Caridha, P. Wipf, 2011, Journal of medicinal chemistry.

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.

P. Rosenthal, K. Reynolds, D. Caridha, 2020, Journal of medicinal chemistry.

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

David M. Shackleford, S. Norval, K. Read, 2011, Malaria Journal.

Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy

D. Caridha, Qigui Li, M. Hickman, 2012, European Journal of Drug Metabolism and Pharmacokinetics.

The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models

D. Caridha, Q. Zeng, Qigui Li, 2014, European journal of drug metabolism and pharmacokinetics.

Causal Prophylactic Efficacy of Primaquine, Tafenoquine, and Atovaquone-Proguanil Against Plasmodium cynomolgi in a Rhesus Monkey Model

Jonathan Berman, C. Ohrt, M. Gettayacamin, 2014, The Journal of parasitology.

Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs

B. Tekwani, L. Walker, R. Rochford, 2016, Antimicrobial Agents and Chemotherapy.